메뉴 건너뛰기




Volumn 68, Issue 6, 2016, Pages 879-891

Natural Polyphenols in Cancer Chemoresistance

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; FLAVONOID; MULTIDRUG RESISTANCE PROTEIN; NATURAL PRODUCT; POLYPHENOL DERIVATIVE; BENZENE DERIVATIVE; POLYPHENOL; TUMOR PROTEIN;

EID: 84978796186     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2016.1192201     Document Type: Review
Times cited : (46)

References (147)
  • 2
    • 84919725343 scopus 로고    scopus 로고
    • Hybrid curcumin compounds: a new strategy for cancer treatment
    • M.H.Teiten, M.Dicato, and M.Diederich: Hybrid curcumin compounds: a new strategy for cancer treatment. Molecules 19, 20839–20863, 2014.
    • (2014) Molecules , vol.19 , pp. 20839-20863
    • Teiten, M.H.1    Dicato, M.2    Diederich, M.3
  • 3
    • 23844481408 scopus 로고    scopus 로고
    • Mechanisms of drug resistance in cancer chemotherapy
    • Y.A.Luqmani: Mechanisms of drug resistance in cancer chemotherapy. Med Princ Pract 14 Suppl 1, 35–48, 2005.
    • (2005) Med Princ Pract , vol.14 , pp. 35-48
    • Luqmani, Y.A.1
  • 4
    • 0028224534 scopus 로고
    • Cell biological mechanisms of multidrug resistance in tumors
    • S.M.Simon and M.Schindler: Cell biological mechanisms of multidrug resistance in tumors. Proc Natl Acad Sci USA 91, 3497–3504, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3497-3504
    • Simon, S.M.1    Schindler, M.2
  • 5
    • 0036519363 scopus 로고    scopus 로고
    • DNA and its associated processes as targets for cancer therapy
    • L.H.Hurley: DNA and its associated processes as targets for cancer therapy. Nat Rev Cancer 2, 188–200, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 188-200
    • Hurley, L.H.1
  • 6
    • 0018569942 scopus 로고
    • A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate
    • J.H.Goldie and A.J.Coldman: A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep 63, 1727–1733, 1979.
    • (1979) Cancer Treat Rep , vol.63 , pp. 1727-1733
    • Goldie, J.H.1    Coldman, A.J.2
  • 7
    • 84914115390 scopus 로고    scopus 로고
    • Predictive biomarkers in renal cell cancer: insights in drug resistance mechanisms
    • J.C.van der Mijn, J.W.Mier, H.J.Broxterman, and H.M.Verheul: Predictive biomarkers in renal cell cancer: insights in drug resistance mechanisms. Drug Resist Updat 17, 77–88, 2014.
    • (2014) Drug Resist Updat , vol.17 , pp. 77-88
    • van der Mijn, J.C.1    Mier, J.W.2    Broxterman, H.J.3    Verheul, H.M.4
  • 8
    • 13644254794 scopus 로고    scopus 로고
    • Molecular mechanisms of drug resistance
    • D.B.Longley and P.G.Johnston: Molecular mechanisms of drug resistance. J Pathol 205, 275–292, 2005.
    • (2005) J Pathol , vol.205 , pp. 275-292
    • Longley, D.B.1    Johnston, P.G.2
  • 9
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • M.M.Gottesman and I.Pastan: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62, 385–427, 1993.
    • (1993) Annu Rev Biochem , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 10
    • 73949102380 scopus 로고    scopus 로고
    • Multidrug resistance in cancer
    • B.C.Baguley: Multidrug resistance in cancer. Methods Mol Biol 596, 1–14, 2010.
    • (2010) Methods Mol Biol , vol.596 , pp. 1-14
    • Baguley, B.C.1
  • 11
    • 53849096994 scopus 로고    scopus 로고
    • An overview of cancer multidrug resistance: a still unsolved problem
    • H.Lage: An overview of cancer multidrug resistance: a still unsolved problem. Cell Mol Life Sci 65, 3145–3167, 2008.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3145-3167
    • Lage, H.1
  • 12
    • 84860689257 scopus 로고    scopus 로고
    • Drug resistance: still a daunting challenge to the successful treatment of AML
    • B.C.Shaffer, J.P.Gillet, C.Patel, M.R.Baer, S.E.Bates, et al.: Drug resistance: still a daunting challenge to the successful treatment of AML. Drug Resist Updat 15, 62–69, 2012.
    • (2012) Drug Resist Updat , vol.15 , pp. 62-69
    • Shaffer, B.C.1    Gillet, J.P.2    Patel, C.3    Baer, M.R.4    Bates, S.E.5
  • 13
    • 33847036752 scopus 로고    scopus 로고
