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Volumn 19, Issue 4, 2017, Pages 409-418

Spotlight on the relevance of mtDNA in cancer

Author keywords

Cancer; Mitochondria; mtDNA; OXPHOS; ROS; Warburg effect

Indexed keywords

CYTOCHROME C; CYTOCHROME C OXIDASE; DIHYDROOROTATE DEHYDROGENASE; GLUTATHIONE PEROXIDASE; NITRATE REDUCTASE (NADH); PEROXIREDOXIN; REACTIVE OXYGEN METABOLITE; UNSPECIFIC MONOOXYGENASE; MITOCHONDRIAL DNA;

EID: 84992217970     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-016-1561-6     Document Type: Review
Times cited : (20)

References (110)
  • 1
    • 85006768050 scopus 로고
    • The metabolism of tumors in the body
    • COI: 1:CAS:528:DyaB2sXitlyhuw%3D%3D, PID: 19872213
    • Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. J Gen Physiol. 1927;8:519–30.
    • (1927) J Gen Physiol , vol.8 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. Elsevier Inc.; 2011;144:646–74.
    • (2011) Cell. Elsevier Inc. , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 84858376953 scopus 로고    scopus 로고
    • Mitochondria: in sickness and in health. Cell. 2012/03/20 ed
    • Nunnari J, Suomalainen A. Mitochondria: in sickness and in health. Cell. 2012/03/20 ed. Elsevier Inc.; 2012;148:1145–59.
    • Elsevier Inc.; 2012 , vol.148 , pp. 1145-1159
    • Nunnari, J.1    Suomalainen, A.2
  • 10
    • 84935030624 scopus 로고    scopus 로고
    • Mechanisms linking mtDNA damage and aging
    • COI: 1:CAS:528:DC%2BC2MXhtVWqsrnO
    • Pinto M, Moraes CT. Mechanisms linking mtDNA damage and aging. Free Radic Biol Med Elsevier. 2015;85:250–8.
    • (2015) Free Radic Biol Med Elsevier , vol.85 , pp. 250-258
    • Pinto, M.1    Moraes, C.T.2
  • 11
    • 78149361243 scopus 로고    scopus 로고
    • Association between a common mitochondrial DNA D-loop polycytosine variant and alteration of mitochondrial copy number in human peripheral blood cells
    • COI: 1:CAS:528:DC%2BC3cXhs1Smt7jK, PID: 20837494
    • Liou C-W, Lin T-K, Chen J-B, Tiao M-M, Weng S-W, Chen S-D, et al. Association between a common mitochondrial DNA D-loop polycytosine variant and alteration of mitochondrial copy number in human peripheral blood cells. J Med Genet. 2010;47:723–8.
    • (2010) J Med Genet , vol.47 , pp. 723-728
    • Liou, C.-W.1    Lin, T.-K.2    Chen, J.-B.3    Tiao, M.-M.4    Weng, S.-W.5    Chen, S.-D.6
  • 12
    • 84864293013 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number.
    • Campbell CT, Kolesar JE, Kaufman B a. Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number. Biochim. Biophys. Acta. Elsevier B.V.; 2012;1819:921–9.
    • (2012) Biochim. Biophys. Acta Elsevier B.V. , vol.1819 , pp. 921-929
    • Campbell, C.T.1    Kolesar, J.E.2    Kaufman, B.A.3    packaging, D.N.A.4
  • 13
    • 79954609874 scopus 로고    scopus 로고
    • Frequent truncating mutation of TFAM induces mitochondrial DNA depletion and apoptotic resistance in microsatellite-unstable colorectal cancer
    • COI: 1:CAS:528:DC%2BC3MXkslWjs7c%3D, PID: 21467167
    • Guo J, Zheng L, Liu W, Wang X, Wang Z, Wang Z, et al. Frequent truncating mutation of TFAM induces mitochondrial DNA depletion and apoptotic resistance in microsatellite-unstable colorectal cancer. Cancer Res. 2011;71:2978–87.
    • (2011) Cancer Res , vol.71 , pp. 2978-2987
    • Guo, J.1    Zheng, L.2    Liu, W.3    Wang, X.4    Wang, Z.5    Wang, Z.6
  • 14
    • 84949810352 scopus 로고    scopus 로고
    • Mitochondrial DNA copy number in colorectal cancer: between tissue comparisons, clinicopathological characteristics and survival
    • PID: 26476438
    • van Osch FHM, Voets AM, Schouten LJ, Gottschalk RWH, Simons CCJM, van Engeland M, et al. Mitochondrial DNA copy number in colorectal cancer: between tissue comparisons, clinicopathological characteristics and survival. Carcinogenesis. 2015;36:1502–10.
    • (2015) Carcinogenesis , vol.36 , pp. 1502-1510
    • van Osch, F.H.M.1    Voets, A.M.2    Schouten, L.J.3    Gottschalk, R.W.H.4    Simons, C.C.J.M.5    van Engeland, M.6
  • 15
    • 84929208723 scopus 로고    scopus 로고
    • The relationship between altered mitochondrial DNA copy number and cancer risk: a meta-analysis
    • Mi J, Tian G, Liu S, Li X, Ni T, Zhang L, et al. The relationship between altered mitochondrial DNA copy number and cancer risk: a meta-analysis. Sci. Rep. Nature Publishing Group; 2015;5:10039.
    • (2015) Sci. Rep. Nature Publishing Group , vol.5 , pp. 10039
    • Mi, J.1    Tian, G.2    Liu, S.3    Li, X.4    Ni, T.5    Zhang, L.6
  • 16
    • 57349183018 scopus 로고    scopus 로고
    • Low copy number and low oxidative damage of mitochondrial DNA are associated with tumor progression in lung cancer tissues after neoadjuvant chemotherapy
    • PID: 18685121
    • Lin C-S, Wang L-S, Tsai C-M, Wei Y-H. Low copy number and low oxidative damage of mitochondrial DNA are associated with tumor progression in lung cancer tissues after neoadjuvant chemotherapy. Interact CardioVasc Thorac Surg. 2008;7:954–8.
