메뉴 건너뛰기




Volumn 37, Issue 1, 2016, Pages 62-72

Smoothened Regulation: A Tale of Two Signals

Author keywords

canonical signaling; GPCR; Hedgehog; noncanonical signaling; Smoothened

Indexed keywords

PROTEIN PATCHED; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI; UNCLASSIFIED DRUG; WNT PROTEIN; DROSOPHILA PROTEIN; G PROTEIN COUPLED RECEPTOR; SMO PROTEIN, HUMAN; SMOOTHENED PROTEIN, DROSOPHILA;

EID: 84951326093     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2015.09.001     Document Type: Review
Times cited : (76)

References (99)
  • 1
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • P.W. Ingham, and A.P. McMahon Hedgehog signaling in animal development: paradigms and principles Genes Dev. 15 2001 3059 3087
    • (2001) Genes Dev. , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMmahon, A.P.2
  • 2
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • J. Jiang, and C.C. Hui Hedgehog signaling in development and cancer Dev. Cell 15 2008 801 812
    • (2008) Dev. Cell , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 3
    • 33744906572 scopus 로고    scopus 로고
    • Inhibitors of the Hedgehog signal transduction pathway
    • D.J. Robbins, and et al. Inhibitors of the Hedgehog signal transduction pathway Curr. Cancer Ther. Rev. 1 2005 227 288
    • (2005) Curr. Cancer Ther. Rev. , vol.1 , pp. 227-288
    • Robbins, D.J.1
  • 4
    • 84920166693 scopus 로고    scopus 로고
    • Generic GPCR residue numbers - Aligning topology maps while minding the gaps
    • V. Isberg, and et al. Generic GPCR residue numbers - aligning topology maps while minding the gaps Trends Pharmacol. Sci. 36 2015 22 31
    • (2015) Trends Pharmacol. Sci. , vol.36 , pp. 22-31
    • Isberg, V.1
  • 5
    • 0011102935 scopus 로고    scopus 로고
    • The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    • D.M. Stone, and et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog Nature 384 1996 129 134
    • (1996) Nature , vol.384 , pp. 129-134
    • Stone, D.M.1
  • 6
    • 0030602796 scopus 로고    scopus 로고
    • The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
    • J. Alcedo, and et al. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal Cell 86 1996 221 232
    • (1996) Cell , vol.86 , pp. 221-232
    • Alcedo, J.1
  • 7
    • 0029784223 scopus 로고    scopus 로고
    • Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
    • M. van den Heuvel, and P.W. Ingham smoothened encodes a receptor-like serpentine protein required for hedgehog signalling Nature 382 1996 547 551
    • (1996) Nature , vol.382 , pp. 547-551
    • Van Den Heuvel, M.1    Ingham, P.W.2
  • 8
    • 0034682719 scopus 로고    scopus 로고
    • Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    • N. Denef, and et al. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened Cell 102 2000 521 531
    • (2000) Cell , vol.102 , pp. 521-531
    • Denef, N.1
  • 9
    • 0031437362 scopus 로고    scopus 로고
    • Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer
    • T. Von Ohlen, and J.E. Hooper Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer Mech. Dev. 68 1997 149 156
    • (1997) Mech. Dev. , vol.68 , pp. 149-156
    • Von Ohlen, T.1    Hooper, J.E.2
  • 10
    • 0029858774 scopus 로고    scopus 로고
    • Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins
    • C. Alexandre, and et al. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins Genes Dev. 10 1996 2003 2013
    • (1996) Genes Dev. , vol.10 , pp. 2003-2013
    • Alexandre, C.1
  • 11
    • 84867799739 scopus 로고    scopus 로고
    • The Hedgehog signal transduction network
    • D.J. Robbins, and et al. The Hedgehog signal transduction network Sci. Signal. 5 2012 re6
    • (2012) Sci. Signal. , vol.5 , pp. re6
    • Robbins, D.J.1
  • 12
    • 84890897900 scopus 로고    scopus 로고
    • Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling
    • R. Rana, and et al. Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling Nat. Commun. 4 2013 2965
