An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

Breast Cancer Research

Volumn 17, Issue 1, 2015, Pages

  Blein, Sophie ^a,b,c   Bardel, Claire ^b,c   Danjean, Vincent ^d,e   McGuffog, Lesley ^f   Healey, Sue ^g   Barrowdale, Daniel ^f   Lee, Andrew ^f   Dennis, Joe ^f   Kuchenbaecker, Karoline B ^f   Soucy, Penny ^h   Terry, Mary Beth ⁱ   Chung, Wendy K ^j   Goldgar, David E ^k   Buys, Saundra S ^k   Janavicius, Ramunas ^m   Tihomirova, Laima ⁿ   Tung, Nadine ^o   Dorfling, Cecilia M ^p   van Rensburg, Elizabeth J ^p   Neuhausen, Susan L ^q   Ding, Yuan Chun ^q   Gerdes, Anne Marie ^r   Ejlertsen, Bent ^r   Nielsen, Finn C ^r   Hansen, Thomas V O ^r   Osorio, Ana ^s,t   Benitez, Javier ^s,t   Conejero, Raquel Andrés ^u   Segota, Ena ^q,v   Weitzel, Jeffrey N ^q   Thelander, Margo ^q,w   Peterlongo, Paolo ^x   Radice, Paolo ^y   Pensotti, Valeria ^q,z   Dolcetti, Riccardo ^aa   Bonanni, Bernardo ^ab   Peissel, Bernard ^y   Zaffaroni, Daniela ^y   Scuvera, Giulietta ^y   Manoukian, Siranoush ^y   Varesco, Liliana ^ac   Capone, Gabriele L ^ad,ae   Papi, Laura ^ae   Ottini, Laura ^af   Yannoukakos, Drakoulis ^ag   Konstantopoulou, Irene ^ah   Garber, Judy ^ai   Hamann, Ute ^aj   Donaldson, Alan ^ak   Brady, Angela ^al   Brewer, Carole ^am   Foo, Claire ^an   Evans, D Gareth ^ao   Frost, Debra ^ap   Eccles, Diana ^aq   Douglas, Fiona ^ar   Cook, Jackie ^as   Adlard, Julian ^at   Barwell, Julian ^au   Walker, Lisa ^av   Izatt, Louise ^aw   Side, Lucy E ^ax   Kennedy, M John ^ax,ay,az   Tischkowitz, Marc ^ba   Rogers, Mark T ^bb   Porteous, Mary E ^bc   Morrison, Patrick J ^bd,be   Platte, Radka ^ap   Eeles, Ros ^bf   Davidson, Rosemarie ^bg   Hodgson, Shirley ^bh   Cole, Trevor ^bi   Godwin, Andrew K ^bj   Isaacs, Claudine ^bk   Claes, Kathleen ^bl   De Leeneer, Kim ^bl   Meindl, Alfons ^bm   Gehrig, Andrea ^bn   Wappenschmidt, Barbara ^bo,bp   Sutter, Christian ^bq   Engel, Christoph ^br   Niederacher, Dieter ^bs   Steinemann, Doris ^bt   Plendl, Hansjoerg ^bu   Kast, Karin ^bv   Rhiem, Kerstin ^bo,bp   Ditsch, Nina ^bm   Arnold, Norbert ^bu   Varon Mateeva, Raymonda ^bw   Schmutzler, Rita K ^bo,bp,bx   Preisler Adams, Sabine ^by   Markov, Nadja Bogdanova ^by   Wang Gohrke, Shan ^bz   de Pauw, Antoine ^ca   Lefol, Cédrick ^ca   Lasset, Christine ^c,cb   Leroux, Dominique ^d,cc   Rouleau, Etienne ^ca   Damiola, Francesca ^a   Dreyfus, Hélène ^d,cc   Barjhoux, Laure ^a   Golmard, Lisa ^ca   Uhrhammer, Nancy ^cd   Bonadona, Valérie ^c,cb   Sornin, Valérie ^a   Bignon, Yves Jean ^cd   Carter, Jonathan ^ce   Van Le, Linda ^cf   Piedmonte, Marion ^cg   DiSilvestro, Paul A ^ch   de la Hoya, Miguel ^ci   Caldes, Trinidad ^ci   Nevanlinna, Heli ^cj   Aittomäki, Kristiina ^cj   Jager, Agnes ^ck   van den Ouweland, Ans M W ^ck   Kets, Carolien M ^cl   Aalfs, Cora M ^cm   van Leeuwen, Flora E ^cn   Hogervorst, Frans B L ^cn   Meijers Heijboer, Hanne E J ^co   Oosterwijk, Jan C ^cp   van Roozendaal, Kees E P ^cq   Rookus, Matti A ^cn   Devilee, Peter ^cr   van der Luijt, Rob B ^cs   Olah, Edith ^ct   Diez, Orland ^cu   Teulé, Alex ^cv   Lazaro, Conxi ^cv   Blanco, Ignacio ^cv   Del Valle, Jesús ^cv   Jakubowska, Anna ^cw   Sukiennicki, Grzegorz ^cw   Gronwald, Jacek ^cw   Lubinski, Jan ^cw   Durda, Katarzyna ^cw   Jaworska Bieniek, Katarzyna ^cw   Agnarsson, Bjarni A ^cx   Maugard, Christine ^cy   Amadori, Alberto ^cz,da   Montagna, Marco ^da   Teixeira, Manuel R ^db,dc   Spurdle, Amanda B ^g   Foulkes, William ^dd   Olswold, Curtis ^de   Lindor, Noralane M ^df   Pankratz, Vernon S ^de   Szabo, Csilla I ^dg   Lincoln, Anne ^dh   Jacobs, Lauren ^dh   Corines, Marina ^dh   Robson, Mark ^dh   Vijai, Joseph ^dh   