-
1
-
-
33847662852
-
Soluble protein oligomers in neuroDegeneration: Lessons from the Alzheimers amyloid b-peptiDe
-
C. Haass, D. J. Selkoe, Soluble protein oligomers in neuroDegeneration: Lessons from the Alzheimers amyloid b-peptiDe. Nat. Rev. Mol. Cell Biol. 8, 101-112 (2007)
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
2
-
-
34249860495
-
Small molecule inhibitors of aggregation indicate that amyloid b oligomerization and fibrillization pathways are inDepenDent and distinct
-
M. Necula, R. Kayed, S. Milton, C. G. Glabe, Small molecule inhibitors of aggregation indicate that amyloid b oligomerization and fibrillization pathways are inDepenDent and distinct. J. Biol. Chem. 282, 10311-10324 (2007)
-
(2007)
J. Biol. Chem
, vol.282
, pp. 10311-10324
-
-
Necula, M.1
Kayed, R.2
Milton, S.3
Glabe, C.G.4
-
3
-
-
78751644048
-
Amyloid-b and tau-A toxic pas de deux in alzheimers disease
-
L. M. Ittner, J. Gtz, Amyloid-b and tau-A toxic pas De Deux in Alzheimers disease. Nat. Rev. Neurosci. 12, 65 (2011)
-
(2011)
Nat. Rev. Neurosci
, vol.12
, pp. 65
-
-
Ittner, L.M.1
Gtz, J.2
-
4
-
-
16044373524
-
Secreted amyloid b-protein similar to that in the senile plaques of Alzheimers disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimers disease
-
D. Scheuner, C. Eckman, M. Jensen, X. Song, M. Citron, N. Suzuki, T. D. Bird, J. Hardy, M. Hutton, W. Kukull, E. Larson, E. Levy-Lahad, M. Viitanen, E. Peskind, P. Poorkaj, G. Schellenberg, R. Tanzi, W. Wasco, L. Lannfelt, D. Selkoe, S. Younkin, Secreted amyloid b-protein similar to that in the senile plaques of Alzheimers disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimers disease. Nat. Med. 2, 864-870 (1996)
-
(1996)
Nat. Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
5
-
-
78650678688
-
Decreased clearance of CNS b-amyloid in Alzheimers disease
-
K. G. Mawuenyega, W. Sigurdson, V. Ovod, L. Munsell, T. Kasten, J. C. Morris, K. E. Yarasheski, R. J. Bateman, Decreased clearance of CNS b-amyloid in Alzheimers disease. Science 330, 1774 (2010)
-
(2010)
Science
, vol.330
, pp. 1774
-
-
Mawuenyega, K.G.1
Sigurdson, W.2
Ovod, V.3
Munsell, L.4
Kasten, T.5
Morris, J.C.6
Yarasheski, K.E.7
Bateman, R.J.8
-
6
-
-
77953518555
-
Alzheimers disease: Clinical trials and drug Development
-
F. Mangialasche, A. Solomon, B. Winblad, P. Mecocci, M. Kivipelto, Alzheimers disease: Clinical trials and drug Development. Lancet Neurol. 9, 702-716 (2010)
-
(2010)
Lancet Neurol
, vol.9
, pp. 702-716
-
-
Mangialasche, F.1
Solomon, A.2
Winblad, B.3
Mecocci, P.4
Kivipelto, M.5
-
7
-
-
76849086405
-
The secretases: Enzymes with therapeutic potential in Alzheimer disease
-
B. De Strooper, R. Vassar, T. GolDe, The secretases: Enzymes with therapeutic potential in Alzheimer disease. Nat. Rev. Neurol. 6, 99-107 (2010)
-
(2010)
Nat. Rev. Neurol
, vol.6
, pp. 99-107
-
-
De Strooper, B.1
Vassar, R.2
Golde, T.3
-
8
-
-
76849091134
-
Can Alzheimer disease be prevented by amyloid-b immunotherapy? Nat
-
C. A. Lemere, E. Masliah, Can Alzheimer disease be prevented by amyloid-b immunotherapy? Nat. Rev. Neurol. 6, 108-119 (2010)
-
(2010)
Rev. Neurol
, vol.6
, pp. 108-119
-
-
Lemere, C.A.1
Masliah, E.2
-
9
-
-
