메뉴 건너뛰기




Volumn 145, Issue , 2015, Pages

The regulation of exosome function in the CNS: Implications for neurodegeneration

Author keywords

ALS; Alzheimer; Amyloid; CNS; Exosomes; Glia; Lipid; miRNAs; Parkinson; Prion

Indexed keywords

ALPHA SYNUCLEIN; BIOLOGICAL MARKER; GANGLIOSIDE GM1; GANGLIOSIDE GM3; LIPID; MESSENGER RNA; MICRORNA; PROTEIN; RNA;

EID: 84982059758     PISSN: 14247860     EISSN: 14243997     Source Type: Journal    
DOI: 10.4414/smw.2015.14204     Document Type: Review
Times cited : (46)

References (173)
  • 1
    • 84938581025 scopus 로고    scopus 로고
    • Extracellular vesicles shuffling intercellular messages: For good or for bad
    • Cicero A Lo, Stahl PD, Raposo G. Extracellular vesicles shuffling intercellular messages: for good or for bad. Curr Opin Cell Biol. 2015;35:69-77.
    • (2015) Curr Opin Cell Biol , vol.35 , pp. 69-77
    • Lo Cicero, A.1    Stahl, P.D.2    Raposo, G.3
  • 2
    • 84907046756 scopus 로고    scopus 로고
    • Extracellular vesicles as shuttles of tumor biomarkers and anti-tumor drugs
    • Zocco D, Ferruzzi P, Cappello F, Kuo WP, Fais S. Extracellular vesicles as shuttles of tumor biomarkers and anti-tumor drugs. Front Oncol. 2014;4:267.
    • (2014) Front Oncol , vol.4 , pp. 267
    • Zocco, D.1    Ferruzzi, P.2    Cappello, F.3    Kuo, W.P.4    Fais, S.5
  • 3
    • 84884585784 scopus 로고    scopus 로고
    • Exosomes: The future of biomarkers in medicine
    • Properzi F, Logozzi M, Fais S. Exosomes: the future of biomarkers in medicine. Biomark Med. 2013;7(5):769-78.
    • (2013) Biomark Med , vol.7 , Issue.5 , pp. 769-778
    • Properzi, F.1    Logozzi, M.2    Fais, S.3
  • 5
    • 84929269782 scopus 로고    scopus 로고
    • Extracellular vesicles - Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases
    • Coleman BM, Hill AF. Extracellular vesicles - Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases. Semin Cell Dev Biol. 2015;40:89-96.
    • (2015) Semin Cell Dev Biol , vol.40 , pp. 89-96
    • Coleman, B.M.1    Hill, A.F.2
  • 6
    • 84894294740 scopus 로고    scopus 로고
    • Exosomes: Mediators of neurodegeneration, neuroprotection and therapeutics
    • Kalani A, Tyagi A, Tyagi N. Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics. Mol Neurobiol. 2014;49(1):590-600.
    • (2014) Mol Neurobiol , vol.49 , Issue.1 , pp. 590-600
    • Kalani, A.1    Tyagi, A.2    Tyagi, N.3
  • 7
    • 72149125838 scopus 로고    scopus 로고
    • The transcellular spread of cytosolic amyloids, prions, and prionoids
    • Aguzzi A, Rajendran L. The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron. 2009;64(6):783-90.
    • (2009) Neuron , vol.64 , Issue.6 , pp. 783-790
    • Aguzzi, A.1    Rajendran, L.2
  • 8
    • 84929506373 scopus 로고    scopus 로고
    • Ectosomes and exosomes: Shedding the confusion between extracellular vesicles
    • Cocucci E, Meldolesi J. Ectosomes and exosomes: shedding the confusion between extracellular vesicles. Trends Cell Biol. 2015;25(6):364-72.
    • (2015) Trends Cell Biol , vol.25 , Issue.6 , pp. 364-372
    • Cocucci, E.1    Meldolesi, J.2
  • 9
    • 0037402527 scopus 로고    scopus 로고
    • Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils
    • Gasser O, Hess C, Miot S, Deon C, Sanchez J-C, Schifferli JA. Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils. Exp Cell Res. 2003;285(2):243-57.
    • (2003) Exp Cell Res , vol.285 , Issue.2 , pp. 243-257
    • Gasser, O.1    Hess, C.2    Miot, S.3    Deon, C.4    Sanchez, J.-C.5    Schifferli, J.A.6
  • 12
    • 65449117971 scopus 로고    scopus 로고
    • High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients
    • Logozzi M, De Milito A, Lugini L, Borghi M, Calabrò L, Spada M, et al. High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. PloS One. 2009;4(4):e5219.
    • (2009) PloS One , vol.4 , Issue.4
    • Logozzi, M.1    De Milito, A.2    Lugini, L.3    Borghi, M.4    Calabrò, L.5    Spada, M.6
  • 13
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654-9.
    • (2007) Nat Cell Biol , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 15
    • 40049112564 scopus 로고    scopus 로고
    • Ceramide triggers budding of exosome vesicles into multivesicular endosomes
    • Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 2008;319(5867):1244-7.
    • (2008) Science , vol.319 , Issue.5867 , pp. 1244-1247
    • Trajkovic, K.1    Hsu, C.2    Chiantia, S.3    Rajendran, L.4    Wenzel, D.5    Wieland, F.6
  • 16
    • 77952920881 scopus 로고    scopus 로고
    • Secretory mechanisms and intercellular transfer of microRNAs in living cells
    • Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem. 2010;285(23):17442-52.
    • (2010) J Biol Chem , vol.285 , Issue.23 , pp. 17442-17452
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3    Takeshita, F.4    Matsuki, Y.5    Ochiya, T.6
  • 18
    • 84922340030 scopus 로고    scopus 로고
    • The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes
    • Guo BB, Bellingham SA, Hill AF. The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes. J Biol Chem. 2015;290(6):3455-67.
    • (2015) J Biol Chem , vol.290 , Issue.6 , pp. 3455-3467
    • Guo, B.B.1    Bellingham, S.A.2    Hill, A.F.3
  • 19
    • 0042991262 scopus 로고    scopus 로고
    • Vps27 recruits ESCRT machinery to endosomes during MVB sorting
    • Katzmann DJ, Stefan CJ, Babst M, Emr SD. Vps27 recruits ESCRT machinery to endosomes during MVB sorting. J Cell Biol. 2003;162(3):413-23.
    • (2003) J Cell Biol , vol.162 , Issue.3 , pp. 413-423
    • Katzmann, D.J.1    Stefan, C.J.2    Babst, M.3    Emr, S.D.4
  • 20
    • 63649086486 scopus 로고    scopus 로고
    • The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
    • Raiborg C, Stenmark H. The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature. 2009;458(7237):445-52.
    • (2009) Nature , vol.458 , Issue.7237 , pp. 445-452
    • Raiborg, C.1    Stenmark, H.2
  • 21
    • 84899964982 scopus 로고    scopus 로고
    • Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc omeostasis and promotes α-Synuclein externalization via exosomes
    • Kong SMY, Chan BKK, Park J-S, Hill KJ, Aitken JB, Cottle L, et al. Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc omeostasis and promotes α-Synuclein externalization via exosomes. Hum Mol Genet. 2014;23(11):2816-33.
    • (2014) Hum Mol Genet , vol.23 , Issue.11 , pp. 2816-2833
    • Kong, S.M.Y.1    Chan, B.K.K.2    Park, J.-S.3    Hill, K.J.4    Aitken, J.B.5    Cottle, L.6
  • 22
    • 84909952796 scopus 로고    scopus 로고
    • ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein
    • Tsunemi T, Hamada K, Krainc D. ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein. J Neurosci Off J Soc Neurosci. 2014;34(46):15281-7.