Berger, Andreas ^di   Fink Retter, Anneliese ^di   Singer, Christian F ^di   Rappaport, Christine ^di   Kaulich, Daphne Geschwantler ^di   Pfeiler, Georg ^di   Tea, Muy Kheng ^di   Greene, Mark H ^dj   Mai, Phuong L ^dj   Rennert, Gad ^ab,dk,dl   Imyanitov, Evgeny N ^dm   Mulligan, Anna Marie ^dn,do   Glendon, Gord ^dp,dq   Andrulis, Irene L ^dn,dq   Tchatchou, Sandrine ^dq   Toland, Amanda Ewart ^dr,ds,dt   Pedersen, Inge Sokilde ^du   Thomassen, Mads ^dv   Kruse, Torben A ^dv   Jensen, Uffe Birk ^dw   Caligo, Maria A ^dx   Friedman, Eitan ^dy   Zidan, Jamal ^dz   Laitman, Yael ^dy   Lindblom, Annika ^ea   Melin, Beatrice ^eb   Arver, Brita ^ea   Loman, Niklas ^ec   Rosenquist, Richard ^ed   Olopade, Olufunmilayo I ^ee   Nussbaum, Robert L ^ef   Ramus, Susan J ^eg   Nathanson, Katherine L ^eh   Domchek, Susan M ^eh   Rebbeck, Timothy R ^eh   Arun, Banu K ^ei   Mitchell, Gillian ^ej,ek   Karlan, Beth Y ^el   Lester, Jenny ^el   Orsulic, Sandra ^el   Stoppa Lyonnet, Dominique ^ca,em,en   Thomas, Gilles ^c,eo   Simard, Jacques ^h   Couch, Fergus J ^de   Offit, Kenneth ^dh   Easton, Douglas F ^f   Chenevix Trench, Georgia ^g   Antoniou, Antonis C ^f   Mazoyer, Sylvie ^a,b,c   Phelan, Catherine M ^ep   Sinilnikova, Olga M ^a,b,c,eq   Cox, David G ^a,b,c   Angelakos, Maggie ^l   Maskiell, Judi ^l   Dite, Gillian ^l   Tsimiklis, Helen ^l   Rudaitis, Vilius ^l   Griškevicius, Laimonas ^l   Eglitis, Drs Janis ^l   Krilova, Anna ^l   Stengrevics, Aivars ^l   Ding, Chun ^l   Steele, Linda ^l   Barroso, Alicia ^l,aa   Alonso, Rosario ^l,aa   Pita, Guillermo ^l,aa   Viel, Alessandra ^l,aa   della Puppa, Lara ^l,aa   Barile, Monica ^l,ab   Tommasi, Stefania ^l,er   Pilato, Brunella ^l,er   Lambo, Rossana ^l,er   Martayan, Aline ^l,es   Tibiletti, Maria Grazia ^l,z,et   Ellis, Steve ^ap,eu   Fineberg, Elena ^ap,eu   Miedzybrodzka, Zosia ^ap,ev   Gregory, Helen ^ap,ev   Jeffers, Lisa ^ap,ew   Ong, Kai Ren ^ap,ex   Hoffman, Jonathan ^ap,ex   James, Margaret ^ap,dr   Paterson, Joan ^ap,ey   Taylor, Amy ^ap,ey   Murray, Alexandra ^ap,ez   McCann, Emma ^ap,ez   Barton, David ^ap,az,gs   Drummond, Sarah ^ap,dr   Kivuva, Emma ^ap,fa   Searle, Anne ^ap,fa   Goodman, Selina ^ap,fa   Hill, Kathryn ^ap,fa   Murday, Victoria ^ap,fb   Bradshaw, Nicola ^ap,fb   Snadden, Lesley ^ap,fb   Longmuir, Mark ^ap,fb   Watt, Catherine ^ap,fb   Gibson, Sarah ^ap,fb   Haque, Eshika ^ap,fb   Tobias, Ed ^ap,fb   Duncan, Alexis ^ap,fb   Jacobs, Chris ^ap,aw   Langman, Caroline ^ap,aw   Dorkins, Huw ^ap,dr   Serra Feliu, Gemma ^ap,fc   Ellis, Ian ^ap,fd   Houghton, Catherine ^ap,fd   Lalloo, Fiona ^ap,fe   Taylor, Jane ^ap,fe   Male, Alison ^ap,dr   Berlin, Cheryl ^ap,dr   Eason, Jacqueline ^ap,ff   Collier, Rebecca ^ap,ff   Claber, Oonagh ^ap,fg   Jobson, Irene ^ap,fg   McLeod, Diane ^ap,fh   Halliday, Dorothy ^ap,fh   Durell, Sarah ^ap,fh   Stayner, Barbara ^ap,fh   Shanley, Susan ^ap,fi   Rahman, Nazneen ^ap,fi   Houlston, Richard ^ap,fi   Bancroft, Elizabeth ^ap,fi   Page, Elizabeth ^ap,fi   Ardern Jones, Audrey ^ap,fi   Kohut, Kelly ^ap,fi   Wiggins, Jennifer ^ap,fi   Castro, Elena ^ap,fi   Killick, Emma ^ap,fi   Martin, Sue ^ap,fi   Rea, Gillian ^ap,fi   Kulkarni, Anjana ^ap,fi   Quarrell, Oliver ^ap,fj   Bardsley, Cathryn ^ap,fj   Goff, Sheila ^ap,dr   Brice, Glen ^ap,dr   Winchester, Lizzie ^ap,dr   Eddy, Charlotte ^ap,dr   Tripathi, Vishakha ^ap,dr   Attard, Virginia ^ap,dr   Lehmann, Anna ^ap,dr   Lucassen, Anneke ^ap,fk   Crawford, Gillian ^ap,fk   McBride, Donna ^ap,fk   Smalley, Sarah ^ap,fk   Weaver, Jo Ellen ^ap   Bove, Betsy ^ap   Verny Pierre, Carole ^a   Calender, Alain ^a   Giraud, Sophie ^a   Léone, Mélanie ^a   Gauthier Villars, Marion ^fl   Buecher, Bruno ^fl   Houdayer, Claude ^fl   Moncoutier, Virginie ^fl   Belotti, Muriel ^fl   Tirapo, Carole ^fl   Bressac de Paillerets, Brigitte ^ca   Caron, Olivier ^ca   Handallou, Sandrine ^cb   Hardouin, Agnès ^fm   Berthet, Pascaline ^fm   Sobol, Hagay ^fn   Bourdon, Violaine ^fn   Noguchi, Tetsuro ^fn   Remenieras, Audrey ^fn   Eisinger, François ^fn   Coupier, Isabelle ^fo   Pujol, Pascal ^fo   Peyrat, Jean Philippe ^fp   Fournier, Joëlle ^fp   Révillion, Françoise ^fp   Vennin, Philippe ^fp   Adenis, Claude ^fp   Lidereau, Rosette ^ca   Demange, Liliane ^ca   Nogues, Catherine ^ca   Muller, Danièle ^fq   Fricker, Jean Pierre ^fq   Barouk Simonet, Emmanuelle ^fr   Bonnet, Françoise ^fr   Bubien, Virginie ^fr   Sevenet, Nicolas ^fr   Longy, Michel ^fr   Toulas, Christine ^fs   Guimbaud, Rosine ^fs   Gladieff, Laurence ^fs   Feillel, Viviane ^fs   Rebischung, Christine ^cc   Peysselon, Magalie ^cc   Coron, Fanny ^ft   Faivre, Laurence ^ft   Prieur, Fabienne ^gt   Lebrun, Marine ^gt   Kientz, Caroline ^gt   Ferrer, Sandra Fert ^fu   Frénay, Marc ^fv   Vénat Bouvet, Laurence ^fw   Delnatte, Capucine ^fx   Mortemousque, Isabelle ^fy   Coulet, Florence ^fz   Colas, Chrystelle ^fz   Soubrier, Florent ^fz   Sokolowska, Johanna ^ga   Bronner, Myriam ^ga   Collonge Rame, Marie Agnès ^gb   Damette, Alexandre ^gb   Lynch, Henry T ^gc   Snyder, Carrie L ^gc   Muranen, Taru A ^q   Blomqvist, Drs Carl ^q   Aaltonen, Kirsimari ^q   Erkkilä, Irja ^q   Palola, Virpi ^q   Verhoef, S ^cn   Schmidt, M K ^cn   de Lange, J L ^cn   Wijnands, R ^cn   Collee J M ^ck   Hooning, M J ^ck   Seynaeve, C ^ck   van Deurzen, C H M ^ck   Obdeijn, I M ^ck   van Asperen, C J ^cr   Wijnen, J T ^cr   Tollenaar, R A E M ^cr   van Cronenburg, T C T E F ^cr   Mensenkamp, A R ^cl   Ausems, M G E M ^cs   van Os, T A M ^cm   Gille, J J P ^co   Waisfisz, Q ^co   Gomez Garcia E B ^cq   Blok, M J ^cq   van der Hout, A H ^cp   Mourits, M J ^cp   de Bock, G H ^cp   Vasen, H F ^gd   Siesling, S ^ge   Overbeek, L I H ^gf   Papp, Janos ^ct   Vaszko, Tibor ^ct   Bozsik, Aniko ^ct   Pocza, Timea ^ct   Franko, Judit ^ct   Balogh, Maria ^ct   Domokos, Gabriella ^ct   Ferenczi, Judit ^ct   Balmana J ^gg   Capella, Gabriel ^gh   Dumont, Martine ^q   Tranchant, Martine ^q   Peixoto, Ana ^q   Santos, Catarina ^q   Rocha, Patrícia ^q   Pinto, Pedro ^q   Thorne, Heather ^gi   Niedermayr, Eveline ^gi   Foretova, Lenka ^gj   Machackova, Eva ^gj   Zikan, Michal ^gk   Pohlreich, Petr ^gk   Kleibl, Zdenek ^gk   Dishon, Sara ^gl   Lejbkowicz, Flavio ^q   Pinchev, Mila ^q   Senter, Leigha ^q   Sweet, Kevin ^q   Craven, Caroline ^q   O'Conor, Michelle ^q   Borg, Ake ^gm   Olsson, Håkan ^gm   Jernström, Helena ^gm   Henriksson, Karin ^gm   Harbst, Katja ^gm   Soller, Maria ^gm   Kristoffersson, Ulf ^gm   öfverholm, Anna ^gn   Nordling, Margareta ^gn   Karlsson, Per ^gn   Einbeigi, Zakaria ^gn   von Wachenfeldt, Anna ^ea   Liljegren, Annelie ^ea   Bustinza, Gisela Barbany ^ea   Rantala, Johanna ^ea   Ardnor, Christina Edwinsdotter ^go   Emanuelsson, Monica ^go   Ehrencrona, Hans ^gp   Pigg, Maritta Hellström ^gp   Stenmark Askmalm, Marie ^gq   Liedgren, Sigrun ^gq   Zvocec, Cecilia ^gr   Niu, Qun ^gr   Seldon, Joyce ^q   Kwan, Lorna ^q   Crawford, Beth ^q   Loranger, Kate ^q   Mak, Julie ^q   Stewart, Nicola ^q   Lee, Robin ^q   Blanco, Amie ^q   Conrad, Peggy ^q   Chan, Salina ^q   Pharoah, Paul D P ^q   Gayther, Simon ^q   Pye, Carole ^q   Harrington, Patricia ^q   Wozniak, Eva ^q   Lindeman, Geoffrey ^q   Harris, Marion ^q   Delatycki, Martin ^q   Sawyer, Sarah ^q   Driessen, Rebecca ^q   Thompson, Ella ^q   Breast Cancer Family Registry, ^l   EMBRACE, ^ap   more..