    • (2008) Interact CardioVasc Thorac Surg , vol.7 , pp. 954-958
    • Lin, C.-S.1    Wang, L.-S.2    Tsai, C.-M.3    Wei, Y.-H.4
  • 18
    • 84930801786 scopus 로고    scopus 로고
    • Extreme-depth re-sequencing of mitochondrial DNA Finds no evidence of paternal transmission in humans
    • PID: 25973765
    • Pyle A, Hudson G, Wilson IJ, Coxhead J, Smertenko T, Herbert M, et al. Extreme-depth re-sequencing of mitochondrial DNA Finds no evidence of paternal transmission in humans. PLoS Genet. 2015;11:e1005040.
    • (2015) PLoS Genet , vol.11
    • Pyle, A.1    Hudson, G.2    Wilson, I.J.3    Coxhead, J.4    Smertenko, T.5    Herbert, M.6
  • 19
    • 0347356538 scopus 로고    scopus 로고
    • Effects of purifying and adaptive selection on regional variation in human mtDNA
    • Ruiz-Pesini E, Mishmar D, Brandon M. Effects of purifying and adaptive selection on regional variation in human mtDNA. Science (80-.). 2004;303:223–7.
    • (2004) Science (80-.). , vol.303 , pp. 223-227
    • Ruiz-Pesini, E.1    Mishmar, D.2    Brandon, M.3
  • 21
    • 84925283482 scopus 로고    scopus 로고
    • Mitochondrial DNA haplogroup N is associated good outcome of gastric cancer
    • COI: 1:CAS:528:DC%2BC2cXhsFKrtL%2FI, PID: 25201064
    • Wang C, Wang Y, Wang H, Zhang R, Guo Z. Mitochondrial DNA haplogroup N is associated good outcome of gastric cancer. Tumour Biol. 2014;35:12555–9.
    • (2014) Tumour Biol , vol.35 , pp. 12555-12559
    • Wang, C.1    Wang, Y.2    Wang, H.3    Zhang, R.4    Guo, Z.5
  • 22
    • 84900544744 scopus 로고    scopus 로고
    • Mitochondrial DNA variation analysis in cervical cancer. Mitochondrion. © Elsevier B.V. and Mitochondria Research Society
    • Kabekkodu SP, Bhat S, Mascarenhas R, Mallya S, Bhat M, Pandey D, et al. Mitochondrial DNA variation analysis in cervical cancer. Mitochondrion. © Elsevier B.V. and Mitochondria Research Society. All rights reserved.; 2014;16:73–82.
    • (2014) All rights reserved. , vol.16 , pp. 73-82
    • Kabekkodu, S.P.1    Bhat, S.2    Mascarenhas, R.3    Mallya, S.4    Bhat, M.5    Pandey, D.6
  • 23
    • 84922014543 scopus 로고    scopus 로고
    • Mitochondrial variations in non-small cell lung cancer (NSCLC) survival
    • Wang Z, Choi S, Lee J, Huang Y-T, Chen F, Zhao Y, et al. Mitochondrial variations in non-small cell lung cancer (NSCLC) survival. Cancer Inf. 2015;14:1–9.
    • (2015) Cancer Inf. , vol.14 , pp. 1-9
    • Wang, Z.1    Choi, S.2    Lee, J.3    Huang, Y.-T.4    Chen, F.5    Zhao, Y.6
  • 25
    • 84932607033 scopus 로고    scopus 로고
    • An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers
    • PID: 25925750
    • Blein S, Bardel C, Danjean V, McGuffog L, Healey S, Barrowdale D, et al. An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers. Breast Cancer Res. 2015;17:61.
    • (2015) Breast Cancer Res , vol.17 , pp. 61
    • Blein, S.1    Bardel, C.2    Danjean, V.3    McGuffog, L.4    Healey, S.5    Barrowdale, D.6
  • 27
    • 84856521481 scopus 로고    scopus 로고
    • Mitochondrial DNA sequence variation and risk of pancreatic cancer
    • Lam ET, Bracci PM, Holly E a, Chu C, Poon A, Wan E, et al. Mitochondrial DNA sequence variation and risk of pancreatic cancer. Cancer Res. 2012;72:686–95.
    • (2012) Cancer Res , vol.72 , pp. 686-695
    • Lam, E.T.1    Bracci, P.M.2    Holly, E.3
  • 28
    • 77955384590 scopus 로고    scopus 로고
    • Cancer type-specific modulation of mitochondrial haplogroups in breast, colorectal and thyroid cancer
    • PID: 20704735
    • Fang H, Shen L, Chen T, He J, Ding Z, Wei J, et al. Cancer type-specific modulation of mitochondrial haplogroups in breast, colorectal and thyroid cancer. BMC Cancer. 2010;10:421.
    • (2010) BMC Cancer , vol.10 , pp. 421
    • Fang, H.1    Shen, L.2    Chen, T.3    He, J.4    Ding, Z.5    Wei, J.6
  • 29
    • 30344471873 scopus 로고    scopus 로고
    • North American White Mitochondrial Haplogroups in Prostate and Renal Cancer
    • COI: 1:CAS:528:DC%2BD28XhtFWns70%3D, PID: 16406974
    • Booker LM, Habermacher GM, Jessie BC, Sun QC, Baumann AK, Amin M, et al. North American White Mitochondrial Haplogroups in Prostate and Renal Cancer. J Urol. 2006;175:468–73.