    • (2014) J Neurosci Off J Soc Neurosci , vol.34 , Issue.46 , pp. 15281-15287
    • Tsunemi, T.1    Hamada, K.2    Krainc, D.3
  • 23
    • 1642408871 scopus 로고    scopus 로고
    • Degradation of AP2 during reticulocyte maturation enhances binding of hsc70 and Alix to a common site on TFR for sorting into exosomes
    • Géminard C, De Gassart A, Blanc L, Vidal M. Degradation of AP2 during reticulocyte maturation enhances binding of hsc70 and Alix to a common site on TFR for sorting into exosomes. Traffic Cph Den. 2004;5(3):181-93.
    • (2004) Traffic Cph Den , vol.5 , Issue.3 , pp. 181-193
    • Géminard, C.1    De Gassart, A.2    Blanc, L.3    Vidal, M.4
  • 25
    • 84926524813 scopus 로고    scopus 로고
    • Heparanase activates the syndecan-syntenin-ALIX exosome pathway
    • Roucourt B, Meeussen S, Bao J, Zimmermann P, David G. Heparanase activates the syndecan-syntenin-ALIX exosome pathway. Cell Res. 2015;25(4):412-28.
    • (2015) Cell Res , vol.25 , Issue.4 , pp. 412-428
    • Roucourt, B.1    Meeussen, S.2    Bao, J.3    Zimmermann, P.4    David, G.5
  • 27
    • 71749102668 scopus 로고    scopus 로고
    • Microenvironmental pH is a key factor for exosome traffic in tumor cells
    • Parolini I, Federici C, Raggi C, Lugini L, Palleschi S, De Milito A, et al. Microenvironmental pH is a key factor for exosome traffic in tumor cells. J Biol Chem. 2009;284(49):34211-22.
    • (2009) J Biol Chem , vol.284 , Issue.49 , pp. 34211-34222
    • Parolini, I.1    Federici, C.2    Raggi, C.3    Lugini, L.4    Palleschi, S.5    De Milito, A.6
  • 28
    • 34250325547 scopus 로고    scopus 로고
    • Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes
    • Fang Y, Wu N, Gan X, Yan W, Morrell JC, Gould SJ. Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes. PLoS Biol. 2007;5(6):e158.
    • (2007) PLoS Biol , vol.5 , Issue.6 , pp. e158
    • Fang, Y.1    Wu, N.2    Gan, X.3    Yan, W.4    Morrell, J.C.5    Gould, S.J.6
  • 29
    • 57749105418 scopus 로고    scopus 로고
    • Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins
    • Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, et al. Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins. J Biol Chem. 2008;283(47):32621-7.
    • (2008) J Biol Chem , vol.283 , Issue.47 , pp. 32621-32627
    • Putz, U.1    Howitt, J.2    Lackovic, J.3    Foot, N.4    Kumar, S.5    Silke, J.6
  • 32
    • 84856707794 scopus 로고    scopus 로고
    • Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
    • Saman S, Kim W, Raya M, Visnick Y, Miro S, Saman S, et al. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J Biol Chem. 2012;287(6):3842-9.
    • (2012) J Biol Chem , vol.287 , Issue.6 , pp. 3842-3849
    • Saman, S.1    Kim, W.2    Raya, M.3    Visnick, Y.4    Miro, S.5    Saman, S.6
  • 34
    • 84859576044 scopus 로고    scopus 로고
    • Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells
    • Guduric-Fuchs J, O'Connor A, Cullen A, Harwood L, Medina RJ, O'Neill CL, et al. Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells. J Cell Biochem. 2012;113(6):2098-111.
    • (2012) J Cell Biochem , vol.113 , Issue.6 , pp. 2098-2111
    • Guduric-Fuchs, J.1    O'Connor, A.2    Cullen, A.3    Harwood, L.4    Medina, R.J.5    O'Neill, C.L.6
  • 36
    • 84860852182 scopus 로고    scopus 로고
    • Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons
    • Koles K, Nunnari J, Korkut C, Barria R, Brewer C, Li Y, et al. Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons. J Biol Chem. 2012;287(20):16820-34.
    • (2012) J Biol Chem , vol.287 , Issue.20 , pp. 16820-16834
    • Koles, K.1    Nunnari, J.2    Korkut, C.3    Barria, R.4    Brewer, C.5    Li, Y.6
  • 37
    • 84875495379 scopus 로고    scopus 로고
    • Regulation of postsynaptic retrograde signaling by presynaptic exosome release
    • Korkut C, Li Y, Koles K, Brewer C, Ashley J, Yoshihara M, et al. Regulation of postsynaptic retrograde signaling by presynaptic exosome release. Neuron. 2013;77(6):1039-46.
    • (2013) Neuron , vol.77 , Issue.6 , pp. 1039-1046
    • Korkut, C.1    Li, Y.2    Koles, K.3    Brewer, C.4    Ashley, J.5    Yoshihara, M.6
  • 39
    • 78751703517 scopus 로고    scopus 로고
    • Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity
    • Lachenal G, Pernet-Gallay K, Chivet M, Hemming FJ, Belly A, Bodon G, et al. Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity. Mol Cell Neurosci. 2011;46(2):409-18.
    • (2011) Mol Cell Neurosci , vol.46 , Issue.2 , pp. 409-418
    • Lachenal, G.1    Pernet-Gallay, K.2    Chivet, M.3    Hemming, F.J.4    Belly, A.5    Bodon, G.6
  • 40
    • 84906220373 scopus 로고    scopus 로고
    • Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons
    • Goldie BJ, Dun MD, Lin M, Smith ND, Verrills NM, Dayas CV, et al. Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons. Nucleic Acids Res. 2014;42(14):9195-208.
    • (2014) Nucleic Acids Res , vol.42 , Issue.14 , pp. 9195-9208
    • Goldie, B.J.1    Dun, M.D.2    Lin, M.3    Smith, N.D.4    Verrills, N.M.5    Dayas, C.V.6
  • 41
    • 84938713652 scopus 로고    scopus 로고
    • Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons
    • Chivet M, Javalet C, Laulagnier K, Blot B, Hemming FJ, Sadoul R. Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons. J Extracell Vesicles. 2014;3:24722.
    • (2014) J Extracell Vesicles , vol.3 , pp. 24722
    • Chivet, M.1    Javalet, C.2    Laulagnier, K.3    Blot, B.4    Hemming, F.J.5    Sadoul, R.6
  • 42
    • 56349139546 scopus 로고    scopus 로고
    • Neuroglia: The 150 years after
    • Kettenmann H, Verkhratsky A. Neuroglia: the 150 years after. Trends Neurosci. 2008;31(12):653-9.
    • (2008) Trends Neurosci , vol.31 , Issue.12 , pp. 653-659
    • Kettenmann, H.1    Verkhratsky, A.2
  • 43
    • 0033767690 scopus 로고    scopus 로고
    • Exosome: From internal vesicle of the multivesicular body to intercellular signaling device
    • Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W, Geuze HJ. Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci. 2000;113 Pt 19:3365-74.
    • (2000) J Cell Sci , vol.113 , pp. 3365-3374
    • Denzer, K.1    Kleijmeer, M.J.2    Heijnen, H.F.3    Stoorvogel, W.4    Geuze, H.J.5
  • 45
    • 84906097556 scopus 로고    scopus 로고
    • Multifaceted effects of oligodendroglial exosomes on neurons: Impact on neuronal firing rate, signal transduction and gene regulation
    • Fröhlich D, Kuo WP, Frühbeis C, Sun J-J, Zehendner CM, Luhmann HJ, et al. Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation. Philos Trans R Soc Lond B Biol Sci. 2014;369(1652).
