메뉴 건너뛰기




Volumn 38, Issue 11, 2015, Pages 674-681

Innate Immunity Fights Alzheimer's Disease

Author keywords

Amyloid; Apolipoprotein E; Immunotherapy; Interleukin 10; Microglia; Phagocytosis

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; INTERLEUKIN 10; STAT3 PROTEIN; CYTOKINE;

EID: 84947781432     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2015.08.008     Document Type: Review
Times cited : (95)

References (69)
  • 1
    • 78751653622 scopus 로고    scopus 로고
    • National estimates of the prevalence of Alzheimer's disease in the United States
    • Brookmeyer R., et al. National estimates of the prevalence of Alzheimer's disease in the United States. Alzheimers Dement. 2011, 7:61-73.
    • (2011) Alzheimers Dement. , vol.7 , pp. 61-73
    • Brookmeyer, R.1
  • 2
    • 84923444904 scopus 로고    scopus 로고
    • Innate immunity in Alzheimer's disease
    • Heneka M.T., et al. Innate immunity in Alzheimer's disease. Nat. Immunol. 2015, 16:229-236.
    • (2015) Nat. Immunol. , vol.16 , pp. 229-236
    • Heneka, M.T.1
  • 3
    • 84894090892 scopus 로고    scopus 로고
    • Targeting the β secretase BACE1 for Alzheimer's disease therapy
    • Yan R., Vassar R. Targeting the β secretase BACE1 for Alzheimer's disease therapy. Lancet Neurol. 2014, 13:319-329.
    • (2014) Lancet Neurol. , vol.13 , pp. 319-329
    • Yan, R.1    Vassar, R.2
  • 4
    • 84885172858 scopus 로고    scopus 로고
    • γ-Secretase inhibitors and modulators
    • Golde T.E., et al. γ-Secretase inhibitors and modulators. Biochim. Biophys. Acta 2013, 1828:2898-2907.
    • (2013) Biochim. Biophys. Acta , vol.1828 , pp. 2898-2907
    • Golde, T.E.1
  • 5
    • 78650678688 scopus 로고    scopus 로고
    • Decreased clearance of CNS beta-amyloid in Alzheimer's disease
    • Mawuenyega K.G., et al. Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science 2010, 330:1774.
    • (2010) Science , vol.330 , pp. 1774
    • Mawuenyega, K.G.1
  • 6
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman S.E., et al. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J. Neurosci. 2008, 28:8354-8360.
    • (2008) J. Neurosci. , vol.28 , pp. 8354-8360
    • Hickman, S.E.1
  • 7
    • 79960880118 scopus 로고    scopus 로고
    • Assessing the contribution of inflammation in models of Alzheimer's disease
    • Johnston H., et al. Assessing the contribution of inflammation in models of Alzheimer's disease. Biochem. Soc. Trans. 2011, 39:886-890.
    • (2011) Biochem. Soc. Trans. , vol.39 , pp. 886-890
    • Johnston, H.1
  • 8
    • 84911991625 scopus 로고    scopus 로고
    • Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction
    • Orre M., et al. Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Neurobiology 2014, 35:2746-2760.
    • (2014) Neurobiology , vol.35 , pp. 2746-2760
    • Orre, M.1
  • 9
    • 84926370173 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease
    • Heneka M.T., et al. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015, 14:388-405.
    • (2015) Lancet Neurol. , vol.14 , pp. 388-405
    • Heneka, M.T.1
  • 10
    • 27744464859 scopus 로고    scopus 로고
    • The microglial 'activation' continuum: from innate to adaptive responses
    • Town T., et al. The microglial 'activation' continuum: from innate to adaptive responses. J. Neuroinflamm. 2005, 2:24.
    • (2005) J. Neuroinflamm. , vol.2 , pp. 24
    • Town, T.1
  • 11
    • 84923377359 scopus 로고    scopus 로고
    • Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease
    • Gjoneska E., et al. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease. Nature 2015, 518:365-369.
    • (2015) Nature , vol.518 , pp. 365-369
    • Gjoneska, E.1
  • 12
    • 84897954407 scopus 로고    scopus 로고
    • Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers
    • Reitz C., Mayeux R. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem. Pharmacol. 2014, 88:640-651.
    • (2014) Biochem. Pharmacol. , vol.88 , pp. 640-651
    • Reitz, C.1    Mayeux, R.2
  • 13
    • 84866745289 scopus 로고    scopus 로고
    • Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism
    • 2949.e5-2949.e12
    • Hazrati L-N., et al. Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism. Neurobiol. Aging 2012, 33. 2949.e5-2949.e12.