^a CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^b UNIVERSITÉ DE LYON   (France)

^c UNIVERSITÉ LYON 1   (France)

^d UNIV GRENOBLE ALPES   (France)

^e INRIA RHÔNE ALPES   (France)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^h LAVAL UNIVERSITY   (Canada)

ⁱ Department of Medicine   (United States)

^j New York Presbyterian Columbia University Medical Center   (United States)

^k UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^l CANCER PREVENTION INSTITUTE OF CALIFORNIA   (United States)

^m VILNIUS UNIVERSITY   (Lithuania)

ⁿ LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE   (Latvia)

^o BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^p UNIVERSITY OF PRETORIA   (South Africa)

^q CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^r University of Copenhagen   (Denmark)

^s Structural Biology and Biocomputing Programme   (Spain)

^t CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^u HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

^v HOLY CROSS HOSPITAL   (United States)

^w John Muir Medical Center   (United States)

^x FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^y NATIONAL CANCER INSTITUTE   (Italy)

^z Hospital Clínico Universitario Lozano Blesa ^*  (Italy)

^aa CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^ab EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^ac UNIVERSITY OF GENOA   (Italy)

^ad Fiorgen Foundation for Pharmacogenomics   (Italy)

^ae UNIVERSITY OF FLORENCE   (Italy)

^af SAPIENZA UNIVERSITY OF ROME   (Italy)

^ag ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^ah INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^ai DANA FARBER CANCER INSTITUTE   (United States)

^aj GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^ak ST MICHAEL'S HOSPITAL   (United Kingdom)