    • (2013) Nat. Commun. , vol.4 , pp. 2965
    • Rana, R.1
  • 13
    • 84887326705 scopus 로고    scopus 로고
    • Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
    • S. Nachtergaele, and et al. Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling Elife 2 2013 e01340
    • (2013) Elife , vol.2
    • Nachtergaele, S.1
  • 14
    • 84863543371 scopus 로고    scopus 로고
    • Structural basis of Wnt recognition by Frizzled
    • C.Y. Janda, and et al. Structural basis of Wnt recognition by Frizzled Science 337 2012 59 64
    • (2012) Science , vol.337 , pp. 59-64
    • Janda, C.Y.1
  • 15
    • 84883051342 scopus 로고    scopus 로고
    • Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response
    • B.R. Myers, and et al. Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response Dev. Cell 26 2013 346 357
    • (2013) Dev. Cell , vol.26 , pp. 346-357
    • Myers, B.R.1
  • 16
    • 84883185477 scopus 로고    scopus 로고
    • Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling
    • D. Nedelcu, and et al. Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling Nat. Chem. Biol. 9 2013 557 564
    • (2013) Nat. Chem. Biol. , vol.9 , pp. 557-564
    • Nedelcu, D.1
  • 17
    • 84878112106 scopus 로고    scopus 로고
    • Structure of the human smoothened receptor bound to an antitumour agent
    • C. Wang, and et al. Structure of the human smoothened receptor bound to an antitumour agent Nature 497 2013 338 343
    • (2013) Nature , vol.497 , pp. 338-343
    • Wang, C.1
  • 18
    • 84904325982 scopus 로고    scopus 로고
    • Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs
    • C. Wang, and et al. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Nat. Commun. 5 2014 4355
    • (2014) Nat. Commun. , vol.5 , pp. 4355
    • Wang, C.1
  • 19
    • 0033590605 scopus 로고    scopus 로고
    • A frequent activated smoothened mutation in sporadic basal cell carcinomas
    • C.W. Lam, and et al. A frequent activated smoothened mutation in sporadic basal cell carcinomas Oncogene 18 1999 833 836
    • (1999) Oncogene , vol.18 , pp. 833-836
    • Lam, C.W.1
  • 20
    • 0031913524 scopus 로고    scopus 로고
    • Activating Smoothened mutations in sporadic basal-cell carcinoma
    • J. Xie, and et al. Activating Smoothened mutations in sporadic basal-cell carcinoma Nature 391 1998 90 92
    • (1998) Nature , vol.391 , pp. 90-92
    • Xie, J.1
  • 21
    • 84922358758 scopus 로고    scopus 로고
    • Smoothened goes molecular: New pieces in the hedgehog signaling puzzle
    • J.M. McCabe, and D.J. Leahy Smoothened goes molecular: new pieces in the hedgehog signaling puzzle J. Biol. Chem. 290 2015 3500 3507
    • (2015) J. Biol. Chem. , vol.290 , pp. 3500-3507
    • McCabe, J.M.1    Leahy, D.J.2
  • 22
    • 84925852119 scopus 로고    scopus 로고
    • Regulation of the oncoprotein Smoothened by small molecules
    • H.J. Sharpe, and et al. Regulation of the oncoprotein Smoothened by small molecules Nat. Chem. Biol. 11 2015 246 255
    • (2015) Nat. Chem. Biol. , vol.11 , pp. 246-255
    • Sharpe, H.J.1
  • 23
    • 84855426679 scopus 로고    scopus 로고
    • The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation
    • C.E. Carroll, and et al. The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation Development 139 2012 612 621
    • (2012) Development , vol.139 , pp. 612-621
    • Carroll, C.E.1
  • 24
    • 1142289021 scopus 로고    scopus 로고
    • Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila
    • Y. Nakano, and et al. Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila Mech. Dev. 121 2004 507 518
    • (2004) Mech. Dev. , vol.121 , pp. 507-518
    • Nakano, Y.1
  • 25
    • 84940732236 scopus 로고    scopus 로고
    • Functional divergence in the role of N-linked glycosylation in Smoothened signaling
    • S. Marada, and et al. Functional divergence in the role of N-linked glycosylation in Smoothened signaling PLoS Genet. 11 2015 e1005473
    • (2015) PLoS Genet. , vol.11
    • Marada, S.1