    • (2014) Philos Trans R Soc Lond B Biol Sci , vol.369 , Issue.1652
    • Fröhlich, D.1    Kuo, W.P.2    Frühbeis, C.3    Sun, J.-J.4    Zehendner, C.M.5    Luhmann, H.J.6
  • 46
    • 38949191397 scopus 로고    scopus 로고
    • Exosomal transfer of proteins and RNAs at synapses in the nervous system
    • Smalheiser NR. Exosomal transfer of proteins and RNAs at synapses in the nervous system. Biol Direct. 2007;2:35.
    • (2007) Biol Direct , vol.2 , pp. 35
    • Smalheiser, N.R.1
  • 48
    • 35848961241 scopus 로고    scopus 로고
    • Regulation of heat shock protein 70 release in astrocytes: Role of signaling kinases
    • Taylor AR, Robinson MB, Gifondorwa DJ, Tytell M, Milligan CE. Regulation of heat shock protein 70 release in astrocytes: role of signaling kinases. Dev Neurobiol. 2007;67(13):1815-29.
    • (2007) Dev Neurobiol , vol.67 , Issue.13 , pp. 1815-1829
    • Taylor, A.R.1    Robinson, M.B.2    Gifondorwa, D.J.3    Tytell, M.4    Milligan, C.E.5
  • 49
    • 79956324370 scopus 로고    scopus 로고
    • Synapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes
    • 201
    • Wang S, Cesca F, Loers G, Schweizer M, Buck F, Benfenati F, et al. Synapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes. J Neurosci Off J Soc Neurosci. 201;31(20):7275-90.
    • J Neurosci Off J Soc Neurosci , vol.31 , Issue.20 , pp. 7275-7290
    • Wang, S.1    Cesca, F.2    Loers, G.3    Schweizer, M.4    Buck, F.5    Benfenati, F.6
  • 50
    • 84922906530 scopus 로고    scopus 로고
    • Serotonin stimulates secretion of exosomes from microglia cells
    • Glebov K, Löchner M, Jabs R, Lau T, Merkel O, Schloss P, et al. Serotonin stimulates secretion of exosomes from microglia cells. Glia. 2015;63(4):626-34.
    • (2015) Glia , vol.63 , Issue.4 , pp. 626-634
    • Glebov, K.1    Löchner, M.2    Jabs, R.3    Lau, T.4    Merkel, O.5    Schloss, P.6
  • 51
    • 38449095118 scopus 로고    scopus 로고
    • Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
    • Krämer-Albers E-M, Bretz N, Tenzer S, Winterstein C, Möbius W, Berger H, et al. Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons? Proteomics Clin Appl. 2007;1(11):1446-61.
    • (2007) Proteomics Clin Appl , vol.1 , Issue.11 , pp. 1446-1461
    • Krämer-Albers, E.-M.1    Bretz, N.2    Tenzer, S.3    Winterstein, C.4    Möbius, W.5    Berger, H.6
  • 52
    • 78650955813 scopus 로고    scopus 로고
    • Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles
    • Bakhti M, Winter C, Simons M. Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles. J Biol Chem. 2011;286(1):787-96.
    • (2011) J Biol Chem , vol.286 , Issue.1 , pp. 787-796
    • Bakhti, M.1    Winter, C.2    Simons, M.3
  • 53
    • 72649095061 scopus 로고    scopus 로고
    • MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47
    • Junker A, Krumbholz M, Eisele S, Mohan H, Augstein F, Bittner R, et al. MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain J Neurol. 2009;132(Pt 12):3342-52.
    • (2009) Brain J Neurol , vol.132 , pp. 3342-3352
    • Junker, A.1    Krumbholz, M.2    Eisele, S.3    Mohan, H.4    Augstein, F.5    Bittner, R.6
  • 54
    • 77649166937 scopus 로고    scopus 로고
    • MicroRNA-mediated control of oligodendrocyte differentiation
    • Zhao X, He X, Han X, Yu Y, Ye F, Chen Y, et al. MicroRNA-mediated control of oligodendrocyte differentiation. Neuron. 2010;65(5):612-26.
    • (2010) Neuron , vol.65 , Issue.5 , pp. 612-626
    • Zhao, X.1    He, X.2    Han, X.3    Yu, Y.4    Ye, F.5    Chen, Y.6
  • 55
    • 84885190763 scopus 로고    scopus 로고
    • Differentiation of human endometrial stromal cells into oligodendrocyte progenitor cells (OPCs)
    • Ebrahimi-Barough S, Kouchesfahani HM, Ai J, Massumi M. Differentiation of human endometrial stromal cells into oligodendrocyte progenitor cells (OPCs). J Mol Neurosci MN. 2013;51(2):265-73.
    • (2013) J Mol Neurosci MN , vol.51 , Issue.2 , pp. 265-273
    • Ebrahimi-Barough, S.1    Kouchesfahani, H.M.2    Ai, J.3    Massumi, M.4
  • 56
    • 84890164626 scopus 로고    scopus 로고
    • Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination
    • Pusic AD, Kraig RP. Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination. Glia. 2014;62(2):284-99.
    • (2014) Glia , vol.62 , Issue.2 , pp. 284-299
    • Pusic, A.D.1    Kraig, R.P.2
  • 57
    • 84906098111 scopus 로고    scopus 로고
    • Extracellular microvesicles from astrocytes contain functional glutamate transporters: Regulation by protein kinase C and cell activation
    • Gosselin R-D, Meylan P, Decosterd I. Extracellular microvesicles from astrocytes contain functional glutamate transporters: regulation by protein kinase C and cell activation. Front Cell Neurosci. 2013;7:251.
    • (2013) Front Cell Neurosci , vol.7 , pp. 251
    • Gosselin, R.-D.1    Meylan, P.2    Decosterd, I.3
  • 58
    • 84874833693 scopus 로고    scopus 로고
    • Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1
    • Morel L, Regan M, Higashimori H, Ng SK, Esau C, Vidensky S, et al. Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. J Biol Chem. 2013;288(10):7105-16.
    • (2013) J Biol Chem , vol.288 , Issue.10 , pp. 7105-7116
    • Morel, L.1    Regan, M.2    Higashimori H, N.3    Esau, C.4    Vidensky, S.5
  • 61
    • 35448956015 scopus 로고    scopus 로고
    • Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis
    • Gomes C, Keller S, Altevogt P, Costa J. Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis. Neurosci Lett. 2007;428(1):43-6.
    • (2007) Neurosci Lett , vol.428 , Issue.1 , pp. 43-46
    • Gomes, C.1    Keller, S.2    Altevogt, P.3    Costa, J.4
  • 63
    • 84885484356 scopus 로고    scopus 로고
    • Prion-like properties of pathological TDP-43 aggregates from diseased brains
    • Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, et al. Prion-like properties of pathological TDP-43 aggregates from diseased brains. Cell Rep. 2013;4(1):124-34.
    • (2013) Cell Rep , vol.4 , Issue.1 , pp. 124-134
    • Nonaka, T.1    Masuda-Suzukake, M.2    Arai, T.3    Hasegawa, Y.4    Akatsu, H.5    Obi, T.6
  • 65
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
    • McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, et al. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol. 1999;46(6):860-6.
    • (1999) Ann Neurol , vol.46 , Issue.6 , pp. 860-866
    • McLean, C.A.1    Cherny, R.A.2    Fraser, F.W.3    Fuller, S.J.4    Smith, M.J.5    Beyreuther, K.6
  • 66
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008;14(8):837-42.
    • (2008) Nat Med , vol.14 , Issue.8 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3    Garcia-Munoz, A.4    Shepardson, N.E.5    Smith, I.6
  • 67
    • 44549087765 scopus 로고    scopus 로고
    • Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior
    • Selkoe DJ. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res. 2008;192(1):106-13.
