-
1
-
-
84879091429
-
Sox2 requirement in sonic hedgehog-associated medulloblastoma
-
Ahlfeld, J., Favaro, R., Pagella, P., Kretzschmar, H.A., Nicolis, S., Schuller, U., Sox2 requirement in sonic hedgehog-associated medulloblastoma. Cancer Res. 73 (2013), 3796–3807.
-
(2013)
Cancer Res.
, vol.73
, pp. 3796-3807
-
-
Ahlfeld, J.1
Favaro, R.2
Pagella, P.3
Kretzschmar, H.A.4
Nicolis, S.5
Schuller, U.6
-
2
-
-
84887512714
-
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
-
Amakye, D., Jagani, Z., Dorsch, M., Unraveling the therapeutic potential of the Hedgehog pathway in cancer. Nat. Med. 19 (2013), 1410–1422.
-
(2013)
Nat. Med.
, vol.19
, pp. 1410-1422
-
-
Amakye, D.1
Jagani, Z.2
Dorsch, M.3
-
3
-
-
84951326093
-
Smoothened regulation: a tale of two signals
-
Arensdorf, A.M., Marada, S., Ogden, S.K., Smoothened regulation: a tale of two signals. Trends Pharmacol. Sci. 37 (2016), 62–72.
-
(2016)
Trends Pharmacol. Sci.
, vol.37
, pp. 62-72
-
-
Arensdorf, A.M.1
Marada, S.2
Ogden, S.K.3
-
4
-
-
84874359079
-
GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas
-
Atwood, S.X., Li, M., Lee, A., Tang, J.Y., Oro, A.E., GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas. Nature 494 (2013), 484–488.
-
(2013)
Nature
, vol.494
, pp. 484-488
-
-
Atwood, S.X.1
Li, M.2
Lee, A.3
Tang, J.Y.4
Oro, A.E.5
-
5
-
-
84924242647
-
Smoothened variants explain the majority of drug resistance in basal cell carcinoma
-
Atwood, S.X., Sarin, K.Y., Whitson, R.J., Li, J.R., Kim, G., Rezaee, M., Ally, M.S., Kim, J., Yao, C., Chang, A.L., et al. Smoothened variants explain the majority of drug resistance in basal cell carcinoma. Cancer Cell 27 (2015), 342–353.
-
(2015)
Cancer Cell
, vol.27
, pp. 342-353
-
-
Atwood, S.X.1
Sarin, K.Y.2
Whitson, R.J.3
Li, J.R.4
Kim, G.5
Rezaee, M.6
Ally, M.S.7
Kim, J.8
Yao, C.9
Chang, A.L.10
-
6
-
-
84896714612
-
BET bromodomain inhibition of MYC-amplified medulloblastoma
-
Bandopadhayay, P., Bergthold, G., Nguyen, B., Schubert, S., Gholamin, S., Tang, Y., Bolin, S., Schumacher, S.E., Zeid, R., Masoud, S., et al. BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin. Cancer Res. 20 (2014), 912–925.
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 912-925
-
-
Bandopadhayay, P.1
Bergthold, G.2
Nguyen, B.3
Schubert, S.4
Gholamin, S.5
Tang, Y.6
Bolin, S.7
Schumacher, S.E.8
Zeid, R.9
Masoud, S.10
-
7
-
-
77955420936
-
Learning from Jekyll to control Hyde: hedgehog signaling in development and cancer
-
Barakat, M.T., Humke, E.W., Scott, M.P., Learning from Jekyll to control Hyde: hedgehog signaling in development and cancer. Trends Mol. Med. 16 (2010), 337–348.
-
(2010)
Trends Mol. Med.
, vol.16
, pp. 337-348
-
-
Barakat, M.T.1
Humke, E.W.2
Scott, M.P.3
-
8
-
-
84930274867
-
Vismodegib in patients with advanced basal cell carcinoma (STEVIE): a pre-planned interim analysis of an international, open-label trial
-
Basset-Seguin, N., Hauschild, A., Grob, J.-J., Kunstfeld, R., Dréno, B., Mortier, L., Ascierto, P.A., Licitra, L., Dutriaux, C., Thomas, L., et al. Vismodegib in patients with advanced basal cell carcinoma (STEVIE): a pre-planned interim analysis of an international, open-label trial. Lancet Oncol. 16 (2015), 729–736.
-
(2015)
Lancet Oncol.
, vol.16
, pp. 729-736
-
-
Basset-Seguin, N.1
Hauschild, A.2
Grob, J.-J.3
Kunstfeld, R.4
Dréno, B.5
Mortier, L.6
Ascierto, P.A.7
Licitra, L.8
Dutriaux, C.9
Thomas, L.10
-
9
-
-
84895875287
-
Transitioning from genotypes to epigenotypes: why the time has come for medulloblastoma epigenomics
-
Batora, N.V., Sturm, D., Jones, D.T., Kool, M., Pfister, S.M., Northcott, P.A., Transitioning from genotypes to epigenotypes: why the time has come for medulloblastoma epigenomics. Neuroscience 264 (2014), 171–185.
-
(2014)
Neuroscience
, vol.264
, pp. 171-185
-
-
Batora, N.V.1
Sturm, D.2
Jones, D.T.3
Kool, M.4
Pfister, S.M.5
Northcott, P.A.6
-
10
-
-
77956814604
-
Interactions between Hedgehog proteins and their binding partners come into view
-
Beachy, P.A., Hymowitz, S.G., Lazarus, R.A., Leahy, D.J., Siebold, C., Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev. 24 (2010), 2001–2012.
-
(2010)
Genes Dev.
, vol.24
, pp. 2001-2012
-
-
Beachy, P.A.1
Hymowitz, S.G.2
Lazarus, R.A.3
Leahy, D.J.4
Siebold, C.5
-
11
-
-
33747332214
-
Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion
-
Bijlsma, M.F., Spek, C.A., Zivkovic, D., van de Water, S., Rezaee, F., Peppelenbosch, M.P., Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. PLoS Biol., 4, 2006, e232.
-
(2006)
PLoS Biol.
, vol.4
, pp. e232
-
-
Bijlsma, M.F.1
Spek, C.A.2
Zivkovic, D.3
van de Water, S.4
Rezaee, F.5
Peppelenbosch, M.P.6
-
12
-
-
84960145215
-
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma
-
Bonilla, X., Parmentier, L., King, B., Bezrukov, F., Kaya, G., Zoete, V., Seplyarskiy, V.B., Sharpe, H.J., McKee, T., Letourneau, A., et al. Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma. Nat. Genet. 48 (2016), 398–406.
-
(2016)
Nat. Genet.
, vol.48
, pp. 398-406
-
-
Bonilla, X.1
Parmentier, L.2
King, B.3
Bezrukov, F.4
Kaya, G.5
Zoete, V.6
Seplyarskiy, V.B.7
Sharpe, H.J.8
McKee, T.9
Letourneau, A.10
-
13
-
-
84899463037
-
Targeting Gli transcription activation by small molecule suppresses tumor growth
-
Bosco-Clement, G., Zhang, F., Chen, Z., Zhou, H.M., Li, H., Mikami, I., Hirata, T., Yagui-Beltran, A., Lui, N., Do, H.T., et al. Targeting Gli transcription activation by small molecule suppresses tumor growth. Oncogene 33 (2014), 2087–2097.
-
(2014)
Oncogene
, vol.33
, pp. 2087-2097
-
-
Bosco-Clement, G.1
Zhang, F.2
Chen, Z.3
Zhou, H.M.4
Li, H.5
Mikami, I.6
Hirata, T.7
Yagui-Beltran, A.8
Lui, N.9
Do, H.T.10
-
14
-
-
77958060845
-
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma
-
Buonamici, S., Williams, J., Morrissey, M., Wang, A., Guo, R., Vattay, A., Hsiao, K., Yuan, J., Green, J., Ospina, B., et al. Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci. Transl. Med., 2, 2010, 51ra70.
-
(2010)
Sci. Transl. Med.