84883153834
-
Optimization of the ultrasound-induced blood-brain barrier opening
-
E. E. Konofagou, Optimization of the ultrasound-induced blood-brain barrier opening. Theranostics 2, 1223-1237 (2012)
-
(2012)
Theranostics
, vol.2
, pp. 1223-1237
-
-
Konofagou, E.E.1
-
10
-
-
80053639355
-
Noninvasive and localized neuronal Delivery using short ultrasonic pulses and microbubbles
-
J. J. Choi, K. Selert, F. Vlachos, A. Wong, E. E. Konofagou, Noninvasive and localized neuronal Delivery using short ultrasonic pulses and microbubbles. Proc. Natl. Acad. Sci. U.S.A. 108, 16539-16544 (2011)
-
(2011)
Proc. Natl. Acad. Sci. U.S.A
, vol.108
, pp. 16539-16544
-
-
Choi, J.J.1
Selert, K.2
Vlachos, F.3
Wong, A.4
Konofagou, E.E.5
-
11
-
-
33846438234
-
Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo
-
S. B. Raymond, J. Skoch, K. Hynynen, B. J. Bacskai, Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo. J. Cereb. Blood Flow Metab. 27, 393-403 (2007)
-
(2007)
J. Cereb. Blood Flow Metab
, vol.27
, pp. 393-403
-
-
Raymond, S.B.1
Skoch, J.2
Hynynen, K.3
Bacskai, B.J.4
-
12
-
-
34547638975
-
Direct observations of ultrasound microbubble contrast agent interaction with the microvessel wall
-
C. F. Caskey, S. M. Stieger, S. Qin, P. A. Dayton, K. W. Ferrara, Direct observations of ultrasound microbubble contrast agent interaction with the microvessel wall. J. Acoust. Soc. Am. 122, 1191-1200 (2007)
-
(2007)
J. Acoust. Soc. Am
, vol.122
, pp. 1191-1200
-
-
Caskey, C.F.1
Stieger, S.M.2
Qin, S.3
Dayton, P.A.4
Ferrara, K.W.5
-
13
-
-
84863952172
-
Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: Safety and efficacy evaluation in rhesus macaques
-
N. McDannold, C. D. Arvanitis, N. Vykhodtseva, M. S. Livingstone, Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: Safety and efficacy evaluation in rhesus macaques. Cancer Res. 72, 3652-3663 (2012)
-
(2012)
Cancer Res
, vol.72
, pp. 3652-3663
-
-
McDannold, N.1
Arvanitis, C.D.2
Vykhodtseva, N.3
Livingstone, M.S.4
-
14
-
-
58149265130
-
Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimers double transgenic mice using focused ultrasound
-
J. J. Choi, S. Wang, T. R. Brown, S. A. Small, K. E. Duff, E. E. Konofagou, Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimers double transgenic mice using focused ultrasound. Ultrason. Imaging 30, 189-200 (2008)
-
(2008)
Ultrason. Imaging
, vol.30
, pp. 189-200
-
-
Choi, J.J.1
Wang, S.2
Brown, T.R.3
Small, S.A.4
Duff, K.E.5
Konofagou, E.E.6
-
15
-
-
84876485354
-
MR-guiDed focused ultrasound thalamotomy for essential tremor: A proof-of-concept study
-
N. Lipsman, M. L. Schwartz, Y. Huang, L. Lee, T. Sankar, M. Chapman, K. Hynynen, A. M. Lozano, MR-guiDed focused ultrasound thalamotomy for essential tremor: A proof-of-concept study. Lancet Neurol. 12, 462-468 (2013)
-
(2013)
Lancet Neurol
, vol.12
, pp. 462-468
-
-
Lipsman, N.1
Schwartz, M.L.2
Huang, Y.3
Lee, L.4
Sankar, T.5
Chapman, M.6
Hynynen, K.7
Lozano, A.M.8
-
16
-
-
76649143711
-
Targeted ultrasound-mediated Delivery of nanoparticles: On the Development of a new HIFU-based therapy and imaging Device
-