    • (2012) Neurobiol. Aging , vol.33
    • Hazrati, L.-N.1
  • 14
    • 84878433339 scopus 로고    scopus 로고
    • Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
    • Griciuc A., et al. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 2013, 78:631-643.
    • (2013) Neuron , vol.78 , pp. 631-643
    • Griciuc, A.1
  • 15
    • 84896691913 scopus 로고    scopus 로고
    • Pathways to Alzheimer's disease
    • Hardy J., et al. Pathways to Alzheimer's disease. J. Intern. Med. 2014, 275:296-303.
    • (2014) J. Intern. Med. , vol.275 , pp. 296-303
    • Hardy, J.1
  • 16
    • 84861314593 scopus 로고    scopus 로고
    • Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease
    • Jaturapatporn D., et al. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. Cochrane Database Syst. Rev. 2012, 2:CD006378.
    • (2012) Cochrane Database Syst. Rev. , vol.2 , pp. CD006378
    • Jaturapatporn, D.1
  • 17
    • 77949892665 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and Alzheimer's disease: the epidemiological evidence
    • Szekely C.A., Zandi P.P. Non-steroidal anti-inflammatory drugs and Alzheimer's disease: the epidemiological evidence. CNS Neurol. Disord. Drug Targets 2010, 9:132-139.
    • (2010) CNS Neurol. Disord. Drug Targets , vol.9 , pp. 132-139
    • Szekely, C.A.1    Zandi, P.P.2
  • 18
    • 79960769591 scopus 로고    scopus 로고
    • Extended results of the Alzheimer's disease anti-inflammatory prevention trial
    • Breitner J.C., et al. Extended results of the Alzheimer's disease anti-inflammatory prevention trial. Alzheimers Dement. 2011, 7:402-411.
    • (2011) Alzheimers Dement. , vol.7 , pp. 402-411
    • Breitner, J.C.1
  • 19
    • 80053383308 scopus 로고    scopus 로고
    • Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial
    • Leoutsakos J-M.S., et al. Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial. Int. J. Geriatr. Psychiatry 2012, 27:364-374.
    • (2012) Int. J. Geriatr. Psychiatry , vol.27 , pp. 364-374
    • Leoutsakos, J.-M.S.1
  • 20
    • 84873087532 scopus 로고    scopus 로고
    • NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
    • Heneka M.T., et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 2013, 493:674-678.
    • (2013) Nature , vol.493 , pp. 674-678
    • Heneka, M.T.1
  • 21
    • 77950188666 scopus 로고    scopus 로고
    • Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease
    • Fuhrmann M., et al. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat. Neurosci. 2010, 13:411-413.
    • (2010) Nat. Neurosci. , vol.13 , pp. 411-413
    • Fuhrmann, M.1
  • 22
    • 84870932482 scopus 로고    scopus 로고
    • Inhibition of IL12/IL23 signaling reduces Alzheimer's disease-like pathology and cognitive decline
    • Berg, vom J., et al. Inhibition of IL12/IL23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nat. Med. 2012, 18:1812-1819.
    • (2012) Nat. Med. , vol.18 , pp. 1812-1819
    • Berg1    vom, J.2
  • 23
    • 77957316313 scopus 로고    scopus 로고
    • CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models
    • Lee S., et al. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am. J. Pathol. 2010, 177:2549-2562.
    • (2010) Am. J. Pathol. , vol.177 , pp. 2549-2562
    • Lee, S.1
  • 24
    • 84907015837 scopus 로고    scopus 로고
    • Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway
    • Lee S., et al. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J. Neurosci. 2014, 34:12538-12546.
    • (2014) J. Neurosci. , vol.34 , pp. 12538-12546
    • Lee, S.1
  • 25
    • 84883187048 scopus 로고    scopus 로고
    • BDNF, TNFα, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer's disease or mild cognitive impairment
    • Gezen-Ak D., et al. BDNF, TNFα, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer's disease or mild cognitive impairment. J. Alzheimers Dis. 2013, 37:185-195.
    • (2013) J. Alzheimers Dis. , vol.37 , pp. 185-195
    • Gezen-Ak, D.1
  • 26
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • Akiyama H., et al. Inflammation and Alzheimer's disease. Neurobiol. Aging 2000, 21:383-421.
    • (2000) Neurobiol. Aging , vol.21 , pp. 383-421
    • Akiyama, H.1
  • 27
    • 33846640591 scopus 로고    scopus 로고
    • Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues
    • Weeraratna A.T., et al. Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues. Exp. Cell Res. 2007, 313:450-461.
