Prognostic value of mitochondrial DNA content and G10398A polymorphism in non-small cell lung cancer

Oncology Reports

Volumn 30, Issue 6, 2013, Pages 3006-3012

  Xu, Hui ^a   He, Wei ^a   Jiang, Huan Gang ^a   Zhao, Hong ^a   Peng, Xiao Hong ^a   Wei, Yue Hua ^a   Wei, Jing Ni ^a   Xie, Cong Hua ^a   Liang, Chen ^a   Zhong, Ya Hua ^a   Zhang, Gong ^a   Deng, Di ^a   Zhou, Yun Feng ^a   Zhou, Fu Xiang ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

A549 0 cells; Mitochondrial DNA; Non small cell lung cancer; Prognosis; Radiosensitivity

Indexed keywords

BIOLOGICAL MARKER; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER PROGNOSIS; CANCER RESISTANCE; CANCER STAGING; CELL STRAIN A549; CONTROLLED STUDY; DISEASE ASSOCIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA POLYMORPHISM; FEMALE; FOLLOW UP; G2 PHASE CELL CYCLE CHECKPOINT; GENE DELETION; GENE DOSAGE; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; DNA COPY NUMBER VARIATIONS; DNA, MITOCHONDRIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA; POLYMORPHISM, GENETIC; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SURVIVAL ANALYSIS;

EID: 84892416671     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2783     Document Type: Article

References (30)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2010.
2. Siegel R, Ward E, Brawley O and Jemal A: Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61: 212-236, 2011.
3. Peng J, Yang LX, Zhao XY, Gao ZQ, Yang J, et al: VCP gene variation predicts outcome of advanced non-small-cell lung cancer platinum-based chemotherapy. Tumour Biol 34: 953-961, 2013.
4. Sánchez-Aragó M, Chamorro M and Cuezva JM: Selection of cancer cells with repressed mitochondria triggers colon cancer progression. Carcinogenesis 31: 567-576, 2010.
5. Chatterjee A, Dasgupta S and Sidransky D: Mitochondrial subversion in cancer. Cancer Prev Res (Phila) 4: 638-654, 2011.
6. Wang H and Dai J: Changes on mitochondrial DNA content in non-small cell lung cancer. Zhongguo Fei Ai Za Zhi 14: 141-145, 2011 (In Chinese).
7. Lin CS, Wang LS, Tsai CM and Wei YH: Low copy number and low oxidative damage of mitochondrial DNA are associated with tumor progression in lung cancer tissues after neoadjuvant chemotherapy. Interact Cardiovasc Thorac Surg 7: 954-958, 2008.
8. Choi SJ, Kim SH, Kang HY, Lee J, Bhak JH, et al: Mutational hotspots in the mitochondrial genome of lung cancer. Biochem Biophys Res Commun 407: 23-27, 2011.
9. Pezzotti A, Kraft P, Hankinson SE, Hunter DJ, Buring J and Cox DG: The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk. PloS One 4: e5356, 2009.
10. Jin X, Zhang J, Gao Y, Ding K, Wang N, et al: Relationship between mitochondrial DNA mutations and clinical characteristics in human lung cancer. Mitochondrion 7: 347-353, 2007.
11. Malik AN, Shahni R, Rodriguez-de-Ledesma A, Laftah A and Cunningham P: Mitochondrial DNA as a non-invasive biomarker: accurate quantification using real time quantitative PCR without co-amplification of pseudogenes and dilution bias. Biochem Biophys Res Commun 412: 1-7, 2011.
12. Kawada I, Soejima K, Watanabe H, Nakachi I, Yasuda H, et al: An alternative method for screening EGFR mutation using RFLP in non-small cell lung cancer patients. J Thorac Oncol 3: 1096-1103, 2007.
13. Datta S, Majumder M, Biswas NK, Sikdar N and Roy B: Increased risk of oral cancer in relation to common Indian mitochondrial polymorphisms and Autosomal GSTP1 locus. Cancer 110: 1991-1999, 2007.
14. Yu M: Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers. Life Sci 89: 65-71, 2011.
15. Yu M: Somatic mitochondrial DNA mutations in human cancers. Adv Clin Chem 57: 99-138, 2012.
16. Kim MM, Clinger JD, Masayesva BG, Ha PK, Zahurak ML, et al: Mitochondrial DNA quantity increases with histopathologic grade in premalignant and malignant head and neck lesions. Clin Cancer Res 10: 8512-8515, 2004.
17. Wang Y, Liu VW, Xue WC, Cheung AN and Ngan HY: Association of decreased mitochondrial DNA content with ovarian cancer progression. Br J Cancer 95: 1087-1091, 2006.
18. Yamada S, Nomoto S, Fujii T, Kaneko T, Takeda S, et al: Correlation between copy number of mitochondrial DNA and clinico-pathologic parameters of hepatocellular carcinoma. Eur J Surg Oncol 32: 303-307, 2006.
19. Xing J, Chen M, Wood CG, Lin J, Spitz MR, et al: Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst 100: 1104-1112, 2008.
20. Hsu CW, Yin PH, Lee HC, Chi CW and Tseng LM: Mitochondrial DNA content as a potential marker to predict response to anthracycline in breast cancer patients. Breast J 16: 264-270, 2010.
21. Wu CW, Yin PH, Hung WY, Li AF, Li SH, et al: Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer. Genes Chromosomes Cancer 44: 19-28, 2005.
22. Canter JA, Kallianpur AR, Parl FF and Millikan RC: Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women. Cancer Res 65: 8028-8033, 2005.
23. Kulawiec M, Owens KM and Singh KK: mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice. J Hum Genet 54: 647-654, 2009.
24. Anoopkumar-Dukie S, Conere T, Sisk GD and Allshire A: Mitochondrial modulation of oxygen-dependent radiosensitivity in some human tumour cell lines. Br J Radiol 82: 847-854, 2009.
25. Armand R, Channon JY, Kintner J, White KA, Miselis KA, et al: The effects of ethidium bromide induced loss of mitochondrial DNA on mitochondrial phenotype and ultrastructure in a human leukemia T-cell line (MOLT-4 cells). Toxicol Appl Pharmacol 196: 68-79, 2004.
26. Yu M, Shi Y, Wei X, Yang Y, Zhou Y, et al: Depletion of mitochondrial DNA by ethidium bromide treatment inhibits the proliferation and tumorigenesis of T47D human breast cancer cells. Toxicol Lett 170: 83-93, 2007.
27. Park SY, Chang I, Kim JY, Kang SW, Park SH, et al: Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase. J Biol Chem 279: 7512-7520, 2004.
28. Cloos CR, Daniels DH, Kalen A, Matthews K, Du J, et al: Mitochondrial DNA depletion induces radioresistance by suppressing G2 checkpoint activation in human pancreatic cancer cells. Radiat Res 171: 581-587, 2009.
29. Kawamura SD, Takai K and Watanabe J, Hayashi J, Hayakawa K and Akashi M: Role of mitochondrial DNA in cells exposed to irradiation: generation of reactive oxygen species (ROS) is required for G2 checkpoint upon irradiation. J Health Sci 51: 385-393, 2005.
30. Kulawiec M, Ayyasamy V and Singh KK: p53 regulates mtDNA copy number and mitocheckpoint pathway. J Carcinog 8: 8, 2009.