Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice

Journal of Biological Chemistry

Volumn 289, Issue 35, 2014, Pages 24488-24498

  Yuyama, Kohei ^a   Sun, Hui ^a   Sakai, Shota ^a   Mitsutake, Susumu ^a,b   Okada, Megumi ^c   Tahara, Hidetoshi ^c   Furukawa, Jun Ichi ^a   Fujitani, Naoki ^a   Shinohara, Yasuro ^a   Igarashi, Yasuyuki ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; LIPIDS; MAMMALS; NEURODEGENERATIVE DISEASES;

ALZHEIMER DISEASE; AMYLOID DEPOSITION; CENTRAL NERVOUS SYSTEMS; GLYCOSPHINGOLIPIDS; LIPID MEMBRANES; PRECURSOR PROTEINS; THERAPEUTIC INTERVENTION; TRANSGENIC MICE;

LOADING;

AMYLOID BETA PROTEIN; GLYCOSPHINGOLIPID;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; CONTROLLED STUDY; EXOSOME; HETEROZYGOSITY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LIGHT SCATTERING; MICROGLIA; MOUSE; NONHUMAN; PHAGOCYTE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; SURFACE PLASMON RESONANCE; SYNAPSE; TISSUE LEVEL; TRANSGENE; ANIMAL; BRAIN; C57BL MOUSE; METABOLISM; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; CELL LINE, TUMOR; EXOSOMES; GLYCOSPHINGOLIPIDS; MICE; MICE, INBRED C57BL; MICROGLIA;

EID: 84906871864     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.577213     Document Type: Article

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