    • (2007) Exp. Cell Res. , vol.313 , pp. 450-461
    • Weeraratna, A.T.1
  • 28
    • 0030764732 scopus 로고    scopus 로고
    • Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease
    • Wyss-Coray T., et al. Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature 1997, 389:603-606.
    • (1997) Nature , vol.389 , pp. 603-606
    • Wyss-Coray, T.1
  • 29
    • 72849147328 scopus 로고    scopus 로고
    • The combinations of TNFalpha-308 and IL-6-174 or IL-10-1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer's disease
    • Vural P., et al. The combinations of TNFalpha-308 and IL-6-174 or IL-10-1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer's disease. Acta Neurol. Scand. 2009, 120:396-401.
    • (2009) Acta Neurol. Scand. , vol.120 , pp. 396-401
    • Vural, P.1
  • 30
    • 2942755836 scopus 로고    scopus 로고
    • Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease
    • Arosio B., et al. Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease. Neurobiol. Aging 2004, 25:1009-1015.
    • (2004) Neurobiol. Aging , vol.25 , pp. 1009-1015
    • Arosio, B.1
  • 31
    • 0038591699 scopus 로고    scopus 로고
    • Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease
    • Lio D., et al. Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease. Genes Immun. 2003, 4:234-238.
    • (2003) Genes Immun. , vol.4 , pp. 234-238
    • Lio, D.1
  • 32
    • 14644414819 scopus 로고    scopus 로고
    • The association between promoter polymorphism of the interleukin-10 gene and Alzheimer's disease
    • Ma S.L., et al. The association between promoter polymorphism of the interleukin-10 gene and Alzheimer's disease. Neurobiol. Aging 2005, 26:1005-1010.
    • (2005) Neurobiol. Aging , vol.26 , pp. 1005-1010
    • Ma, S.L.1
  • 33
    • 0242417473 scopus 로고    scopus 로고
    • Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease
    • Depboylu C., et al. Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease. Neurosci. Lett. 2003, 342:132-134.
    • (2003) Neurosci. Lett. , vol.342 , pp. 132-134
    • Depboylu, C.1
  • 34
    • 33747203455 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease
    • Ramos E.M., et al. Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease. Arch. Neurol. 2006, 63:1165-1169.
    • (2006) Arch. Neurol. , vol.63 , pp. 1165-1169
    • Ramos, E.M.1
  • 35
    • 1642554417 scopus 로고    scopus 로고
    • Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's disease
    • Scassellati C., et al. Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's disease. Neurosci. Lett. 2004, 356:119-122.
    • (2004) Neurosci. Lett. , vol.356 , pp. 119-122
    • Scassellati, C.1
  • 36
    • 0035728362 scopus 로고    scopus 로고
    • Interleukin-10 in the brain
    • Strle K., et al. Interleukin-10 in the brain. Crit. Rev. Immunol. 2001, 21:427-449.
    • (2001) Crit. Rev. Immunol. , vol.21 , pp. 427-449
    • Strle, K.1
  • 37
    • 84922026428 scopus 로고    scopus 로고
    • Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology
    • Guillot-Sestier M-V., et al. Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology. Neuron 2015, 85:534-548.
    • (2015) Neuron , vol.85 , pp. 534-548
    • Guillot-Sestier, M.-V.1
  • 38
    • 84876907931 scopus 로고    scopus 로고
    • Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease
    • Zhang B., et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell 2013, 153:707-720.
    • (2013) Cell , vol.153 , pp. 707-720
    • Zhang, B.1
  • 39
    • 84937835203 scopus 로고    scopus 로고
    • Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease
    • Li X., et al. Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease. Sci. Rep. 2015, 5:12393.
    • (2015) Sci. Rep. , vol.5 , pp. 12393
    • Li, X.1
  • 40
    • 44949173099 scopus 로고    scopus 로고
    • Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
    • Town T., et al. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat. Med. 2008, 14:681-687.
    • (2008) Nat. Med. , vol.14 , pp. 681-687
    • Town, T.1
  • 41
    • 77956954550 scopus 로고    scopus 로고
    • Macrophages in Alzheimer's disease: the blood-borne identity
    • Gate D., et al. Macrophages in Alzheimer's disease: the blood-borne identity. J. Neural Transm. 2010, 117:961-970.