    • (2008) Behav Brain Res , vol.192 , Issue.1 , pp. 106-113
    • Selkoe, D.J.1
  • 68
    • 84861914969 scopus 로고    scopus 로고
    • Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model
    • Brouillette J, Caillierez R, Zommer N, Alves-Pires C, Benilova I, Blum D, et al. Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model. J Neurosci Off J Soc Neurosci. 2012;32(23):7852-61.
    • (2012) J Neurosci Off J Soc Neurosci , vol.32 , Issue.23 , pp. 7852-7861
    • Brouillette, J.1    Caillierez, R.2    Zommer, N.3    Alves-Pires, C.4    Benilova, I.5    Blum, D.6
  • 69
    • 84884552363 scopus 로고    scopus 로고
    • Extracellular membrane microvesicles and nanotubes in the brain: Understanding their nature, their function in cell-to-cell communication, their role in transcellular spreading of pathological agents and their therapeutic potential
    • Verderio C. Extracellular membrane microvesicles and nanotubes in the brain: understanding their nature, their function in cell-to-cell communication, their role in transcellular spreading of pathological agents and their therapeutic potential. Front Physiol. 2013;4:163.
    • (2013) Front Physiol , vol.4 , pp. 163
    • Verderio, C.1
  • 70
    • 84903362492 scopus 로고    scopus 로고
    • Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles
    • Joshi P, Turola E, Ruiz A, Bergami A, Libera DD, Benussi L, et al. Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles. Cell Death Differ. 2014;21(4):582-93.
    • (2014) Cell Death Differ , vol.21 , Issue.4 , pp. 582-593
    • Joshi, P.1    Turola, E.2    Ruiz, A.3    Bergami, A.4    Libera, D.D.5    Benussi, L.6
  • 71
    • 77954375412 scopus 로고    scopus 로고
    • Astrocytic A beta 1-42 uptake is determined by A beta-aggregation state and the presence of amyloid-associated proteins
    • Nielsen HM, Mulder SD, Beliën JAM, Musters RJP, Eikelenboom P, Veerhuis R. Astrocytic A beta 1-42 uptake is determined by A beta-aggregation state and the presence of amyloid-associated proteins. Glia. 2010;58(10):1235-46.
    • (2010) Glia , vol.58 , Issue.10 , pp. 1235-1246
    • Nielsen, H.M.1    Mulder, S.D.2    Beliën, J.A.M.3    Musters, R.J.P.4    Eikelenboom, P.5    Veerhuis, R.6
  • 72
    • 84913583564 scopus 로고    scopus 로고
    • Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease
    • Agosta F, Dalla Libera D, Spinelli EG, Finardi A, Canu E, Bergami A, et al. Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease. Ann Neurol. 2014;76(6):813-25.
    • (2014) Ann Neurol , vol.76 , Issue.6 , pp. 813-825
    • Agosta, F.1    Dalla Libera, D.2    Spinelli, E.G.3    Finardi, A.4    Canu, E.5    Bergami, A.6
  • 73
    • 40049084797 scopus 로고    scopus 로고
    • Cell biology. No ESCRTs for exosomes
    • Marsh M, van Meer G. Cell biology. No ESCRTs for exosomes. Science. 2008;319(5867):1191-2.
    • (2008) Science , vol.319 , Issue.5867 , pp. 1191-1192
    • Marsh, M.1    Van Meer, G.2
  • 74
    • 84859499570 scopus 로고    scopus 로고
    • Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia
    • Yuyama K, Sun H, Mitsutake S, Igarashi Y. Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia. J Biol Chem. 2012;287(14):10977-89.
    • (2012) J Biol Chem , vol.287 , Issue.14 , pp. 10977-10989
    • Yuyama, K.1    Sun, H.2    Mitsutake, S.3    Igarashi, Y.4
  • 75
    • 84906871864 scopus 로고    scopus 로고
    • Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice
    • Yuyama K, Sun H, Sakai S, Mitsutake S, Okada M, Tahara H, et al. Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice. J Biol Chem. 2014;289(35):24488-98.
    • (2014) J Biol Chem , vol.289 , Issue.35 , pp. 24488-24498
    • Yuyama, K.1    Sun, H.2    Sakai, S.3    Mitsutake, S.4    Okada, M.5    Tahara, H.6
  • 76
    • 84899968840 scopus 로고    scopus 로고
    • Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
    • Dinkins MB, Dasgupta S, Wang G, Zhu G, Bieberich E. Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Aging. 2014;35(8):1792-800.
    • (2014) Neurobiol Aging , vol.35 , Issue.8 , pp. 1792-1800
    • Dinkins, M.B.1    Dasgupta, S.2    Wang, G.3    Zhu, G.4    Bieberich, E.5
  • 77
    • 77956404647 scopus 로고    scopus 로고
    • Exosomes: Extracellular organelles important in intercellular communication
    • Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics. 2010;73(10):1907-20.
    • (2010) J Proteomics , vol.73 , Issue.10 , pp. 1907-1920
    • Mathivanan, S.1    Ji, H.2    Simpson, R.J.3
  • 78
    • 84868149990 scopus 로고    scopus 로고
    • Prion-infected cells regulate the release of exosomes with distinct ultrastructural features
    • Coleman BM, Hanssen E, Lawson VA, Hill AF. Prion-infected cells regulate the release of exosomes with distinct ultrastructural features. FASEB J Off Publ Fed Am Soc Exp Biol. 2012;26(10):4160-73.
    • (2012) FASEB J Off Publ Fed Am Soc Exp Biol , vol.26 , Issue.10 , pp. 4160-4173
    • Coleman, B.M.1    Hanssen, E.2    Lawson, V.A.3    Hill, A.F.4
  • 81
    • 43249087541 scopus 로고    scopus 로고
    • Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes
    • Sharples RA, Vella LJ, Nisbet RM, Naylor R, Perez K, Barnham KJ, et al. Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes. FASEB J Off Publ Fed Am Soc Exp Biol. 2008;22(5):1469-78.
    • (2008) FASEB J Off Publ Fed Am Soc Exp Biol , vol.22 , Issue.5 , pp. 1469-1478
    • Sharples, R.A.1    Vella, L.J.2    Nisbet, R.M.3    Naylor, R.4    Perez, K.5    Barnham, K.J.6
  • 82
    • 84887392802 scopus 로고    scopus 로고
    • Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo
    • An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, et al. Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo. Mol Brain. 2013;6:47.
    • (2013) Mol Brain , vol.6 , pp. 47
    • An, K.1    Klyubin, I.2    Kim, Y.3    Jung, J.H.4    Mably, A.J.5    O'Dowd, S.T.6
  • 83
    • 84918776208 scopus 로고    scopus 로고
    • A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide
    • Yuyama K, Sun H, Usuki S, Sakai S, Hanamatsu H, Mioka T, et al. A potential function for neuronal exosomes: sequestering intracerebral amyloid-β peptide. FEBS Lett. 2015;589(1):84-8.
    • (2015) FEBS Lett , vol.589 , Issue.1 , pp. 84-88
    • Yuyama, K.1    Sun, H.2    Usuki, S.3    Sakai, S.4    Hanamatsu, H.5    Mioka, T.6
  • 85
    • 69149089854 scopus 로고    scopus 로고
    • Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
    • Desplats P, Lee H-J, Bae E-J, Patrick C, Rockenstein E, Crews L, et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A. 2009;106(31):13010-5.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.31 , pp. 13010-13015
    • Desplats, P.1    Lee, H.-J.2    Bae, E.-J.3    Patrick, C.4    Rockenstein, E.5    Crews, L.6
  • 86
    • 84870599244 scopus 로고    scopus 로고
    • Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells
    • Bellingham SA, Coleman BM, Hill AF. Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells. Nucleic Acids Res. 2012;40(21):10937-49.
