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Volumn 48, Issue 4, 2016, Pages 398-406

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

(27)  Bonilla, Ximena a   Parmentier, Laurent b   King, Bryan c   Bezrukov, Fedor d,e   Kaya, Gürkan f   Zoete, Vincent g   Seplyarskiy, Vladimir B h,i,j   Sharpe, Hayley J k   McKee, Thomas f   Letourneau, Audrey a   Ribaux, Pascale G a   Popadin, Konstantin a   Basset Seguin, Nicole l   Chaabene, Rouaa Ben a   Santoni, Federico A a,f   Andrianova, Maria A h,i,j   Guipponi, Michel f   Garieri, Marco a   Verdan, Carole f   Grosdemange, Kerstin f   more..


Author keywords

[No Author keywords available]

Indexed keywords

SONIC HEDGEHOG PROTEIN; ANILIDE; ANTINEOPLASTIC AGENT; PYRIDINE DERIVATIVE; TRANSCRIPTOME; VISMODEGIB;

EID: 84960145215     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3525     Document Type: Article
Times cited : (364)

References (87)
  • 1
    • 84859847132 scopus 로고    scopus 로고
    • The molecular genetics underlying basal cell carcinoma pathogenesis and links to targeted therapeutics
    • Iwasaki, J.K., Srivastava, D., Moy, R.L., Lin, H.J., & Kouba, D.J. The molecular genetics underlying basal cell carcinoma pathogenesis and links to targeted therapeutics. J. Am. Acad. Dermatol. 66, e167-e178 (2012
    • (2012) J. Am. Acad. Dermatol. , vol.66 , pp. e167-e178
    • Iwasaki, J.K.1    Srivastava, D.2    Moy, R.L.3    Lin, H.J.4    Kouba, D.J.5
  • 2
    • 77649258546 scopus 로고    scopus 로고
    • Identification of the cell lineage at the origin of basal cell carcinoma
    • Youssef K.K., et al. Identification of the cell lineage at the origin of basal cell carcinoma. Nat. Cell Biol. 12, 299-305 (2010
    • (2010) Nat. Cell Biol. , vol.12 , pp. 299-305
    • Youssef, K.K.1
  • 3
    • 15844386165 scopus 로고    scopus 로고
    • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    • Hahn H., et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85, 841-851 (1996
    • (1996) Cell , vol.85 , pp. 841-851
    • Hahn, H.1
  • 4
    • 19944433687 scopus 로고    scopus 로고
    • Somatic mutations in the PTCH SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas
    • Reifenberger, J., et al. Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. Br. J. Dermatol. 152, 43-51 (2005
    • (2005) Br. J. Dermatol. , vol.152 , pp. 43-51
    • Reifenberger, J.1
  • 5
    • 84924262003 scopus 로고    scopus 로고
    • Genomic analysis of Smoothened inhibitor resistance in basal cell carcinoma
    • Sharpe H.J., et al. Genomic analysis of Smoothened inhibitor resistance in basal cell carcinoma. Cancer Cell 27, 327-341 (2015
    • (2015) Cancer Cell , vol.27 , pp. 327-341
    • Sharpe, H.J.1
  • 6
    • 84924242647 scopus 로고    scopus 로고
    • Smoothened variants explain the majority of drug resistance in basal cell carcinoma
    • Atwood S.X., et al. Smoothened variants explain the majority of drug resistance in basal cell carcinoma. Cancer Cell 27, 342-353 (2015
    • (2015) Cancer Cell , vol.27 , pp. 342-353
    • Atwood, S.X.1
  • 7
    • 84919767719 scopus 로고    scopus 로고
    • Germline mutations in SUFU cause Gorlin syndrome-Associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations
    • Smith M.J., et al. Germline mutations in SUFU cause Gorlin syndrome-Associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations. J. Clin. Oncol. 32, 4155-4161 (2014
    • (2014) J. Clin. Oncol. , vol.32 , pp. 4155-4161
    • Smith, M.J.1
  • 8
    • 84903637379 scopus 로고    scopus 로고
    • Identification of recurrent SMO and BRAF mutations in ameloblastomas
    • Sweeney R.T., et al. Identification of recurrent SMO and BRAF mutations in ameloblastomas. Nat. Genet. 46, 722-725 (2014
    • (2014) Nat. Genet. , vol.46 , pp. 722-725
    • Sweeney, R.T.1
  • 9
    • 77954288457 scopus 로고    scopus 로고
    • Gene expression profiling of the hedgehog signaling pathway in human meningiomas
    • Laurendeau I., et al. Gene expression profiling of the hedgehog signaling pathway in human meningiomas. Mol. Med. 16, 262-270 (2010
