The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers

Journal of Biological Chemistry

Volumn 289, Issue 51, 2014, Pages 35494-35502

  Long, Jun ^a   Li, Bin ^a   Rodriguez Blanco, Jezabel ^a   Pastori, Chiara ^a   Volmar, Claude Henry ^a   Wahlestedt, Claes ^a,b   Capobianco, Anthony ^a,b   Bai, Feng ^a   Pei, Xin Hai ^a,b   Ayad, Nagi G ^a,b   Robbins, David J ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELL CULTURE; CELL PROLIFERATION; CELLS; CYTOLOGY; DISEASES; GENE EXPRESSION; MOLECULES; PROTEINS; SIGNAL TRANSDUCTION;

HEDGEHOG SIGNALING; HISTONE DEACETYLASE INHIBITOR; MOUSE EMBRYONIC FIBROBLASTS; PROTEIN INHIBITORS; REPORTER CELL LINE; SIGNAL TRANSDUCTION PATHWAYS; SIGNALING PATHWAYS; THERAPEUTIC STRATEGY;

CELL SIGNALING;

7 (3,5 DIMETHYL 4 ISOXAZOLYL) 1,3 DIHYDRO 8 METHOXY 1 [1 (2 PYRIDINYL)ETHYL] 2H IMIDAZO[4,5 C]QUINOLIN 2 ONE; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; VISMODEGIB; BRD4 PROTEIN, MOUSE; FUSED HETEROCYCLIC RINGS; G PROTEIN COUPLED RECEPTOR; GLI PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; NUCLEAR PROTEIN; REPRESSOR PROTEIN; SMO PROTEIN, MOUSE; SUFU PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CELL VIABILITY; CONTROLLED STUDY; EPIGENETICS; FIBROBLAST; GENE LOCUS; IN VITRO STUDY; IN VIVO STUDY; MEDULLOBLASTOMA; MODULATION; MOUSE; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CELL LINE; CELL PROLIFERATION; CYTOLOGY; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; MAMMALIAN EMBRYO; METABOLISM; NUDE MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

ERINACEIDAE;

ANIMALS; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MEDULLOBLASTOMA; MICE, KNOCKOUT; MICE, NUDE; NUCLEAR PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84919473753     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.595348     Document Type: Article

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