    • (2012) Nucleic Acids Res , vol.40 , Issue.21 , pp. 10937-10949
    • Bellingham, S.A.1    Coleman, B.M.2    Hill, A.F.3
  • 87
    • 84938743829 scopus 로고    scopus 로고
    • Prion-like features of misfolded Aβ and tau aggregates
    • Jan 6
    • Morales R, Callegari K, Soto C. Prion-like features of misfolded Aβ and tau aggregates. Virus Res. 2015 Jan 6;
    • (2015) Virus Res
    • Morales, R.1    Callegari, K.2    Soto, C.3
  • 91
    • 33645290776 scopus 로고    scopus 로고
    • The prion protein and lipid rafts
    • Taylor DR, Hooper NM. The prion protein and lipid rafts. Mol Membr Biol. 2006;23(1):89-99.
    • (2006) Mol Membr Biol , vol.23 , Issue.1 , pp. 89-99
    • Taylor, D.R.1    Hooper, N.M.2
  • 92
    • 0036500554 scopus 로고    scopus 로고
    • Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes
    • Baron GS, Wehrly K, Dorward DW, Chesebro B, Caughey B. Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J. 2002;21(5):1031-40.
    • (2002) EMBO J , vol.21 , Issue.5 , pp. 1031-1040
    • Baron, G.S.1    Wehrly, K.2    Dorward, D.W.3    Chesebro, B.4    Caughey, B.5
  • 93
    • 79952187533 scopus 로고    scopus 로고
    • Conversion of bacterially expressed recombinant prion protein
    • Wang F, Wang X, Ma J. Conversion of bacterially expressed recombinant prion protein. Methods San Diego Calif. 2011;53(3):208-13.
    • (2011) Methods San Diego Calif , vol.53 , Issue.3 , pp. 208-213
    • Wang, F.1    Wang, X.2    Ma, J.3
  • 94
    • 84904497397 scopus 로고    scopus 로고
    • Synthesis of high titer infectious prions with cofactor molecules
    • Supattapone S. Synthesis of high titer infectious prions with cofactor molecules. J Biol Chem. 2014;289(29):19850-4.
    • (2014) J Biol Chem , vol.289 , Issue.29 , pp. 19850-19854
    • Supattapone, S.1
  • 95
    • 28644451007 scopus 로고    scopus 로고
    • Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin
    • Grimm MOW, Grimm HS, Pätzold AJ, Zinser EG, Halonen R, Duering M, et al. Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol. 2005;7(11):1118-23.
    • (2005) Nat Cell Biol , vol.7 , Issue.11 , pp. 1118-1123
    • Grimm, M.O.W.1    Grimm, H.S.2    Pätzold, A.J.3    Zinser, E.G.4    Halonen, R.5    Duering, M.6
  • 96
    • 77953235479 scopus 로고    scopus 로고
    • Abeta polymerization through interaction with membrane gangliosides
    • Matsuzaki K, Kato K, Yanagisawa K. Abeta polymerization through interaction with membrane gangliosides. Biochim Biophys Acta. 2010;1801(8):868-77.
    • (2010) Biochim Biophys Acta , vol.1801 , Issue.8 , pp. 868-877
    • Matsuzaki, K.1    Kato, K.2    Yanagisawa, K.3
  • 97
    • 84931577633 scopus 로고    scopus 로고
    • Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study
    • Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, et al. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimers Dement J Alzheimers Assoc. 2015;11(6):600-7.e1.
    • (2015) Alzheimers Dement J Alzheimers Assoc , vol.11 , Issue.6 , pp. 600-607.e1
    • Fiandaca, M.S.1    Kapogiannis, D.2    Mapstone, M.3    Boxer, A.4    Eitan, E.5    Schwartz, J.B.6
  • 98
    • 84937020256 scopus 로고    scopus 로고
    • Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease
    • Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, et al. Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease. Neurology. 2015;85(1):40-7.
    • (2015) Neurology , vol.85 , Issue.1 , pp. 40-47
    • Goetzl, E.J.1    Boxer, A.2    Schwartz, J.B.3    Abner, E.L.4    Petersen, R.C.5    Miller, B.L.6
  • 100
    • 84942549499 scopus 로고    scopus 로고
    • Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment
    • Oct 28
    • Cheng L, Doecke JD, Sharples RA, Villemagne VL, Fowler CJ, Rembach A, et al. Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment. Mol Psychiatry. 2014 Oct 28;
    • (2014) Mol Psychiatry
    • Cheng, L.1    Doecke, J.D.2    Sharples, R.A.3    Villemagne, V.L.4    Fowler, C.J.5    Rembach, A.6
  • 103
    • 84883732254 scopus 로고    scopus 로고
    • MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons
    • Absalon S, Kochanek DM, Raghavan V, Krichevsky AM. MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci Off J Soc Neurosci. 2013;33(37):14645-59.
    • (2013) J Neurosci Off J Soc Neurosci , vol.33 , Issue.37 , pp. 14645-14659
    • Absalon, S.1    Kochanek, D.M.2    Raghavan, V.3    Krichevsky, A.M.4
  • 105
    • 34548537573 scopus 로고    scopus 로고
    • A MicroRNA feedback circuit in midbrain dopamine neurons
    • Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, et al. A MicroRNA feedback circuit in midbrain dopamine neurons. Science. 2007;317(5842):1220-4.
    • (2007) Science , vol.317 , Issue.5842 , pp. 1220-1224
    • Kim, J.1    Inoue, K.2    Ishii, J.3    Vanti, W.B.4    Voronov, S.V.5    Murchison, E.6
  • 107
    • 84872394361 scopus 로고    scopus 로고
    • MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein
    • Cho HJ, Liu G, Jin SM, Parisiadou L, Xie C, Yu J, et al. MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein. Hum Mol Genet. 2013;22(3):608-20.
    • (2013) Hum Mol Genet , vol.22 , Issue.3 , pp. 608-620
    • Cho, H.J.1    Liu, G.2    Jin, S.M.3    Parisiadou, L.4    Xie, C.5    Yu, J.6
  • 108
    • 84864503916 scopus 로고    scopus 로고
    • MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
    • Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A. 2012;109(31):E2110-6.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.31 , pp. E2110-E2116
    • Fabbri, M.1    Paone, A.2    Calore, F.3    Galli, R.4    Gaudio, E.5    Santhanam, R.6
  • 109
    • 84926650926 scopus 로고    scopus 로고
    • Synthetic scrapie infectivity: Interaction between recombinant PrP and scrapie brain-derived RNA
    • Simoneau S, Thomzig A, Ruchoux M-M, Vignier N, Daus ML, Poleggi A, et al. Synthetic scrapie infectivity: interaction between recombinant PrP and scrapie brain-derived RNA. Virulence. 2015;6(2):132-44.
    • (2015) Virulence , vol.6 , Issue.2 , pp. 132-144
    • Simoneau, S.1    Thomzig, A.2    Ruchoux, M.-M.3    Vignier, N.4    Daus, M.L.5    Poleggi, A.6
  • 110
    • 84922318925 scopus 로고    scopus 로고
    • Sporadic and hereditary amyotrophic lateral sclerosis (ALS)
    • Ajroud-Driss S, Siddique T. Sporadic and hereditary amyotrophic lateral sclerosis (ALS). Biochim Biophys Acta. 2015;1852(4):679-84.