    • (2010) Mol. Med. , vol.16 , pp. 262-270
    • Laurendeau, I.1
  • 10
    • 84874645692 scopus 로고    scopus 로고
    • Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations
    • Brastianos P.K., et al. Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat. Genet. 45, 285-289 (2013
    • (2013) Nat. Genet. , vol.45 , pp. 285-289
    • Brastianos, P.K.1
  • 11
    • 0037165140 scopus 로고    scopus 로고
    • Prediction of central nervous system embryonal tumour outcome based on gene expression
    • Pomeroy S.L., et al. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415, 436-442 (2002
    • (2002) Nature , vol.415 , pp. 436-442
    • Pomeroy, S.L.1
  • 12
    • 84874372046 scopus 로고    scopus 로고
    • Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7 KLF4, AKT1, and SMO
    • Clark, V.E., et al. Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science 339, 1077-1080 (2013
    • (2013) Science , vol.339 , pp. 1077-1080
    • Clark, V.E.1
  • 13
    • 84890991184 scopus 로고    scopus 로고
    • Mutational landscape of basal cell carcinomas by whole-exome sequencing
    • Jayaraman, S.S., Rayhan, D.J., Hazany, S., & Kolodney, M.S. Mutational landscape of basal cell carcinomas by whole-exome sequencing. J. Invest. Dermatol. 134, 213-220 (2014
    • (2014) J. Invest. Dermatol. , vol.134 , pp. 213-220
    • Jayaraman, S.S.1    Rayhan, D.J.2    Hazany, S.3    Kolodney, M.S.4
  • 14
    • 84930274867 scopus 로고    scopus 로고
    • Vismodegib in patients with advanced basal cell carcinoma (STEVIE): A pre-planned interim analysis of an international open-label trial
    • Basset-Seguin, N., et al. Vismodegib in patients with advanced basal cell carcinoma (STEVIE): a pre-planned interim analysis of an international, open-label trial. Lancet Oncol. 16, 729-736 (2015
    • (2015) Lancet Oncol. , vol.16 , pp. 729-736
    • Basset-Seguin, N.1
  • 15
    • 70349238733 scopus 로고    scopus 로고
    • Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
    • Von Hoff D.D., et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N. Engl. J. Med. 361, 1164-1172 (2009
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1164-1172
    • Von Hoff, D.D.1
  • 16
    • 84861856844 scopus 로고    scopus 로고
    • Efficacy and safety of vismodegib in advanced basal-cell carcinoma
    • Sekulic A., et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N. Engl. J. Med. 366, 2171-2179 (2012
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2171-2179
    • Sekulic, A.1
  • 17
    • 84905485738 scopus 로고    scopus 로고
    • Clinical benefit assessment of vismodegib therapy in patients with advanced basal cell carcinoma
    • Dreno, B., Basset-Seguin, N., Caro, I., Yue, H., & Schadendorf, D. Clinical benefit assessment of vismodegib therapy in patients with advanced basal cell carcinoma. Oncologist 19, 790-796 (2014
    • (2014) Oncologist , vol.19 , pp. 790-796
    • Dreno, B.1    Basset-Seguin, N.2    Caro, I.3    Yue, H.4    Schadendorf, D.5
  • 18
    • 84869131318 scopus 로고    scopus 로고
    • Initial assessment of tumor regrowth after vismodegib in advanced basal cell carcinoma
    • Chang, A.L., & Oro, A.E. Initial assessment of tumor regrowth after vismodegib in advanced basal cell carcinoma. Arch. Dermatol. 148, 1324-1325 (2012
    • (2012) Arch. Dermatol. , vol.148 , pp. 1324-1325
    • Chang, A.L.1    Oro, A.E.2
  • 19
    • 84892833777 scopus 로고    scopus 로고
    • Discovery and saturation analysis of cancer genes across 21 tumour types
    • Lawrence M.S., et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505, 495-501 (2014
    • (2014) Nature , vol.505 , pp. 495-501
    • Lawrence, M.S.1
  • 20
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis E., et al. A landscape of driver mutations in melanoma. Cell 150, 251-263 (2012
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1
  • 21
    • 84935009372 scopus 로고    scopus 로고
    • Genomic classification of cutaneous melanoma
    • Cancer Genome Atlas Network.