    • (2006) J Urol , vol.175 , pp. 468-473
    • Booker, L.M.1    Habermacher, G.M.2    Jessie, B.C.3    Sun, Q.C.4    Baumann, A.K.5    Amin, M.6
  • 31
    • 84858297200 scopus 로고    scopus 로고
    • SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress
    • D’Aquila P, Rose G, Panno ML, Passarino G, Bellizzi D. SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress. Gene Elsevier B.V.; 2012;497:323–9.
    • (2012) Gene Elsevier B.V. , vol.497 , pp. 323-329
    • D’Aquila, P.1    Rose, G.2    Panno, M.L.3    Passarino, G.4    Bellizzi, D.5
  • 32
    • 57049107271 scopus 로고    scopus 로고
    • Mitochondrial DNA background modulates the assembly kinetics of OXPHOS complexes in a cellular model of mitochondrial disease
    • Pello, Martin MA, Carelli V, Nijtmans LG, Achilli A, Pala M et al
    • Pello, Martin MA, Carelli V, Nijtmans LG, Achilli A, Pala M, et al. Mitochondrial DNA background modulates the assembly kinetics of OXPHOS complexes in a cellular model of mitochondrial disease. Hum Mol Genet. 2008;17:4001–11.
    • (2008) Hum Mol Genet , vol.17 , pp. 4001-4011
  • 33
    • 84890154942 scopus 로고    scopus 로고
    • Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases
    • Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, et al. Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases. Biochim. Biophys. Acta. Elsevier B.V.; 2014;1842:208–19.
    • (2014) Biochim. Biophys. Acta. Elsevier B.V. , vol.1842 , pp. 208-219
    • Kenney, M.C.1    Chwa, M.2    Atilano, S.R.3    Falatoonzadeh, P.4    Ramirez, C.5    Malik, D.6
  • 34
    • 84906242596 scopus 로고    scopus 로고
    • a, Francklyn CS, Robey-Bond SM. Transfer RNA and human disease
    • Abbott J a, Francklyn CS, Robey-Bond SM. Transfer RNA and human disease. Front Genet. 2014;5:158.
    • (2014) Front Genet , vol.5 , pp. 158
    • Abbott, J.1
  • 35
    • 84890797290 scopus 로고    scopus 로고
    • Mitochondrial DNA rearrangements in health and disease—a comprehensive study
    • COI: 1:CAS:528:DC%2BC3sXhvFyrtLbJ, PID: 24115352
    • Damas J, Samuels DC, Carneiro J, Amorim A, Pereira F. Mitochondrial DNA rearrangements in health and disease—a comprehensive study. Hum Mutat. 2014;35:1–14.
    • (2014) Hum Mutat , vol.35 , pp. 1-14
    • Damas, J.1    Samuels, D.C.2    Carneiro, J.3    Amorim, A.4    Pereira, F.5
  • 36
    • 84964697610 scopus 로고    scopus 로고
    • Datta S, Ray A, Roy R, Roy B. Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer. Gene. Elsevier B.V.; 2016;575:650–4.
    • (2016) Elsevier B.V. , vol.575 , pp. 650-654
  • 37
    • 84868198798 scopus 로고    scopus 로고
    • Germline variants of base excision repair genes and breast cancer: a polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk
    • COI: 1:CAS:528:DC%2BC38XptVyhu74%3D, PID: 22684821
    • Popanda O, Seibold P, Nikolov I, Oakes CC, Burwinkel B, Hausmann S, et al. Germline variants of base excision repair genes and breast cancer: a polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk. Int J Cancer. 2013;132:55–62.
    • (2013) Int J Cancer , vol.132 , pp. 55-62
    • Popanda, O.1    Seibold, P.2    Nikolov, I.3    Oakes, C.C.4    Burwinkel, B.5    Hausmann, S.6
  • 38
    • 80052107378 scopus 로고    scopus 로고
    • A polymorphism of the POLG2 gene is genetically associated with the invasiveness of urinary bladder cancer in Japanese males
    • COI: 1:CAS:528:DC%2BC3MXhtVOktLvO, PID: 21734712
    • Ratanajaraya C, Nishiyama H, Takahashi M, Kawaguchi T, Saito R, Mikami Y, et al. A polymorphism of the POLG2 gene is genetically associated with the invasiveness of urinary bladder cancer in Japanese males. J Hum Genet. 2011;56:572–6.
    • (2011) J Hum Genet , vol.56 , pp. 572-576
    • Ratanajaraya, C.1    Nishiyama, H.2    Takahashi, M.3    Kawaguchi, T.4    Saito, R.5    Mikami, Y.6
  • 39
    • 84929353033 scopus 로고    scopus 로고
    • Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA
    • COI: 1:CAS:528:DC%2BC2MXht1eitLfN, PID: 25984607
    • Ding L, Liu Y. Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA. Int J Mol Sci. 2015;16:10870–87.
    • (2015) Int J Mol Sci , vol.16 , pp. 10870-10887
    • Ding, L.1    Liu, Y.2
  • 40
    • 84856870147 scopus 로고    scopus 로고
    • Correlated tissue expression of genes of cytoplasmic and mitochondrial nucleotide metabolisms in normal tissues is disrupted in transformed tissues
    • COI: 1:CAS:528:DC%2BC38XhvVOht74%3D, PID: 22303991
    • Gandhi VV, Samuels DC. Correlated tissue expression of genes of cytoplasmic and mitochondrial nucleotide metabolisms in normal tissues is disrupted in transformed tissues. Nucleosides, Nucleotides Nucleic Acids. 2012;31:112–29.