    • (2015) Biochim Biophys Acta , vol.1852 , Issue.4 , pp. 679-684
    • Ajroud-Driss, S.1    Siddique, T.2
  • 111
    • 29444443348 scopus 로고    scopus 로고
    • Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
    • Urushitani M, Sik A, Sakurai T, Nukina N, Takahashi R, Julien J-P. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci. 2006;9(1):108-18.
    • (2006) Nat Neurosci , vol.9 , Issue.1 , pp. 108-118
    • Urushitani, M.1    Sik, A.2    Sakurai, T.3    Nukina, N.4    Takahashi, R.5    Julien, J.-P.6
  • 112
    • 84895796816 scopus 로고    scopus 로고
    • Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms
    • Grad LI, Yerbury JJ, Turner BJ, Guest WC, Pokrishevsky E, O'Neill MA, et al. Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms. Proc Natl Acad Sci U S A. 2014;111(9):3620-5.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.9 , pp. 3620-3625
    • Grad, L.I.1    Yerbury, J.J.2    Turner, B.J.3    Guest, W.C.4    Pokrishevsky, E.5    O'Neill, M.A.6
  • 114
    • 84878005741 scopus 로고    scopus 로고
    • Altered microRNA expression profile in amyotrophic lateral sclerosis: A role in the regulation of NFL mRNA levels
    • Campos-Melo D, Droppelmann CA, He Z, Volkening K, Strong MJ. Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels. Mol Brain. 2013;6:26.
    • (2013) Mol Brain , vol.6 , pp. 26
    • Campos-Melo, D.1    Droppelmann, C.A.2    He, Z.3    Volkening, K.4    Strong, M.J.5
  • 115
    • 84891767879 scopus 로고    scopus 로고
    • Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation
    • Parisi C, Arisi I, D'Ambrosi N, Storti AE, Brandi R, D'Onofrio M, et al. Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation. Cell Death Dis. 2013;4:e959.
    • (2013) Cell Death Dis , vol.4 , pp. e959
    • Parisi, C.1    Arisi, I.2    D'Ambrosi, N.3    Storti, A.E.4    Brandi, R.5    D'Onofrio, M.6
  • 116
  • 117
    • 72149131804 scopus 로고    scopus 로고
    • MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice
    • Williams AH, Valdez G, Moresi V, Qi X, McAnally J, Elliott JL, et al. MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science. 2009;326(5959):1549-54.
    • (2009) Science , vol.326 , Issue.5959 , pp. 1549-1554
    • Williams, A.H.1    Valdez, G.2    Moresi, V.3    Qi, X.4    McAnally, J.5    Elliott, J.L.6
  • 118
  • 120
    • 78651247933 scopus 로고    scopus 로고
    • MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway
    • Ponomarev ED, Veremeyko T, Barteneva N, Krichevsky AM, Weiner HL. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway. Nat Med. 2011;17(1):64-70.
    • (2011) Nat Med , vol.17 , Issue.1 , pp. 64-70
    • Ponomarev, E.D.1    Veremeyko, T.2    Barteneva, N.3    Krichevsky, A.M.4    Weiner, H.L.5
  • 121
    • 84911454956 scopus 로고    scopus 로고
    • MicroRNA expression analysis of adult-onset Drosophila Alzheimer's disease model
    • Kong Y, Wu J, Yuan L. MicroRNA expression analysis of adult-onset Drosophila Alzheimer's disease model. Curr Alzheimer Res. 2014;11(9):882-91.
    • (2014) Curr Alzheimer Res , vol.11 , Issue.9 , pp. 882-891
    • Kong, Y.1    Wu, J.2    Yuan, L.3
  • 122
    • 65749093295 scopus 로고    scopus 로고
    • Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex
    • Sethi P, Lukiw WJ. Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci Lett. 2009;459(2):100-4.
    • (2009) Neurosci Lett , vol.459 , Issue.2 , pp. 100-104
    • Sethi, P.1    Lukiw, W.J.2
  • 123
    • 33847203593 scopus 로고    scopus 로고
    • Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
    • Lukiw WJ. Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport. 2007;18(3):297-300.
    • (2007) Neuroreport , vol.18 , Issue.3 , pp. 297-300
    • Lukiw, W.J.1
  • 124
    • 47849124269 scopus 로고    scopus 로고
    • Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
    • Cogswell JP, Ward J, Taylor IA, Waters M, Shi Y, Cannon B, et al. Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis JAD. 2008;14(1):27-41.
    • (2008) J Alzheimers Dis JAD , vol.14 , Issue.1 , pp. 27-41
    • Cogswell, J.P.1    Ward, J.2    Taylor, I.A.3    Waters, M.4    Shi, Y.5    Cannon, B.6
  • 125
    • 0141631876 scopus 로고    scopus 로고
    • A microRNA array reveals extensive regulation of microRNAs during brain development
    • Krichevsky AM, King KS, Donahue CP, Khrapko K, Kosik KS. A microRNA array reveals extensive regulation of microRNAs during brain development. RNA N Y N. 2003;9(10):1274-81.
    • (2003) RNA N Y N , vol.9 , Issue.10 , pp. 1274-1281
    • Krichevsky, A.M.1    King, K.S.2    Donahue, C.P.3    Khrapko, K.4    Kosik, K.S.5
  • 127
    • 84892156798 scopus 로고    scopus 로고
    • Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease
    • Sala Frigerio C, Lau P, Salta E, Tournoy J, Bossers K, Vandenberghe R, et al. Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease. Neurology. 2013;81(24):2103-6.
    • (2013) Neurology , vol.81 , Issue.24 , pp. 2103-2106
    • Sala Frigerio, C.1    Lau, P.2    Salta, E.3    Tournoy, J.4    Bossers, K.5    Vandenberghe, R.6
  • 129
    • 77952336221 scopus 로고    scopus 로고
    • Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3
    • Shioya M, Obayashi S, Tabunoki H, Arima K, Saito Y, Ishida T, et al. Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3. Neuropathol Appl Neurobiol. 2010;36(4):320-30.
    • (2010) Neuropathol Appl Neurobiol , vol.36 , Issue.4 , pp. 320-330
    • Shioya, M.1    Obayashi, S.2    Tabunoki, H.3    Arima, K.4    Saito, Y.5    Ishida, T.6
  • 130
    • 44049108170 scopus 로고    scopus 로고
    • Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression
    • Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A. 2008;105(17):6415-20.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.17 , pp. 6415-6420
    • Hébert, S.S.1    Horré, K.2    Nicolaï, L.3    Papadopoulou, A.S.4    Mandemakers, W.5    Silahtaroglu, A.N.6
  • 131
    • 84893946623 scopus 로고    scopus 로고
    • MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease
    • Kiko T, Nakagawa K, Tsuduki T, Furukawa K, Arai H, Miyazawa T. MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease. J Alzheimers Dis JAD. 2014;39(2):253-9.
    • (2014) J Alzheimers Dis JAD , vol.39 , Issue.2 , pp. 253-259
    • Kiko, T.1    Nakagawa, K.2    Tsuduki, T.3    Furukawa, K.4    Arai, H.5    Miyazawa, T.6
  • 132
    • 84928157381 scopus 로고    scopus 로고
    • Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer's disease
    • Lei X, Lei L, Zhang Z, Zhang Z, Cheng Y. Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer's disease. Int J Clin Exp Pathol. 2015;8(2):1565-74.
    • (2015) Int J Clin Exp Pathol , vol.8 , Issue.2 , pp. 1565-1574
    • Lei, X.1    Lei, L.2    Zhang, Z.3    Zhang, Z.4    Cheng, Y.5
  • 133
    • 70349558133 scopus 로고    scopus 로고
    • miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation
    • Wang X, Liu P, Zhu H, Xu Y, Ma C, Dai X, et al. miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res Bull. 2009;80(4-5):268-73.
