Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

Journal of Biological Chemistry

Volumn 287, Issue 6, 2012, Pages 3842-3849

  Saman, Sudad ^a   Kim, WonHee ^a   Raya, Mario ^b   Visnick, Yvonne ^b   Miro, Suhad ^b   Saman, Sarmad ^b   Jackson, Bruce ^b   McKee, Ann C ^c,d   Alvarez, Victor E ^c,d   Lee, Norman C Y ^e   Hall, Garth F ^a  

^a UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

^b STEM Division   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; CEREBRO SPINAL FLUIDS; EXOSOMES; NEURODEGENERATION; PRELIMINARY ANALYSIS; PRION PROTEIN; SYNUCLEIN;

CEREBROSPINAL FLUID; PHOSPHORYLATION; PHYSIOLOGY; PROTEINS;

NEURODEGENERATIVE DISEASES;

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; PRION PROTEIN; TAU PROTEIN; THREONINE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOSOME; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MASS SPECTROMETRY; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROBLASTOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TAUOPATHY; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BIOLOGICAL MARKERS; CELL LINE, TUMOR; EXOSOMES; FEMALE; HUMANS; MALE; MODELS, BIOLOGICAL; PHOSPHORYLATION; TAU PROTEINS;

EID: 84856707794     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.277061     Document Type: Article

References (50)