^al Kennedy Galton Centre   (United Kingdom)

^am ROYAL DEVON AND EXETER HOSPITAL   (United Kingdom)

^an LIVERPOOL WOMEN'S NHS FOUNDATION TRUST   (United Kingdom)

^ao MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^ap UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^aq UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^ar NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^as SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^at LEEDS GENERAL INFIRMARY   (United Kingdom)

^au LEICESTER ROYAL INFIRMARY   (United Kingdom)

^av CHURCHILL HOSPITAL   (United Kingdom)

^aw GUY S HOSPITAL   (United Kingdom)

^ax GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^ay TRINITY COLLEGE DUBLIN   (Ireland)

^az ST JAMES S HOSPITAL   (Ireland)

^ba ADDENBROOKE S HOSPITAL   (United Kingdom)

^bb UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^bc WESTERN GENERAL HOSPITAL   (United Kingdom)

^bd QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^be BELFAST CITY HOSPITAL   (United Kingdom)

^bf INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^bg ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^bh ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^bi BIRMINGHAM CHILDREN S HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^bj UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^bk GEORGETOWN UNIVERSITY HOSPITAL   (United States)

^bl GHENT UNIVERSITY HOSPITAL   (Belgium)

^bm TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^bn UNIVERSITY OF WÜRZBURG   (Germany)

^bo Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases   (Germany)

^bp UNIVERSITY OF COLOGNE   (Germany)

^bq UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^br UNIVERSITY OF LEIPZIG   (Germany)

^bs UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^bt HANNOVER MEDICAL SCHOOL   (Germany)

^bu UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^bv UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^bw CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^bx German Consortium of Hereditary Breast and Ovarian Cancer (GC HBOC)   (Germany)

^by UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^bz UNIVERSITY HOSPITAL ULM   (Germany)

^ca INSTITUT CURIE   (France)

^cb CENTRE LÉON BÉRARD   (France)

^cc GRENOBLE UNIVERSITY HOSPITAL   (France)

^cd UNIVERSITÉ CLERMONT AUVERGNE   (France)

^ce ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^cf UNIVERSITY OF NORTH CAROLINA   (United States)

^cg Buffalo Niagara Enterprise   (United States)

^ch WOMEN AND INFANTS HOSPITAL   (United States)

^ci HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^cj HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^ck ERASMUS MEDICAL CENTER   (Netherlands)

^cl RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^cm ACADEMIC MEDICAL CENTER   (Netherlands)

^cn NETHERLANDS CANCER INSTITUTE   (Netherlands)

^co VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^cp UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^cq MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^cr LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^cs UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^ct NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^cu HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^cv HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^cw POMERANIAN MEDICAL UNIVERSITY   (Poland)

^cx UNIVERSITY OF ICELAND   (Iceland)

^cy HÔPITAL CIVIL   (France)

^cz UNIVERSITY OF PADOVA   (Italy)

^da VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^db PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^dc UNIVERSITY OF PORTO   (Portugal)

^dd MCGILL UNIVERSITY   (Canada)

^de MAYO CLINIC   (United States)

^df MAYO CLINIC   (United States)

^dg NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^dh MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^di UNIVERSITY OF VIENNA   (Austria)

^dj NATIONAL CANCER INSTITUTE   (United States)

^dk CLALIT HEALTH SERVICES   (Israel)

^dl TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^dm N N PETROV RESEARCH INSTITUTE OF ONCOLOGY   (Russian Federation)

^dn UNIVERSITY OF TORONTO   (Canada)

^do ST MICHAEL'S HOSPITAL   (Canada)

^dp CANCER CARE ONTARIO   (Canada)

^dq MOUNT SINAI HOSPITAL   (Canada)

^dr The Ohio State University Comprehensive Cancer Center Arthur G James Cancer Hospital and Richard J Solove Research Institute ^*  (United Kingdom)

^ds THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^dt OHIO STATE UNIVERSITY   (United States)

^du AALBORG UNIVERSITY HOSPITAL   (Denmark)

^dv ODENSE UNIVERSITY HOSPITAL   (Denmark)

^dw AARHUS UNIVERSITY HOSPITAL   (Denmark)

^dx UNIVERSITY HOSPITAL OF PISA   (Italy)

^dy GERTNER INSTITUTE FOR EPIDEMIOLOGY AND HEALTH POLICY RESEARCH   (Israel)

^dz Rebecca Sieff Government Hospital   (Israel)

^ea KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^eb UMEÅ UNIVERSITY   (Sweden)

^ec LUND UNIVERSITY HOSPITAL   (Sweden)

^ed UPPSALA UNIVERSITY   (Sweden)

^ee UNIVERSITY OF CHICAGO   (United States)

^ef UNIVERSITY OF CALIFORNIA   (United States)