    • (2009) Brain Res Bull , vol.80 , Issue.4-5 , pp. 268-273
    • Wang, X.1    Liu, P.2    Zhu, H.3    Xu, Y.4    Ma, C.5    Dai, X.6
  • 137
    • 84980052130 scopus 로고    scopus 로고
    • Identification of microRNAs involved in Alzheimer's progression using a rabbit model of the disease
    • Liu QY, Chang MNV, Lei JX, Koukiekolo R, Smith B, Zhang D, et al. Identification of microRNAs involved in Alzheimer's progression using a rabbit model of the disease. Am J Neurodegener Dis. 2014;3(1):33-44.
    • (2014) Am J Neurodegener Dis , vol.3 , Issue.1 , pp. 33-44
    • Liu, Q.Y.1    Chang, M.N.V.2    Lei, J.X.3    Koukiekolo, R.4    Smith, B.5    Zhang, D.6
  • 138
    • 84930677807 scopus 로고    scopus 로고
    • MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer's Disease
    • Denk J, Boelmans K, Siegismund C, Lassner D, Arlt S, Jahn H. MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer's Disease. PloS One. 2015;10(5):e0126423.
    • (2015) PloS One , vol.10 , Issue.5
    • Denk, J.1    Boelmans, K.2    Siegismund, C.3    Lassner, D.4    Arlt, S.5    Jahn, H.6
  • 139
    • 77954996105 scopus 로고    scopus 로고
    • MiR-107 is reduced in Alzheimer's disease brain neocortex: Validation study
    • Nelson PT, Wang W-X. MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. J Alzheimers Dis JAD. 2010;21(1):75-9.
    • (2010) J Alzheimers Dis JAD , vol.21 , Issue.1 , pp. 75-79
    • Nelson, P.T.1    Wang, W.-X.2
  • 140
    • 84885178226 scopus 로고    scopus 로고
    • MicroRNAs in Alzheimer's disease: Differential expression in hippocampus and cell-free cerebrospinal fluid
    • Müller M, Kuiperij HB, Claassen JA, Küsters B, Verbeek MM. MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid. Neurobiol Aging. 2014;35(1):152-8.
    • (2014) Neurobiol Aging , vol.35 , Issue.1 , pp. 152-158
    • Müller, M.1    Kuiperij, H.B.2    Claassen, J.A.3    Küsters, B.4    Verbeek, M.M.5
  • 141
    • 84892584524 scopus 로고    scopus 로고
    • Circulating miR-125b as a biomarker of Alzheimer's disease
    • Tan L, Yu J-T, Liu Q-Y, Tan M-S, Zhang W, Hu N, et al. Circulating miR-125b as a biomarker of Alzheimer's disease. J Neurol Sci. 2014;336(1-2):52-6.
    • (2014) J Neurol Sci , vol.336 , Issue.1-2 , pp. 52-56
    • Tan, L.1    Yu, J.-T.2    Liu, Q.-Y.3    Tan, M.-S.4    Zhang, W.5    Hu, N.6
  • 142
    • 79958109878 scopus 로고    scopus 로고
    • Tumour necrosis factor-α (TNF-α) and miRNA expression in frontal and temporal neocortex in Alzheimer's disease and the effect of TNF-α on miRNA expression in vitro
    • Culpan D, Kehoe PG, Love S. Tumour necrosis factor-α (TNF-α) and miRNA expression in frontal and temporal neocortex in Alzheimer's disease and the effect of TNF-α on miRNA expression in vitro. Int J Mol Epidemiol Genet. 2011;2(2):156-62.
    • (2011) Int J Mol Epidemiol Genet , vol.2 , Issue.2 , pp. 156-162
    • Culpan, D.1    Kehoe, P.G.2    Love, S.3
  • 143
    • 84964315274 scopus 로고    scopus 로고
    • MicroRNA and messenger RNA profiling reveals new biomarkers and mechanisms for RDX induced neurotoxicity
    • Deng Y, Ai J, Guan X, Wang Z, Yan B, Zhang D, et al. MicroRNA and messenger RNA profiling reveals new biomarkers and mechanisms for RDX induced neurotoxicity. BMC Genomics. 2014;15(Suppl 11):S1.
    • (2014) BMC Genomics , vol.15 , pp. S1
    • Deng, Y.1    Ai, J.2    Guan, X.3    Wang, Z.4    Yan, B.5    Zhang, D.6
  • 144
    • 84860387544 scopus 로고    scopus 로고
    • MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2
    • Liang C, Zhu H, Xu Y, Huang L, Ma C, Deng W, et al. MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2. Brain Res. 2012;1455:103-13.
    • (2012) Brain Res , vol.1455 , pp. 103-113
    • Liang, C.1    Zhu, H.2    Xu, Y.3    Huang, L.4    Ma, C.5    Deng, W.6
  • 146
    • 84864778051 scopus 로고    scopus 로고
    • Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are downregulated by amyloid-β
    • Schonrock N, Humphreys DT, Preiss T, Götz J. Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are downregulated by amyloid-β. J Mol Neurosci MN. 2012;46(2):324-35.
    • (2012) J Mol Neurosci MN , vol.46 , Issue.2 , pp. 324-335
    • Schonrock, N.1    Humphreys, D.T.2    Preiss, T.3    Götz, J.4
  • 147
    • 84899968131 scopus 로고    scopus 로고
    • MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease
    • Tian N, Cao Z, Zhang Y. MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease. Neurosci Bull. 2014;30(2):191-7.
    • (2014) Neurosci Bull , vol.30 , Issue.2 , pp. 191-197
    • Tian, N.1    Cao, Z.2    Zhang, Y.3
  • 148
    • 84865582770 scopus 로고    scopus 로고
    • miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model
    • Lee S-T, Chu K, Jung K-H, Kim JH, Huh J-Y, Yoon H, et al. miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model. Ann Neurol. 2012;72(2):269-77.
    • (2012) Ann Neurol , vol.72 , Issue.2 , pp. 269-277
    • Lee, S.-T.1    Chu, K.2    Jung, K.-H.3    Kim, J.H.4    Huh, J.-Y.5    Yoon, H.6
  • 149
    • 84922195168 scopus 로고    scopus 로고
    • Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau
    • Santa-Maria I, Alaniz ME, Renwick N, Cela C, Fulga TA, Van Vactor D, et al. Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau. J Clin Invest. 2015;125(2):681-6.
    • (2015) J Clin Invest , vol.125 , Issue.2 , pp. 681-686
    • Santa-Maria, I.1    Alaniz, M.E.2    Renwick, N.3    Cela, C.4    Fulga, T.A.5    Van Vactor, D.6
  • 150
    • 79960367942 scopus 로고    scopus 로고
    • Role of hnRNP-A1 and miR-590-3p in neuronal death: Genetics and expression analysis in patients with Alzheimer disease and frontotemporal lobar degeneration
    • Villa C, Fenoglio C, De Riz M, Clerici F, Marcone A, Benussi L, et al. Role of hnRNP-A1 and miR-590-3p in neuronal death: genetics and expression analysis in patients with Alzheimer disease and frontotemporal lobar degeneration. Rejuvenation Res. 2011;14(3):275-81.
    • (2011) Rejuvenation Res , vol.14 , Issue.3 , pp. 275-281
    • Villa, C.1    Fenoglio, C.2    De Riz, M.3    Clerici, F.4    Marcone, A.5    Benussi, L.6
  • 151
    • 79952898846 scopus 로고    scopus 로고
    • Identification of blood microRNAs associated to Parkinsonǐs disease
    • Margis R, Margis R, Rieder CRM. Identification of blood microRNAs associated to Parkinsonǐs disease. J Biotechnol. 2011;152(3):96-101.