, vol.2
, pp. 51ra70
-
-
Buonamici, S.1
Williams, J.2
Morrissey, M.3
Wang, A.4
Guo, R.5
Vattay, A.6
Hsiao, K.7
Yuan, J.8
Green, J.9
Ospina, B.10
-
15
-
-
84939469323
-
Modulation of ciliary phosphoinositide content regulates trafficking and sonic hedgehog signaling output
-
Chavez, M., Ena, S., Van Sande, J., de Kerchove d'Exaerde, A., Schurmans, S., Schiffmann, S.N., Modulation of ciliary phosphoinositide content regulates trafficking and sonic hedgehog signaling output. Dev. Cell 34 (2015), 338–350.
-
(2015)
Dev. Cell
, vol.34
, pp. 338-350
-
-
Chavez, M.1
Ena, S.2
Van Sande, J.3
de Kerchove d'Exaerde, A.4
Schurmans, S.5
Schiffmann, S.N.6
-
16
-
-
84873735792
-
Decoding the phosphorylation code in Hedgehog signal transduction
-
Chen, Y., Jiang, J., Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res. 23 (2013), 186–200.
-
(2013)
Cell Res.
, vol.23
, pp. 186-200
-
-
Chen, Y.1
Jiang, J.2
-
17
-
-
0030297553
-
Dual roles for patched in sequestering and transducing hedgehog
-
Chen, Y., Struhl, G., Dual roles for patched in sequestering and transducing hedgehog. Cell 87 (1996), 553–563.
-
(1996)
Cell
, vol.87
, pp. 553-563
-
-
Chen, Y.1
Struhl, G.2
-
18
-
-
69249245332
-
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
-
Chen, M.H., Wilson, C.W., Li, Y.J., Law, K.K., Lu, C.S., Gacayan, R., Zhang, X., Hui, C.C., Chuang, P.T., Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 (2009), 1910–1928.
-
(2009)
Genes Dev.
, vol.23
, pp. 1910-1928
-
-
Chen, M.H.1
Wilson, C.W.2
Li, Y.J.3
Law, K.K.4
Lu, C.S.5
Gacayan, R.6
Zhang, X.7
Hui, C.C.8
Chuang, P.T.9
-
19
-
-
79959804711
-
Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened
-
Chen, Y., Sasai, N., Ma, G., Yue, T., Jia, J., Briscoe, J., Jiang, J., Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol., 9, 2011, e1001083.
-
(2011)
PLoS Biol.
, vol.9
, pp. e1001083
-
-
Chen, Y.1
Sasai, N.2
Ma, G.3
Yue, T.4
Jia, J.5
Briscoe, J.6
Jiang, J.7
-
20
-
-
79953858623
-
Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium
-
Chen, Y., Yue, S., Xie, L., Pu, X.H., Jin, T., Cheng, S.Y., Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium. J. Biol. Chem. 286 (2011), 13502–13511.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 13502-13511
-
-
Chen, Y.1
Yue, S.2
Xie, L.3
Pu, X.H.4
Jin, T.5
Cheng, S.Y.6
-
21
-
-
69449084098
-
The kinesin protein Kif7 is a critical regulator of gli transcription factors in mammalian hedgehog signaling
-
Cheung, H.O.L., Zhang, X., Ribeiro, A., Mo, R., Makino, S., Puviindran, V., Law, K.K.L., Briscoe, J., Hui, C.C., The kinesin protein Kif7 is a critical regulator of gli transcription factors in mammalian hedgehog signaling. Sci. Signal., 2, 2009, ra29.
-
(2009)
Sci. Signal.
, vol.2
, pp. ra29
-
-
Cheung, H.O.L.1
Zhang, X.2
Ribeiro, A.3
Mo, R.4
Makino, S.5
Puviindran, V.6
Law, K.K.L.7
Briscoe, J.8
Hui, C.C.9
-
22
-
-
84922145020
-
Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5
-
Chong, Y.C., Mann, R.K., Zhao, C., Kato, M., Beachy, P.A., Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5. Genes Dev. 29 (2015), 262–276.
-
(2015)
Genes Dev.
, vol.29
, pp. 262-276
-
-
Chong, Y.C.1
Mann, R.K.2
Zhao, C.3
Kato, M.4
Beachy, P.A.5
-
23
-
-
84961627529
-
The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint
-
Di Magno, L., Basile, A., Coni, S., Manni, S., Sdruscia, G., D'Amico, D., Antonucci, L., Infante, P., De Smaele, E., Cucchi, D., et al. The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint. Oncotarget 7 (2016), 9538–9549.
-
(2016)
Oncotarget
, vol.7
, pp. 9538-9549
-
-
Di Magno, L.1
Basile, A.2
Coni, S.3
Manni, S.4
Sdruscia, G.5
D'Amico, D.6
Antonucci, L.7
Infante, P.8
De Smaele, E.9
Cucchi, D.10
-
24
-
-
84926407491
-
The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis
-
Eisner, A., Pazyra-Murphy, M.F., Durresi, E., Zhou, P., Zhao, X., Chadwick, E.C., Xu, P.X., Hillman, R.T., Scott, M.P., Greenberg, M.E., et al. The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis. Dev. Cell 33 (2015), 22–35.
-
(2015)
Dev. Cell
, vol.33
, pp. 22-35
-
-
Eisner, A.1
Pazyra-Murphy, M.F.2
Durresi, E.3
Zhou, P.4
Zhao, X.5
Chadwick, E.C.6
Xu, P.X.7
Hillman, R.T.8
Scott, M.P.9
Greenberg, M.E.10
-
25
-
-
68149178664
-
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
-
Endoh-Yamagami, S., Evangelista, M., Wilson, D., Wen, X., Theunissen, J.W., Phamluong, K., Davis, M., Scales, S.J., Solloway, M.J., de Sauvage, F.J., et al. The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr. Biol. 19 (2009), 1320–1326.
-
(2009)
Curr. Biol.
, vol.19
, pp. 1320-1326
-
-
Endoh-Yamagami, S.1
Evangelista, M.2
Wilson, D.3
Wen, X.4
Theunissen, J.W.5
Phamluong, K.6
Davis, M.7
Scales, S.J.8
Solloway, M.J.9
de Sauvage, F.J.10
-
26
-
-
84897065629
-
PI3K class II alpha controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function
-
Franco, I., Gulluni, F., Campa, C.C., Costa, C., Margaria, J.P., Ciraolo, E., Martini, M., Monteyne, D., De Luca, E., Germena, G., et al. PI3K class II alpha controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function. Dev. Cell 28 (2014), 647–658.
-
(2014)
Dev. Cell
, vol.28
, pp. 647-658
-
-
Franco, I.1
Gulluni, F.2
Campa, C.C.3
Costa, C.4
Margaria, J.P.5
Ciraolo, E.6
Martini, M.7
Monteyne, D.8
De Luca, E.9
Germena, G.10
-
27
-
-
84888082077
-
Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study
-
Gajjar, A., Stewart, C.F., Ellison, D.W., Kaste, S., Kun, L.E., Packer, R.J., Goldman, S., Chintagumpala, M., Wallace, D., Takebe, N., et al. Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study. Clin. Cancer Res. 19 (2013), 6305–6312.
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 6305-6312
-
-
Gajjar, A.1
Stewart, C.F.2
Ellison, D.W.3
Kaste, S.4
Kun, L.E.5
Packer, R.J.6
Goldman, S.7
Chintagumpala, M.8
Wallace, D.9
Takebe, N.10
-
28
-
-
84939787559
-
Phosphoinositides regulate ciliary protein trafficking to modulate hedgehog signaling
-
Garcia-Gonzalo, F.R., Phua, S.C., Roberson, E.C., Garcia, G. 3rd, Abedin, M., Schurmans, S., Inoue, T., Reiter, J.F., Phosphoinositides regulate ciliary protein trafficking to modulate hedgehog signaling. Dev. Cell 34 (2015), 400–409.