    • Cancer Genome Atlas Network. Genomic classification of cutaneous melanoma. Cell 161 1681-1696 (2015
    • (2015) Cell , vol.161 , pp. 1681-1696
  • 22
    • 84856268319 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma
    • Nikolaev S.I., et al. Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nat. Genet. 44, 133-139 (2012
    • (2012) Nat. Genet. , vol.44 , pp. 133-139
    • Nikolaev, S.I.1
  • 23
    • 0027519326 scopus 로고
    • UV-induced G:C-A:T transitions at the APRT locus of Chinese hamster ovary cells cluster at frequently damaged 5'-TCC-3' sequences
    • Drobetsky, E.A., & Sage, E. UV-induced G:C-A:T transitions at the APRT locus of Chinese hamster ovary cells cluster at frequently damaged 5'-TCC-3' sequences. Mutat. Res. 289, 131-138 (1993
    • (1993) Mutat. Res. , vol.289 , pp. 131-138
    • Drobetsky, E.A.1    Sage, E.2
  • 24
    • 0029096805 scopus 로고
    • Characteristics of UV-induced mutation spectra in human XP-D/ERCC2 gene-mutated xeroderma pigmentosum and trichothiodystrophy cells
    • Marionnet, C., Benoit, A., Benhamou, S., Sarasin, A., & Stary, A. Characteristics of UV-induced mutation spectra in human XP-D/ERCC2 gene-mutated xeroderma pigmentosum and trichothiodystrophy cells. J. Mol. Biol. 252, 550-562 (1995
    • (1995) J. Mol. Biol. , vol.252 , pp. 550-562
    • Marionnet, C.1    Benoit, A.2    Benhamou, S.3    Sarasin, A.4    Stary, A.5
  • 25
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov L.B., et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1
  • 27
    • 34347226353 scopus 로고    scopus 로고
    • Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by Vitamin C
    • Besaratinia, A., Kim, S.I., Bates, S.E., & Pfeifer, G.P. Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by vitamin C. Proc. Natl. Acad. Sci. USA 104, 5953-5958 (2007
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 5953-5958
    • Besaratinia, A.1    Kim, S.I.2    Bates, S.E.3    Pfeifer, G.P.4
  • 28
    • 84921519652 scopus 로고    scopus 로고
    • UV signature mutations
    • Brash, D.E. UV signature mutations. Photochem. Photobiol. 91, 15-26 (2015
    • (2015) Photochem. Photobiol. , vol.91 , pp. 15-26
    • Brash, D.E.1
  • 29
    • 84929463303 scopus 로고    scopus 로고
    • Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution
    • Hu, J., Adar, S., Selby, C.P., Lieb, J.D., & Sancar, A. Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution. Genes Dev. 29, 948-960 (2015
    • (2015) Genes Dev. , vol.29 , pp. 948-960
    • Hu, J.1    Adar, S.2    Selby, C.P.3    Lieb, J.D.4    Sancar, A.5
  • 30
    • 0033052124 scopus 로고    scopus 로고
    • Spectrum of p53 gene mutations suggests a possible role for ultraviolet radiation in the pathogenesis of advanced cutaneous lymphomas
    • McGregor J.M., et al. Spectrum of p53 gene mutations suggests a possible role for ultraviolet radiation in the pathogenesis of advanced cutaneous lymphomas. J. Invest. Dermatol. 112, 317-321 (1999
    • (1999) J. Invest. Dermatol. , vol.112 , pp. 317-321
    • McGregor, J.M.1
  • 31
    • 84949107950 scopus 로고    scopus 로고
    • The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome
    • da Silva Almeida A.C., et al. The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome. Nat. Genet. 47, 1465-1470 (2015
    • (2015) Nat. Genet. , vol.47 , pp. 1465-1470
    • Da Silva Almeida, A.C.1
  • 32
    • 34047205431 scopus 로고    scopus 로고
    • Mutant p53: An oncogenic transcription factor
