Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan

Oncogene

Volumn 32, Issue 9, 2013, Pages 1193-1201

  Chen, P L ^a   Chen, C F ^a   Chen, Y ^a   Guo, X E ^a   Huang, C K ^b   Shew, J Y ^b   Reddick, R L ^c   Wallace, D C ^a   Lee, W H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENOMICS RESEARCH CENTER   (Taiwan)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

animal model; mitochondrial dysfunction; Suv3; tumorigenesis

Indexed keywords

HELICASE; MITOCHONDRIAL DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST TUMOR; CARCINOGENESIS; CONTROLLED STUDY; GENOMIC INSTABILITY; HAPLOINSUFFICIENCY; LIFESPAN; MITOCHONDRIAL GENOME; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DEAD-BOX RNA HELICASES; DNA COPY NUMBER VARIATIONS; EMBRYO LOSS; FEMALE; GENOME, MITOCHONDRIAL; GENOMIC INSTABILITY; HAPLOINSUFFICIENCY; HETEROZYGOTE; HUMANS; LIFE STYLE; LONGEVITY; MICE;

ANIMALIA; MUS;

EID: 84874679741     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.120     Document Type: Article

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