MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 39, Issue 2, 2014, Pages 253-259

  Kiko, Takehiro ^a   Nakagawa, Kiyotaka ^a   Tsuduki, Tsuyoshi ^a   Furukawa, Katsutoshi ^a   Arai, Hiroyuki ^a   Miyazawa, Teruo ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; cerebrospinal fluid; miRNA; plasma

Indexed keywords

MICRORNA; MICRORNA 125B; MICRORNA 146A; MICRORNA 29A; MICRORNA 29B; MICRORNA 34A; MICRORNA 9;

AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD LEVEL; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VERY ELDERLY;

ALZHEIMER'S DISEASE; CEREBROSPINAL FLUID; MIRNA; PLASMA;

AGE FACTORS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BIOLOGICAL MARKERS; FEMALE; HUMANS; MALE; MICRORNAS; PEPTIDE FRAGMENTS; PSYCHIATRIC STATUS RATING SCALES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TAU PROTEINS;

EID: 84893946623     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-130932     Document Type: Article

References (53)

1. de la Torre JC (2004) Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol 3, 184-190.
2. Younkin SG (1995) Evidence that Aβ42 is the real culprit in Alzheimer's disease. Ann Neurol 37, 287-288.
3. Orešič M, Hyötyläinen T, Herukka SK, Sysi-Aho M, Mattila I, Seppänan-Laakso T, Julkunen V, Gopalacharyulu PV, Hallikainen M, Koikkalainen J, Kivipelto M, Helisalmi S, Lötjönen J, Soininen H (2011) Metabolome in progression to Alzheimer's disease. Transl Psychiatry 1, e57.
4. Han X, Rozen S, Boyle SH, Hellegers C, Cheng H, Burke JR, Welsh-Bohmer KA, Doraiswamy PM, Kaddurah-Daouk R (2011) Metabolomics in early Alzheimer's disease: Identification of altered plasma sphingolipidome using shotgun lipidomics. PLoS One 6, e21643.
5. Thambisetty M, Tripaldi R, Riddoch-Contreras J, Hye A, An Y, Campbell J, Sojkova J, Kinsey A, Lynham S, Zhou Y, Ferrucci L, Wong DF, Lovestone S, Resnick SM (2010) Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals. J Alzheimers Dis 22, 1099-1109.
6. Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper C, Rijsdijk F, Tabrizi SJ, Banner S, Shaw CE, Foy C, Poppe M, Archer N, Hamilton G, Powell J, Brown RG, Sham P, Ward M, Lovestone S (2006) Proteome-based plasma biomarkers for Alzheimer's disease. Brain 129, 3042-3050.
7. Bartel DP (2004) MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
8. Dillhoff M, Wojcik SE, Bloomston M (2009) MicroRNAs in solid tumors. J Surg Res 154, 349-354.
9. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, TewariM(2008) Circulating microRNAs as stable bloodbased markers for cancer detection. Proc Natl Acad Sci U S A 105, 10513-10518.
10. Ura S, Honda M,Yamashita T, Ueda T, Takatori H, Nishino R, Sunakozaka H, SakaiY, Horimoto K, Kaneko S (2009) Differential microRNAexpression between hepatitisBand hepatitis C leading disease progression to hepatocellular carcinoma. Hepatology 49, 1098-1112.
11. Ikeda S, Kong SW, Lu J, Bisping E, Zhang H, Allen PD, Golub TR, Pieske B, Pu WT (2007) Altered microRNA expression in human heart disease. Physiol Genomics 31, 367-373.
12. Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, AmbrosV(2004) Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol 5, R13.
13. Kosik KS, Krichevsky AM (2005) The elegance of the microRNAs: A neuronal perspective. Neuron 47, 779-782.
14. Kosik KS (2006) The neuronal microRNA system. Nat Rev Neurosci 7, 911-920.
15. Maes OC, Chertkow HM, Wang E, Schipper HM (2009) MicroRNA: Implications for Alzheimer Disease and other human CNS disorders. Curr Genomics 10, 154-168.
16. Hebert SS, Horre K, Nicolai L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B (2008) Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/betasecretase expression. Proc Natl Acad Sci U S A 105, 6415-6420.
17. Ohyagi Y, Asahara H, Chui DH, Tsuruta Y, Sakae N, Miyoshi K, Yamada T, Kikuchi H, Taniwaki T, Murai H, Ikezoe K, Furuya H, Kawarabayashi T, Shoji M, Checler F, Iwaki T, Makifuchi T, Takeda K, Kira J, Tabira T (2005) Intracellular Abeta42 activates p53 promoter: A pathway to neurodegeneration in Alzheimer's disease. FASEB J 19, 255-257.
18. He L, He X, Lim LP, de Stanchina E, Xuan Z, LiangY, XueW, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C, Lowe SW, Cleary MA, Hannon GJ (2007) A microRNA component of the p53 tumour suppressor network. Nature 447, 1130-1134.
19. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, TewariM(2008) Circulating microRNAs as stable bloodbased markers for cancer detection. Proc Natl Acad Sci U S A 105, 10513-10518.
20. Baraniskin A, Kuhnhenn J, Schlegel U, Chan A, Deckert M, Gold R, Maghnouj A, Zöllner H, Reinacher-Schick A, Schmiegel W, Hahn SA, Schroers R (2011) Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system. Blood 117, 3140-3146.
21. Hanke M, Hoefig K, Merz H, Feller AC, Kausch I, Jocham D, Warnecke JM, Sczakiel G (2010) A robust methodology to study urine microRNA as tumor marker: MicroRNA-126 and microRNA-182 are related to urinary bladder cancer. Urol Oncol 28, 655-661.
22. Park NJ, Zhou H, Elashoff D, Henson BS, Kastratovic DA, Abemayor E, Wong DT (2009) Salivary microRNA: Discovery, characterization, and clinical utility for oral cancer detection. Clin Cancer Res 15, 5473-5477.