    • Strano S., et al. Mutant p53: an oncogenic transcription factor. Oncogene 26, 2212-2219 (2007
    • (2007) Oncogene , vol.26 , pp. 2212-2219
    • Strano, S.1
  • 33
    • 0026639972 scopus 로고
    • Function of the c-Myc oncoprotein
    • Kato, G.J., & Dang, C.V. Function of the c-Myc oncoprotein. FASEB J. 6, 3065-3072 (1992
    • (1992) FASEB J. , vol.6 , pp. 3065-3072
    • Kato, G.J.1    Dang, C.V.2
  • 34
    • 0034653998 scopus 로고    scopus 로고
    • C-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover
    • Bahram, F., von der Lehr, N., Cetinkaya, C., & Larsson, L.G. c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover. Blood 95, 2104-2110 (2000
    • (2000) Blood , vol.95 , pp. 2104-2110
    • Bahram, F.1    Von Der Lehr, N.2    Cetinkaya, C.3    Larsson, L.G.4
  • 35
    • 2942650133 scopus 로고    scopus 로고
    • The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
    • Welcker M., et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc. Natl. Acad. Sci. USA 101, 9085-9090 (2004
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 9085-9090
    • Welcker, M.1
  • 36
    • 33745005741 scopus 로고    scopus 로고
    • Recurrent NMYC copy number gain and high protein expression in basal cell carcinoma
    • Freier K., et al. Recurrent NMYC copy number gain and high protein expression in basal cell carcinoma. Oncol. Rep. 15, 1141-1145 (2006
    • (2006) Oncol. Rep. , vol.15 , pp. 1141-1145
    • Freier, K.1
  • 37
    • 84927605530 scopus 로고    scopus 로고
    • New basal cell carcinoma susceptibility loci
    • Stacey S.N., et al. New basal cell carcinoma susceptibility loci. Nat. Commun. 6, 6825 (2015
    • (2015) Nat. Commun. , vol.6 , pp. 6825
    • Stacey, S.N.1
  • 38
    • 33645211987 scopus 로고    scopus 로고
    • Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes
    • Knoepfler, P.S., & Kenney, A.M. Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes. Cell Cycle 5, 47-52 (2006
    • (2006) Cell Cycle , vol.5 , pp. 47-52
    • Knoepfler, P.S.1    Kenney, A.M.2
  • 39
    • 34547555987 scopus 로고    scopus 로고
    • KinasePhos 2.0: A web server for identifying protein kinase-specific phosphorylation sites based on sequences and coupling patterns
    • Wong Y.H., et al. KinasePhos 2.0: a web server for identifying protein kinase-specific phosphorylation sites based on sequences and coupling patterns. Nucleic Acids Res. 35, W588-W594 (2007
    • (2007) Nucleic Acids Res. , vol.35 , pp. W588-W594
    • Wong, Y.H.1
  • 40
    • 84865840957 scopus 로고    scopus 로고
    • PTPN14 is required for the density-dependent control of YAP1
    • Wang W., et al. PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 26, 1959-1971 (2012
    • (2012) Genes Dev. , vol.26 , pp. 1959-1971
    • Wang, W.1
  • 41
    • 38549086019 scopus 로고    scopus 로고
    • FBW7 ubiquitin ligase: A tumour suppressor at the crossroads of cell division, growth and differentiation
    • Welcker, M., & Clurman, B.E. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat. Rev. Cancer 8, 83-93 (2008
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 83-93
    • Welcker, M.1    Clurman, B.E.2
  • 42
    • 84879364450 scopus 로고    scopus 로고
    • The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
    • King B., et al. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell 153, 1552-1566 (2013
    • (2013) Cell , vol.153 , pp. 1552-1566
    • King, B.1
  • 43