    • (2010) J. Neural Transm. , vol.117 , pp. 961-970
    • Gate, D.1
  • 42
    • 79954514213 scopus 로고    scopus 로고
    • How to get from here to there: macrophage recruitment in Alzheimer's disease
    • Rezai-Zadeh K., et al. How to get from here to there: macrophage recruitment in Alzheimer's disease. Curr. Alzheimer Res. 2011, 8:156-163.
    • (2011) Curr. Alzheimer Res. , vol.8 , pp. 156-163
    • Rezai-Zadeh, K.1
  • 43
    • 84922064574 scopus 로고    scopus 로고
    • IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior
    • Chakrabarty P., et al. IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior. Neuron 2015, 85:519-533.
    • (2015) Neuron , vol.85 , pp. 519-533
    • Chakrabarty, P.1
  • 44
    • 8144226985 scopus 로고    scopus 로고
    • Interleukin-10 suppression of myeloid cell activation - a continuing puzzle
    • Williams L.M., et al. Interleukin-10 suppression of myeloid cell activation - a continuing puzzle. Immunology 2004, 113:281-292.
    • (2004) Immunology , vol.113 , pp. 281-292
    • Williams, L.M.1
  • 45
    • 33745700364 scopus 로고    scopus 로고
    • Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response
    • Murray P.J. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Curr. Opin. Pharmacol. 2006, 6:379-386.
    • (2006) Curr. Opin. Pharmacol. , vol.6 , pp. 379-386
    • Murray, P.J.1
  • 46
    • 84866555886 scopus 로고    scopus 로고
    • From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines
    • Banchereau J., et al. From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Nat. Immunol. 2012, 13:925-931.
    • (2012) Nat. Immunol. , vol.13 , pp. 925-931
    • Banchereau, J.1
  • 47
    • 84937634728 scopus 로고    scopus 로고
    • The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?
    • Doty K.R., et al. The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?. Brain Res. 2014, 1617:155-173.
    • (2014) Brain Res. , vol.1617 , pp. 155-173
    • Doty, K.R.1
  • 48
    • 77955842718 scopus 로고    scopus 로고
    • Th1 responses to beta-amyloid in young humans convert to regulatory IL-10 responses in Down syndrome and Alzheimer's disease
    • Loewenbrueck K.F., et al. Th1 responses to beta-amyloid in young humans convert to regulatory IL-10 responses in Down syndrome and Alzheimer's disease. Neurobiol. Aging 2010, 31:1732-1742.
    • (2010) Neurobiol. Aging , vol.31 , pp. 1732-1742
    • Loewenbrueck, K.F.1
  • 49
    • 0027474061 scopus 로고
    • Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins
    • Holness C.L., Simmons D.L. Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood 1993, 81:1607-1613.
    • (1993) Blood , vol.81 , pp. 1607-1613
    • Holness, C.L.1    Simmons, D.L.2
  • 51
    • 70449534695 scopus 로고    scopus 로고
    • CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease?
    • Rezai-Zadeh K., et al. CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease?. J. Neuroimm. Pharmacol. 2009, 4:462-475.
    • (2009) J. Neuroimm. Pharmacol. , vol.4 , pp. 462-475
    • Rezai-Zadeh, K.1
  • 52
    • 84863672009 scopus 로고    scopus 로고
    • Microglia in Alzheimer's disease: it's all about context
    • Weitz T.M., Town T. Microglia in Alzheimer's disease: it's all about context. Int. J. Alzheimers Dis. 2012, 2012:314185.
    • (2012) Int. J. Alzheimers Dis. , vol.2012 , pp. 314185
    • Weitz, T.M.1    Town, T.2
  • 53
    • 84872737307 scopus 로고    scopus 로고
    • Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology
    • Lee D.C., et al. Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology. Neuropathol. Appl. Neurobiol. 2013, 39:69-85.
    • (2013) Neuropathol. Appl. Neurobiol. , vol.39 , pp. 69-85
    • Lee, D.C.1
  • 54
    • 84896726518 scopus 로고    scopus 로고
    • ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?
    • Kanekiyo T., et al. ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?. Neuron 2014, 81:740-754.
    • (2014) Neuron , vol.81 , pp. 740-754
    • Kanekiyo, T.1
  • 55
    • 84874334207 scopus 로고    scopus 로고
    • Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples
    • Tai L.M., et al. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. J. Biol. Chem. 2013, 288:5914-5926.