-
(2015)
Dev. Cell
, vol.34
, pp. 400-409
-
-
Garcia-Gonzalo, F.R.1
Phua, S.C.2
Roberson, E.C.3
Garcia, G.4
Abedin, M.5
Schurmans, S.6
Inoue, T.7
Reiter, J.F.8
-
29
-
-
84942026102
-
Phosphodiesterase 4D acts downstream of neuropilin to control hedgehog signal transduction and the growth of medulloblastoma
-
Ge, X., Milenkovic, L., Suyama, K., Hartl, T., Purzner, T., Winans, A., Meyer, T., Scott, M.P., Phosphodiesterase 4D acts downstream of neuropilin to control hedgehog signal transduction and the growth of medulloblastoma. Elife, 4, 2015, e07068, 10.7554/eLife.07068.
-
(2015)
Elife
, vol.4
, pp. e07068
-
-
Ge, X.1
Milenkovic, L.2
Suyama, K.3
Hartl, T.4
Purzner, T.5
Winans, A.6
Meyer, T.7
Scott, M.P.8
-
30
-
-
77951101203
-
The primary cilium: a signalling centre during vertebrate development
-
Goetz, S.C., Anderson, K.V., The primary cilium: a signalling centre during vertebrate development. Nat. Rev. Genet. 11 (2010), 331–344.
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 331-344
-
-
Goetz, S.C.1
Anderson, K.V.2
-
31
-
-
0030866154
-
Altered neural cell fates and medulloblastoma in mouse patched mutants
-
Goodrich, L.V., Milenkovic, L., Higgins, K.M., Scott, M.P., Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277 (1997), 1109–1113.
-
(1997)
Science
, vol.277
, pp. 1109-1113
-
-
Goodrich, L.V.1
Milenkovic, L.2
Higgins, K.M.3
Scott, M.P.4
-
32
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
Hahn, H., Wicking, C., Zaphiropoulous, P.G., Gailani, M.R., Shanley, S., Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A.B., Gillies, S., et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85 (1996), 841–851.
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
Wicking, C.2
Zaphiropoulous, P.G.3
Gailani, M.R.4
Shanley, S.5
Chidambaram, A.6
Vorechovsky, I.7
Holmberg, E.8
Unden, A.B.9
Gillies, S.10
-
33
-
-
33749024194
-
N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth
-
Hatton, B.A., Knoepfler, P.S., Kenney, A.M., Rowitch, D.H., de Alboran, I.M., Olson, J.M., Eisenman, R.N., N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res. 66 (2006), 8655–8661.
-
(2006)
Cancer Res.
, vol.66
, pp. 8655-8661
-
-
Hatton, B.A.1
Knoepfler, P.S.2
Kenney, A.M.3
Rowitch, D.H.4
de Alboran, I.M.5
Olson, J.M.6
Eisenman, R.N.7
-
34
-
-
40949158954
-
The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread
-
Hatton, B.A., Villavicencio, E.H., Tsuchiya, K.D., Pritchard, J.I., Ditzler, S., Pullar, B., Hansen, S., Knoblaugh, S.E., Lee, D., Eberhart, C.G., et al. The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread. Cancer Res. 68 (2008), 1768–1776.
-
(2008)
Cancer Res.
, vol.68
, pp. 1768-1776
-
-
Hatton, B.A.1
Villavicencio, E.H.2
Tsuchiya, K.D.3
Pritchard, J.I.4
Ditzler, S.5
Pullar, B.6
Hansen, S.7
Knoblaugh, S.E.8
Lee, D.9
Eberhart, C.G.10
-
35
-
-
84903701173
-
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment
-
He, M., Subramanian, R., Bangs, F., Omelchenko, T., Liem, K.F. Jr., Kapoor, T.M., Anderson, K.V., The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment. Nat. Cell Biol. 16 (2014), 663–672.
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 663-672
-
-
He, M.1
Subramanian, R.2
Bangs, F.3
Omelchenko, T.4
Liem, K.F.5
Kapoor, T.M.6
Anderson, K.V.7
-
36
-
-
84908343987
-
The G protein alpha subunit Galphas is a tumor suppressor in Sonic hedgehog-driven medulloblastoma
-
He, X., Zhang, L., Chen, Y., Remke, M., Shih, D., Lu, F., Wang, H., Deng, Y., Yu, Y., Xia, Y., et al. The G protein alpha subunit Galphas is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nat. Med. 20 (2014), 1035–1042.
-
(2014)
Nat. Med.
, vol.20
, pp. 1035-1042
-
-
He, X.1
Zhang, L.2
Chen, Y.3
Remke, M.4
Shih, D.5
Lu, F.6
Wang, H.7
Deng, Y.8
Yu, Y.9
Xia, Y.10
-
37
-
-
81255195354
-
Neuropilins are positive regulators of Hedgehog signal transduction
-
Hillman, R.T., Feng, B.Y., Ni, J., Woo, W.M., Milenkovic, L., Hayden Gephart, M.G., Teruel, M.N., Oro, A.E., Chen, J.K., Scott, M.P., Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev. 25 (2011), 2333–2346.
-
(2011)
Genes Dev.
, vol.25
, pp. 2333-2346
-
-
Hillman, R.T.1
Feng, B.Y.2
Ni, J.3
Woo, W.M.4
Milenkovic, L.5
Hayden Gephart, M.G.6
Teruel, M.N.7
Oro, A.E.8
Chen, J.K.9
Scott, M.P.10
-
38
-
-
84897479933
-
Novel nonsense GNAS mutation in a 14-month-old boy with plate-like osteoma cutis and medulloblastoma
-
Huh, J.Y., Kwon, M.J., Seo, K.Y., Kim, M.K., Chae, K.Y., Kim, S.H., Ki, C.S., Yoon, M.S., Kim, D.H., Novel nonsense GNAS mutation in a 14-month-old boy with plate-like osteoma cutis and medulloblastoma. J. Dermatol. 41 (2014), 319–321.
-
(2014)
J. Dermatol.
, vol.41
, pp. 319-321
-
-
Huh, J.Y.1
Kwon, M.J.2
Seo, K.Y.3
Kim, M.K.4
Chae, K.Y.5
Kim, S.H.6
Ki, C.S.7
Yoon, M.S.8
Kim, D.H.9
-
39
-
-
80054022786
-
Gli proteins in development and disease
-
Hui, C.C., Angers, S., Gli proteins in development and disease. Annu. Rev. Cell Dev. Biol. 27 (2011), 513–537.
-
(2011)
Annu. Rev. Cell Dev. Biol.
, vol.27
, pp. 513-537
-
-
Hui, C.C.1
Angers, S.2
-
40
-
-
77950463564
-
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
-
Humke, E.W., Dorn, K.V., Milenkovic, L., Scott, M.P., Rohatgi, R., The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 24 (2010), 670–682.
-
(2010)
Genes Dev.
, vol.24
, pp. 670-682
-
-
Humke, E.W.1
Dorn, K.V.2
Milenkovic, L.3
Scott, M.P.4
Rohatgi, R.5
-
41
-
-
84930181195
-
Inactivation of a Galpha(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis
-
Iglesias-Bartolome, R., Torres, D., Marone, R., Feng, X., Martin, D., Simaan, M., Chen, M., Weinstein, L.S., Taylor, S.S., Molinolo, A.A., et al. Inactivation of a Galpha(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat. Cell Biol. 17 (2015), 793–803.
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 793-803
-
-
Iglesias-Bartolome, R.1
Torres, D.2
Marone, R.3
Feng, X.4
Martin, D.5
Simaan, M.6
Chen, M.7
Weinstein, L.S.8
Taylor, S.S.9
Molinolo, A.A.10
-
42
-
-
12944272018
-
Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1
-
Incardona, J.P., Lee, J.H., Robertson, C.P., Enga, K., Kapur, R.P., Roelink, H., Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1. Proc. Natl. Acad. Sci. USA 97 (2000), 12044–12049.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 12044-12049
-
-
Incardona, J.P.1
Lee, J.H.2
Robertson, C.P.3
Enga, K.4
Kapur, R.P.5
Roelink, H.6
-
43
-
-
0035577854
-
Hedgehog signaling in animal development: paradigms and principles
-
Ingham, P.W., McMahon, A.P., Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15 (2001), 3059–3087.
-
(2001)
Genes Dev.