    • (2012) Nucleosides, Nucleotides Nucleic Acids , vol.31 , pp. 112-129
    • Gandhi, V.V.1    Samuels, D.C.2
  • 42
    • 84874679741 scopus 로고    scopus 로고
    • Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan
    • COI: 1:CAS:528:DC%2BC38XmsFyjt7g%3D, PID: 22562243
    • Chen P-L, Chen C-F, Chen Y, Guo XE, Huang C-K, Shew J-Y, et al. Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Oncogene. 2013;32:1193–201.
    • (2013) Oncogene , vol.32 , pp. 1193-1201
    • Chen, P.-L.1    Chen, C.-F.2    Chen, Y.3    Guo, X.E.4    Huang, C.-K.5    Shew, J.-Y.6
  • 43
    • 84887565780 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations and breast tumorigenesis
    • Yadav N, Chandra D. Mitochondrial DNA mutations and breast tumorigenesis. Biochim. Biophys. Acta - Rev. Cancer. Elsevier B.V.; 2013;1836:336–44.
    • (2013) Biochim. Biophys. Acta - Rev. Cancer. , vol.1836 , pp. 336-344
    • Yadav, N.1    Chandra, D.2
  • 44
    • 84929145418 scopus 로고    scopus 로고
    • Nonsense and Missense Mutation of Mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma
    • PID: 25934296
    • Yuan Y, Wang W, Li H, Yu Y, Tao J, Huang S, et al. Nonsense and Missense Mutation of Mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma. BMC Cancer. 2015;15:346.
    • (2015) BMC Cancer , vol.15 , pp. 346
    • Yuan, Y.1    Wang, W.2    Li, H.3    Yu, Y.4    Tao, J.5    Huang, S.6
  • 45
    • 84892416671 scopus 로고    scopus 로고
    • Prognostic value of mitochondrial DNA content and G10398A polymorphism in non-small cell lung cancer
    • COI: 1:CAS:528:DC%2BC3sXhvFens7jI, PID: 24101028
    • Xu H, He W, Jiang H-G, Zhao H, Peng X-H, Wei Y-H, et al. Prognostic value of mitochondrial DNA content and G10398A polymorphism in non-small cell lung cancer. Oncol Rep. 2013;30:3006–12.
    • (2013) Oncol Rep , vol.30 , pp. 3006-3012
    • Xu, H.1    He, W.2    Jiang, H.-G.3    Zhao, H.4    Peng, X.-H.5    Wei, Y.-H.6
  • 46
    • 84900483723 scopus 로고    scopus 로고
    • Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria
    • COI: 1:CAS:528:DC%2BC2cXpslOjtrc%3D, PID: 24746616
    • Hey-Mogensen M, Goncalves RLS, Orr AL, Brand MD. Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria. Free Radic Biol Med. 2014;72:149–55.
    • (2014) Free Radic Biol Med , vol.72 , pp. 149-155
    • Hey-Mogensen, M.1    Goncalves, R.L.S.2    Orr, A.L.3    Brand, M.D.4
  • 47
    • 84885012414 scopus 로고    scopus 로고
    • Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload
    • COI: 1:CAS:528:DC%2BC3sXhvFylurjK, PID: 24056031
    • Fisher-Wellman KH, Gilliam LAA, Lin C-T, Cathey BL, Lark DS, Neufer PD. Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload. Free Radic Biol Med. 2013;65:1201–8.
    • (2013) Free Radic Biol Med , vol.65 , pp. 1201-1208
    • Fisher-Wellman, K.H.1    Gilliam, L.A.A.2    Lin, C.-T.3    Cathey, B.L.4    Lark, D.S.5    Neufer, P.D.6
  • 48
    • 84923868391 scopus 로고    scopus 로고
    • Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species
    • Mailloux RJ. Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species. Redox Biol Elsevier. 2015;4C:381–98.
    • (2015) Redox Biol Elsevier , vol.4C , pp. 381-398
    • Mailloux, R.J.1
  • 51
    • 31144469322 scopus 로고    scopus 로고
    • Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors. Cancer Biol
    • Desouki MM, Kulawiec M, Bansal S, Das GC, Singh KK. Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors. Cancer Biol. Ther. Landes Bioscience Inc.; 2005;4:1367–73.
    • (2005) Ther. Landes Bioscience Inc. , vol.4 , pp. 1367-1373
    • Desouki, M.M.1    Kulawiec, M.2    Bansal, S.3    Das, G.C.4    Singh, K.K.5
  • 53
    • 78650894319 scopus 로고    scopus 로고
    • Crosstalk of reactive oxygen species and NF-kappaB signaling
    • Morgan MJ, Liu ZG. Crosstalk of reactive oxygen species and NF-kappaB signaling. Cell Res. 2010/12/29 ed. 2011;21:103–15.
    • Cell Res. 2010/12/29 ed. 2011 , vol.21 , pp. 103-115
    • Morgan, M.J.1    Liu, Z.G.2
  • 54
    • 81255190755 scopus 로고    scopus 로고
    • Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation
    • Sharma LK, Fang H, Liu J, Vartak R, Deng J, Bai Y. Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation. Hum Mol Genet. 2011/09/06 ed. 2011;20:4605–16.
    • Hum Mol Genet. 2011/09/06 ed. 2011 , vol.20 , pp. 4605-4616
    • Sharma, L.K.1    Fang, H.2    Liu, J.3    Vartak, R.4    Deng, J.5    Bai, Y.6
  • 55
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and the response to hypoxic stress.
    • Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. Elsevier Inc.; 2010;40:294–309.
    • (2010) Mol Cell. Elsevier Inc. , vol.40 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 58
    • 84859071848 scopus 로고    scopus 로고
    • The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response
    • COI: 1:CAS:528:DC%2BC38Xis1eru7o%3D, PID: 22342343
    • Formentini L, Sanchez-Arago M, Sanchez-Cenizo L, Cuezva JM. The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response. Mol Cell. 2012;45:731–42.