    • Ability to acquire drug resistance arises early during the tumorigenesis process
    • E.Yague, A.Arance, L.Kubitza, M.O'Hare, P.Jat, et al.: Ability to acquire drug resistance arises early during the tumorigenesis process. Cancer Res 67, 1130–1137, 2007.
    • (2007) Cancer Res , vol.67 , pp. 1130-1137
    • Yague, E.1    Arance, A.2    Kubitza, L.3    O'Hare, M.4    Jat, P.5
  • 14
    • 48349098840 scopus 로고    scopus 로고
    • Resistance to chemotherapy: new treatments and novel insights into an old problem
    • S.Raguz and E.Yague: Resistance to chemotherapy: new treatments and novel insights into an old problem. Br J Cancer 99, 387–391, 2008.
    • (2008) Br J Cancer , vol.99 , pp. 387-391
    • Raguz, S.1    Yague, E.2
  • 15
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • M.M.Gottesman: Mechanisms of cancer drug resistance. Annu Rev Med 53, 615–627, 2002.
    • (2002) Annu Rev Med , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 16
    • 34447258681 scopus 로고    scopus 로고
    • Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize
    • D.Fukumura and R.K.Jain: Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. J Cell Biochem 101, 937–949, 2007.
    • (2007) J Cell Biochem , vol.101 , pp. 937-949
    • Fukumura, D.1    Jain, R.K.2
  • 17
    • 0032412571 scopus 로고    scopus 로고
    • Role of oxygenation and vascularization in drug resistance
    • J.Mattern and M.Volm: Role of oxygenation and vascularization in drug resistance. Cytotechnology 27, 249–256, 1998.
    • (1998) Cytotechnology , vol.27 , pp. 249-256
    • Mattern, J.1    Volm, M.2
  • 19
    • 28544444487 scopus 로고    scopus 로고
    • Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cells
    • W.Bardenheuer, K.Lehmberg, I.Rattmann, A.Brueckner, A.Schneider, et al.: Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cells. Leukemia 19, 2281–2288, 2005.
    • (2005) Leukemia , vol.19 , pp. 2281-2288
    • Bardenheuer, W.1    Lehmberg, K.2    Rattmann, I.3    Brueckner, A.4    Schneider, A.5
  • 20
    • 0642374221 scopus 로고    scopus 로고
    • The role of glutathione-S-transferase in anti-cancer drug resistance
    • D.M.Townsend and K.D.Tew: The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 22, 7369–7375, 2003.
    • (2003) Oncogene , vol.22 , pp. 7369-7375
    • Townsend, D.M.1    Tew, K.D.2
  • 21
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: the multidrug resistance-associated proteins
    • P.Borst, R.Evers, M.Kool, and J.Wijnholds: A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 92, 1295–1302, 2000.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 22
    • 84919882525 scopus 로고    scopus 로고
    • Suppression of c-Myc is involved in multi-walled carbon nanotubes' down-regulation of ATP-binding cassette transporters in human colon adenocarcinoma cells
    • Z.Wang, Y.Xu, X.Meng, F.Watari, H.Liu, et al.: Suppression of c-Myc is involved in multi-walled carbon nanotubes' down-regulation of ATP-binding cassette transporters in human colon adenocarcinoma cells. Toxicol Appl Pharmacol 282, 42–51, 2014.
    • (2014) Toxicol Appl Pharmacol , vol.282 , pp. 42-51
    • Wang, Z.1    Xu, Y.2    Meng, X.3    Watari, F.4    Liu, H.5
  • 23
    • 0030685129 scopus 로고    scopus 로고
    • Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence
    • C.Kast and P.Gros: Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence. J Biol Chem 272, 26479–26487, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 26479-26487
    • Kast, C.1    Gros, P.2
  • 25
    • 0034917716 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfamily
    • M.Dean, A.Rzhetsky, and R.Allikmets: The human ATP-binding cassette (ABC) transporter superfamily. Genome Res 11, 1156–1166, 2001.
    • (2001) Genome Res , vol.11 , pp. 1156-1166
    • Dean, M.1    Rzhetsky, A.2    Allikmets, R.3
  • 27
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: role of ATP-dependent transporters
    • M.M.Gottesman, T.Fojo, and S.E.Bates: Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2, 48–58, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 28
