Cell-free Circulating Mitochondrial DNA in the Serum: A Potential Non-invasive Biomarker for Ewing's Sarcoma

Archives of Medical Research

Volumn 43, Issue 5, 2012, Pages 389-394

  Yu, Man ^a   Wan, Yan Fang ^b   Zou, Qing Hua ^c  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c CHINA NATIONAL PETROLEUM CORPORATION   (China)

Author keywords

Biomarker; Circulating cell free mitochondrial DNA; Ewing's sarcoma; Serum

Indexed keywords

MITOCHONDRIAL DNA;

ADOLESCENT; ADULT; ARTICLE; CELL FREE SYSTEM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DNA EXTRACTION; EWING SARCOMA; FEMALE; HUMAN; HUMAN TISSUE; INFANT; MALE; METASTASIS; MOLECULAR DIAGNOSIS; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIMARY TUMOR; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; TUMOR VOLUME;

ADOLESCENT; ADULT; BONE NEOPLASMS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DNA, MITOCHONDRIAL; FEMALE; HUMANS; INFANT; MALE; ROC CURVE; SARCOMA, EWING; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84866175262     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2012.06.007     Document Type: Article

References (20)

1. Riggi N., Stamenkovic I. The biology of Ewing sarcoma. Cancer Lett 2007, 254:1-10.
2. Toomey E.C., Schiffman J.D., Lessnick S.L. Recent advances in the molecular pathogenesis of Ewing's sarcoma. Oncogene 2010, 29:4504-4516.
3. Balamuth N.J., Womer R.B. Ewing's sarcoma. Lancet Oncol 2010, 11:184-192.
4. Greaves L.C., Reeve A.K., Taylor R.W., et al. Mitochondrial DNA and disease. J Pathol 2012, 226:274-286.
5. Yu M. Somatic mitochondrial DNA mutations in human cancers. Adv Clin Chem 2012, 57:99-138.
6. Yu M. Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers. Life Sci 2011, 89:65-71.
7. Yu M., Wan Y., Zou Q., et al. High frequency of mitochondrial DNA D-loop mutations in Ewing's sarcoma. Biochem Biophys Res Commun 2009, 390:447-450.
8. Yu M., Wan Y., Zou Q. Decreased copy number of mitochondrial DNA in Ewing's sarcoma. Clin Chim Acta 2010, 411:679-683.
9. Kohler C., Radpour R., Barekati Z., et al. Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors. Mol Cancer 2009, 8:105.
10. Ellinger J., Albers P., Müller S.C., et al. Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker. BJU Int 2009, 104:48-52.
11. Ellinger J., Müller D.C., Müller S.C., et al. Circulating mitochondrial DNA in serum: a universal diagnostic biomarker for patients with urological malignancies. Urol Oncol September 25, 2010, (Epub ahead of print).
12. Schisterman E.F., Perkins N.J., Liu A., et al. Optimal cut-point and its corresponding Youden Index to discriminate individuals using pooled blood samples. Epidemiology 2005, 16:73-81.
13. Parrella P., Seripa D., Matera M.G., et al. Mutations of the D310 mitochondrial mononucleotide repeat in primary tumors and cytological specimens. Cancer Lett 2003, 190:73-77.
14. Goebel G., Zitt M., Zitt M., et al. Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias. Dis Markers 2005, 21:105-120.
15. Vlassov V.V., Laktionov P.P., Rykova E.Y. Circulating nucleic acids as a potential source for cancer biomarkers. Curr Mol Med 2010, 10:142-165.
16. Zachariah R.R., Schmid S., Buerki N., et al. Levels of circulating cell-free nuclear and mitochondrial DNA in benign and malignant ovarian tumors. Obstet Gynecol 2008, 112:843-850.
17. Qu F., Liu X., Zhou F., et al. Association between mitochondrial DNA content in leukocytes and colorectal cancer risk: a case-control analysis. Cancer 2011, 117:3148-3155.
18. Xia P., An H.X., Dang C.X., et al. Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer. BMC Cancer 2009, 9:454.
19. Mehra N., Penning M., Maas J., et al. Circulating mitochondrial nucleic acids have prognostic value for survival in patients with advanced prostate cancer. Clin Cancer Res 2007, 13:421-426.
20. Ellinger J., Müller S.C., Wernert N., et al. Mitochondrial DNA in serum of patients with prostate cancer: a predictor of biochemical recurrence after prostatectomy. BJU Int 2008, 102:628-632.