Target Gene Repression Mediated by miRNAs miR-181c and miR-9 Both of Which Are Down-regulated by Amyloid-β

Journal of Molecular Neuroscience

Volumn 46, Issue 2, 2012, Pages 324-335

  Schonrock, Nicole ^a,d   Humphreys, David T ^a   Preiss, Thomas ^a,b,c   Götz, Jürgen ^d  

^a VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c Biology and Environment   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Alzheimer; Amyloid ; A ; HeLa cell; microRNA; Neurodegeneration; Sirtuin

Indexed keywords

AMYLOID BETA PROTEIN; BETAIG H3 PROTEIN; BETAIG-H3 PROTEIN; BTBD3 PROTEIN, HUMAN; MICRORNA; MIRN181 MICRORNA, HUMAN; MIRN9 MICRORNA, HUMAN; NARF PROTEIN, HUMAN; NERVE PROTEIN; NUCLEAR PROTEIN; RECOMBINANT DNA; SCLEROPROTEIN; SIRT1 PROTEIN, HUMAN; SIRTUIN 1; TRANSFORMING GROWTH FACTOR BETA;

3' UNTRANSLATED REGION; ALZHEIMER DISEASE; ANIMAL; ARTICLE; BIOSYNTHESIS; BRAIN; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HELA CELL; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY; REPORTER GENE;

3' UNTRANSLATED REGIONS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; DNA, RECOMBINANT; DOWN-REGULATION; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, REPORTER; HELA CELLS; HUMANS; MICE; MICRORNAS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; SIRTUIN 1; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 84864778051     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9587-2     Document Type: Article

References (53)