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
44
-
-
84890991184
-
Mutational landscape of basal cell carcinomas by whole-exome sequencing
-
Jayaraman, S.S., Rayhan, D.J., Hazany, S., Kolodney, M.S., Mutational landscape of basal cell carcinomas by whole-exome sequencing. J. Invest. Dermatol. 134 (2014), 213–220.
-
(2014)
J. Invest. Dermatol.
, vol.134
, pp. 213-220
-
-
Jayaraman, S.S.1
Rayhan, D.J.2
Hazany, S.3
Kolodney, M.S.4
-
45
-
-
84878037234
-
Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors
-
Jimeno, A., Weiss, G.J., Miller, W.H. Jr., Gettinger, S., Eigl, B.J., Chang, A.L., Dunbar, J., Devens, S., Faia, K., Skliris, G., et al. Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors. Clin. Cancer Res. 19 (2013), 2766–2774.
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 2766-2774
-
-
Jimeno, A.1
Weiss, G.J.2
Miller, W.H.3
Gettinger, S.4
Eigl, B.J.5
Chang, A.L.6
Dunbar, J.7
Devens, S.8
Faia, K.9
Skliris, G.10
-
46
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
Johnson, R.L., Rothman, A.L., Xie, J., Goodrich, L.V., Bare, J.W., Bonifas, J.M., Quinn, A.G., Myers, R.M., Cox, D.R., Epstein, E.H. Jr., et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272 (1996), 1668–1671.
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
Goodrich, L.V.4
Bare, J.W.5
Bonifas, J.M.6
Quinn, A.G.7
Myers, R.M.8
Cox, D.R.9
Epstein, E.H.10
-
47
-
-
0037232580
-
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
-
Kenney, A.M., Cole, M.D., Rowitch, D.H., Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development 130 (2003), 15–28.
-
(2003)
Development
, vol.130
, pp. 15-28
-
-
Kenney, A.M.1
Cole, M.D.2
Rowitch, D.H.3
-
48
-
-
84925240113
-
Endocannabinoids are conserved inhibitors of the Hedgehog pathway
-
Khaliullina, H., Bilgin, M., Sampaio, J.L., Shevchenko, A., Eaton, S., Endocannabinoids are conserved inhibitors of the Hedgehog pathway. Proc. Natl. Acad. Sci. USA 112 (2015), 3415–3420.
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 3415-3420
-
-
Khaliullina, H.1
Bilgin, M.2
Sampaio, J.L.3
Shevchenko, A.4
Eaton, S.5
-
49
-
-
77950492233
-
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
-
Kim, J., Tang, J.Y., Gong, R., Kim, J., Lee, J.J., Clemons, K.V., Chong, C.R., Chang, K.S., Fereshteh, M., Gardner, D., et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 17 (2010), 388–399.
-
(2010)
Cancer Cell
, vol.17
, pp. 388-399
-
-
Kim, J.1
Tang, J.Y.2
Gong, R.3
Kim, J.4
Lee, J.J.5
Clemons, K.V.6
Chong, C.R.7
Chang, K.S.8
Fereshteh, M.9
Gardner, D.10
-
50
-
-
77955804589
-
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
-
Kim, J., Lee, J.J., Kim, J., Gardner, D., Beachy, P.A., Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc. Natl. Acad. Sci. USA 107 (2010), 13432–13437.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 13432-13437
-
-
Kim, J.1
Lee, J.J.2
Kim, J.3
Gardner, D.4
Beachy, P.A.5
-
51
-
-
84872417679
-
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
-
Kim, J., Aftab, B.T., Tang, J.Y., Kim, D., Lee, A.H., Rezaee, M., Kim, J., Chen, B., King, E.M., Borodovsky, A., et al. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell 23 (2013), 23–34.
-
(2013)
Cancer Cell
, vol.23
, pp. 23-34
-
-
Kim, J.1
Aftab, B.T.2
Tang, J.Y.3
Kim, D.4
Lee, A.H.5
Rezaee, M.6
Kim, J.7
Chen, B.8
King, E.M.9
Borodovsky, A.10
-
52
-
-
40149091426
-
Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
-
Kimura, H., Ng, J.M., Curran, T., Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell 13 (2008), 249–260.
-
(2008)
Cancer Cell
, vol.13
, pp. 249-260
-
-
Kimura, H.1
Ng, J.M.2
Curran, T.3
-
53
-
-
84896096387
-
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
-
Kool, M., Jones, D.T., Jager, N., Northcott, P.A., Pugh, T.J., Hovestadt, V., Piro, R.M., Esparza, L.A., Markant, S.L., Remke, M., et al. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell 25 (2014), 393–405.
-
(2014)
Cancer Cell
, vol.25
, pp. 393-405
-
-
Kool, M.1
Jones, D.T.2
Jager, N.3
Northcott, P.A.4
Pugh, T.J.5
Hovestadt, V.6
Piro, R.M.7
Esparza, L.A.8
Markant, S.L.9
Remke, M.10
-
54
-
-
34249867843
-
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
-
Lauth, M., Bergstrom, A., Shimokawa, T., Toftgard, R., Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc. Natl. Acad. Sci. USA 104 (2007), 8455–8460.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 8455-8460
-
-
Lauth, M.1
Bergstrom, A.2
Shimokawa, T.3
Toftgard, R.4
-
55
-
-
34848893044
-
Loss of suppressor-of-fused function promotes tumorigenesis
-
Lee, Y., Kawagoe, R., Sasai, K., Li, Y., Russell, H.R., Curran, T., McKinnon, P.J., Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene 26 (2007), 6442–6447.
-
(2007)
Oncogene
, vol.26
, pp. 6442-6447
-
-
Lee, Y.1
Kawagoe, R.2
Sasai, K.3
Li, Y.4
Russell, H.R.5
Curran, T.6
McKinnon, P.J.7
-
56
-
-
84904994417
-
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
-
Lee, J.J., Perera, R.M., Wang, H., Wu, D.C., Liu, X.S., Han, S., Fitamant, J., Jones, P.D., Ghanta, K.S., Kawano, S., et al. Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc. Natl. Acad. Sci. USA 111 (2014), E3091–E3100.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E3091-E3100
-
-
Lee, J.J.1
Perera, R.M.2
Wang, H.3
Wu, D.C.4
Liu, X.S.5
Han, S.6
Fitamant, J.7
Jones, P.D.8
Ghanta, K.S.9
Kawano, S.10
-
57
-
-
84905216453
-
Cyclopamine: from cyclops lambs to cancer treatment
-
Lee, S.T., Welch, K.D., Panter, K.E., Gardner, D.R., Garrossian, M., Chang, C.W., Cyclopamine: from cyclops lambs to cancer treatment. J. Agric. Food Chem. 62 (2014), 7355–7362.
-
(2014)
J. Agric. Food Chem.
, vol.62
, pp. 7355-7362
-
-
Lee, S.T.1
Welch, K.D.2
Panter, K.E.3
Gardner, D.R.4
Garrossian, M.5
Chang, C.W.6
-
58
-
-
84901239611
-
Evasion of p53 and G2/M checkpoints are characteristic of Hh-driven basal cell carcinoma
-
Li, Z.J., Mack, S.C., Mak, T.H., Angers, S., Taylor, M.D., Hui, C.C., Evasion of p53 and G2/M checkpoints are characteristic of Hh-driven basal cell carcinoma. Oncogene 33 (2014), 2674–2680.
-
(2014)
Oncogene
, vol.33
, pp. 2674-2680
-
-
Li, Z.J.1
Mack, S.C.2
Mak, T.H.3
Angers, S.4
Taylor, M.D.5
Hui, C.C.6
-
59
-
-
84947038316
-
AMP-activated protein kinase directly phosphorylates and destabilizes Hedgehog pathway transcription factor GLI1 in medulloblastoma
-
Li, Y.H., Luo, J., Mosley, Y.Y., Hedrick, V.E., Paul, L.N., Chang, J., Zhang, G., Wang, Y.K., Banko, M.R., Brunet, A., et al. AMP-activated protein kinase directly phosphorylates and destabilizes Hedgehog pathway transcription factor GLI1 in medulloblastoma. Cell Rep. 12 (2015), 599–609.
-
(2015)
Cell Rep.