    • 79952297528 scopus 로고    scopus 로고
    • Yes-Associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
    • Zhang, H., Pasolli, H.A., & Fuchs, E. Yes-Associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc. Natl. Acad. Sci. USA 108, 2270-2275 (2011
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 2270-2275
    • Zhang, H.1    Pasolli, H.A.2    Fuchs, E.3
  • 44
    • 79952298459 scopus 로고    scopus 로고
    • Yap1 acts downstream of a-catenin to control epidermal proliferation
    • Schlegelmilch K., et al. Yap1 acts downstream of a-catenin to control epidermal proliferation. Cell 144, 782-795 (2011
    • (2011) Cell , vol.144 , pp. 782-795
    • Schlegelmilch, K.1
  • 45
    • 84906539718 scopus 로고    scopus 로고
    • PTPN14 forms a complex with Kibra and LATS1 proteins and negatively regulates the YAP oncogenic function
    • Wilson K.E., et al. PTPN14 forms a complex with Kibra and LATS1 proteins and negatively regulates the YAP oncogenic function. J. Biol. Chem. 289, 23693-23700 (2014
    • (2014) J. Biol. Chem. , vol.289 , pp. 23693-23700
    • Wilson, K.E.1
  • 46
    • 41949138130 scopus 로고    scopus 로고
    • Tumor suppressor LATS1 is a negative regulator of oncogene YAP
    • Hao, Y., Chun, A., Cheung, K., Rashidi, B., & Yang, X. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J. Biol. Chem. 283, 5496-5509 (2008
    • (2008) J. Biol. Chem. , vol.283 , pp. 5496-5509
    • Hao, Y.1    Chun, A.2    Cheung, K.3    Rashidi, B.4    Yang, X.5
  • 47
    • 84941426600 scopus 로고    scopus 로고
    • Biallelic alterations of the large tumor suppressor 1 (LATS1) gene in infiltrative, but not superficial, basal cell carcinomas in a Japanese patient with nevoid basal cell carcinoma syndrome
    • Tate, G., Kishimoto, K., & Mitsuya, T. Biallelic alterations of the large tumor suppressor 1 (LATS1) gene in infiltrative, but not superficial, basal cell carcinomas in a Japanese patient with nevoid basal cell carcinoma syndrome. Med. Mol. Morphol. 48, 177-182 (2015
    • (2015) Med. Mol. Morphol. , vol.48 , pp. 177-182
    • Tate, G.1    Kishimoto, K.2    Mitsuya, T.3
  • 48
    • 84865684161 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
    • Krauthammer M., et al. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat. Genet. 44, 1006-1014 (2012
    • (2012) Nat. Genet. , vol.44 , pp. 1006-1014
    • Krauthammer, M.1
  • 49
    • 84883368399 scopus 로고    scopus 로고
    • Melanoma-Associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A
    • Hammond D., et al. Melanoma-Associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A. J. Cell Sci. 126, 3429-3440 (2013
    • (2013) J. Cell Sci. , vol.126 , pp. 3429-3440
    • Hammond, D.1
  • 50
    • 0037118056 scopus 로고    scopus 로고
    • Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin e
    • Duman-Scheel, M., Weng, L., Xin, S., & Du, W. Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin E. Nature 417, 299-304 (2002
    • (2002) Nature , vol.417 , pp. 299-304
    • Duman-Scheel, M.1    Weng, L.2    Xin, S.3    Du, W.4
  • 51
    • 34547697828 scopus 로고    scopus 로고
    • Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells
    • Stefansson, B., & Brautigan, D.L. Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells. Cell Cycle 6, 1386-1392 (2007
    • (2007) Cell Cycle , vol.6 , pp. 1386-1392
    • Stefansson, B.1    Brautigan, D.L.2
  • 52
    • 84888100485 scopus 로고    scopus 로고
    • Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
