Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 9, 2014, Pages 3620-3625

  Grad, Leslie I ^a   Yerbury, Justin J ^b   Turner, Bradley J ^c   Guest, William C ^a   Pokrishevsky, Edward ^a   O'Neill, Megan A ^a   Yanai, Anat ^a   Silverman, Judith M ^a   Zeineddine, Rafaa ^b   Corcoran, Lisa ^b   Kumita, Janet R ^d   Luheshi, Leila M ^d   Yousefi, Masoud ^a   Coleman, Bradley M ^e   Hill, Andrew F ^e   Plotkin, Steven S ^f   Mackenzie, Ian R ^f   Cashman, Neil R ^a  

^a VANCOUVER COASTAL HEALTH RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WOLLONGONG   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Disease specific epitope; Intercellular transmission; Prion like; Protein misfolding

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; PROTEINASE;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL DEATH; CELL INTERACTION; CELL STRAIN HEK293; EXOSOME; HUMAN; MOTONEURON; MOUSE; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN AGGREGATION;

DISEASE-SPECIFIC EPITOPE; INTERCELLULAR TRANSMISSION; PRION-LIKE; PROTEIN MISFOLDING;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EXOSOMES; HUMANS; MICE; MICROSCOPY, ELECTRON; PINOCYTOSIS; PROTEIN FOLDING; RNA INTERFERENCE; RNA, SMALL INTERFERING; SUPEROXIDE DISMUTASE;

EID: 84895796816     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1312245111     Document Type: Article

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