, vol.12
, pp. 599-609
-
-
Li, Y.H.1
Luo, J.2
Mosley, Y.Y.3
Hedrick, V.E.4
Paul, L.N.5
Chang, J.6
Zhang, G.7
Wang, Y.K.8
Banko, M.R.9
Brunet, A.10
-
60
-
-
69449099121
-
Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
-
Liem, K.F. Jr., He, M., Ocbina, P.J., Anderson, K.V., Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc. Natl. Acad. Sci. USA 106 (2009), 13377–13382.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 13377-13382
-
-
Liem, K.F.1
He, M.2
Ocbina, P.J.3
Anderson, K.V.4
-
61
-
-
84910677833
-
Regulation of Sufu activity by p66beta and Mycbp provides new insight into vertebrate Hedgehog signaling
-
Lin, C., Yao, E., Wang, K., Nozawa, Y., Shimizu, H., Johnson, J.R., Chen, J.N., Krogan, N.J., Chuang, P.T., Regulation of Sufu activity by p66beta and Mycbp provides new insight into vertebrate Hedgehog signaling. Genes Dev. 28 (2014), 2547–2563.
-
(2014)
Genes Dev.
, vol.28
, pp. 2547-2563
-
-
Lin, C.1
Yao, E.2
Wang, K.3
Nozawa, Y.4
Shimizu, H.5
Johnson, J.R.6
Chen, J.N.7
Krogan, N.J.8
Chuang, P.T.9
-
62
-
-
84957573186
-
Active medulloblastoma enhancers reveal subgroup-specific cellular origins
-
Lin, C.Y., Erkek, S., Tong, Y., Yin, L., Federation, A.J., Zapatka, M., Haldipur, P., Kawauchi, D., Risch, T., Warnatz, H.J., et al. Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature 530 (2016), 57–62.
-
(2016)
Nature
, vol.530
, pp. 57-62
-
-
Lin, C.Y.1
Erkek, S.2
Tong, Y.3
Yin, L.4
Federation, A.J.5
Zapatka, M.6
Haldipur, P.7
Kawauchi, D.8
Risch, T.9
Warnatz, H.J.10
-
63
-
-
84916605727
-
The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling
-
Liu, Y.C., Couzens, A.L., Deshwar, A.R., McBroom-Cerajewski, L.D.B., Zhang, X., Puviindran, V., Scott, I.C., Gingras, A.C., Hui, C.C., Angers, S., The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling. Sci. Signal., 7, 2014, ra117.
-
(2014)
Sci. Signal.
, vol.7
, pp. ra117
-
-
Liu, Y.C.1
Couzens, A.L.2
Deshwar, A.R.3
McBroom-Cerajewski, L.D.B.4
Zhang, X.5
Puviindran, V.6
Scott, I.C.7
Gingras, A.C.8
Hui, C.C.9
Angers, S.10
-
64
-
-
84919473753
-
The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers
-
Long, J., Li, B., Rodriguez-Blanco, J., Pastori, C., Volmar, C.H., Wahlestedt, C., Capobianco, A., Bai, F., Pei, X.H., Ayad, N.G., et al. The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers. J. Biol. Chem. 289 (2014), 35494–35502.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 35494-35502
-
-
Long, J.1
Li, B.2
Rodriguez-Blanco, J.3
Pastori, C.4
Volmar, C.H.5
Wahlestedt, C.6
Capobianco, A.7
Bai, F.8
Pei, X.H.9
Ayad, N.G.10
-
65
-
-
0029948270
-
Biochemical evidence that patched is the hedgehog receptor
-
Marigo, V., Davey, R.A., Zuo, Y., Cunningham, J.M., Tabin, C.J., Biochemical evidence that patched is the hedgehog receptor. Nature 384 (1996), 176–179.
-
(1996)
Nature
, vol.384
, pp. 176-179
-
-
Marigo, V.1
Davey, R.A.2
Zuo, Y.3
Cunningham, J.M.4
Tabin, C.J.5
-
66
-
-
77954214394
-
Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations
-
Mas, C., Ruiz i Altaba, A., Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations. Biochem. Pharmacol. 80 (2010), 712–723.
-
(2010)
Biochem. Pharmacol.
, vol.80
, pp. 712-723
-
-
Mas, C.1
Ruiz i Altaba, A.2
-
67
-
-
84919873637
-
Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling
-
Mathew, E., Zhang, Y., Holtz, A.M., Kane, K.T., Song, J.Y., Allen, B.L., Pasca di Magliano, M., Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling. Cell Rep. 9 (2014), 484–494.
-
(2014)
Cell Rep.
, vol.9
, pp. 484-494
-
-
Mathew, E.1
Zhang, Y.2
Holtz, A.M.3
Kane, K.T.4
Song, J.Y.5
Allen, B.L.6
Pasca di Magliano, M.7
-
68
-
-
84890288884
-
PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition
-
Metcalfe, C., Alicke, B., Crow, A., Lamoureux, M., Dijkgraaf, G.J., Peale, F., Gould, S.E., de Sauvage, F.J., PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition. Cancer Res. 73 (2013), 7034–7042.
-
(2013)
Cancer Res.
, vol.73
, pp. 7034-7042
-
-
Metcalfe, C.1
Alicke, B.2
Crow, A.3
Lamoureux, M.4
Dijkgraaf, G.J.5
Peale, F.6
Gould, S.E.7
de Sauvage, F.J.8
-
69
-
-
84930273662
-
Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial
-
Migden, M.R., Guminski, A., Gutzmer, R., Dirix, L., Lewis, K.D., Combemale, P., Herd, R.M., Kudchadkar, R., Trefzer, U., Gogov, S., et al. Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial. Lancet Oncol. 16 (2015), 716–728.
-
(2015)
Lancet Oncol.
, vol.16
, pp. 716-728
-
-
Migden, M.R.1
Guminski, A.2
Gutzmer, R.3
Dirix, L.4
Lewis, K.D.5
Combemale, P.6
Herd, R.M.7
Kudchadkar, R.8
Trefzer, U.9
Gogov, S.10
-
70
-
-
84907982605
-
The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors
-
Mille, F., Tamayo-Orrego, L., Levesque, M., Remke, M., Korshunov, A., Cardin, J., Bouchard, N., Izzi, L., Kool, M., Northcott, P.A., et al. The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors. Dev. Cell 31 (2014), 34–47.
-
(2014)
Dev. Cell
, vol.31
, pp. 34-47
-
-
Mille, F.1
Tamayo-Orrego, L.2
Levesque, M.3
Remke, M.4
Korshunov, A.5
Cardin, J.6
Bouchard, N.7
Izzi, L.8
Kool, M.9
Northcott, P.A.10
-
71
-
-
84872508509
-
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
-
Mukhopadhyay, S., Wen, X., Ratti, N., Loktev, A., Rangell, L., Scales, S.J., Jackson, P.K., The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Cell 152 (2013), 210–223.
-
(2013)
Cell
, vol.152
, pp. 210-223
-
-
Mukhopadhyay, S.1
Wen, X.2
Ratti, N.3
Loktev, A.4
Rangell, L.5
Scales, S.J.6
Jackson, P.K.7
-
72
-
-
0009603803
-
Sonic hedgehog signaling by the patched-smoothened receptor complex
-
Murone, M., Rosenthal, A., de Sauvage, F.J., Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr. Biol. 9 (1999), 76–84.
-
(1999)
Curr. Biol.
, vol.9
, pp. 76-84
-
-
Murone, M.1
Rosenthal, A.2
de Sauvage, F.J.3
-
73
-
-
84883051342
-
Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response
-
Myers, B.R., Sever, N., Chong, Y.C., Kim, J., Belani, J.D., Rychnovsky, S., Bazan, J.F., Beachy, P.A., Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Dev. Cell 26 (2013), 346–357.
-
(2013)
Dev. Cell
, vol.26
, pp. 346-357
-
-
Myers, B.R.1
Sever, N.2
Chong, Y.C.3
Kim, J.4
Belani, J.D.5
Rychnovsky, S.6
Bazan, J.F.7
Beachy, P.A.8
-
74
-
-
84887326705
-
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
-
Nachtergaele, S., Whalen, D.M., Mydock, L.K., Zhao, Z., Malinauskas, T., Krishnan, K., Ingham, P.W., Covey, D.F., Siebold, C., Rohatgi, R., Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife, 2, 2013, e01340.