  • 26
    • 77953301324 scopus 로고    scopus 로고
    • N-linked glycosylation of protease-activated receptor-1 second extracellular loop: A critical determinant for ligand-induced receptor activation and internalization
    • A.G. Soto, and J. Trejo N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization J. Biol. Chem. 285 2010 18781 18793
    • (2010) J. Biol. Chem. , vol.285 , pp. 18781-18793
    • Soto, A.G.1    Trejo, J.2
  • 27
    • 23944441721 scopus 로고    scopus 로고
    • Importance of N-glycosylation positioning for cell-surface expression, targeting, affinity and quality control of the human AT1 receptor
    • P.M. Lanctot, and et al. Importance of N-glycosylation positioning for cell-surface expression, targeting, affinity and quality control of the human AT1 receptor Biochem. J. 390 2005 367 376
    • (2005) Biochem. J. , vol.390 , pp. 367-376
    • Lanctot, P.M.1
  • 28
    • 0036392325 scopus 로고    scopus 로고
    • Glycosylation of beta(1)-adrenergic receptors regulates receptor surface expression and dimerization
    • J. He, and et al. Glycosylation of beta(1)-adrenergic receptors regulates receptor surface expression and dimerization Biochem. Biophys. Res. Commun. 297 2002 565 572
    • (2002) Biochem. Biophys. Res. Commun. , vol.297 , pp. 565-572
    • He, J.1
  • 29
    • 0032799753 scopus 로고    scopus 로고
    • Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: Its occurrence and role
    • M. Wheatley, and S.R. Hawtin Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role Hum. Reprod. Update 5 1999 356 364
    • (1999) Hum. Reprod. Update , vol.5 , pp. 356-364
    • Wheatley, M.1    Hawtin, S.R.2
  • 30
    • 84906232914 scopus 로고    scopus 로고
    • Visualization of arrestin recruitment by a G-protein-coupled receptor
    • A.K. Shukla, and et al. Visualization of arrestin recruitment by a G-protein-coupled receptor Nature 512 2014 218 222
    • (2014) Nature , vol.512 , pp. 218-222
    • Shukla, A.K.1
  • 31
    • 84884999937 scopus 로고    scopus 로고
    • Structural features of the G-protein/GPCR interactions
    • I.S. Moreira Structural features of the G-protein/GPCR interactions Biochim. Biophys. Acta 1840 2014 16 33
    • (2014) Biochim. Biophys. Acta , vol.1840 , pp. 16-33
    • Moreira, I.S.1
  • 32
    • 33747614580 scopus 로고    scopus 로고
    • Activation of heterotrimeric G proteins by Smoothened
    • N.A. Riobo, and et al. Activation of heterotrimeric G proteins by Smoothened Proc. Natl. Acad. Sci. U.S.A. 103 2006 12607 12612
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 12607-12612
    • Riobo, N.A.1
  • 33
    • 57049085407 scopus 로고    scopus 로고
    • G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling
    • S.K. Ogden, and et al. G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling Nature 456 2008 967 970
    • (2008) Nature , vol.456 , pp. 967-970
    • Ogden, S.K.1
  • 34
    • 0034716851 scopus 로고    scopus 로고
    • Activation of the AT1 angiotensin receptor is dependent on adjacent apolar residues in the carboxyl terminus of the third cytoplasmic loop
    • M. Zhang, and et al. Activation of the AT1 angiotensin receptor is dependent on adjacent apolar residues in the carboxyl terminus of the third cytoplasmic loop J. Biol. Chem. 275 2000 15782 15788
    • (2000) J. Biol. Chem. , vol.275 , pp. 15782-15788
    • Zhang, M.1
  • 35
    • 34548472626 scopus 로고    scopus 로고
    • Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth
    • J.R. Remsberg, and et al. Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth J. Med. Chem. 50 2007 4534 4538
    • (2007) J. Med. Chem. , vol.50 , pp. 4534-4538
    • Remsberg, J.R.1
  • 36
    • 36049033946 scopus 로고    scopus 로고
    • Hedgehog regulates smoothened activity by inducing a conformational switch
    • Y. Zhao, and et al. Hedgehog regulates smoothened activity by inducing a conformational switch Nature 450 2007 252 258
    • (2007) Nature , vol.450 , pp. 252-258
    • Zhao, Y.1