    • (2011) J Biotechnol , vol.152 , Issue.3 , pp. 96-101
    • Margis, R.1    Margis, R.2    Rieder, C.R.M.3
  • 152
    • 84902309873 scopus 로고    scopus 로고
    • Identification of circulating microRNAs for the differential diagnosis of Parkinson's disease and Multiple System Atrophy
    • Vallelunga A, Ragusa M, Di Mauro S, Iannitti T, Pilleri M, Biundo R, et al. Identification of circulating microRNAs for the differential diagnosis of Parkinson's disease and Multiple System Atrophy. Front Cell Neurosci. 2014;8:156.
    • (2014) Front Cell Neurosci , vol.8 , pp. 156
    • Vallelunga, A.1    Ragusa, M.2    Di Mauro, S.3    Iannitti, T.4    Pilleri, M.5    Biundo, R.6
  • 153
    • 79960135400 scopus 로고    scopus 로고
    • MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function
    • Miñones-Moyano E, Porta S, Escaramís G, Rabionet R, Iraola S, Kagerbauer B, et al. MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function. Hum Mol Genet. 2011;20(15):3067-78.
    • (2011) Hum Mol Genet , vol.20 , Issue.15 , pp. 3067-3078
    • Miñones-Moyano, E.1    Porta, S.2    Escaramís, G.3    Rabionet, R.4    Iraola, S.5    Kagerbauer, B.6
  • 154
    • 77950188650 scopus 로고    scopus 로고
    • Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models
    • Asikainen S, Rudgalvyte M, Heikkinen L, Louhiranta K, Lakso M, Wong G, et al. Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models. J Mol Neurosci MN. 2010;41(1):210-8.
    • (2010) J Mol Neurosci MN , vol.41 , Issue.1 , pp. 210-218
    • Asikainen, S.1    Rudgalvyte, M.2    Heikkinen, L.3    Louhiranta, K.4    Lakso, M.5    Wong, G.6
  • 155
    • 34548537573 scopus 로고    scopus 로고
    • A MicroRNA feedback circuit in midbrain dopamine neurons
    • Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, et al. A MicroRNA feedback circuit in midbrain dopamine neurons. Science. 2007;317(5842):1220-4.
    • (2007) Science , vol.317 , Issue.5842 , pp. 1220-1224
    • Kim, J.1    Inoue, K.2    Ishii, J.3    Vanti, W.B.4    Voronov, S.V.5    Murchison, E.6
  • 156
    • 84891391234 scopus 로고    scopus 로고
    • Profile of microRNAs in the plasma of Parkinson's disease patients and healthy controls
    • Cardo LF, Coto E, de Mena L, Ribacoba R, Moris G, Menéndez M, et al. Profile of microRNAs in the plasma of Parkinson's disease patients and healthy controls. J Neurol. 2013;260(5):1420-2.
    • (2013) J Neurol , vol.260 , Issue.5 , pp. 1420-1422
    • Cardo, L.F.1    Coto, E.2    De Mena, L.3    Ribacoba, R.4    Moris, G.5    Menéndez, M.6
  • 159
    • 84896913442 scopus 로고    scopus 로고
    • Microdissection and transcriptional profiling: A window into the pathobiology of preclinical prion disease
    • 201
    • Majer A, Booth SA. Microdissection and transcriptional profiling: a window into the pathobiology of preclinical prion disease. Prion. 201;8(1):67-74.
    • Prion , vol.8 , Issue.1 , pp. 67-74
    • Majer, A.1    Booth, S.A.2
  • 160
    • 81255152428 scopus 로고    scopus 로고
    • Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome
    • Lukiw WJ, Dua P, Pogue AI, Eicken C, Hill JM. Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome. J Toxicol Environ Health A. 2011;74(22-24):1460-8.
    • (2011) J Toxicol Environ Health A , vol.74 , Issue.22-24 , pp. 1460-1468
    • Lukiw, W.J.1    Dua, P.2    Pogue, A.I.3    Eicken, C.4    Hill, J.M.5
  • 161
    • 84870847550 scopus 로고    scopus 로고
    • Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice
    • Majer A, Medina SJ, Niu Y, Abrenica B, Manguiat KJ, Frost KL, et al. Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice. PLoS Pathog. 2012;8(11):e1003002.
    • (2012) PLoS Pathog , vol.8 , Issue.11
    • Majer, A.1    Medina, S.J.2    Niu, Y.3    Abrenica, B.4    Manguiat, K.J.5    Frost, K.L.6
  • 164
    • 84885357213 scopus 로고    scopus 로고
    • miRNA-9 expression is upregulated in the spinal cord of G93A-SOD1 transgenic mice
    • Zhou F, Guan Y, Chen Y, Zhang C, Yu L, Gao H, et al. miRNA-9 expression is upregulated in the spinal cord of G93A-SOD1 transgenic mice. Int J Clin Exp Pathol. 2013;6(9):1826-38.
    • (2013) Int J Clin Exp Pathol , vol.6 , Issue.9 , pp. 1826-1838
    • Zhou, F.1    Guan, Y.2    Chen, Y.3    Zhang, C.4    Yu, L.5    Gao, H.6
  • 165
    • 84924125314 scopus 로고    scopus 로고
    • Up-regulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage
    • Marcuzzo S, Bonanno S, Kapetis D, Barzago C, Cavalcante P, D'Alessandro S, et al. Up-regulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage. Mol Brain. 2015;8(1):5.
    • (2015) Mol Brain , vol.8 , Issue.1 , pp. 5
    • Marcuzzo, S.1    Bonanno, S.2    Kapetis, D.3    Barzago, C.4    Cavalcante, P.5    D'Alessandro, S.6
  • 166
    • 84885444052 scopus 로고    scopus 로고
    • Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations
    • Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, et al. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PloS One. 2013;8(10):e76055.
    • (2013) PloS One , vol.8 , Issue.10
    • Zhang, Z.1    Almeida, S.2    Lu, Y.3    Nishimura, A.L.4    Peng, L.5    Sun, D.6
  • 167
    • 84866491615 scopus 로고    scopus 로고
    • Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis
    • Russell AP, Wada S, Vergani L, Hock MB, Lamon S, Léger B, et al. Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis. Neurobiol Dis. 2013;49:107-17.
    • (2013) Neurobiol Dis , vol.49 , pp. 107-117
    • Russell, A.P.1    Wada, S.2    Vergani, L.3    Hock, M.B.4    Lamon, S.5    Léger, B.6
  • 170
  • 171
    • 84939884820 scopus 로고    scopus 로고
    • Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases
    • Jun 29
    • Tan L, Yu J-T, Tan L. Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases. Mol Neurobiol. 2014 Jun 29;
    • (2014) Mol Neurobiol
    • Tan, L.1    Yu, J.-T.2    Tan, L.3
  • 172
    • 84919475780 scopus 로고    scopus 로고
    • miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients
    • De Felice B, Annunziata A, Fiorentino G, Borra M, Biffali E, Coppola C, et al. miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients. Neurogenetics. 2014;15(4):243-53.
    • (2014) Neurogenetics , vol.15 , Issue.4 , pp. 243-253
    • De Felice, B.1    Annunziata, A.2    Fiorentino, G.3    Borra, M.4    Biffali, E.5    Coppola, C.6
  • 173
    • 84865536102 scopus 로고    scopus 로고
    • A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis
    • De Felice B, Guida M, Guida M, Coppola C, De Mieri G, Cotrufo R. A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis. Gene. 2012;508(1):35-40.
    • (2012) Gene , vol.508 , Issue.1 , pp. 35-40
    • De Felice, B.1    Guida, M.2    Guida, M.3    Coppola, C.4    De Mieri, G.5    Cotrufo, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.