    • (2012) Mol Cell , vol.45 , pp. 731-742
    • Formentini, L.1    Sanchez-Arago, M.2    Sanchez-Cenizo, L.3    Cuezva, J.M.4
  • 60
    • 82955237531 scopus 로고    scopus 로고
    • Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity
    • COI: 1:CAS:528:DC%2BC3MXhs1Sktr7L, PID: 22100406
    • Tello D, Balsa E, Acosta-Iborra B, Fuertes-Yebra E, Elorza A, Ordóñez Á, et al. Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity. Cell Metab. 2011;14:768–79.
    • (2011) Cell Metab , vol.14 , pp. 768-779
    • Tello, D.1    Balsa, E.2    Acosta-Iborra, B.3    Fuertes-Yebra, E.4    Elorza, A.5    Ordóñez, Á.6
  • 61
    • 80051783174 scopus 로고    scopus 로고
    • Mailloux RJ, Harper M-E. Uncoupling proteins and the control of mitochondrial reactive oxygen species production. Free Radic. Biol. Med. Elsevier Inc.; 2011;51:1106–15.
    • (2011) Elsevier Inc. , vol.51 , pp. 1106-1115
    • Mailloux, R.J.1    proteins, H.M.-E.U.2
  • 62
    • 84902242573 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation.
    • Elsevier B.V
    • Dröse S, Brandt U, Wittig I. Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation. Biochim. Biophys. Acta. Elsevier B.V.; 2014;1844:1344–54.
    • (2014) Biochim. Biophys. Acta , vol.1844 , pp. 1344-1354
    • Dröse, S.1    Brandt, U.2    Wittig, I.3
  • 64
    • 43249112094 scopus 로고    scopus 로고
    • ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis
    • COI: 1:CAS:528:DC%2BD1cXltFyisrc%3D, PID: 18388260
    • Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, et al. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science. 2008;320:661–4.
    • (2008) Science , vol.320 , pp. 661-664
    • Ishikawa, K.1    Takenaga, K.2    Akimoto, M.3    Koshikawa, N.4    Yamaguchi, A.5    Imanishi, H.6
  • 65
    • 84908213474 scopus 로고    scopus 로고
    • Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles’ heel?
    • COI: 1:CAS:528:DC%2BC2cXhvVSmtLbO, PID: 25342630
    • Sabharwal SS, Schumacker PT. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles’ heel? Nat Rev Cancer. 2014;14:709–21.
    • (2014) Nat Rev Cancer , vol.14 , pp. 709-721
    • Sabharwal, S.S.1    Schumacker, P.T.2
  • 66
    • 0024448458 scopus 로고    scopus 로고
    • Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation
    • King MP, Attardi G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science (80-.). 1989/10/27 ed. 1989;246:500–3.
    • Science (80-.). 1989/10/27 ed. 1989 , vol.246 , pp. 500-503
    • King, M.P.1    Attardi, G.2
  • 67
    • 80054697979 scopus 로고    scopus 로고
    • A comparative analysis approach to determining the pathogenicity of mitochondrial tRNA mutations
    • COI: 1:CAS:528:DC%2BC3MXhtlagurrL, PID: 21882289
    • Yarham JW, Al-Dosary M, Blakely EL, Alston CL, Taylor RW, Elson JL, et al. A comparative analysis approach to determining the pathogenicity of mitochondrial tRNA mutations. Hum Mutat. 2011;32:1319–25.
    • (2011) Hum Mutat , vol.32 , pp. 1319-1325
    • Yarham, J.W.1    Al-Dosary, M.2    Blakely, E.L.3    Alston, C.L.4    Taylor, R.W.5    Elson, J.L.6
  • 68
    • 0018193434 scopus 로고
    • Tumorigenicity and its suppression in cybrids of mouse and Chinese hamster cell lines
    • Howell a N, Sager R. Tumorigenicity and its suppression in cybrids of mouse and Chinese hamster cell lines. Proc Natl Acad Sci USA. 1978;75:2358–62.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 2358-2362
    • Howell a, N.1    Sager, R.2
  • 69
    • 0022458948 scopus 로고
    • Effects of normal human fibroblast mitochondrial DNA on segregation of HeLaTG Mitochondrial DNA and on tumorigenicity of HeLaTG cells
    • COI: 1:CAS:528:DyaL28XkvFGgurc%3D, PID: 3731069
    • Hayashi J, Werbin H, Shay JW. Effects of normal human fibroblast mitochondrial DNA on segregation of HeLaTG Mitochondrial DNA and on tumorigenicity of HeLaTG cells. Cancer Res. 1986;46:4001–6.
    • (1986) Cancer Res , vol.46 , pp. 4001-4006
    • Hayashi, J.1    Werbin, H.2    Shay, J.W.3
  • 70
    • 0026697079 scopus 로고
    • Recovery of the missing tumorigenicity in mitochondrial DNA-less HeLa cells by introduction of mitochondrial DNA from normal human cells
    • COI: 1:CAS:528:DyaK38Xkt1equ7c%3D, PID: 1574738
    • Hayashi J, Takemitsu M, Nonaka I. Recovery of the missing tumorigenicity in mitochondrial DNA-less HeLa cells by introduction of mitochondrial DNA from normal human cells. Somat Cell Mol Genet. 1992;18:123–9.
    • (1992) Somat Cell Mol Genet , vol.18 , pp. 123-129
    • Hayashi, J.1    Takemitsu, M.2    Nonaka, I.3
  • 71
    • 80051607526 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations regulate metastasis of human breast cancer cells
    • Imanishi H, Hattori K, Wada R, Ishikawa K, Fukuda S, Takenaga K, et al. Mitochondrial DNA mutations regulate metastasis of human breast cancer cells. PLoS One. 2011;6:e23401.