  • 37
    • 79959804711 scopus 로고    scopus 로고
    • Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened
    • Y. Chen, and et al. Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened PLoS Biol. 9 2011 e1001083
    • (2011) PLoS Biol. , vol.9
    • Chen, Y.1
  • 38
    • 84873735792 scopus 로고    scopus 로고
    • Decoding the phosphorylation code in Hedgehog signal transduction
    • Y. Chen, and J. Jiang Decoding the phosphorylation code in Hedgehog signal transduction Cell Res. 23 2013 186 200
    • (2013) Cell Res. , vol.23 , pp. 186-200
    • Chen, Y.1    Jiang, J.2
  • 39
    • 80052038573 scopus 로고    scopus 로고
    • Beta-Arrestin-mediated receptor trafficking and signal transduction
    • S.K. Shenoy, and R.J. Lefkowitz beta-Arrestin-mediated receptor trafficking and signal transduction Trends Pharmacol. Sci. 32 2011 521 533
    • (2011) Trends Pharmacol. Sci. , vol.32 , pp. 521-533
    • Shenoy, S.K.1    Lefkowitz, R.J.2
  • 40
    • 70450221494 scopus 로고    scopus 로고
    • Regulation of smoothened by Drosophila G-protein-coupled receptor kinases
    • S. Cheng, and et al. Regulation of smoothened by Drosophila G-protein-coupled receptor kinases Dev. Biol. 337 2010 99 109
    • (2010) Dev. Biol. , vol.337 , pp. 99-109
    • Cheng, S.1
  • 41
    • 34249950014 scopus 로고    scopus 로고
    • The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
    • C. Molnar, and et al. The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila Proc. Natl. Acad. Sci. U.S.A. 104 2007 7963 7968
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 7963-7968
    • Molnar, C.1
  • 42
    • 79953754361 scopus 로고    scopus 로고
    • Role of the Drosophila non-visual ss-arrestin kurtz in hedgehog signalling
    • C. Molnar, and et al. Role of the Drosophila non-visual ss-arrestin kurtz in hedgehog signalling PLoS Genet. 7 2011 e1001335
    • (2011) PLoS Genet. , vol.7
    • Molnar, C.1
  • 43
    • 84905457341 scopus 로고    scopus 로고
    • A broadly conserved G-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila Smoothened activity
    • D. Maier, and et al. A broadly conserved G-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila Smoothened activity PLoS Genet. 10 2014 e1004399
    • (2014) PLoS Genet. , vol.10
    • Maier, D.1
  • 44
    • 33749590571 scopus 로고    scopus 로고
    • Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2
    • A.R. Meloni, and et al. Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2 Mol. Cell. Biol. 26 2006 7550 7560
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 7550-7560
    • Meloni, A.R.1
  • 45
    • 11144256194 scopus 로고    scopus 로고
    • Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
    • W. Chen, and et al. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2 Science 306 2004 2257 2260
    • (2004) Science , vol.306 , pp. 2257-2260
    • Chen, W.1
  • 46
    • 46449127054 scopus 로고    scopus 로고
    • Beta-arrestin-mediated localization of smoothened to the primary cilium
    • J.J. Kovacs, and et al. Beta-arrestin-mediated localization of smoothened to the primary cilium Science 320 2008 1777 1781
    • (2008) Science , vol.320 , pp. 1777-1781
    • Kovacs, J.J.1
  • 47
    • 84863012620 scopus 로고    scopus 로고
    • USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization
    • R. Xia, and et al. USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization PLoS Biol. 10 2012 e1001238
    • (2012) PLoS Biol. , vol.10
    • Xia, R.1
  • 48
    • 84893003052 scopus 로고    scopus 로고
    • Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling
    • J. Fan, and et al. Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling PLoS ONE 8 2013 e79021
    • (2013) PLoS ONE , vol.8
    • Fan, J.1
  • 49
    • 84863012714 scopus 로고    scopus 로고
    • Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila
    • S. Li, and et al. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila PLoS Biol. 10 2012 e1001239
    • (2012) PLoS Biol. , vol.10