-
(2013)
Elife
, vol.2
, pp. e01340
-
-
Nachtergaele, S.1
Whalen, D.M.2
Mydock, L.K.3
Zhao, Z.4
Malinauskas, T.5
Krishnan, K.6
Ingham, P.W.7
Covey, D.F.8
Siebold, C.9
Rohatgi, R.10
-
75
-
-
84883185477
-
Oxysterol binding to the extracellular domain of smoothened in Hedgehog signaling
-
Nedelcu, D., Liu, J., Xu, Y., Jao, C., Salic, A., Oxysterol binding to the extracellular domain of smoothened in Hedgehog signaling. Nat. Chem. Biol. 9 (2013), 557–564.
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 557-564
-
-
Nedelcu, D.1
Liu, J.2
Xu, Y.3
Jao, C.4
Salic, A.5
-
76
-
-
84892542938
-
Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling
-
Niewiadomski, P., Kong, J.H., Ahrends, R., Ma, Y., Humke, E.W., Khan, S., Teruel, M.N., Novitch, B.G., Rohatgi, R., Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Rep. 6 (2014), 168–181.
-
(2014)
Cell Rep.
, vol.6
, pp. 168-181
-
-
Niewiadomski, P.1
Kong, J.H.2
Ahrends, R.3
Ma, Y.4
Humke, E.W.5
Khan, S.6
Teruel, M.N.7
Novitch, B.G.8
Rohatgi, R.9
-
77
-
-
84880039755
-
Patched knockout mouse models of basal cell carcinoma
-
Nitzki, F., Becker, M., Frommhold, A., Schulz-Schaeffer, W., Hahn, H., Patched knockout mouse models of basal cell carcinoma. J. Skin Cancer, 2012, 2012, 907543.
-
(2012)
J. Skin Cancer
, vol.2012
, pp. 907543
-
-
Nitzki, F.1
Becker, M.2
Frommhold, A.3
Schulz-Schaeffer, W.4
Hahn, H.5
-
78
-
-
79960842253
-
Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
-
Northcott, P.A., Hielscher, T., Dubuc, A., Mack, S., Shih, D., Remke, M., Al-Halabi, H., Albrecht, S., Jabado, N., Eberhart, C.G., et al. Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathol. 122 (2011), 231–240.
-
(2011)
Acta Neuropathol.
, vol.122
, pp. 231-240
-
-
Northcott, P.A.1
Hielscher, T.2
Dubuc, A.3
Mack, S.4
Shih, D.5
Remke, M.6
Al-Halabi, H.7
Albrecht, S.8
Jabado, N.9
Eberhart, C.G.10
-
79
-
-
84884280494
-
Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction
-
Nozawa, Y.I., Lin, C., Chuang, P.T., Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction. Curr. Opin. Genet. Dev. 23 (2013), 429–437.
-
(2013)
Curr. Opin. Genet. Dev.
, vol.23
, pp. 429-437
-
-
Nozawa, Y.I.1
Lin, C.2
Chuang, P.T.3
-
80
-
-
84924061466
-
Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure
-
Pagliarini, R., Shao, W., Sellers, W.R., Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure. EMBO Rep. 16 (2015), 280–296.
-
(2015)
EMBO Rep.
, vol.16
, pp. 280-296
-
-
Pagliarini, R.1
Shao, W.2
Sellers, W.R.3
-
81
-
-
84978103999
-
Smoothened determines beta-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium
-
Pal, K., Hwang, S.H., Somatilaka, B., Badgandi, H., Jackson, P.K., DeFea, K., Mukhopadhyay, S., Smoothened determines beta-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium. J. Cell Biol. 212 (2016), 861–875.
-
(2016)
J. Cell Biol.
, vol.212
, pp. 861-875
-
-
Pal, K.1
Hwang, S.H.2
Somatilaka, B.3
Badgandi, H.4
Jackson, P.K.5
DeFea, K.6
Mukhopadhyay, S.7
-
82
-
-
34249717798
-
A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
-
Pan, Y., Wang, B., A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome. J. Biol. Chem. 282 (2007), 10846–10852.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 10846-10852
-
-
Pan, Y.1
Wang, B.2
-
83
-
-
33646270662
-
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
-
Pan, Y., Bai, C.B., Joyner, A.L., Wang, B., Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell Biol. 26 (2006), 3365–3377.
-
(2006)
Mol. Cell Biol.
, vol.26
, pp. 3365-3377
-
-
Pan, Y.1
Bai, C.B.2
Joyner, A.L.3
Wang, B.4
-
84
-
-
58549117286
-
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development
-
Pan, Y., Wang, C., Wang, B., Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev. Biol. 326 (2009), 177–189.
-
(2009)
Dev. Biol.
, vol.326
, pp. 177-189
-
-
Pan, Y.1
Wang, C.2
Wang, B.3
-
85
-
-
0033566844
-
Vertebrate homologs of Drosophila suppressor of fused Interact with the gli family of transcriptional regulators
-
Pearse, R.V. II, Collier, L.S., Scott, M.P., Tabin, C.J., Vertebrate homologs of Drosophila suppressor of fused Interact with the gli family of transcriptional regulators. Dev. Biol. 212 (1999), 323–336.
-
(1999)
Dev. Biol.
, vol.212
, pp. 323-336
-
-
Pearse, R.V.1
Collier, L.S.2
Scott, M.P.3
Tabin, C.J.4
-
86
-
-
84896733610
-
EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia
-
Pusapati, G.V., Hughes, C.E., Dorn, K.V., Zhang, D., Sugianto, P., Aravind, L., Rohatgi, R., EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Dev. Cell 28 (2014), 483–496.
-
(2014)
Dev. Cell
, vol.28
, pp. 483-496
-
-
Pusapati, G.V.1
Hughes, C.E.2
Dorn, K.V.3
Zhang, D.4
Sugianto, P.5
Aravind, L.6
Rohatgi, R.7
-
87
-
-
84862907577
-
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
-
Rausch, T., Jones, D.T., Zapatka, M., Stutz, A.M., Zichner, T., Weischenfeldt, J., Jager, N., Remke, M., Shih, D., Northcott, P.A., et al. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell 148 (2012), 59–71.
-
(2012)
Cell
, vol.148
, pp. 59-71
-
-
Rausch, T.1
Jones, D.T.2
Zapatka, M.3
Stutz, A.M.4
Zichner, T.5
Weischenfeldt, J.6
Jager, N.7
Remke, M.8
Shih, D.9
Northcott, P.A.10
-
88
-
-
84940482116
-
Vismodegib exerts targeted efficacy against recurrent sonic hedgehog-subgroup medulloblastoma: results from phase II pediatric brain tumor consortium studies PBTC-025B and PBTC-032
-
Robinson, G.W., Orr, B.A., Wu, G., Gururangan, S., Lin, T., Qaddoumi, I., Packer, R.J., Goldman, S., Prados, M.D., Desjardins, A., et al. Vismodegib exerts targeted efficacy against recurrent sonic hedgehog-subgroup medulloblastoma: results from phase II pediatric brain tumor consortium studies PBTC-025B and PBTC-032. J. Clin. Oncol. 33 (2015), 2646–2654.
-
(2015)
J. Clin. Oncol.
, vol.33
, pp. 2646-2654
-
-
Robinson, G.W.1
Orr, B.A.2
Wu, G.3
Gururangan, S.4
Lin, T.5
Qaddoumi, I.6
Packer, R.J.7
Goldman, S.8
Prados, M.D.9
Desjardins, A.10
-
89
-
-
84898721363
-
A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors
-
Rodon, J., Tawbi, H.A., Thomas, A.L., Stoller, R.G., Turtschi, C.P., Baselga, J., Sarantopoulos, J., Mahalingam, D., Shou, Y., Moles, M.A., et al. A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors. Clin. Cancer Res. 20 (2014), 1900–1909.