    • (2011) PLoS One , vol.e23401 , pp. 6
    • Imanishi, H.1    Hattori, K.2    Wada, R.3    Ishikawa, K.4    Fukuda, S.5    Takenaga, K.6
  • 73
    • 16444386967 scopus 로고    scopus 로고
    • Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis
    • COI: 1:CAS:528:DC%2BD2MXitVOjs7g%3D, PID: 15753359
    • Shidara Y, Yamagata K, Kanamori T, Nakano K, Kwong JQ, Manfredi G, et al. Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis. Cancer Res. 2005;65:1655–63.
    • (2005) Cancer Res , vol.65 , pp. 1655-1663
    • Shidara, Y.1    Yamagata, K.2    Kanamori, T.3    Nakano, K.4    Kwong, J.Q.5    Manfredi, G.6
  • 74
    • 64549098628 scopus 로고    scopus 로고
    • A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis
    • COI: 1:CAS:528:DC%2BD1MXksVeitLw%3D, PID: 19208652
    • Park JS, Sharma LK, Li H, Xiang R, Holstein D, Wu J, et al. A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum Mol Genet. 2009;18:1578–89.
    • (2009) Hum Mol Genet , vol.18 , pp. 1578-1589
    • Park, J.S.1    Sharma, L.K.2    Li, H.3    Xiang, R.4    Holstein, D.5    Wu, J.6
  • 75
    • 77955299384 scopus 로고    scopus 로고
    • Functional effects of cancer mitochondria on energy metabolism and tumorigenesis: utility of transmitochondrial cybrids
    • COI: 1:CAS:528:DC%2BC3cXhtFegsLvI, PID: 20649550
    • Kaipparettu BA, Ma Y, Wong LJ. Functional effects of cancer mitochondria on energy metabolism and tumorigenesis: utility of transmitochondrial cybrids. Ann N Y Acad Sci. 2010;1201:137–46.
    • (2010) Ann N Y Acad Sci , vol.1201 , pp. 137-146
    • Kaipparettu, B.A.1    Ma, Y.2    Wong, L.J.3
  • 76
    • 84894292944 scopus 로고    scopus 로고
    • Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment
    • COI: 1:CAS:528:DC%2BC2cXivFOntbw%3D, PID: 24163135
    • Iommarini L, Kurelac I, Capristo M, Calvaruso MA, Giorgio V, Bergamini C, et al. Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment. Hum Mol Genet. 2014;23:1453–66.
    • (2014) Hum Mol Genet , vol.23 , pp. 1453-1466
    • Iommarini, L.1    Kurelac, I.2    Capristo, M.3    Calvaruso, M.A.4    Giorgio, V.5    Bergamini, C.6
  • 78
    • 84920560830 scopus 로고    scopus 로고
    • Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA. Cell Metab
    • Tan AS, Baty JW, Dong L-F, Bezawork-Geleta A, Endaya B, Goodwin J, et al. Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA. Cell Metab. Elsevier Inc.; 2015;21:81–94.
    • (2015) Elsevier Inc. , vol.21 , pp. 81-94
    • Tan, A.S.1    Baty, J.W.2    Dong, L.-F.3    Bezawork-Geleta, A.4    Endaya, B.5    Goodwin, J.6
  • 79
    • 84942895449 scopus 로고    scopus 로고
    • Mitochondrial DNA in tumor initiation, progression, and metastasis: role of horizontal mtDNA transfer
    • COI: 1:CAS:528:DC%2BC2MXhtlequ7zN, PID: 26224121
    • Berridge MV, Dong L, Neuzil J. Mitochondrial DNA in tumor initiation, progression, and metastasis: role of horizontal mtDNA transfer. Cancer Res. 2015;75:3203–8.
    • (2015) Cancer Res , vol.75 , pp. 3203-3208
    • Berridge, M.V.1    Dong, L.2    Neuzil, J.3
  • 80
    • 84866665390 scopus 로고    scopus 로고
    • Mitochondria and cancer
    • Nature Publishing Group
    • Wallace DC. Mitochondria and cancer. Nat. Rev. Cancer. Nature Publishing Group; 2012;12:685–98.
    • (2012) Nat. Rev. Cancer. , vol.12 , pp. 685-698
    • Wallace, D.C.1
  • 81
    • 84887623625 scopus 로고    scopus 로고
    • From evolutionary bystander to master manipulator: the emerging roles for the mitochondrial genome as a modulator of nuclear gene expression
    • COI: 1:CAS:528:DC%2BC3sXhslyrtr3K, PID: 23612574
    • Horan MP, Gemmell NJ, Wolff JN. From evolutionary bystander to master manipulator: the emerging roles for the mitochondrial genome as a modulator of nuclear gene expression. Eur J Hum Genet. 2013;21:1335–7.
    • (2013) Eur J Hum Genet , vol.21 , pp. 1335-1337
    • Horan, M.P.1    Gemmell, N.J.2    Wolff, J.N.3
  • 82
    • 84858604270 scopus 로고    scopus 로고
    • metabolic reprogramming: a cancer hallmark even warburg did not anticipate
    • COI: 1:CAS:528:DC%2BC38Xkt1ylsbc%3D
    • Ward PS, Thompson CB. metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell. Elsevier. 2012;21:297–308.