R. Seip, C. T. Chin, C. S. Hall, B. I. Raju, A. Ghanem, K. Tiemann, Targeted ultrasound-mediated Delivery of nanoparticles: On the Development of a new HIFU-based therapy and imaging Device. IEEE Trans. Biomed. Eng. 57, 61-70 (2010)
-
(2010)
IEEE Trans. Biomed. Eng
, vol.57
, pp. 61-70
-
-
Seip, R.1
Chin, C.T.2
Hall, C.S.3
Raju, B.I.4
Ghanem, A.5
Tiemann, K.6
-
17
-
-
77955322042
-
Dendritic function of tau mediates amyloid-b toxicity in Alzheimers disease mouse moDels
-
L. M. Ittner, Y. D. Ke, F. Delerue, M. Bi, A. Gladbach, J. van Eersel, H. Wlfing, B. C. Chieng, M. J. Christie, I. A. Napier, A. Eckert, M. Staufenbiel, E. HarDeman, J. Gtz, Dendritic function of tau mediates amyloid-b toxicity in Alzheimers disease mouse moDels. Cell 142, 387-397 (2010)
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
Van Eersel, J.6
Wlfing, H.7
Chieng, B.C.8
Christie, M.J.9
Napier, I.A.10
Eckert, A.11
Staufenbiel, M.12
Hardeman, E.13
Gtz, J.14
-
18
-
-
84901779689
-
Genetic modulation of soluble Ab rescues cognitive and synaptic impairment in a mouse moDel of Alzheimers disease
-
S. W. Fowler, A. C. Chiang, R. R. Savjani, M. E. Larson, M. A. Sherman, D. R. Schuler, J. R. Cirrito, S. E. Lesn, J. L. Jankowsky, Genetic modulation of soluble Ab rescues cognitive and synaptic impairment in a mouse moDel of Alzheimers disease. J. Neurosci. 34, 7871-7885 (2014)
-
(2014)
J. Neurosci
, vol.34
, pp. 7871-7885
-
-
Fowler, S.W.1
Chiang, A.C.2
Savjani, R.R.3
Larson, M.E.4
Sherman, M.A.5
Schuler, D.R.6
Cirrito, J.R.7
Lesn, S.E.8
Jankowsky, J.L.9
-
19
-
-
33645038471
-
A specific amyloid-b protein assembly in the brain impairs memory
-
S. Lesn, M. T. Koh, L. Kotilinek, R. Kayed, C. G. Glabe, A. Yang, M. Gallagher, K. H. Ashe, A specific amyloid-b protein assembly in the brain impairs memory. Nature 440, 352-357 (2006)
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesn, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
Gallagher, M.7
Ashe, K.H.8
-
20
-
-
79952775194
-
Robust amyloid clearance in a mouse moDel of Alzheimers disease proviDes novel insights into the mechanism of amyloid-b immunotherapy
-
A. Wang, P. Das, R. C. Switzer 3rd, T. E. GolDe, J. L. Jankowsky, Robust amyloid clearance in a mouse moDel of Alzheimers disease proviDes novel insights into the mechanism of amyloid-b immunotherapy. J. Neurosci. 31, 4124-4136 (2011)
-
(2011)
J. Neurosci
, vol.31
, pp. 4124-4136
-
-
Wang, A.1
Das, P.2
Switzer, R.C.3
Golde, T.E.4
Jankowsky, J.L.5
-
21
-
-
84862816040
-
Passive immunization against pyroglutamate-3 amyloid-b reduces plaque burDen in Alzheimer-like transgenic mice: A pilot study
-
J. L. Frost, B. Liu, M. Kleinschmidt, S. Schilling, H. U. Demuth, C. A. Lemere, Passive immunization against pyroglutamate-3 amyloid-b reduces plaque burDen in Alzheimer-like transgenic mice: A pilot study. NeuroDegener. Dis. 10, 265-270 (2012)
-
(2012)
NeuroDegener. Dis
, vol.10
, pp. 265-270
-
-
Frost, J.L.1
Liu, B.2
Kleinschmidt, M.3
Schilling, S.4
Demuth, H.U.5
Lemere, C.A.6
-
22
-
-
47949132196
-
Active and passive immunotherapy for neuroDegenerative disorDers
-
D. L. Brody, D. M. Holtzman, Active and passive immunotherapy for neuroDegenerative disorDers. Annu. Rev. Neurosci. 31, 175-193 (2008)
-
(2008)
Annu. Rev. Neurosci
, vol.31