^eg UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^eh UNIVERSITY OF PENNSYLVANIA   (United States)

^ei UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^ej PETER MACCALLUM CANCER CENTRE   (Australia)

^ek UNIVERSITY OF MELBOURNE   (Australia)

^el CEDARS SINAI MEDICAL CENTER   (United States)

^em INSTITUT CURIE   (France)

^en UNIVERSITÉ PARIS DESCARTES   (France)

^eo INSTITUT NATIONAL DU CANCER   (France)

^ep H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^eq HOSPICES CIVILS DE LYON   (France)

^er NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^es REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^et OSPEDALE DI CIRCOLO   (Italy)

^eu Cambridge ESOL   (United Kingdom)

^ev North of Scotland Regional Genetics Service   (United Kingdom)

^ew Northern Ireland Regional Genetics Service   (United Kingdom)

^ex West Midlands Regional Clinical Genetics Service   (United Kingdom)

^ey East Anglian Regional Genetics Service   (United Kingdom)

^ez Medical Genetics Services for Wales   (United Kingdom)

^fa Peninsula Clinical Genetics Service   (United Kingdom)

^fb West of Scotland Regional Genetics Service   (United Kingdom)

^fc Yorkshire Regional Genetics Service   (United Kingdom)

^fd Merseyside and Cheshire Clinical Genetics Service   (United Kingdom)

^fe Manchester Regional Genetics Service   (United Kingdom)

^ff NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^fg Northern Clinical Genetics Service   (United Kingdom)

^fh Oxford Regional Genetics Service   (United Kingdom)

^fi INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^fj North Trent Clinical Genetics Service   (United Kingdom)

^fk PRINCESS ANNE HOSPITAL   (United Kingdom)

^fl INSTITUT GUSTAVE ROUSSY   (France)

^fm CENTRE FRANÇOIS BACLESSE   (France)

^fn INSTITUT PAOLI CALMETTES   (France)

^fo HÔPITAL ARNAUD DE VILLENEUVE   (France)

^fp CENTRE OSCAR LAMBRET   (France)

^fq CENTRE PAUL STRAUSS   (France)

^fr INSTITUT BERGONIÉ   (France)

^fs INSTITUT CLAUDIUS REGAUD   (France)

^ft DIJON UNIVERSITY HOSPITAL   (France)

^fu UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

^fv CENTRE ANTOINE LACASSAGNE   (France)

^fw LIMOGES UNIVERSITY HOSPITAL   (France)

^fx NANTES UNIVERSITY HOSPITAL   (France)

^fy CHU BRETONNEAU   (France)

^fz PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^ga UNIVERSITY HOSPITAL OF NANCY   (France)

^gb UNIVERSITY HOSPITAL JEAN MINJOZ   (France)

^gc CREIGHTON UNIVERSITY   (United States)

^gd Netherlands Foundation for the Detection of Hereditary Tumors   (Netherlands)

^ge Netherlands Cancer Registry   (Netherlands)

^gf The Dutch Pathology Registry (PALGA)   (Netherlands)

^gg HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^gh ICO Hereditary Cancer Program   (Spain)

^gi Family Cancer Clinics   (Australia)

^gj MASARYK UNIVERSITY   (Czech Republic)

^gk CHARLES UNIVERSITY   (Czech Republic)

^gl National Israeli Cancer Control Center (NICCC) National Familial Cancer Consultation Service   (Israel)

^gm SHEBA MEDICAL CENTER   (Israel)

^gn SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^go UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^gp UPPSALA UNIVERSITY   (Sweden)

^gq LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^gr The University of Chicago Medicine   (United States)

^gs National Centre for Medical Genetics   (Ireland)

^gt CENTRE HOSPITALIER DE CHAMBÉRY   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BREAST CANCER; FEMALE; GENE LOCATION; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MITOCHONDRIAL GENOME; MITOCHONDRIAL HAPLOGROUP; MITOCHONDRIAL HAPLOGROUP T1A1; MOLECULAR EVOLUTION; MOLECULAR PHYLOGENY; PHYLOGENETIC TREE; RISK ASSESSMENT; TUMOR SUPPRESSOR GENE; BREAST TUMOR; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; MITOCHONDRIAL GENE; MUTATION; PHYLOGENY; RISK;

BRCA1 PROTEIN;

BRCA1 PROTEIN; BREAST NEOPLASMS; FEMALE; GENES, BRCA2; GENES, MITOCHONDRIAL; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HETEROZYGOTE; HUMANS; MUTATION; PHYLOGENY; RISK;

EID: 84932607033     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/s13058-015-0567-2     Document Type: Article

References (53)