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 1900-1909
-
-
Rodon, J.1
Tawbi, H.A.2
Thomas, A.L.3
Stoller, R.G.4
Turtschi, C.P.5
Baselga, J.6
Sarantopoulos, J.7
Mahalingam, D.8
Shou, Y.9
Moles, M.A.10
-
90
-
-
4544285754
-
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice
-
Romer, J.T., Kimura, H., Magdaleno, S., Sasai, K., Fuller, C., Baines, H., Connelly, M., Stewart, C.F., Gould, S., Rubin, L.L., et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell 6 (2004), 229–240.
-
(2004)
Cancer Cell
, vol.6
, pp. 229-240
-
-
Romer, J.T.1
Kimura, H.2
Magdaleno, S.3
Sasai, K.4
Fuller, C.5
Baines, H.6
Connelly, M.7
Stewart, C.F.8
Gould, S.9
Rubin, L.L.10
-
91
-
-
70349244812
-
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
-
Rudin, C.M., Hann, C.L., Laterra, J., Yauch, R.L., Callahan, C.A., Fu, L., Holcomb, T., Stinson, J., Gould, S.E., Coleman, B., et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N. Engl. J. Med. 361 (2009), 1173–1178.
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1173-1178
-
-
Rudin, C.M.1
Hann, C.L.2
Laterra, J.3
Yauch, R.L.4
Callahan, C.A.5
Fu, L.6
Holcomb, T.7
Stinson, J.8
Gould, S.E.9
Coleman, B.10
-
92
-
-
67650289584
-
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
-
Scales, S.J., de Sauvage, F.J., Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol. Sci. 30 (2009), 303–312.
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 303-312
-
-
Scales, S.J.1
de Sauvage, F.J.2
-
93
-
-
84959421964
-
Hedgehog pathway inhibition
-
Sekulic, A., Von Hoff, D., Hedgehog pathway inhibition. Cell, 164, 2016, 831.
-
(2016)
Cell
, vol.164
, pp. 831
-
-
Sekulic, A.1
Von Hoff, D.2
-
94
-
-
84861856844
-
Efficacy and safety of vismodegib in advanced basal-cell carcinoma
-
Sekulic, A., Migden, M.R., Oro, A.E., Dirix, L., Lewis, K.D., Hainsworth, J.D., Solomon, J.A., Yoo, S., Arron, S.T., Friedlander, P.A., et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N. Engl. J. Med. 366 (2012), 2171–2179.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 2171-2179
-
-
Sekulic, A.1
Migden, M.R.2
Oro, A.E.3
Dirix, L.4
Lewis, K.D.5
Hainsworth, J.D.6
Solomon, J.A.7
Yoo, S.8
Arron, S.T.9
Friedlander, P.A.10
-
95
-
-
84929629820
-
Pivotal ERIVANCE basal cell carcinoma (BCC) study: 12-month update of efficacy and safety of vismodegib in advanced BCC
-
Sekulic, A., Migden, M.R., Lewis, K., Hainsworth, J.D., Solomon, J.A., Yoo, S., Arron, S.T., Friedlander, P.A., Marmur, E., Rudin, C.M., et al. Pivotal ERIVANCE basal cell carcinoma (BCC) study: 12-month update of efficacy and safety of vismodegib in advanced BCC. J. Am. Acad. Dermatol. 72 (2015), 1021–1026.e1028.
-
(2015)
J. Am. Acad. Dermatol.
, vol.72
, pp. 1021-1026.e1028
-
-
Sekulic, A.1
Migden, M.R.2
Lewis, K.3
Hainsworth, J.D.4
Solomon, J.A.5
Yoo, S.6
Arron, S.T.7
Friedlander, P.A.8
Marmur, E.9
Rudin, C.M.10
-
96
-
-
84924262003
-
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma
-
Sharpe, H.J., Pau, G., Dijkgraaf, G.J., Basset-Seguin, N., Modrusan, Z., Januario, T., Tsui, V., Durham, A.B., Dlugosz, A.A., Haverty, P.M., et al. Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma. Cancer Cell 27 (2015), 327–341.
-
(2015)
Cancer Cell
, vol.27
, pp. 327-341
-
-
Sharpe, H.J.1
Pau, G.2
Dijkgraaf, G.J.3
Basset-Seguin, N.4
Modrusan, Z.5
Januario, T.6
Tsui, V.7
Durham, A.B.8
Dlugosz, A.A.9
Haverty, P.M.10
-
97
-
-
84923337150
-
An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth
-
Shi, X., Zhang, Z., Zhan, X., Cao, M., Satoh, T., Akira, S., Shpargel, K., Magnuson, T., Li, Q., Wang, R., et al. An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat. Commun., 5, 2014, 5425.
-
(2014)
Nat. Commun.
, vol.5
, pp. 5425
-
-
Shi, X.1
Zhang, Z.2
Zhan, X.3
Cao, M.4
Satoh, T.5
Akira, S.6
Shpargel, K.7
Magnuson, T.8
Li, Q.9
Wang, R.10
-
98
-
-
84961266647
-
PI-3K inhibitors preferentially target cd15+ cancer stem cell population in SHH driven medulloblastoma
-
Singh, A.R., Joshi, S., Zulcic, M., Alcaraz, M., Garlich, J.R., Morales, G.A., Cho, Y.J., Bao, L., Levy, M.L., Newbury, R., et al. PI-3K inhibitors preferentially target cd15+ cancer stem cell population in SHH driven medulloblastoma. PLoS One, 11, 2016, e0150836.
-
(2016)
PLoS One
, vol.11
, pp. e0150836
-
-
Singh, A.R.1
Joshi, S.2
Zulcic, M.3
Alcaraz, M.4
Garlich, J.R.5
Morales, G.A.6
Cho, Y.J.7
Bao, L.8
Levy, M.L.9
Newbury, R.10
-
99
-
-
84919767719
-
Germline mutations in SUFU cause Gorlin syndrome-associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations
-
Smith, M.J., Beetz, C., Williams, S.G., Bhaskar, S.S., O'Sullivan, J., Anderson, B., Daly, S.B., Urquhart, J.E., Bholah, Z., Oudit, D., et al. Germline mutations in SUFU cause Gorlin syndrome-associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations. J. Clin. Oncol. 32 (2014), 4155–4161.
-
(2014)
J. Clin. Oncol.
, vol.32
, pp. 4155-4161
-
-
Smith, M.J.1
Beetz, C.2
Williams, S.G.3
Bhaskar, S.S.4
O'Sullivan, J.5
Anderson, B.6
Daly, S.B.7
Urquhart, J.E.8
Bholah, Z.9
Oudit, D.10
-
100
-
-
0011102935
-
The tumour-suppressor gene patched encodes a candidate receptor for sonic hedgehog
-
Stone, D.M., Hynes, M., Armanini, M., Swanson, T.A., Gu, Q., Johnson, R.L., Scott, M.P., Pennica, D., Goddard, A., Phillips, H., et al. The tumour-suppressor gene patched encodes a candidate receptor for sonic hedgehog. Nature 384 (1996), 129–134.
-
(1996)
Nature
, vol.384
, pp. 129-134
-
-
Stone, D.M.1
Hynes, M.2
Armanini, M.3
Swanson, T.A.4
Gu, Q.5
Johnson, R.L.6
Scott, M.P.7
Pennica, D.8
Goddard, A.9
Phillips, H.10
-
101
-
-
0033491071
-
Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli
-
Stone, D.M., Murone, M., Luoh, S., Ye, W., Armanini, M.P., Gurney, A., Phillips, H., Brush, J., Goddard, A., de Sauvage, F.J., et al. Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J. Cell Sci. 112 (1999), 4437–4448.
-
(1999)
J. Cell Sci.
, vol.112
, pp. 4437-4448
-
-
Stone, D.M.1
Murone, M.2
Luoh, S.3
Ye, W.4
Armanini, M.P.5
Gurney, A.6
Phillips, H.7
Brush, J.8
Goddard, A.9
de Sauvage, F.J.10
-
102
-
-
0037158748
-
Patched acts catalytically to suppress the activity of Smoothened
-
Taipale, J., Cooper, M.K., Maiti, T., Beachy, P.A., Patched acts catalytically to suppress the activity of Smoothened. Nature 418 (2002), 892–897.