    • Li, S.1
  • 50
    • 23844485210 scopus 로고    scopus 로고
    • Cilia and Hedgehog responsiveness in the mouse
    • D. Huangfu, and K.V. Anderson Cilia and Hedgehog responsiveness in the mouse Proc. Natl. Acad. Sci. U.S.A. 102 2005 11325 11330
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 11325-11330
    • Huangfu, D.1    Anderson, K.V.2
  • 52
    • 77953662946 scopus 로고    scopus 로고
    • Primary cilium as a Hedgehog signal transduction machine
    • S.C. Goetz, and et al. primary cilium as a Hedgehog signal transduction machine Methods Cell Biol. 94 2009 199 222
    • (2009) Methods Cell Biol. , vol.94 , pp. 199-222
    • Goetz, S.C.1
  • 53
    • 84930518703 scopus 로고    scopus 로고
    • The role of ciliary trafficking in Hedgehog receptor signaling
    • J. Kim, and et al. The role of ciliary trafficking in Hedgehog receptor signaling Sci. Signal. 8 2015 ra55
    • (2015) Sci. Signal. , vol.8 , pp. ra55
    • Kim, J.1
  • 54
    • 26644460824 scopus 로고    scopus 로고
    • Vertebrate Smoothened functions at the primary cilium
    • K.C. Corbit, and et al. Vertebrate Smoothened functions at the primary cilium Nature 437 2005 1018 1021
    • (2005) Nature , vol.437 , pp. 1018-1021
    • Corbit, K.C.1
  • 55
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • R. Rohatgi, and et al. Patched1 regulates hedgehog signaling at the primary cilium Science 317 2007 372 376
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1
  • 56
    • 65249123996 scopus 로고    scopus 로고
    • Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium
    • C.W. Wilson, and et al. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium PLoS ONE 4 2009 e5182
    • (2009) PLoS ONE , vol.4
    • Wilson, C.W.1
  • 57
    • 75549090700 scopus 로고    scopus 로고
    • Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
    • L. Milenkovic, and et al. Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium J. Cell Biol. 187 2009 365 374
    • (2009) J. Cell Biol. , vol.187 , pp. 365-374
    • Milenkovic, L.1
  • 58
    • 84936817681 scopus 로고    scopus 로고
    • Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1
    • L. Milenkovic, and et al. Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1 Proc. Natl. Acad. Sci. U.S.A. 112 2015 8320 8325
    • (2015) Proc. Natl. Acad. Sci. U.S.A. , vol.112 , pp. 8320-8325
    • Milenkovic, L.1
  • 59
    • 77954949822 scopus 로고    scopus 로고
    • Role of lipid metabolism in smoothened derepression in hedgehog signaling
    • A. Yavari, and et al. Role of lipid metabolism in smoothened derepression in hedgehog signaling Dev. Cell 19 2010 54 65
    • (2010) Dev. Cell , vol.19 , pp. 54-65
    • Yavari, A.1
  • 60
    • 80052186347 scopus 로고    scopus 로고
    • Membrane-trafficking sorting hubs: Cooperation between PI4P and small GTPases at the trans-Golgi network
    • F.H. Santiago-Tirado, and A. Bretscher Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network Trends Cell Biol. 21 2011 515 525
    • (2011) Trends Cell Biol. , vol.21 , pp. 515-525
    • Santiago-Tirado, F.H.1    Bretscher, A.2
  • 61
    • 84897065629 scopus 로고    scopus 로고
    • PI3K class II alpha controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function
    • I. Franco, and et al. PI3K class II alpha controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function Dev. Cell 28 2014 647 658
    • (2014) Dev. Cell , vol.28 , pp. 647-658
    • Franco, I.1
  • 62
    • 84925240113 scopus 로고    scopus 로고
    • Endocannabinoids are conserved inhibitors of the Hedgehog pathway
    • H. Khaliullina, and et al. Endocannabinoids are conserved inhibitors of the Hedgehog pathway Proc. Natl. Acad. Sci. U.S.A. 112 2015 3415 3420
    • (2015) Proc. Natl. Acad. Sci. U.S.A. , vol.112 , pp. 3415-3420
    • Khaliullina, H.1
  • 63
    • 71449084811 scopus 로고    scopus 로고
    • Patched regulates Smoothened trafficking using lipoprotein-derived lipids
