A microRNA feedback circuit in midbrain dopamine neurons

Science

Volumn 317, Issue 5842, 2007, Pages 1220-1224

  Kim, Jongpil ^a   Inoue, Keiichi ^a   Ishii, Jennifer ^a   Vanti, William B ^a   Voronov, Sergey V ^a   Murchison, Elizabeth ^b   Hannon, Gregory ^b   Abeliovich, Asa ^a  

^a College of Physicians and Surgeons 15 403 ^*  (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICER; MICRORNA; MICRORNA 133B; NUCLEIC ACID BINDING PROTEIN; TRANSCRIPTION FACTOR PITX3; UNCLASSIFIED DRUG; DOPAMINE; HOMEOBOX PROTEIN PITX3; HOMEODOMAIN PROTEIN; RIBONUCLEASE III; TRANSCRIPTION FACTOR;

BRAIN; EVOLUTIONARY BIOLOGY; GENE EXPRESSION; LOCOMOTION; MAMMAL; NERVOUS SYSTEM DISORDER; PROTEIN; RNA;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL SURVIVAL; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; GENE FUNCTION; MESENCEPHALON; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; 3' UNTRANSLATED REGION; AGED; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CELL LINE; CYTOLOGY; EMBRYONIC STEM CELL; FEEDBACK SYSTEM; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; LOCOMOTION; MALE; METABOLISM; MIDDLE AGED; MOUSE; NERVE CELL; RAT;

MAMMALIA;

3' UNTRANSLATED REGIONS; AGED; AGED, 80 AND OVER; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; DOPAMINE; EMBRYONIC STEM CELLS; FEEDBACK, BIOCHEMICAL; FEMALE; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; LOCOMOTION; MALE; MESENCEPHALON; MICE; MICRORNAS; MIDDLE AGED; MODELS, BIOLOGICAL; NEURONS; PARKINSON DISEASE; RATS; RIBONUCLEASE III; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 34548537573     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1140481     Document Type: Article

References (18)

1. L. He, G. J. Hannon, Nat. Rev. Genet. 5, 522 (2004).
2. V. Ambros, Cell 113, 673 (2003).
3. A. Wallen, T. Perlmann, Ann. N. Y. Acad. Sci. 991, 48 (2003).
4. J. H. Kim et al., Nature 418, 50 (2002).
5. C. Martinat et al., Proc. Natl. Acad. Sci. U.S.A. 103, 2874 (2006).
6. E. P. Murchison, J. F. Partridge, O. H. Tam, S. Cheloufi, G. J. Hannon, Proc. Natl. Acad. Sci. U.S.A. 102, 12135 (2005).
7. Materials and methods are available as supporting material on Science Online.
8. N. Chuhma et al., J. Neurosci. 24, 972 (2004).
9. D. Y. Hwang, P. Ardayfio, U. J. Kang, E. V. Semina, K. S. Kim, Brain Res. Mol. Brain Res. 114, 123 (2003).
10. I. Nunes, L. T. Tovmasian, R. M. Silva, R. E. Burke, S. P. Goff, Proc. Natl. Acad. Sci. U.S.A. 100, 4245 (2003).
11. P. van den Munckhof et al., Development 130, 2535 (2003).
12. T. J. Davidson et al., J. Neurosci. 24, 10040 (2004).
13. D. P. Bartel, Cell 116, 281 (2004).
14. B. John et al., PLoS Biol. 2, e363 (2004).
15. B. P. Lewis, I. H. Shih, M. W. Jones-Rhoades, D. P. Bartel, C. B. Burge, Cell 115, 787 (2003).
16. M. P. Smidt, S. M. Smits, J. P. Burbach, Cell Tissue Res. 318, 35 (2004).
17. A. Becskei, L. Serrano, Nature 405, 590 (2000).
18. We thank O. Hobert and R. Liem for comments and F. Beal for technical assistance. This work was funded by NINDS and Spitzer Funds.