    • Couzens A.L., et al. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci. Signal. 6, rs15 (2013
    • (2013) Sci. Signal. , vol.6 , pp. rs15
    • Couzens, A.L.1
  • 53
    • 84948714355 scopus 로고    scopus 로고
    • Mutations in the kinetochore gene KNSTRN in basal cell carcinoma
    • Jaju P.D., et al. Mutations in the kinetochore gene KNSTRN in basal cell carcinoma. J. Invest. Dermatol. 135, 3197-3200 (2015
    • (2015) J. Invest. Dermatol. , vol.135 , pp. 3197-3200
    • Jaju, P.D.1
  • 54
    • 84922061611 scopus 로고    scopus 로고
    • Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma
    • Lee C.S., et al. Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma. Nat. Genet. 46, 1060-1062 (2014
    • (2014) Nat. Genet. , vol.46 , pp. 1060-1062
    • Lee, C.S.1
  • 56
    • 67649412006 scopus 로고    scopus 로고
    • TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
    • Zhang H., et al. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J. Biol. Chem. 284, 13355-13362 (2009
    • (2009) J. Biol. Chem. , vol.284 , pp. 13355-13362
    • Zhang, H.1
  • 57
    • 84869779376 scopus 로고    scopus 로고
    • Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification
    • Valentijn L.J., et al. Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification. Proc. Natl. Acad. Sci. USA 109, 19190-19195 (2012
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 19190-19195
    • Valentijn, L.J.1
  • 58
    • 63749118521 scopus 로고    scopus 로고
    • Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci
    • Pfister S., et al. Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. J. Clin. Oncol. 27, 1627-1636 (2009
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1627-1636
    • Pfister, S.1
  • 59
    • 84863980527 scopus 로고    scopus 로고
    • Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth
    • Xu L., et al. Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth. Mol. Cell. Biochem. 364, 235-241 (2012
    • (2012) Mol. Cell. Biochem. , vol.364 , pp. 235-241
    • Xu, L.1
  • 60
    • 75749133243 scopus 로고    scopus 로고
    • Increased expression of the hedgehog signaling pathway in pediatric solid malignancies
    • Oue, T., Yoneda, A., Uehara, S., Yamanaka, H., & Fukuzawa, M. Increased expression of the hedgehog signaling pathway in pediatric solid malignancies. J. Pediatr. Surg. 45, 387-392 (2010
    • (2010) J. Pediatr. Surg. , vol.45 , pp. 387-392
    • Oue, T.1    Yoneda, A.2    Uehara, S.3    Yamanaka, H.4    Fukuzawa, M.5
  • 61
    • 84890863499 scopus 로고    scopus 로고
    • Aberrant activation nuclear localization, and phosphorylation of Yes-Associated protein-1 in the embryonic kidney and Wilms tumor
    • Murphy, A.J., et al. Aberrant activation, nuclear localization, and phosphorylation of Yes-Associated protein-1 in the embryonic kidney and Wilms tumor. Pediatr. Blood Cancer 61, 198-205 (2014
    • (2014) Pediatr. Blood Cancer , vol.61 , pp. 198-205
    • Murphy, A.J.1
  • 62
    • 84874664731 scopus 로고    scopus 로고
    • The genetic landscape of high-risk neuroblastoma
    • Pugh T.J., et al. The genetic landscape of high-risk neuroblastoma. Nat. Genet. 45, 279-284 (2013
    • (2013) Nat. Genet. , vol.45 , pp. 279-284
    • Pugh, T.J.1
  • 63
    • 79954444747 scopus 로고    scopus 로고
    • Medulloblastoma: Clinicopathological correlates of SHH WNT, and non-SHH/WNT molecular subgroups