    • H. Khaliullina, and et al. Patched regulates Smoothened trafficking using lipoprotein-derived lipids Development 136 2009 4111 4121
    • (2009) Development , vol.136 , pp. 4111-4121
    • Khaliullina, H.1
  • 64
    • 84864614812 scopus 로고    scopus 로고
    • Lipoproteins in Drosophila melanogaster: Assembly, function, and influence on tissue lipid composition
    • W. Palm, and et al. Lipoproteins in Drosophila melanogaster: assembly, function, and influence on tissue lipid composition PLoS Genet. 8 2012 e1002828
    • (2012) PLoS Genet. , vol.8
    • Palm, W.1
  • 65
    • 84875452685 scopus 로고    scopus 로고
    • Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals
    • W. Palm, and et al. Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals PLoS Biol. 11 2013 e1001505
    • (2013) PLoS Biol. , vol.11
    • Palm, W.1
  • 66
    • 79957613017 scopus 로고    scopus 로고
    • Heterotrimeric Gi Proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration
    • A.H. Polizio, and et al. Heterotrimeric Gi Proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration J. Biol. Chem. 286 2011 19589 19596
    • (2011) J. Biol. Chem. , vol.286 , pp. 19589-19596
    • Polizio, A.H.1
  • 67
    • 79952733097 scopus 로고    scopus 로고
    • Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord
    • Y.H. Belgacem, and L.N. Borodinsky Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord Proc. Natl. Acad. Sci. U.S.A. 108 2011 4482 4487
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 4482-4487
    • Belgacem, Y.H.1    Borodinsky, L.N.2
  • 68
    • 84905583145 scopus 로고    scopus 로고
    • Canonical and non-canonical Hedgehog signalling and the control of metabolism
    • R. Teperino, and et al. Canonical and non-canonical Hedgehog signalling and the control of metabolism Semin. Cell. Dev. Biol. 33 2014 81 92
    • (2014) Semin. Cell. Dev. Biol. , vol.33 , pp. 81-92
    • Teperino, R.1
  • 69
    • 84867536639 scopus 로고    scopus 로고
    • Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat
    • R. Teperino, and et al. Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat Cell 151 2012 414 426
    • (2012) Cell , vol.151 , pp. 414-426
    • Teperino, R.1
  • 70
    • 84892542938 scopus 로고    scopus 로고
    • Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling
    • P. Niewiadomski, and et al. Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling Cell Rep. 6 2014 168 181
    • (2014) Cell Rep. , vol.6 , pp. 168-181
    • Niewiadomski, P.1
  • 71
    • 77950463564 scopus 로고    scopus 로고
    • The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
    • E.W. Humke, and et al. The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins Genes Dev. 24 2010 670 682
    • (2010) Genes Dev. , vol.24 , pp. 670-682
    • Humke, E.W.1
  • 72
    • 77958508124 scopus 로고    scopus 로고
    • A mechanism for vertebrate Hedgehog signaling: Recruitment to cilia and dissociation of SuFu-Gli protein complexes
    • H. Tukachinsky, and et al. A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes J. Cell Biol. 191 2010 415 428
    • (2010) J. Cell Biol. , vol.191 , pp. 415-428
    • Tukachinsky, H.1
  • 73
    • 84867678037 scopus 로고    scopus 로고
    • A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia
    • K.V. Dorn, and et al. A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia Dev. Cell 23 2012 823 835
    • (2012) Dev. Cell , vol.23 , pp. 823-835
    • Dorn, K.V.1
  • 74
    • 84896733610 scopus 로고    scopus 로고
    • EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia
    • G.V. Pusapati, and et al. EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia Dev. Cell 28 2014 483 496
    • (2014) Dev. Cell , vol.28 , pp. 483-496
    • Pusapati, G.V.1
  • 75
    • 84922145020 scopus 로고    scopus 로고
    • Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5
    • Y.C. Chong, and et al. Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5 Genes Dev. 29 2015 262 276
    • (2015) Genes Dev. , vol.29 , pp. 262-276