, pp. 175-193
-
-
Brody, D.L.1
Holtzman, D.M.2
-
23
-
-
78751692575
-
Anti-ab therapeutics in Alzheimers disease: The need for a paradigm shift
-
T. E. GolDe, L. S. SchneiDer, E. H. Koo, Anti-ab therapeutics in Alzheimers disease: The need for a paradigm shift. Neuron 69, 203-213 (2011)
-
(2011)
Neuron
, vol.69
, pp. 203-213
-
-
Golde, T.E.1
Schneider, L.S.2
Koo, E.H.3
-
24
-
-
84885961431
-
Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Ab Deposition and tau pathology in 3xTg-AD mice
-
S. Rasool, H. Martinez-Coria, J. W. Wu, F. LaFerla, C. G. Glabe, Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Ab Deposition and tau pathology in 3xTg-AD mice. J. Neurochem. 126, 473-482 (2013)
-
(2013)
J. Neurochem
, vol.126
, pp. 473-482
-
-
Rasool, S.1
Martinez-Coria, H.2
Wu, J.W.3
Laferla, F.4
Glabe, C.G.5
-
26
-
-
84893860052
-
Sustained peripheral Depletion of amyloid-b with a novel form of neprilysin does not affect central levels of amyloid-b
-
S. J. HenDerson, C. AnDersson, R. Narwal, J. Janson, T. J. Goldschmidt, P. Appelkvist, A. Bogstedt, A. C. Steffen, U. Haupts, J. Tebbe, P. O. Freskgrd, L. Jermutus, M. Burrell, S. B. Fowler, C. I. Webster, Sustained peripheral Depletion of amyloid-b with a novel form of neprilysin does not affect central levels of amyloid-b. Brain 137, 553-564 (2014)
-
(2014)
Brain
, vol.137
, pp. 553-564
-
-
Henderson, S.J.1
Andersson, C.2
Narwal, R.3
Janson, J.4
Goldschmidt, T.J.5
Appelkvist, P.6
Bogstedt, A.7
Steffen, A.C.8
Haupts, U.9
Tebbe, J.10
Freskgrd, P.O.11
Jermutus, L.12
Burrell, M.13
Fowler, S.B.14
Webster, C.I.15
-
27
-
-
80052032970
-
Clearance of albumin following ultrasound-induced blood-brain barrier opening is mediated by glial but not neuronal cells
-
A. Alonso, E. Reinz, M. Fatar, M. G. Hennerici, S. Meairs, Clearance of albumin following ultrasound-induced blood-brain barrier opening is mediated by glial but not neuronal cells. Brain Res. 1411, 9-16 (2011)
-
(2011)
Brain Res
, vol.1411
, pp. 9-16
-
-
Alonso, A.1
Reinz, E.2
Fatar, M.3
Hennerici, M.G.4
Meairs, S.5
-
28
-
-
84890542927
-
In vitro amyloid-b binding and inhibition of amyloid-b self-association by therapeutic albumin
-
J. Milojevic, M. Costa, A. M. Ortiz, J. I. Jorquera, G. Melacini, In vitro amyloid-b binding and inhibition of amyloid-b self-association by therapeutic albumin. J. Alzheimers Dis. 38, 753-765 (2014)
-
(2014)
J. Alzheimers Dis
, vol.38
, pp. 753-765
-
-
Milojevic, J.1
Costa, M.2
Ortiz, A.M.3
Jorquera, J.I.4
Melacini, G.5
-
29
-
-
84901477538
-
Transcranial cavitation Detection in primates during blood-brain barrier opening-A performance assessment study
-
S. Y. Wu, Y. S. Tung, F. Marquet, M. Downs, C. Sanchez, C. Chen, V. Ferrera, E. Konofagou, Transcranial cavitation Detection in primates during blood-brain barrier opening-a performance assessment study. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 61, 966-978 (2014)
-
(2014)
IEEE Trans. Ultrason. Ferroelectr. Freq. Control
, vol.61
, pp. 966-978
-
-
Wu, S.Y.1
Tung, Y.S.2
Marquet, F.3
Downs, M.4
Sanchez, C.5
Chen, C.6
Ferrera, V.7
Konofagou, E.8
-
30
-
-
70349807619
-
Immune activation in brain aging and neuroDegeneration: Too much or too little?