-
(2002)
Nature
, vol.418
, pp. 892-897
-
-
Taipale, J.1
Cooper, M.K.2
Maiti, T.3
Beachy, P.A.4
-
103
-
-
84904036266
-
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition
-
Tang, Y., Gholamin, S., Schubert, S., Willardson, M.I., Lee, A., Bandopadhayay, P., Bergthold, G., Masoud, S., Nguyen, B., Vue, N., et al. Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat. Med. 20 (2014), 732–740.
-
(2014)
Nat. Med.
, vol.20
, pp. 732-740
-
-
Tang, Y.1
Gholamin, S.2
Schubert, S.3
Willardson, M.I.4
Lee, A.5
Bandopadhayay, P.6
Bergthold, G.7
Masoud, S.8
Nguyen, B.9
Vue, N.10
-
104
-
-
14744268335
-
A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
-
Tay, S.Y., Ingham, P.W., Roy, S., A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo. Development 132 (2005), 625–634.
-
(2005)
Development
, vol.132
, pp. 625-634
-
-
Tay, S.Y.1
Ingham, P.W.2
Roy, S.3
-
105
-
-
84860821444
-
Molecular subgroups of medulloblastoma: the current consensus
-
Taylor, M.D., Northcott, P.A., Korshunov, A., Remke, M., Cho, Y.J., Clifford, S.C., Eberhart, C.G., Parsons, D.W., Rutkowski, S., Gajjar, A., et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 123 (2012), 465–472.
-
(2012)
Acta Neuropathol.
, vol.123
, pp. 465-472
-
-
Taylor, M.D.1
Northcott, P.A.2
Korshunov, A.3
Remke, M.4
Cho, Y.J.5
Clifford, S.C.6
Eberhart, C.G.7
Parsons, D.W.8
Rutkowski, S.9
Gajjar, A.10
-
106
-
-
77649337790
-
Hedgehog beyond medulloblastoma and basal cell carcinoma
-
Teglund, S., Toftgard, R., Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim. Biophys. Acta 1805 (2010), 181–208.
-
(2010)
Biochim. Biophys. Acta
, vol.1805
, pp. 181-208
-
-
Teglund, S.1
Toftgard, R.2
-
107
-
-
33646869503
-
Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP
-
Tempé, D., Casas, M., Karaz, S., Blanchet-Tournier, M.F., Concordet, J.P., Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Mol. Cell Biol. 26 (2006), 4316–4326.
-
(2006)
Mol. Cell Biol.
, vol.26
, pp. 4316-4326
-
-
Tempé, D.1
Casas, M.2
Karaz, S.3
Blanchet-Tournier, M.F.4
Concordet, J.P.5
-
108
-
-
63149124772
-
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
-
Tian, H., Callahan, C.A., DuPree, K.J., Darbonne, W.C., Ahn, C.P., Scales, S.J., de Sauvage, F.J., Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc. Natl. Acad. Sci. USA 106 (2009), 4254–4259.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 4254-4259
-
-
Tian, H.1
Callahan, C.A.2
DuPree, K.J.3
Darbonne, W.C.4
Ahn, C.P.5
Scales, S.J.6
de Sauvage, F.J.7
-
109
-
-
84904264545
-
Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma
-
Vanner, R.J., Remke, M., Gallo, M., Selvadurai, H.J., Coutinho, F., Lee, L., Kushida, M., Head, R., Morrissy, S., Zhu, X., et al. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell 26 (2014), 33–47.
-
(2014)
Cancer Cell
, vol.26
, pp. 33-47
-
-
Vanner, R.J.1
Remke, M.2
Gallo, M.3
Selvadurai, H.J.4
Coutinho, F.5
Lee, L.6
Kushida, M.7
Head, R.8
Morrissy, S.9
Zhu, X.10
-
110
-
-
30444437000
-
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing
-
Wang, B., Li, Y., Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc. Natl. Acad. Sci. USA 103 (2006), 33–38.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 33-38
-
-
Wang, B.1
Li, Y.2
-
111
-
-
77953050811
-
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
-
Wang, C., Pan, Y., Wang, B., Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. Development 137 (2010), 2001–2009.
-
(2010)
Development
, vol.137
, pp. 2001-2009
-
-
Wang, C.1
Pan, Y.2
Wang, B.3
-
112
-
-
0032959871
-
Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog
-
Wechsler-Reya, R.J., Scott, M.P., Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog. Neuron 22 (1999), 103–114.
-
(1999)
Neuron
, vol.22
, pp. 103-114
-
-
Wechsler-Reya, R.J.1
Scott, M.P.2
-
113
-
-
0031913524
-
Activating Smoothened mutations in sporadic basal-cell carcinoma
-
Xie, J., Murone, M., Luoh, S.M., Ryan, A., Gu, Q., Zhang, C., Bonifas, J.M., Lam, C.W., Hynes, M., Goddard, A., et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391 (1998), 90–92.
-
(1998)
Nature
, vol.391
, pp. 90-92
-
-
Xie, J.1
Murone, M.2
Luoh, S.M.3
Ryan, A.4
Gu, Q.5
Zhang, C.6
Bonifas, J.M.7
Lam, C.W.8
Hynes, M.9
Goddard, A.10
-
114
-
-
70350496540
-
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
-
Yauch, R.L., Dijkgraaf, G.J., Alicke, B., Januario, T., Ahn, C.P., Holcomb, T., Pujara, K., Stinson, J., Callahan, C.A., Tang, T., et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 326 (2009), 572–574.
-
(2009)
Science
, vol.326
, pp. 572-574
-
-
Yauch, R.L.1
Dijkgraaf, G.J.2
Alicke, B.3
Januario, T.4
Ahn, C.P.5
Holcomb, T.6
Pujara, K.7
Stinson, J.8
Callahan, C.A.9
Tang, T.10
-
115
-
-
84904193969
-
Requirement of Smurf-mediated endocytosis of patched1 in sonic hedgehog signal reception
-
Yue, S., Tang, L., Tang, Y., Tang, Y., Shen, Q., Ding, J., Chen, Y., Zhang, Z., Yu, T., Zhang, Y.E., et al. Requirement of Smurf-mediated endocytosis of patched1 in sonic hedgehog signal reception. Elife, 3, 2014, e02555.
-
(2014)
Elife
, vol.3
, pp. e02555
-
-
Yue, S.1
Tang, L.2
Tang, Y.3
Tang, Y.4
Shen, Q.5
Ding, J.6
Chen, Y.7
Zhang, Z.8
Yu, T.9
Zhang, Y.E.10
-
116
-
-
84942857407
-
RAS/MAPK activation drives resistance to smo inhibition, metastasis, and tumor evolution in shh pathway-dependent tumors
-
Zhao, X., Ponomaryov, T., Ornell, K.J., Zhou, P., Dabral, S.K., Pak, E., Li, W., Atwood, S.X., Whitson, R.J., Chang, A.L., et al. RAS/MAPK activation drives resistance to smo inhibition, metastasis, and tumor evolution in shh pathway-dependent tumors. Cancer Res. 75 (2015), 3623–3635.
-
(2015)
Cancer Res.
, vol.75
, pp. 3623-3635
-
-
Zhao, X.1
Ponomaryov, T.2
Ornell, K.J.3
Zhou, P.4
Dabral, S.K.5
Pak, E.6
Li, W.7
Atwood, S.X.8
Whitson, R.J.9
Chang, A.L.10
-
117
-
-
84885423998
-
Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma
-
Zhukova, N., Ramaswamy, V., Remke, M., Pfaff, E., Shih, D.J., Martin, D.C., Castelo-Branco, P., Baskin, B., Ray, P.N., Bouffet, E., et al. Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma. J. Clin. Oncol. 31 (2013), 2927–2935.
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 2927-2935
-
-
Zhukova, N.1
Ramaswamy, V.2
Remke, M.3
Pfaff, E.4
Shih, D.J.5
Martin, D.C.6
Castelo-Branco, P.7
Baskin, B.8
Ray, P.N.9
Bouffet, E.10
|