    • (2012) Cancer Cell. Elsevier , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 83
    • 84907267817 scopus 로고    scopus 로고
    • Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming
    • COI: 1:CAS:528:DC%2BC2cXhsVyrtb7E, PID: 25192935
    • Picard M, Zhang J, Hancock S, Derbeneva O, Golhar R, Golik P, et al. Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming. Proc Natl Acad Sci USA. 2014;111:E4033–42.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E4033-E4042
    • Picard, M.1    Zhang, J.2    Hancock, S.3    Derbeneva, O.4    Golhar, R.5    Golik, P.6
  • 84
    • 0035901495 scopus 로고    scopus 로고
    • Klein-Szanto a, Vijayasarathy C, Avadhani NG. Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion
    • Amuthan G, Biswas G, Zhang SY, Klein-Szanto a, Vijayasarathy C, Avadhani NG. Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion. EMBO J. 2001;20:1910–20.
    • (2001) EMBO J , vol.20 , pp. 1910-1920
    • Amuthan, G.1    Biswas, G.2    Zhang, S.Y.3
  • 85
    • 84865532797 scopus 로고    scopus 로고
    • Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo
    • COI: 1:CAS:528:DC%2BC38Xht1KjtrjF, PID: 22637744
    • Tang W, Chowdhury AR, Guha M, Huang L, Van Winkle T, Rustgi AK, et al. Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo. Carcinogenesis. 2012;33:1762–8.
    • (2012) Carcinogenesis , vol.33 , pp. 1762-1768
    • Tang, W.1    Chowdhury, A.R.2    Guha, M.3    Huang, L.4    Van Winkle, T.5    Rustgi, A.K.6
  • 86
    • 2442693092 scopus 로고    scopus 로고
    • The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation
    • COI: 1:CAS:528:DC%2BD2cXktVWhsbc%3D, PID: 15150115
    • Mitsushita J, Lambeth JD, Kamata T. The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation. Cancer Res. 2004;64:3580–5.
    • (2004) Cancer Res , vol.64 , pp. 3580-3585
    • Mitsushita, J.1    Lambeth, J.D.2    Kamata, T.3
  • 87
    • 67549136242 scopus 로고    scopus 로고
    • a, Nelson ZW, Gottschling DE. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell
    • Veatch JR, McMurray M a, Nelson ZW, Gottschling DE. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell. Elsevier Ltd; 2009;137:1247–58.
    • (2009) Elsevier Ltd , vol.137 , pp. 1247-1258
    • Veatch, J.R.1    McMurray, M.2
  • 88
    • 33845718704 scopus 로고    scopus 로고
    • Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism
    • COI: 1:CAS:528:DC%2BD2sXpsVA%3D, PID: 17158952
    • Pelicano H, Xu RH, Du M, Feng L, Sasaki R, Carew JS, et al. Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol. 2006;175:913–23.
    • (2006) J Cell Biol , vol.175 , pp. 913-923
    • Pelicano, H.1    Xu, R.H.2    Du, M.3    Feng, L.4    Sasaki, R.5    Carew, J.S.6
  • 89
    • 84924358856 scopus 로고    scopus 로고
    • The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
    • COI: 1:CAS:528:DC%2BC2MXjt1alur4%3D, PID: 25738459
    • Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21:443–54.
    • (2015) Cell Metab , vol.21 , pp. 443-454
    • Lee, C.1    Zeng, J.2    Drew, B.G.3    Sallam, T.4    Martin-Montalvo, A.5    Wan, J.6
  • 90
    • 84873390153 scopus 로고    scopus 로고
    • The emerging role of the mitochondrial-derived peptide humanin in stress resistance
    • COI: 1:CAS:528:DC%2BC3sXjsFansr8%3D, PID: 23239898
    • Yen K, Lee C, Mehta H, Cohen P. The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol. 2013;50:R11–9.
    • (2013) J Mol Endocrinol , vol.50 , pp. R11-R19
    • Yen, K.1    Lee, C.2    Mehta, H.3    Cohen, P.4
  • 94
    • 79959723691 scopus 로고    scopus 로고
    • Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells
    • COI: 1:CAS:528:DC%2BC3MXnvFansrw%3D, PID: 21520032
    • Ye X-Q, Li Q, Wang G-H, Sun F-F, Huang G-J, Bian X-W, et al. Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells. Int J Cancer. 2011;129:820–31.
    • (2011) Int J Cancer , vol.129 , pp. 820-831
    • Ye, X.-Q.1    Li, Q.2    Wang, G.-H.3    Sun, F.-F.4    Huang, G.-J.5    Bian, X.-W.6
  • 95
    • 84907022547 scopus 로고    scopus 로고
    • Metabostemness: a new cancer hallmark
    • Menendez JA, Alarcón T. Metabostemness: a new cancer hallmark. Front. Oncol. 2014;4:262.
    • (2014) Front. Oncol , vol.4 , pp. 262
    • Menendez, J.A.1    Alarcón, T.2
  • 97
    • 80053384729 scopus 로고    scopus 로고
    • Side population cells isolated from human osteosarcoma are enriched with tumor-initiating cells
    • COI: 1:CAS:528:DC%2BC3MXhsVSisrfE, PID: 21740477
    • Yang M, Yan M, Zhang R, Li J, Luo Z. Side population cells isolated from human osteosarcoma are enriched with tumor-initiating cells. Cancer Sci. 2011;102:1774–81.
    • (2011) Cancer Sci , vol.102 , pp. 1774-1781
    • Yang, M.1    Yan, M.2    Zhang, R.3    Li, J.4    Luo, Z.5
  • 98
    • 84859187031 scopus 로고    scopus 로고
    • Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line. BMC Cancer
    • Martins-Neves SR, Lopes ÁO, do Carmo A, Paiva A a, Simões PC, Abrunhosa AJ, et al. Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line. BMC Cancer. BioMed Central Ltd; 2012;12:139.
    • (2012) BioMed Central Ltd , vol.12 , pp. 139
    • Martins-Neves, S.R.1    Lopes, Á.O.2    do Carmo, A.3    Paiva, A.4
  • 99
    • 66249108601 scopus 로고    scopus 로고
    • Vander, Cantley L, Thompson C. Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Heiden M Vander, Cantley L, Thompson C. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (80-.). 2009;324:1029–34.
