Loss of suppressor-of-fused function promotes tumorigenesis

Oncogene

Volumn 26, Issue 44, 2007, Pages 6442-6447

  Lee, Y ^a   Kawagoe, R ^a   Sasai, K ^a   Li, Y ^a   Russell, H R ^a   Curran, T ^a,b   McKinnon, P J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Hedgehog; HhAntag; Medulloblastoma; Patched1; Sufu; Suppressor of fused

Indexed keywords

CYCLIN D1; PROTEIN DERIVATIVE; PROTEIN P53; PROTEIN PATCHED 1; PROTEIN PATCHED 2; SFRP1 PROTEIN; SONIC HEDGEHOG PROTEIN; SUPPRESSOR OF FUSED PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; GENE EXPRESSION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; MEDULLOBLASTOMA; NUCLEOTIDE SEQUENCE; ONCOGENE C MYB; PRIORITY JOURNAL; PROTEIN DEPLETION; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; SUPPRESSOR OF FUSED; TUMOR GROWTH; UPREGULATION;

ANIMALS; APOPTOSIS; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION PROFILING; GENES, LETHAL; GENES, TUMOR SUPPRESSOR; GENETIC PREDISPOSITION TO DISEASE; LOSS OF HETEROZYGOSITY; MEDULLOBLASTOMA; MICE; MICE, KNOCKOUT; RECEPTORS, CELL SURFACE; REPRESSOR PROTEINS; RHABDOMYOSARCOMA; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; ERINACEIDAE; MUS;

EID: 34848893044     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210467     Document Type: Article

References (27)

1. Callahan CA, Ofstad T, Horng L, Wang JK, Zhen HH, Coulombe PA et al. (2004). MIM/BEG4, a sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev 18: 2724-2729.
2. Chen MH, Gao N, Kawakami T, Chuang PT. (2005). Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Mol Cell Biol 25: 7042-7053.
3. Cheng SY, Bishop JM. (2002). Suppressor of fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc Natl Acad Sci USA 99: 5442-5447.
4. Cooper AF, Yu KP, Brueckner M, Brailey LL, Johnson L, McGrath JM et al. (2005). Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development 132: 4407-4417.
5. Dellovade T, Romer JT, Curran T, Rubin LL. (2006). The hedgehog pathway and neurological disorders. Annu Rev Neurosci 29: 539-563.
6. Di Marcotullio L, Ferretti E, De Smaele E, Argenti B, Mincione C, Zazzeroni F et al. (2004). REN(KCTD11) is a suppressor of hedgehog signaling and is deleted in human medulloblastoma. Proc Natl Acad Sci USA 101: 10833-10838.
7. Dunaeva M, Michelson P, Kogerman P, Toftgard R. (2003). Characterization of the physical interaction of Gli proteins with SUFU proteins. J Biol Chem 278: 5116-5122.
8. Ferretti E, De Smaele E, Di Marcotullio L, Screpanti I, Gulino A. (2005). Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm. Trends Mol Med 11: 537-545.
9. Goodrich LV, Milenkovic L, Higgins KM, Scott MP. (1997). Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277: 1109-1113.
10. Hooper JE, Scott MP. (2005). Communicating with hedgehogs. Nat Rev Mol Cell Biol 6: 306-317.
11. Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT et al. (1994). Tumor spectrum analysis in p53-mutant mice. Curr Biol 4: 1-7.
12. Kimura H, Stephen D, Joyner A, Curran T. (2005). Gli1 is important for medulloblastoma formation in Ptc1+/-mice. Oncogene 24: 4026-4036.
13. Lawinger P, Venugopal R, Guo ZS, Immaneni A, Sengupta D, Lu W et al. (2000). The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells. Nat Med 6: 826-831.
14. Lee Y, Miller HL, Jensen P, Hernan R, Connelly M, Wetmore C et al. (2003). A molecular fingerprint for medulloblastoma. Cancer Res 63: 5428-5437.
15. Lee Y, Miller HL, Russell HR, Boyd K, Curran T, McKinnon PJ. (2006). Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res 66: 6964-6971.
16. Lum L, Beachy PA. (2004). The hedgehog response network: sensors, switches, and routers. Science 304: 1755-1759.
17. Marino S. (2005). Medulloblastoma: developmental mechanisms out of control. Trends Mol Med 11: 17-22.
18. Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT et al. (2005). Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. Development 132: 2425-2439.
19. Paces-Fessy M, Boucher D, Petit E, Paute-Briand S, Blanchet-Tournier MF. (2004). The negative regulator of Gli, suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Biochem J 378: 353-362.
20. Romer JT, Kimura H, Magdaleno S, Sasai K, Fuller C, Baines H et al. (2004). Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell 6: 229-240.
21. Sasai K, Romer JT, Lee Y, Finkelstein D, Fuller C, McKinnon PJ et al. (2006). Shh pathway activity is downregulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res 66: 4215-4222.
22. Svard J, Heby-Henricson K, Persson-Lek M, Rozell B, Lauth M, Bergstrom A et al. (2006). Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway. Dev Cell 10: 187-197.
23. Taylor MD, Liu L, Raffel C, Hui CC, Mainprize TG, Zhang X et al. (2002). Mutations in SUFU predispose to medulloblastoma. Nat Genet 31: 306-310.
24. Varjosalo M, Li SP, Taipale J. (2006). Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev Cell 10: 177-186.
25. Weiner HL, Bakst R, Hurlbert MS, Ruggiero J, Ahn E, Lee WS et al. (2002). Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1. Cancer Res 62: 6385-6389.
26. Wetmore C, Eberhart DE, Curran T. (2001). Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61: 513-516.
27. Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C et al. (2006). XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci USA 103: 7378-7830.