    • Chong, Y.C.1
  • 76
    • 68149178664 scopus 로고    scopus 로고
    • The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
    • S. Endoh-Yamagami, and et al. The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development Curr. Biol. 19 2009 1320 1326
    • (2009) Curr. Biol. , vol.19 , pp. 1320-1326
    • Endoh-Yamagami, S.1
  • 77
    • 69449084098 scopus 로고    scopus 로고
    • The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling
    • H.O. Cheung, and et al. The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling Sci. Signal. 2 2009 ra29
    • (2009) Sci. Signal. , vol.2 , pp. ra29
    • Cheung, H.O.1
  • 78
    • 69449099121 scopus 로고    scopus 로고
    • Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
    • K.F. Liem Jr, and et al. Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling Proc. Natl. Acad. Sci U.S.A. 106 2009 13377 13382
    • (2009) Proc. Natl. Acad. Sci U.S.A. , vol.106 , pp. 13377-13382
    • Liem, K.F.1
  • 79
    • 0032519906 scopus 로고    scopus 로고
    • The effect of pertussis toxin on zebrafish development: A possible role for inhibitory G-proteins in hedgehog signaling
    • M. Hammerschmidt, and A.P. McMahon The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in hedgehog signaling Dev. Biol. 194 1998 166 171
    • (1998) Dev. Biol. , vol.194 , pp. 166-171
    • Hammerschmidt, M.1    McMahon, A.P.2
  • 80
    • 0034713934 scopus 로고    scopus 로고
    • Smoothened activates Galphai-mediated signaling in frog melanophores
    • D.L. DeCamp, and et al. Smoothened activates Galphai-mediated signaling in frog melanophores J. Biol. Chem. 275 2000 26322 26327
    • (2000) J. Biol. Chem. , vol.275 , pp. 26322-26327
    • DeCamp, D.L.1
  • 81
    • 79953138390 scopus 로고    scopus 로고
    • Sonic Hedgehog-induced proliferation requires specific Galpha inhibitory proteins
    • M. Barzi, and et al. Sonic Hedgehog-induced proliferation requires specific Galpha inhibitory proteins J. Biol. Chem. 286 2011 8067 8074
    • (2011) J. Biol. Chem. , vol.286 , pp. 8067-8074
    • Barzi, M.1
  • 82
    • 49049108307 scopus 로고    scopus 로고
    • The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning
    • W.C. Low, and et al. The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning Dev. Biol. 321 2008 188 196
    • (2008) Dev. Biol. , vol.321 , pp. 188-196
    • Low, W.C.1
  • 83
    • 84903589937 scopus 로고    scopus 로고
    • Gi proteins mediate activation of the canonical Hedgehog pathway in the myocardium
    • C.J. Carbe, and et al. Gi proteins mediate activation of the canonical Hedgehog pathway in the myocardium Am. J. Physiol. Heart Circ. Physiol. 307 2014 H66 H72
    • (2014) Am. J. Physiol. Heart Circ. Physiol. , vol.307 , pp. H66-H72
    • Carbe, C.J.1
  • 84
    • 77951932085 scopus 로고    scopus 로고
    • Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways
    • P. Chinchilla, and et al. Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways Cell Cycle 9 2010 570 579
    • (2010) Cell Cycle , vol.9 , pp. 570-579
    • Chinchilla, P.1
  • 85
    • 0037195074 scopus 로고    scopus 로고
    • Small molecule modulation of Smoothened activity
    • J.K. Chen, and et al. Small molecule modulation of Smoothened activity Proc. Natl. Acad. Sci. U.S.A. 99 2002 14071 14076
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 14071-14076
    • Chen, J.K.1
  • 86
    • 0032413830 scopus 로고    scopus 로고
    • In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex
    • Y. Chen, and G. Struhl In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex Development 125 1998 4943 4948
    • (1998) Development , vol.125 , pp. 4943-4948
    • Chen, Y.1    Struhl, G.2
  • 87
    • 0037158748 scopus 로고    scopus 로고
    • Patched acts catalytically to suppress the activity of Smoothened
    • J. Taipale, and et al. Patched acts catalytically to suppress the activity of Smoothened Nature 418 2002 892 897
    • (2002) Nature , vol.418 , pp. 892-897
    • Taipale, J.1