    • (2009) Science (80-.). , vol.324 , pp. 1029-1034
    • Heiden, M.1
  • 100
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • COI: 1:CAS:528:DC%2BD2cXkt1Ons7k%3D, PID: 15164064
    • Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004;429:417–23.
    • (2004) Nature , vol.429 , pp. 417-423
    • Trifunovic, A.1    Wredenberg, A.2    Falkenberg, M.3    Spelbrink, J.N.4    Rovio, A.T.5    Bruder, C.E.6
  • 101
    • 85069238542 scopus 로고    scopus 로고
    • Mitochondria as biosynthetic factories for cancer proliferation
    • PID: 25621173
    • Ahn CS, Metallo CM. Mitochondria as biosynthetic factories for cancer proliferation. Cancer Metab. 2015;3:1.
    • (2015) Cancer Metab. , vol.3 , pp. 1
    • Ahn, C.S.1    Metallo, C.M.2
  • 103
    • 3242660673 scopus 로고    scopus 로고
    • Detection of mitochondrial DNA alterations in plasma of malignant melanoma patients
    • COI: 1:CAS:528:DC%2BD2cXmsl2ktb8%3D, PID: 15251939
    • Takeuchi H, Fujimoto A, Hoon DSB. Detection of mitochondrial DNA alterations in plasma of malignant melanoma patients. Ann N Y Acad Sci. 2004;1022:50–4.
    • (2004) Ann N Y Acad Sci , vol.1022 , pp. 50-54
    • Takeuchi, H.1    Fujimoto, A.2    Hoon, D.S.B.3
  • 104
    • 0036716827 scopus 로고    scopus 로고
    • Detection of mitochondrial DNA alterations in the serum of hepatocellular carcinoma patients
    • COI: 1:CAS:528:DC%2BD38XnvVWisbs%3D, PID: 12231530
    • Okochi O, Hibi K, Uemura T, Inoue S, Takeda S, Kanek T, et al. Detection of mitochondrial DNA alterations in the serum of hepatocellular carcinoma patients. Clin Cancer Res. 2002;8:2875–8.
    • (2002) Clin Cancer Res , vol.8 , pp. 2875-2878
    • Okochi, O.1    Hibi, K.2    Uemura, T.3    Inoue, S.4    Takeda, S.5    Kanek, T.6
  • 105
    • 0035501563 scopus 로고    scopus 로고
    • Detection of mitochondrial DNA alterations in primary tumors and corresponding serum of colorectal cancer patients
    • COI: 1:CAS:528:DC%2BD3MXnsVersLc%3D, PID: 11745425
    • Hibi K, Nakayama H, Yamazaki T, Takase T, Taguchi M, Kasai Y, et al. Detection of mitochondrial DNA alterations in primary tumors and corresponding serum of colorectal cancer patients. Int J Cancer. 2001;94:429–31.
    • (2001) Int J Cancer , vol.94 , pp. 429-431
    • Hibi, K.1    Nakayama, H.2    Yamazaki, T.3    Takase, T.4    Taguchi, M.5    Kasai, Y.6
  • 106
    • 84866175262 scopus 로고    scopus 로고
    • Cell-free circulating mitochondrial DNA in the serum: a potential non-invasive biomarker for Ewing’s Sarcoma
    • Yu M, Wan YF, Zou QH. Cell-free circulating mitochondrial DNA in the serum: a potential non-invasive biomarker for Ewing’s Sarcoma. Arch Med Res Elsevier Inc; 2012;43:389–94.
    • (2012) Arch Med Res Elsevier Inc , vol.43 , pp. 389-394
    • Yu, M.1    Wan, Y.F.2    Zou, Q.H.3
  • 108
    • 17944367327 scopus 로고    scopus 로고
    • Mitochondrial mutations in early stage prostate cancer and bodily fluids
    • PID: 11526508
    • Jerónimo C, Nomoto S, Caballero OL, Usadel H, Henrique R, Varzim G, et al. Mitochondrial mutations in early stage prostate cancer and bodily fluids. Oncogene. 2001;20:5195–8.
    • (2001) Oncogene , vol.20 , pp. 5195-5198
    • Jerónimo, C.1    Nomoto, S.2    Caballero, O.L.3    Usadel, H.4    Henrique, R.5    Varzim, G.6
  • 109
    • 0041742269 scopus 로고    scopus 로고
    • Detection of mitochondrial DNA mutations in the tumor and cerebrospinal fluid of medulloblastoma patients
    • COI: 1:CAS:528:DC%2BD3sXlsFOjtLo%3D, PID: 12873974
    • Wong LJC, Lueth M, Li XN, Lau CC, Vogel H. Detection of mitochondrial DNA mutations in the tumor and cerebrospinal fluid of medulloblastoma patients. Cancer Res. 2003;63:3866–71.
    • (2003) Cancer Res , vol.63 , pp. 3866-3871
    • Wong, L.J.C.1    Lueth, M.2    Li, X.N.3    Lau, C.C.4    Vogel, H.5
  • 110
    • 13444283964 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in breast cancer tissue and in matched nipple aspirate fluid
    • PID: 15375011
    • Zhu W, Qin W, Bradley P, Wessel A, Puckett CL, Sauter ER. Mitochondrial DNA mutations in breast cancer tissue and in matched nipple aspirate fluid. Carcinogenesis. 2005;26:145–52.
    • (2005) Carcinogenesis , vol.26 , pp. 145-152
    • Zhu, W.1    Qin, W.2    Bradley, P.3    Wessel, A.4    Puckett, C.L.5    Sauter, E.R.6


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