    • Ellison, D.W., et al. Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta Neuropathol. 121, 381-396 (2011
    • (2011) Acta Neuropathol. , vol.121 , pp. 381-396
    • Ellison, D.W.1
  • 64
    • 84924682507 scopus 로고    scopus 로고
    • Multiple mechanisms of MYCN dysregulation in Wilms tumour
    • Williams R.D., et al. Multiple mechanisms of MYCN dysregulation in Wilms tumour. Oncotarget 6, 7232-7243 (2015
    • (2015) Oncotarget , vol.6 , pp. 7232-7243
    • Williams, R.D.1
  • 65
    • 84907341405 scopus 로고    scopus 로고
    • Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations
    • Nikolaev S.I., et al. Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations. Nat. Commun. 5, 4654 (2014
    • (2014) Nat. Commun. , vol.5 , pp. 4654
    • Nikolaev, S.I.1
  • 66
    • 84875490185 scopus 로고    scopus 로고
    • Cancer genome landscapes
    • Vogelstein B., et al. Cancer genome landscapes. Science 339, 1546-1558 (2013
    • (2013) Science , vol.339 , pp. 1546-1558
    • Vogelstein, B.1
  • 67
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows-Wheeler transform
    • Li, H., & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754-1760 (2009
    • (2009) Bioinformatics , vol.25 , pp. 1754-1760
    • Li, H.1    Durbin, R.2
  • 68
    • 77956295988 scopus 로고    scopus 로고
    • The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
    • McKenna A., et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 1297-1303 (2010
    • (2010) Genome Res. , vol.20 , pp. 1297-1303
    • McKenna, A.1
  • 69
    • 84874025843 scopus 로고    scopus 로고
    • Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
    • Cibulskis K., et al. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat. Biotechnol. 31, 213-219 (2013
    • (2013) Nat. Biotechnol. , vol.31 , pp. 213-219
    • Cibulskis, K.1
  • 70
    • 84923320523 scopus 로고    scopus 로고
    • Extrachromosomal driver mutations in glioblastoma and low-grade glioma
    • Nikolaev S., et al. Extrachromosomal driver mutations in glioblastoma and low-grade glioma. Nat. Commun. 5, 5690 (2014
    • (2014) Nat. Commun. , vol.5 , pp. 5690
    • Nikolaev, S.1
  • 71
    • 79955166265 scopus 로고    scopus 로고
    • GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
    • Mermel C.H., et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 12, R41 (2011
    • (2011) Genome Biol. , vol.12 , pp. R41
    • Mermel, C.H.1
  • 72
    • 84880507665 scopus 로고    scopus 로고
    • Mutational heterogeneity in cancer and the search for new cancer-Associated genes
    • Lawrence M.S., et al. Mutational heterogeneity in cancer and the search for new cancer-Associated genes. Nature 499, 214-218 (2013
    • (2013) Nature , vol.499 , pp. 214-218
    • Lawrence, M.S.1
  • 73
    • 84923362619 scopus 로고    scopus 로고
    • Integrative analysis of 111 reference human epigenomes
    • Roadmap Epigenomics Consortium.
    • Roadmap Epigenomics Consortium. Integrative analysis of 111 reference human epigenomes. Nature 518 317-330 (2015
    • (2015) Nature , vol.518 , pp. 317-330
  • 74
    • 77950661675 scopus 로고    scopus 로고
    • Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes
    • Chen C.L., et al. Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes. Genome Res. 20, 447-457 (2010
    • (2010) Genome Res. , vol.20 , pp. 447-457
    • Chen, C.L.1
  • 75
    • 84923197605 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of head and neck squamous cell carcinomas
    • Cancer Genome Atlas Network.