1. Kim, W., Lee, S., Jung, C., Ahmed, A., Lee, G., and Hall, G. F. (2010) J. Alzheimers Dis. 19, 647-664
2. Kim, W., Lee, S., and Hall, G. F. (2010) FEBS Lett. 584, 3085-3088
3. Lee, S., Kim, W., Li, Z., and Hall, G. F. (2012) Int. J. Alz Dis., in press
4. Gómez-Ramos, A., Díaz-Hernández, M., Cuadros, R., Hernández, F., and Avila, J. (2006) FEBS Lett. 580, 4842-4850
5. Frost, B., Jacks, R. L., and Diamond, M. I. (2009) J. Biol. Chem. 284, 12845-12852
6. Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., Jucker, M., Goedert, M., and Tolnay, M. (2009) Nat. Cell Biol. 11, 909-913
7. Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., and Simons, K. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 11172-11177
8. Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., and Vekrellis, K. (2010) J. Neurosci. 30, 6838-6851
9. Fevrier, B., Vilette, D., Archer, F., Loew, D., Faigle, W., Vidal, M., Laude, H., and Raposo, G. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 9683-9688
10. Cushman, M., Johnson, B. S., King, O. D., Gitler, A. D., and Shorter, J. (2010) J. Cell Sci. 123, 1191-1201
11. Hall, G. F. (2011) in Neurodegenerative Diseases-Processes, Prevention, Protection and Monitoring (Chang, R. C.-C., ed) pp. 1-32, InTech, Rijeka, Croatia
12. Clinton, L. K., Blurton-Jones, M., Myczek, K., Trojanowski, J. Q., and LaFerla, F. M. (2010) J. Neurosci. 30, 7281-7289
13. Gadad, B. S., Britton, G. B., and Rao, K. S. (2011) J. Alzheimers Dis. 24, 223-232
14. Sharples, R. A., Vella, L. J., Nisbet, R. M., Naylor, R., Perez, K., Barnham, K. J., Masters, C. L., and Hill, A. F. (2008) FASEB J. 22, 1469-1478
15. Ko, L. W., Rush, T., Sahara, N., Kersh, J. S., Easson, C., Deture, M., Lin, W. L., Connor, Y. D., and Yen, S. H. (2004) J. Alzheimers Dis. 6, 605-622
16. Vanderstichele, H., De Vreese, K., Blennow, K., Andreasen, N., Sindic, C., Ivanoiu, A., Hampel, H., Bürger, K., Parnetti, L., Lanari, A., Padovani, A., DiLuca, M., Bläser, M., Olsson, A. O., Pottel, H., Hulstaert, F., and Vanmechelen, E. (2006) Clin. Chem. Lab. Med. 44, 1472-1480
17. Arai, H., Satoh-Nakagawa, T., Higuchi, M., Morikawa, Y., Miura, M., Kawakami, H., Seki, H., Takase, S., and Sasaki, H. (1998) Neurosci. Lett. 256, 174-176
18. Parnetti, L., Lanari, A., Amici, S., Gallai, V., Vanmechelen, E., and Hulstaert, F. (2001) Neurol. Sci. 22, 77-78
19. Braak, H., and Braak, E. (1991) Acta Neuropathol. 82, 239-259
20. Théry, C., Clayton, A., Amigorena, S., and Raposo, G. (2006) Curr. Protocols Cell Biol. Suppl. 30, 3.22.1-3.22.29
21. Nickel, W. (2005) Traffic 6, 607-614
22. Simpson, R. J., Lim, J. W., Moritz, R. L., and Mathivanan, S. (2009) Expert Rev. Proteomics 6, 267-283
23. Mathivanan, S., and Simpson, R. J. (2009) Proteomics 9, 4997-5000
24. Pan, S., Aebersold, R., Chen, R., Rush, J., Goodlett, D. R., McIntosh, M. W., Zhang, J., and Brentnall, T. A. (2009) J. Proteome Res. 8, 787-797
25. Harrington, M. G., Fonteh, A. N., Oborina, E., Liao, P., Cowan, R. P., McComb, G., Chavez, J. N., Rush, J., Biringer, R. G., and Hühmer, A. F. (2009) Cerebrospinal Fluid Res. 6, 10
26. Fang, Y., Wu, N., Gan, X., Yan, W., Morrell, J. C., and Gould, S. J. (2007) PLoS Biol. 5, e158
27. Lee, G., Newman, S. T., Gard, D. L., Band, H., and Panchamoorthy, G. (1998) J. Cell Sci. 111, 3167-3177
28. Vega, I. E., Cui, L., Propst, J. A., Hutton, M. L., Lee, G., and Yen, S. H. (2005) Brain Res. Mol. Brain Res. 138, 135-144
29. Busciglio, J., Lorenzo, A., Yeh, J., Yankner, B. A. (1995) Neuron 14, 879-888
30. Stoothoff, W. H., and Johnson, G. V. (2005) Biochim. Biophys. Acta 1739, 280-297
31. Wang, J. Z., Grundke-Iqbal, I., and Iqbal, K. (2007) Eur. J. Neurosci. 25, 59-68
32. Lee, V. M., Balin, B. J., Otvos, L., Jr., and Trojanowski, J. Q. (1991) Science 251, 675-678
33. Buée, L., and Delacourte, A. (1999) Brain Pathol. 9, 681-693
34. Zilka, N., Korenova, M., Kovacech, B., Iqbal, K., and Novak, M. (2010) Acta Neuropathol. 119, 679-687
35. Weingarten, M. D., Lockwood, A. H., Hwo, S. Y., and Kirschner, M. W. (1975) Proc. Natl. Acad. Sci. U.S.A. 72, 1858-1862
36. Makrides, V., Shen, T. E., Bhatia, R., Smith, B. L., Thimm, J., Lal, R., and Feinstein, S. C. (2003) J. Biol. Chem. 278, 33298-33304
37. Chirita, C. N., Necula, M., and Kuret, J. (2003) J. Biol. Chem. 278, 25644-25650
38. Guillozet-Bongaarts, A. L., Garcia-Sierra, F., Reynolds, M. R., Horowitz, P. M., Fu, Y., Wang, T., Cahill, M. E., Bigio, E. H., Berry, R. W., and Binder, L. I. (2005) Neurobiol. Aging 26, 1015-1022
39. Braak, H., Alafuzoff I., Arzberger, T., Kretzschmar, H., and Del Tredici, K. (2006) Acta Neuropathol. 112, 389-404
40. Berger, Z., Roder, H., Hanna, A., Carlson, A., Rangachari, V., Yue, M., Wszolek, Z., Ashe, K., Knight, J., Dickson, D., Andorfer, C., Rosenberry, T. L., Lewis, J., Hutton, M., and Janus, C. (2007) J. Neurosci. 27, 3650-3662
41. Johnson, G. V., Seubert, P., Cox, T. M., Motter, R., Brown, J. P., and Galasko, D. (1997) J. Neurochem. 68, 430-433
42. Urakami, K., Wada, K., Arai, H., Sasaki, H., Kanai, M., Shoji, M., Ishizu, H., Kashihara, K., Yamamoto, M., Tsuchiya-Ikemoto, K., Morimatsu, M., Takashima, H., Nakagawa, M., Kurokawa, K., Maruyama, H., Kaseda, Y., Nakamura, S., Hasegawa, K., Oono, H., Hikasa, C., Ikeda, K., Yamagata, K., Wakutani, Y., Takeshima, T., and Nakashima, K. (2001) J. Neurol. Sci. 183, 95-98
43. Borroni, B., Gardoni, F., Parnetti, L., Magno, L., Malinverno, M., Saggese, E., Calabresi, P., Spillantini, M. G., Padovani, A., and Di Luca, M. (2009) Neurobiol. Aging 30, 34-40
44. Hall, G. F., Lee, V. M., Lee, G., and Yao, J. (2001) Am. J. Pathol. 158, 235-246
45. Hall, G. F., Lee, S., and Yao, J. (2002) J. Mol. Neurosci. 19, 253-260
46. Sahara, N., Maeda, S., and Takashima, A. (2008) Curr. Alzheimer Res. 5, 591-598
47. Patterson, K. R., Remmers, C., Fu, Y., Brooker, S., Kanaan, N. M., Vana, L., Ward, S., Reyes, J. F., Philibert, K., Glucksman, M. J., and Binder, L. I. (2011) J. Biol. Chem. 286, 23063-23076
48. Sverdlov, M., Shajahan, A. N., and Minshall, R. D. (2007) J. Cell. Mol. Med. 11, 1239-1250
49. Dickey, C. A., Yue, M., Lin, W. L., Dickson, D. W., Dunmore, J. H., Lee, W. C., Zehr, C., West, G., Cao, S., Clark, A. M., Caldwell, G. A., Caldwell, K. A., Eckman, C., Patterson, C., Hutton, M., and Petrucelli, L. (2006) J. Neurosci. 26, 6985-6996
50. Boland, B., Kumar, A., Lee, S., Platt, F. M., Wegiel, J., Yu, W. H., and Nixon, R. A. (2008) J. Neurosci. 28, 6926-6937