Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 1201-1208

  Fisher Wellman, Kelsey H ^a,b   Gilliam, Laura A A ^a,b   Lin, Chien Te ^a,b   Cathey, Brook L ^a,b   Lark, Daniel S ^a   Darrell Neufer, P ^a,b  

^a EAST CAROLINA UNIVERSITY   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Free radicals; Glutathione; Mitochondria; Pyruvate dehydrogenase complex; Reactive oxygen species; Skeletal muscle

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; GLUTATHIONE; HYDROGEN PEROXIDE; PYRUVATE DEHYDROGENASE COMPLEX;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIFFUSION; MALE; MITOCHONDRION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

RODENTIA;

FREE RADICALS; GLUTATHIONE; MITOCHONDRIA; PYRUVATE DEHYDROGENASE COMPLEX; REACTIVE OXYGEN SPECIES; SKELETAL MUSCLE;

ADULT; ANIMALS; FEMALE; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, MUSCLE; NAD; OXIDATION-REDUCTION; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATION; SUPEROXIDES;

EID: 84885012414     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.09.008     Document Type: Article

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