1. Newman B, Austin MA, Lee M, King MC. Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families. Proc Natl Acad Sci U S A. 1988;85:3044-8.
2. Hall JM, Lee MK, Newman B, Morrow JE, Anderson LA, Huey B, et al. Linkage of early-onset familial breast cancer to chromosome 17q21. Science. 1990;250:1684-9.
3. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994;266:66-71.
4. Evans DG, Shenton A, Woodward E, Lalloo F, Howell A, Maher ER. Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a clinical cancer genetics service setting: risks of breast/ovarian cancer quoted should reflect the cancer burden in the family. BMC Cancer. 2008;8:155.
5. Antoniou A, Pharoah PDP, Narod S, Risch HA, Eyfjord JE, Hopper JL, et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet. 2003;72:1117-30. A published erratum appears in. Am J Hum Genet. 2003;73:709.
6. Lynch HT, Snyder C, Casey MJ. Hereditary ovarian and breast cancer: what have we learned? Ann Oncol. 2013;24 Suppl 8:viii83-viii95.
7. Caestecker KW, Van de Walle GR. The role of BRCA1 in DNA double-strand repair: past and present. Exp Cell Res. 2013;319:575-87.
8. Negritto C. Repairing double-strand DNA breaks. Nat Educ. 2010;3:26.
9. Osorio A, Milne RL, Kuchenbaecker K, Vaclová T, Pita G, Alonso R, et al. DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers. PLoS Genet. 2014;10:e1004256.
10. Klaunig JE, Kamendulis LM, Hocevar BA. Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol. 2010;38:96-109.
11. Loft S, Poulsen HE. Cancer risk and oxidative DNA damage in man. J Mol Med Berl. 1996;74:297-312.
12. Weng SW, Lin TK, Wang PW, Chen SD, Chuang YC, Liou CW. Single nucleotide polymorphisms in the mitochondrial control region are associated with metabolic phenotypes and oxidative stress. Gene. 2013;531:370-6.
13. Ma J, Zhang Q, Chen S, Fang B, Yang Q, Chen C, et al. Mitochondrial dysfunction promotes breast cancer cell migration and invasion through HIF1α accumulation via increased production of reactive oxygen species. PLoS One. 2013;8:e69485.
14. Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, et al. Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases. Biochim Biophys Acta. 1842;2014:208-19.
15. Mishmar D, Ruiz-Pesini E, Golik P, Macaulay V, Clark AG, Hosseini S, et al. Natural selection shaped regional mtDNA variation in humans. Proc Natl Acad Sci U S A. 2003;100:171-6.
16. Nishimura T, Watanuki S. Relationship between mitochondrial haplogroup and seasonal changes of physiological responses to cold. J Physiol Anthropol. 2014;33:27.
17. Van der Walt JM, Dementieva YA, Martin ER, Scott WK, Nicodemus KK, Kroner CC, et al. Analysis of European mitochondrial haplogroups with Alzheimer disease risk. Neurosci Lett. 2004;365:28-32.
18. Castro MG, Huerta C, Reguero JR, Soto MI, Doménech E, Alvarez V, et al. Mitochondrial DNA haplogroups in Spanish patients with hypertrophic cardiomyopathy. Int J Cardiol. 2006;112:202-6.
19. Malik D, Hsu T, Falatoonzadeh P, Cáceres-del-Carpio J, Tarek M, Chwa M, et al. Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases. PLoS One. 2014;9:e99003.
20. Mueller EE, Schaier E, Brunner SM, Eder W, Mayr JA, Egger SF, et al. Mitochondrial haplogroups and control region polymorphisms in age-related macular degeneration: a case-control study. PLoS One. 2012;7:e30874.
21. Wei L, Zhao Y, Guo T, Li P, Wu H, Xie H, et al. Association of mtDNA D-loop polymorphisms with risk of gastric cancer in Chinese population. Pathol Oncol Res. 2011;17:735-42.
22. Zhang J, Guo Z, Bai Y, Cui L, Zhang S, Xu J. Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for renal cell carcinoma. Biomed Rep. 2013;1:563-6.
23. Liu VWS, Wang Y, Yang HJ, Tsang PCK, Ng TY, Wong LC, et al. Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer. Hum Mutat. 2003;22:173-4.
24. Permuth-Wey J, Chen YA, Tsai YY, Chen Z, Qu X, Lancaster JM, et al. Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 2011;20:1131-45.
25. Czarnecka AM, Krawczyk T, Zdrozny M, Lubiński J, Arnold RS, Kukwa W, et al. Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland. Breast Cancer Res Treat. 2010;121:511-8.
26. Mims MP, Hayes TG, Zheng S, Leal SM, Frolov A, Ittmann MM, et al. Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women. Cancer Res. 2006;66:1880-1.
27. Tommasi S, Favia P, Weigl S, Bianco A, Pilato B, Russo L, et al. Mitochondrial DNA variants and risk of familial breast cancer: an exploratory study. Int J Oncol. 2014;44:1691-8.