1. Baek D, Villen J, Shin C, Camargo FD et al (2008) The impact of microRNAs on protein output. Nature 455:64–71
2. Balastik M, Ferraguti F, Pires-da Silva A, Lee TH et al (2008) Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Proc Natl Acad Sci U S A 105:12016–12021
3. Baur JA, Pearson KJ, Price NL, Jamieson HA et al (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337–342
4. Beilharz TH, Humphreys DT, Clancy JL, Thermann R et al (2009) microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells. PLoS ONE 4: e6783
5. Boissonneault V, Plante I, Rivest S, Provost P (2009) MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem 284:1971– 1981
6. Clancy JL, Nousch M, Humphreys DT, Westman BJ et al (2007) Methods to analyze microRNA-mediated control of mRNA translation. Methods Enzymol 431:83–111
7. Cogswell JP, Ward J, Taylor IA, Waters M et al (2008) Identification of miRNA changes in Alzheimer’s disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 14:27–41
8. Cole AR, Noble W, van Aalten L, Plattner F et al (2007) Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer’s disease progression. J Neurochem 103:1132–1144
9. da Cruz e Silva OA, Henriques AG, Domingues SC, da Cruz e Silva EF (2010) Wnt signalling is a relevant pathway contributing to amyloid beta-peptide-mediated neuropathology in Alzheimer’s disease. CNS Neurol Disord Drug Targets 9:720–726
10. Damgaard T, Knudsen LM, Dahl IM, Gimsing P et al (2009) Regulation of the CD56 promoter and its association with proliferation, anti-apoptosis and clinical factors in multiple myeloma. Leuk Lymphoma 50:236–246
11. David D, Hoerndli F, Gotz J (2005) Functional genomics meets neurodegenerative disorders: Part I. Transcriptomic and proteomic technology. Prog Neurobiol 76:153–168
12. Fabian MR, Sonenberg N, Filipowicz W (2010) Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem 79:351–379
13. Gotz J, Ittner LM, Fandrich M, Schonrock N (2008a) Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods? J Alzheimers Dis 14:423– 429
14. Gotz J, Ittner LM, Schonrock N, Cappai R (2008b) An update on the toxicity of Abeta in Alzheimer’s disease. Neuropsychiatr Dis Treat 4:1033–1042
15. Haramati S, Chapnik E, Sztainberg Y, Eilam R et al (2010) miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci U S A 107:13111–13116
16. Hebert SS, De Strooper B (2009) Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci 32:199–206
17. Hebert SS, Horre K, Nicolai L, Papadopoulou AS et al (2008) Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer’s disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A 105:6415–6420
18. Hebert SS, Horre K, Nicolai L, Bergmans B et al (2009) MicroRNA regulation of Alzheimer’s Amyloid precursor protein expression. Neurobiol Dis 33:422–428
19. Hoerndli FJ, Toigo M, Schild A, Gotz J et al (2004) Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction. Anal Biochem 335:30–41
20. Hoerndli F, David D, Gotz J (2005) Functional genomics meets neurodegenerative disorders: Part II. Application and data integration. Prog Neurobiol 76:169–188
21. Humphreys DT, Westman BJ, Martin DI, Preiss T (2005) MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function. Proc Natl Acad Sci U S A 102:16961–16966
22. Hutchison ER, Okun E, Mattson MP (2009) The therapeutic potential of microRNAs in nervous system damage, degeneration, and repair. Neuromol Med 11:153–161
23. Ittner LM, Ke YD, Delerue F, Bi M et al (2010) Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer’s disease mouse models. Cell 142:387–397
24. Kurosinski P, Gotz J (2002) Glial cells under physiologic and pathological conditions. Arch Neurol 59:1524–1528
25. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H et al (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127:1109–1122
26. Landgraf P, Rusu M, Sheridan R, Sewer A et al (2007) A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129:1401–1414
27. Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15–20
28. Lim Y-A, Rhein V, Baysang G, Meier F et al (2010) Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics 10:1621–1633
29. Lin B, Madan A, Yoon JG, Fang X et al (2010) Massively parallel signature sequencing and bioinformatics analysis identifies up-regulation of TGFBI and SOX4 in human glioblastoma. PLoS ONE 5:e10210
30. Ma C, Rong Y, Radiloff DR, Datto MB et al (2008) Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Genes Dev 22:308– 321
31. Nelson PT, Wang WX (2010) MiR-107 is reduced in Alzheimer’s disease brain neocortex: validation study. J Alzheimers Dis 21:75–79
32. Nunez-Iglesias J, Liu CC, Morgan TE, Finch CE et al (2010) Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer’s disease cortex reveals altered miRNA regulation. PLoS ONE 5:e8898
33. Ohkawa N, Kokura K, Matsu-Ura T, Obinata T et al (2001) Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family is a candidate for the partner of myosin V. J Neurochem 78:75–87
34. Ono K, Condron MM, Teplow DB (2009) Structure–neurotoxicity relationships of amyloid beta-protein oligomers. Proc Natl Acad Sci U S A 106:14745–14750
35. Palop JJ, Mucke L (2010) Amyloid-beta-induced neuronal dysfunction in Alzheimer’s disease: from synapses toward neural networks. Nat Neurosci 13:812–818
36. Qin W, Yang T, Ho L, Zhao Z et al (2006) Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem 281:21745–21754
37. Rane S, He M, Sayed D, Vashistha H et al (2009) Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 104:879–886
38. Salminen A, Kaarniranta K (2009) SIRT1: regulation of longevity via autophagy. Cell Signal 21:1356–1360
39. Saunders LR, Sharma AD, Tawney J, Nakagawa M et al (2010) miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany, NY) 2:415–431
40. Schild A, Schmidt K, Lim YA, Ke Y et al (2006) Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation. Int J Dev Neurosci 24:437–443
41. Schonrock N, Ke YD, Humphreys D, Staufenbiel M et al (2010) Neuronal microRNA deregulation in response to Alzheimer’s disease amyloid-beta. PLoS ONE 5:e11070
42. Selbach M, Schwanhausser B, Thierfelder N, Fang Z et al (2008) Widespread changes in protein synthesis induced by microRNAs. Nature 455:58–63
43. Selkoe DJ, Podlisny MB (2002) Deciphering the genetic basis of Alzheimer’s disease. Annu Rev Genomics Hum Genet 3:67– 99
44. Siomi H, Siomi MC (2010) Posttranscriptional regulation of micro-RNA biogenesis in animals. Mol Cell 38:323–332
45. Sud A, Del Bono EA, Haines JL, Wiggs JL (2008) Fine mapping of the GLC1K juvenile primary open-angle glaucoma locus and exclusion of candidate genes. Mol Vis 14:1319– 1326
46. Tesseur I, Zou K, Esposito L, Bard F et al (2006) Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer’s pathology. J Clin Invest 116:3060–3069
47. Tomiyama T, Matsuyama S, Iso H, Umeda T et al (2010) A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci 30:4845– 4856
48. Vilardo E, Barbato C, Ciotti M, Cogoni C et al (2010) MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons. J Biol Chem 285:18344–18351
49. Wang WX, Rajeev BW, Stromberg AJ, Ren N et al (2008) The expression of microRNA miR-107 decreases early in Alzheimer’s disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci 28:1213–1223
50. Wang WX, Wilfred BR, Madathil SK, Tang G et al (2010) miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease. Am J Pathol 177:334–345
51. Wilquet V, De Strooper B (2004) Amyloid-beta precursor protein processing in neurodegeneration. Curr Opin Neurobiol 14:582– 588
52. Wu C, Xu B, Yuan P, Ott J et al (2010) Genome-wide examination of genetic variants associated with response to platinum-based chemotherapy in patients with small-cell lung cancer. Pharmaco-genet Genomics 20:389–395
53. Yamakuchi M, Ferlito M, Lowenstein CJ (2008) miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A 105:13421–13426