    • (2013) J. Biol. Chem. , vol.288 , pp. 5914-5926
    • Tai, L.M.1
  • 56
    • 0032491512 scopus 로고    scopus 로고
    • Isoform-specific vasoconstriction induced by apolipoprotein E and modulation of this effect by Alzheimer's beta-amyloid peptide
    • Paris D., et al. Isoform-specific vasoconstriction induced by apolipoprotein E and modulation of this effect by Alzheimer's beta-amyloid peptide. Neurosci. Lett. 1998, 256:73-76.
    • (1998) Neurosci. Lett. , vol.256 , pp. 73-76
    • Paris, D.1
  • 57
    • 84902759627 scopus 로고    scopus 로고
    • Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition
    • Rodriguez G.A., et al. Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition. J. Neuroinflamm. 2014, 11:111.
    • (2014) J. Neuroinflamm. , vol.11 , pp. 111
    • Rodriguez, G.A.1
  • 58
    • 84890365334 scopus 로고    scopus 로고
    • Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain
    • 212ra161
    • Hudry E., et al. Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Sci. Transl. Med. 2013, 5:212ra161.
    • (2013) Sci. Transl. Med. , vol.5
    • Hudry, E.1
  • 59
    • 84867797446 scopus 로고    scopus 로고
    • Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide
    • Hashimoto T., et al. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. J. Neurosci. 2012, 32:15181-15192.
    • (2012) J. Neurosci. , vol.32 , pp. 15181-15192
    • Hashimoto, T.1
  • 60
    • 84908032605 scopus 로고    scopus 로고
    • The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation
    • Garai K., et al. The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation. Biochemistry 2014, 53:6323-6331.
    • (2014) Biochemistry , vol.53 , pp. 6323-6331
    • Garai, K.1
  • 61
    • 79955663093 scopus 로고    scopus 로고
    • High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease
    • Cerf E., et al. High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease. FASEB J. 2011, 25:1585-1595.
    • (2011) FASEB J. , vol.25 , pp. 1585-1595
    • Cerf, E.1
  • 62
    • 84927547425 scopus 로고    scopus 로고
    • Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE e2 and e4 targeted replacement Alzheimer model mice
    • Pankiewicz J.E., et al. Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE e2 and e4 targeted replacement Alzheimer model mice. Acta Neuropathol. Commun. 2014, 2:75.
    • (2014) Acta Neuropathol. Commun. , vol.2 , pp. 75
    • Pankiewicz, J.E.1
  • 63
    • 84893736391 scopus 로고    scopus 로고
    • Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro
    • Mulder S.D., et al. Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro. Glia 2014, 62:493-503.
    • (2014) Glia , vol.62 , pp. 493-503
    • Mulder, S.D.1
  • 64
    • 84904678185 scopus 로고    scopus 로고
    • Apolipoprotein E in Alzheimer's disease: an update
    • Yu J-T., et al. Apolipoprotein E in Alzheimer's disease: an update. Annu. Rev. Neurosci. 2014, 37:79-100.
    • (2014) Annu. Rev. Neurosci. , vol.37 , pp. 79-100
    • Yu, J.-T.1
  • 65
    • 84921047621 scopus 로고    scopus 로고
    • Manipulating IL-10 signalling blockade for better immunotherapy
    • Ni G., et al. Manipulating IL-10 signalling blockade for better immunotherapy. Cell. Immunol. 2015, 293:126-129.
    • (2015) Cell. Immunol. , vol.293 , pp. 126-129
    • Ni, G.1
  • 66
    • 84899998947 scopus 로고    scopus 로고
    • STAT3 inhibitors: finding a home in lymphoma and leukemia
    • Munoz J., et al. STAT3 inhibitors: finding a home in lymphoma and leukemia. Oncologist 2014, 19:536-544.
    • (2014) Oncologist , vol.19 , pp. 536-544
    • Munoz, J.1
  • 67
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • Simard A.R., et al. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 2006, 49:489-502.
    • (2006) Neuron , vol.49 , pp. 489-502
    • Simard, A.R.1
  • 68
    • 33645528251 scopus 로고    scopus 로고
    • Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease
    • Simard A.R., Rivest S. Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease. Mol. Psychiatry 2006, 11:327-335.
    • (2006) Mol. Psychiatry , vol.11 , pp. 327-335
    • Simard, A.R.1    Rivest, S.2
  • 69
    • 84930927235 scopus 로고    scopus 로고
    • The therapeutic potential of interleukin-10 in neuroimmune diseases
    • Kwilasz A.J., et al. The therapeutic potential of interleukin-10 in neuroimmune diseases. Neuropharmacology 2014, 96:55-69.
    • (2014) Neuropharmacology , vol.96 , pp. 55-69
    • Kwilasz, A.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.