28. Bahcall OG. iCOGS collection provides a collaborative model. Nat Genet. 2013;45:343.
29. Breast Cancer Association Consortium. Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium. J Natl Cancer Inst. 2006;98:1382-96. A published erratum appears in J Natl Cancer Inst. 2007;99:411.
30. Berchuck A, Schildkraut JM, Pearce CL, Chenevix-Trench G, Pharoah PD. Role of genetic polymorphisms in ovarian cancer susceptibility: development of an international ovarian cancer association consortium. Adv Exp Med Biol. 2008;622:53-67.
31. Kote-Jarai Z, Easton DF, Stanford JL, Ostrander EA, Schleutker J, Ingles SA, et al. Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium. Cancer Epidemiol Biomarkers Prev. 2008;17:2052-61.
32. Chenevix-Trench G, Milne RL, Antoniou AC, Couch FJ, Easton DF, Goldgar DE, et al. An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA). Breast Cancer Res. 2007;9:104.
33. Bardel C, Danjean V, Génin E. ALTree: association detection and localization of susceptibility sites using haplotype phylogenetic trees. Bioinformatics. 2006;22:1402-3.
34. Bardel C, Danjean V, Morange P, Génin E, Darlu P. On the use of phylogeny-based tests to detect association between quantitative traits and haplotypes. Genet Epidemiol. 2009;33:729-39.
35. Couch FJ, Wang X, McGuffog L, Lee A, Olswold C, Kuchenbaecker KB, et al. Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet. 2013;9:e1003212.
36. Gaudet MM, Kuchenbaecker KB, Vijai J, Klein RJ, Kirchhoff T, McGuffog L, et al. Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet. 2013;9:e1003173.
37. Center for Cancer Genetic Epidemiology, Department of Public Health and Primary Care/Department of Oncology, University of Cambridge: iCOGS custom Illumina iSelect genotyping array: access information for iCOGS data. http://ccge.medschl.cam.ac.uk/research/consortia/icogs/ . Accessed 4 May 2015.
38. van Oven M, Kayser M. Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum Mutat. 2009;30:E386-94.
39. Behar DM, van Oven M, Rosset S, Metspalu M, Loogväli EL, Silva NM, et al. A "Copernican" reassessment of the human mitochondrial DNA tree from its root. Am J Hum Genet. 2012;90:675-84.
40. Ge Y, Dudoit S, Speed TP. Resampling-based multiple testing for microarray data analysis. Test. 2003;12:1-77.
41. Yang Z. PAML 4: phylogenetic analysis by maximum likelihood. Mol Biol Evol. 2007;24:1586-91.
42. Antoniou AC, Goldgar DE, Andrieu N, Chang-Claude J, Brohet R, Rookus MA, et al. A weighted cohort approach for analysing factors modifying disease risks in carriers of high-risk susceptibility genes. Genet Epidemiol. 2005;29:1-11.
43. MITOMAP Web. HaplogroupMarkers. http://www.mitomap.org/bin/view.pl/MITOMAP/HaplogroupMarkers . Accessed 4 May 2015.
44. Shuen AY, Foulkes WD. Inherited mutations in breast cancer genes-risk and response. J Mammary Gland Biol Neoplasia. 2011;16:3-15.
45. Jönsson G, Naylor TL, Vallon-Christersson J, Staaf J, Huang J, Ward MR, et al. Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridization. Cancer Res. 2005;65:7612-21.
46. Hughes DJ. Use of association studies to define genetic modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. Fam Cancer. 2008;7:233-44.
47. Antoniou AC, Sinilnikova OM, Simard J, Léoné M, Dumont M, Neuhausen SL, et al. RAD51 135G-C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. Am J Hum Genet. 2007;81:1186-200.
48. Bandelt HJ, Kloss-Brandstätter A, Richards MB, Yao YG, Logan I. The case for the continuing use of the revised Cambridge Reference Sequence (rCRS) and the standardization of notation in human mitochondrial DNA studies. J Hum Genet. 2014;59:66-77.
49. Yu X, Wieczorek S, Franke A, Yin H, Pierer M, Sina C, et al. Association of UCP2-866 G/A polymorphism with chronic inflammatory diseases. Genes Immun. 2009;10:601-5.
50. Parrella P, Xiao Y, Fliss M, Sanchez-Cespedes M, Mazzarelli P, Rinaldi M, et al. Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates. Cancer Res. 2001;61:7623-6.
51. Brandon M, Baldi P, Wallace DC. Mitochondrial mutations in cancer. Oncogene. 2006;25:4647-62.
52. Bai RK, Leal SM, Covarrubias D, Liu A, Wong LJC. Mitochondrial genetic background modifies breast cancer risk. Cancer Res. 2007;67:4687-94.
53. Risch HA, McLaughlin JR, Cole DEC, Rosen B, Bradley L, Fan I, et al. Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario. Canada J Natl Cancer Inst. 2006;98:1694-706.