-
K. M. Lucin, T. Wyss-Coray, Immune activation in brain aging and neuroDegeneration: Too much or too little? Neuron 64, 110-122 (2009)
-
(2009)
Neuron
, vol.64
, pp. 110-122
-
-
Lucin, K.M.1
Wyss-Coray, T.2
-
31
-
-
33746851261
-
Noninvasive localized Delivery of Herceptin to the mouse brain by MRI-guiDed focused ultrasound-induced bloodbrain barrier disruption
-
M. Kinoshita, N. McDannold, F. A. Jolesz, K. Hynynen, Noninvasive localized Delivery of Herceptin to the mouse brain by MRI-guiDed focused ultrasound-induced bloodbrain barrier disruption. Proc. Natl. Acad. Sci. U.S.A. 103, 11719-11723 (2006)
-
(2006)
Proc. Natl. Acad. Sci. U.S.A
, vol.103
, pp. 11719-11723
-
-
Kinoshita, M.1
McDannold, N.2
Jolesz, F.A.3
Hynynen, K.4
-
32
-
-
77956287949
-
Antibodies targeted to the brain with image-guiDed focused ultrasound reduces amyloid-b plaque load in the TgCRND8 mouse moDel of Alzheimers disease
-
J. F. Jordo, C. A. Ayala-Grosso, K. Markham, Y. Huang, R. Chopra, J. McLaurin, K. Hynynen, I. Aubert, Antibodies targeted to the brain with image-guiDed focused ultrasound reduces amyloid-b plaque load in the TgCRND8 mouse moDel of Alzheimers disease. PLOS One 5, e10549 (2010)
-
(2010)
PLOS One
, vol.5
, pp. e10549
-
-
Jordo, J.F.1
Ayala-Grosso, C.A.2
Markham, K.3
Huang, Y.4
Chopra, R.5
McLaurin, J.6
Hynynen, K.7
Aubert, I.8
-
33
-
-
84869002324
-
Targeted Delivery of self-complementary aDeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guiDed focused ultrasound
-
E. Thvenot, J. F. Jordo, M. A. OReilly, K. Markham, Y. Q. Weng, K. D. Foust, B. K. Kaspar, K. Hynynen, I. Aubert, Targeted Delivery of self-complementary aDeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guiDed focused ultrasound. Hum. Gene Ther. 23, 1144-1155 (2012)
-
(2012)
Hum. Gene Ther
, vol.23
, pp. 1144-1155
-
-
Thvenot, E.1
Jordo, J.F.2
Oreilly, M.A.3
Markham, K.4
Weng, Y.Q.5
Foust, K.D.6
Kaspar, B.K.7
Hynynen, K.8
Aubert, I.9
-
34
-
-
84879380571
-
Amyloid-b plaque reduction, endogenous antibody Delivery and glial activation by brain-targeted, transcranial focused ultrasound
-
J. F. Jordo, E. Thvenot, K. Markham-Coultes, T. Scarcelli, Y. Q. Weng, K. Xhima, M. OReilly, Y. Huang, J.McLaurin, K. Hynynen, I. Aubert, Amyloid-b plaque reduction, endogenous antibody Delivery and glial activation by brain-targeted, transcranial focused ultrasound. Exp. Neurol. 248, 16-29 (2013)
-
(2013)
Exp. Neurol
, vol.248
, pp. 16-29
-
-
Jordo, J.F.1
Thvenot, E.2
Markham-Coultes, K.3
Scarcelli, T.4
Weng, Y.Q.5
Xhima, K.6
Oreilly, M.7
Huang, Y.8
McLaurin, J.9
Hynynen, K.10
Aubert, I.11
-
35
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse moDels with Alzheimer diseaselike pathology
-
C. Sturchler-Pierrat, D. Abramowski, M. Duke, K. H.WieDerhold, C.Mistl, S. Rothacher, B. LeDermann, K. Brki, P. Frey, P. A. Paganetti, C. WariDel, M. E. Calhoun, M. Jucker, A. Probst, M. Staufenbiel, B. Sommer, Two amyloid precursor protein transgenic mouse moDels with Alzheimer diseaselike pathology. Proc. Natl. Acad. Sci. U.S.A. 94, 13287-13292 (1997)
-
(1997)
Proc. Natl. Acad. Sci. U.S.A
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.H.4
Mistl, C.5
Rothacher, S.6
Ledermann, B.7
Brki, K.8
Frey, P.9
Paganetti, P.A.10
Waridel, C.11
Calhoun, M.E.12
Jucker, M.13
Probst, A.14
Staufenbiel, M.15
Sommer, B.16
-
36
-
-
0037172826
-
Phases of Ab-Deposition in the human brain and its relevance for the Development of AD
-
D. R. Thal, U. Rb, M. Orantes, H. Braak, Phases of Ab-Deposition in the human brain and its relevance for the Development of AD. Neurology 58, 1791-1800 (2002)
-
(2002)
Neurology
, vol.58
, pp. 1791-1800
-
-
Thal, D.R.1
Rb, U.2
Orantes, M.3
Braak, H.4
-
37
-
-
84872149088
-
A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion
-
H. W. Morrison, J. A. Filosa, A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion. J. Neuroinflammation 10, 4 (2013)
-
(2013)
J. Neuroinflammation
, vol.10
, pp. 4
-
-
Morrison, H.W.1
Filosa, J.A.2
|