23. Michael A, Bajracharya SD, Yuen PS, Zhou H, Star RA, Illei GG, Alevizos I (2010) Exosomes from human saliva as a source of microRNA biomarkers. Oral Dis 16, 34-38.
24. Cogswell JP, Ward J, Taylor IA, Waters M, Shi Y, Cannon B, Kelnar K, Kemppainen J, Brown D, Chen C, Prinjha RK, Richardson JC, SaundersAM,Roses AD, RichardsCA(2008) Identification of miRNAchanges in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 14, 27-41.
25. Schipper HM, Maes OC, Chertkow HM, Wang E (2007) MicroRNAexpression in Alzheimer blood mononuclear cells. Gene Regul Syst Bio 1, 263-274.
26. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
27. Waldman SA, Terzic A (2008) MicroRNA signatures as diagnostic and therapeutic targets. Clin Chem 54, 943-944.
28. Chen X, Ba Y, Ma L, Cai X, Yin Y,Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X,WangW, Zhang Y,Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Wang J, Zen K, Zhang J, Zhang CY (2008) Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18, 997-1006.
29. Huang Z, Huang D, Ni S, Peng Z, Sheng W, Du X (2010) Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer. Int J Cancer 127, 118-126.
30. Laterza OF, Lim L, Garrett-Engele PW, Vlasakova K, Muniappa N, Tanaka WK, Johnson JM, Sina JF, Fare TL, Sistare FD, Glaab WE (2009) Plasma microRNAs as sensitive and specific biomarkers of tissue injury. Clinl Chem 55, 1977-1983.
31. Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, Hood LE, Galas DJ (2009) Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci U S A 106, 4402-4407.
32. Schonrock N, Matamales M, Ittner LM, Götz J (2012) MicroRNA networks surrounding APP and amyloid-β metabolism-implications for Alzheimer's disease. Exp Neurol 235, 447-454.
33. Tan L, Yu JT, Hu N, Tan L (2013) Non-coding RNAs in Alzheimer's disease. Mol Neurobiol 47, 382-393.
34. Alexandrov PN, Dua P, Hill JM, Bhattacharjee S, Zhao Y, Lukiw WJ (2012) microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF). Int J Biochem Mol Biol 3, 365-373.
35. Fukumoto H, Cheung BS, Hyman BT, Irizarry MC (2002) Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol 59, 1381-1389.
36. Holsinger RM, McLean CA, Beyreuther K, Masters CL, Evin G (2002) Increased expression of the amyloid precursor betasecretase in Alzheimer's disease. Ann Neurol 51, 783-786.
37. Achard P, Herr A, Baulcombe DC, Harberd NP (2004) Modulation of floral development by a gibberellin-regulated microRNA. Development 131, 3357-3365.
38. Calin GA, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C, Fabbri M, Cimmino A, Lee EJ, Wojcik SE, Shimizu M, Tili E, Rossi S, Taccioli C, Pichiorri F, Liu X, Zupo S, HerleaV, Gramantieri L, Lanza G, Alder H, Rassenti L,Volinia S, Schmittgen TD, Kipps TJ,NegriniM,CroceCM(2007) Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 12, 215-229.
39. Mattson MP, Shea TB (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 26, 137-146.
40. Shioya M, Obayashi S, Tabunoki H, Arima K, Saito Y, Ishida T, Satoh J (2010) Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3. Neuropathol Appl Neurobiol 36, 320-330.
41. Li X, Khanna A, Li N,Wang E (2011) Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging. Aging (Albany NY) 3, 985-1002.
42. Wang X, Liu P, Zhu H, Xu Y, Ma C, Dai X, Huang L, Liu Y, Zhang L, Qin C (2010) miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res Bull 80, 268-273.
43. Ferreiro E, Eufrasio A, Pereira C, Oliveira CR, Rego AC (2007) Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells. J Alzheimers Dis 12, 223-228.
44. Rohn TT, Vyas V, Hernandez-Estrada T, Nichol KE, Christie LA, Head E (2008) Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. J Neurosci 19, 3051-3059.
45. Li YY, Cui JG, Hill JM, Bhattacharjee S, Zhao Y, Lukiw WJ (2011) Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models. Neurosci Lett 487, 94-98.
46. Mattick JS, Makunin IV (2005) Small regulatory RNAs in mammals. Hum Mol Genet 14, 121-132.
47. Sethi P, Lukiw WJ (2009) Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci Lett 459, 100-104.
48. Ferretti E, De Smaele E, Po A, Di Marcotullio L, Tosi E, Espinola MS, Di Rocco C, Riccardi R, Giangaspero F, Farcomeni A, Nofroni I, Laneve P, Gioia U, Caffarelli E, Bozzoni I, Screpanti I, Gulino A (2009) MicroRNA profiling in human medulloblastoma. Int J Cancer 124, 568-577.
49. Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, HorsburghK, YanknerBA,Wyllie DJ, Ikonomidou C, Hardingham GE (2008) Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci 11, 476-487.
50. Mehler MF, Mattick JS (2007) Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease. Physiol Rev 87, 799-823.
51. Lukiw WJ (2007) Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport 18, 297-300.
52. Kosaka N, Iguchi H, Ochiya T (2010) Circulating microRNA in body fluid: A new potential biomarker for cancer diagnosis and prognosis. Cancer Sci 101, 2087-2092.
53. Baraniskin A, Kuhnhenn J, Schlegel U, Chan A, Deckert M, Gold R, Maghnouj A, Zöllner H, Reinacher-Schick A, Schmiegel W, Hahn SA, Schroers R (2011) Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system. Blood 117, 3140-3146.