    • Cancer Genome Atlas Network. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 517 576-582 (2015
    • (2015) Nature , vol.517 , pp. 576-582
  • 76
    • 84921425131 scopus 로고    scopus 로고
    • EdgeR for differential RNA-seq and ChIP-seq analysis: An application to stem cell biology
    • Nikolayeva, O., & Robinson, M.D. edgeR for differential RNA-seq and ChIP-seq analysis: an application to stem cell biology. Methods Mol. Biol. 1150, 45-79 (2014
    • (2014) Methods Mol. Biol. , vol.1150 , pp. 45-79
    • Nikolayeva, O.1    Robinson, M.D.2
  • 77
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang, W., Sherman, B.T., & Lempicki, R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57 (2009
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 78
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang, W., Sherman, B.T., & Lempicki, R.A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37, 1-13 (2009
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1-13
    • Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 79
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A., et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545-15550 (2005
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 81
    • 84891752434 scopus 로고    scopus 로고
    • The eukaryotic linear motif resource ELM: 10 years and counting
    • Dinkel H., et al. The eukaryotic linear motif resource ELM: 10 years and counting. Nucleic Acids Res. 42, D259-D266 (2014
    • (2014) Nucleic Acids Res. , vol.42 , pp. D259-D266
    • Dinkel, H.1
  • 82
    • 48849113878 scopus 로고    scopus 로고
    • Comparative protein structure modeling using MODELLER
    • Unit 2.9
    • Eswar N., et al. Comparative protein structure modeling using MODELLER. Curr. Protoc. Protein Sci. Chapter 2, Unit 2.9 (2007
    • (2007) Curr. Protoc. Protein Sci. Chapter , vol.2
    • Eswar, N.1
  • 83
    • 0036291145 scopus 로고    scopus 로고
    • Predicting changes in the stability of proteins and protein complexes: A study of more than 1000 mutations
    • Guerois, R., Nielsen, J.E., & Serrano, L. Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations. J. Mol. Biol. 320, 369-387 (2002
    • (2002) J. Mol. Biol. , vol.320 , pp. 369-387
    • Guerois, R.1    Nielsen, J.E.2    Serrano, L.3
  • 84
    • 84880215077 scopus 로고    scopus 로고
    • MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma
    • Lodrini M., et al. MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma. Nucleic Acids Res. 41, 6018-6033 (2013
    • (2013) Nucleic Acids Res. , vol.41 , pp. 6018-6033
    • Lodrini, M.1
  • 85
    • 84884279358 scopus 로고    scopus 로고
    • Mutual interaction between YAP and c-Myc is critical for carcinogenesis in liver cancer
    • Xiao W., et al. Mutual interaction between YAP and c-Myc is critical for carcinogenesis in liver cancer. Biochem. Biophys. Res. Commun. 439, 167-172 (2013
    • (2013) Biochem. Biophys. Res. Commun. , vol.439 , pp. 167-172
    • Xiao, W.1
  • 86
    • 84888642428 scopus 로고    scopus 로고
    • MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer
    • Li L., et al. MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. FEBS Lett. 587, 3921-3927 (2013
    • (2013) FEBS Lett. , vol.587 , pp. 3921-3927
    • Li, L.1
  • 87
    • 0026615953 scopus 로고
    • Immunohistological detection of tumour growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues
    • Gerdes, J., Becker, M.H., Key, G., & Cattoretti, G. Immunohistological detection of tumour growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues. J. Pathol. 168, 85-86 (1992
    • (1992) J. Pathol. , vol.168 , pp. 85-86
    • Gerdes, J.1    Becker, M.H.2    Key, G.3    Cattoretti, G.4


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