Astrocyte-microglia cross talk through complement activation modulates amyloid pathology in mouse models of alzheimer’s disease

Journal of Neuroscience

Volumn 36, Issue 2, 2016, Pages 577-589

  Lian, Hong ^a   Litvinchuk, Alexandra ^a   Chiang, Angie C A ^a   Aithmitti, Nadia ^a   Jankowsky, Joanna L ^a   Zheng, Hui ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer s disease; Amyloid; C3; C3a receptor; Mice; Microglia

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; COMPLEMENT COMPONENT C3A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; COMPLEMENT COMPONENT C3; GLIAL FIBRILLARY ACIDIC PROTEIN; I KAPPA B; PRESENILIN 1; PSEN1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; AMYLOIDOSIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL INTERACTION; COGNITION; COMPLEMENT ACTIVATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE ACTIVATION; GENE DELETION; GENE OVEREXPRESSION; GLIOSIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MICROGLIA; MOUSE; MOUSE MODEL; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PATHOLOGY; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASTROCYTES; CELLS, CULTURED; COMPLEMENT ACTIVATION; COMPLEMENT C3; DISEASE MODELS, ANIMAL; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; I-KAPPA B PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; PHAGOCYTOSIS; PRESENILIN-1; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84954326957     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2117-15.2016     Document Type: Article

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