  • 88
    • 84905566797 scopus 로고    scopus 로고
    • G-protein-coupled receptors, Hedgehog signaling and primary cilia
    • S. Mukhopadhyay, and R. Rohatgi G-protein-coupled receptors, Hedgehog signaling and primary cilia Semin. Cell Dev. Biol. 33 2014 63 72
    • (2014) Semin. Cell Dev. Biol. , vol.33 , pp. 63-72
    • Mukhopadhyay, S.1    Rohatgi, R.2
  • 89
    • 34548306769 scopus 로고    scopus 로고
    • Patching the gaps in Hedgehog signalling
    • R. Rohatgi, and M.P. Scott Patching the gaps in Hedgehog signalling Nat. Cell Biol. 9 2007 1005 1009
    • (2007) Nat. Cell Biol. , vol.9 , pp. 1005-1009
    • Rohatgi, R.1    Scott, M.P.2
  • 90
    • 33744788672 scopus 로고    scopus 로고
    • Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
    • R.B. Corcoran, and M.P. Scott Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells Proc. Natl. Acad. Sci. U.S.A. 103 2006 8408 8413
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 8408-8413
    • Corcoran, R.B.1    Scott, M.P.2
  • 91
    • 84856098531 scopus 로고    scopus 로고
    • Oxysterols are allosteric activators of the oncoprotein Smoothened
    • S. Nachtergaele, and et al. Oxysterols are allosteric activators of the oncoprotein Smoothened Nat. Chem. Biol. 8 2012 211 220
    • (2012) Nat. Chem. Biol. , vol.8 , pp. 211-220
    • Nachtergaele, S.1
  • 92
    • 77955420936 scopus 로고    scopus 로고
    • Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer
    • M.T. Barakat, and et al. Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer Trends Mol. Med. 16 2011 337 348
    • (2011) Trends Mol. Med. , vol.16 , pp. 337-348
    • Barakat, M.T.1
  • 93
    • 84937628121 scopus 로고    scopus 로고
    • Rolling the genetic dice: Neutral and deleterious Smoothened mutations in drug-resistant basal cell carcinoma
    • S.X. Atwood, and et al. Rolling the genetic dice: neutral and deleterious Smoothened mutations in drug-resistant basal cell carcinoma J. Invest. Dermatol. 135 2015 2138 2141
    • (2015) J. Invest. Dermatol. , vol.135 , pp. 2138-2141
    • Atwood, S.X.1
  • 94
    • 84924242647 scopus 로고    scopus 로고
    • Smoothened variants explain the majority of drug resistance in basal cell carcinoma
    • S.X. Atwood, and et al. Smoothened variants explain the majority of drug resistance in basal cell carcinoma Cancer Cell 27 2015 342 353
    • (2015) Cancer Cell , vol.27 , pp. 342-353
    • Atwood, S.X.1
  • 95
    • 84924262003 scopus 로고    scopus 로고
    • Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma
    • H.J. Sharpe, and et al. Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma Cancer Cell 27 2015 327 341
    • (2015) Cancer Cell , vol.27 , pp. 327-341
    • Sharpe, H.J.1
  • 96
    • 84919473753 scopus 로고    scopus 로고
    • The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers
    • J. Long, and et al. The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers J. Biol. Chem. 289 2014 35494 35502
    • (2014) J. Biol. Chem. , vol.289 , pp. 35494-35502
    • Long, J.1
  • 97
    • 84872417679 scopus 로고    scopus 로고
    • Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
    • J. Kim, and et al. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists Cancer Cell 23 2013 23 34
    • (2013) Cancer Cell , vol.23 , pp. 23-34
    • Kim, J.1
  • 98
    • 84865528807 scopus 로고    scopus 로고
    • Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity
    • Y. Wang, and et al. Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity Chem. Biol. 19 2012 972 982
    • (2012) Chem. Biol. , vol.19 , pp. 972-982
    • Wang, Y.1
  • 99
    • 84878997806 scopus 로고    scopus 로고
    • The unfolded protein response selectively targets active smoothened mutants
    • S. Marada, and et al. The unfolded protein response selectively targets active smoothened mutants Mol. Cell. Biol. 33 2013 2375 2387
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 2375-2387
    • Marada, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.