    • 84918586982 scopus 로고    scopus 로고
    • Cancer-targeted MDR-1 siRNA delivery using self-cross-linked glycol chitosan nanoparticles to overcome drug resistance
    • J.Y.Yhee, S.Song, S.J.Lee, S.Park, K.Kim, et al.: Cancer-targeted MDR-1 siRNA delivery using self-cross-linked glycol chitosan nanoparticles to overcome drug resistance. J Control Release 198C, 1–9, 2014.
    • (2014) J Control Release , vol.198C , pp. 1-9
    • Yhee, J.Y.1    Song, S.2    Lee, S.J.3    Park, S.4    Kim, K.5
  • 29
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • E.M.Leslie, R.G.Deeley, and S.P.Cole: Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol 204, 216–237, 2005.
    • (2005) Toxicol Appl Pharmacol , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 30
    • 0028855891 scopus 로고
    • Expression of the multidrug resistance-associated protein (MRP) gene in human cancers
    • K.Nooter, A.M.Westerman, M.J.Flens, G.J.Zaman, R.J.Scheper, et al.: Expression of the multidrug resistance-associated protein (MRP) gene in human cancers. Clin Cancer Res 1, 1301–1310, 1995.
    • (1995) Clin Cancer Res , vol.1 , pp. 1301-1310
    • Nooter, K.1    Westerman, A.M.2    Flens, M.J.3    Zaman, G.J.4    Scheper, R.J.5
  • 31
    • 0842284169 scopus 로고    scopus 로고
    • Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction
    • J.Sun, Z.G.He, G.Cheng, S.J.Wang, X.H.Hao, et al.: Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction. Med Sci Monit 10, RA5–14, 2004.
    • (2004) Med Sci Monit , vol.10 , pp. RA5-RA14
    • Sun, J.1    He, Z.G.2    Cheng, G.3    Wang, S.J.4    Hao, X.H.5
  • 32
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • H.E.Bryant, N.Schultz, H.D.Thomas, K.M.Parker, D.Flower, et al.: Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913–917, 2005.
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3    Parker, K.M.4    Flower, D.5
  • 33
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • H.Farmer, N.McCabe, C.J.Lord, A.N.Tutt, D.A.Johnson, et al.: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917–921, 2005.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3    Tutt, A.N.4    Johnson, D.A.5
  • 34
    • 84870855799 scopus 로고    scopus 로고
    • Tankyrase-targeted therapeutics: expanding opportunities in the PARP family
    • J.L.Riffell, C.J.Lord, and A.Ashworth: Tankyrase-targeted therapeutics: expanding opportunities in the PARP family. Nat Rev Drug Discov 11, 923–936, 2012.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 923-936
    • Riffell, J.L.1    Lord, C.J.2    Ashworth, A.3
  • 35
    • 84855773635 scopus 로고    scopus 로고
    • A snapshot of chemoresistance to PARP inhibitors
    • A.Chiarugi: A snapshot of chemoresistance to PARP inhibitors. Trends Pharmacol Sci 33, 42–48, 2012.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 42-48
    • Chiarugi, A.1
  • 37
    • 79952234403 scopus 로고    scopus 로고
    • Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation
    • Y.Wang, Y.A.Suh, M.Y.Fuller, J.G.Jackson, S.Xiong, et al.: Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest 121, 893–904, 2011.
    • (2011) J Clin Invest , vol.121 , pp. 893-904
    • Wang, Y.1    Suh, Y.A.2    Fuller, M.Y.3    Jackson, J.G.4    Xiong, S.5
  • 38
    • 84906091529 scopus 로고    scopus 로고
    • Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma
    • L.Chen, Y.Zhao, G.C.Halliday, P.Berry, R.F.Rousseau, et al.: Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma. Br J Cancer 111, 716–725, 2014.
    • (2014) Br J Cancer , vol.111 , pp. 716-725
    • Chen, L.1    Zhao, Y.2    Halliday, G.C.3    Berry, P.4    Rousseau, R.F.5
  • 39
    • 0036240701 scopus 로고    scopus 로고
    • The proteasome: a novel target for cancer chemotherapy
    • J.B.Almond and G.M.Cohen: The proteasome: a novel target for cancer chemotherapy. Leukemia 16, 433–443, 2002.
    • (2002) Leukemia , vol.16 , pp. 433-443
    • Almond, J.B.1    Cohen, G.M.2
  • 40
    • 80052697287 scopus 로고    scopus 로고
    • The role of autophagy in cancer: therapeutic implications
    • Z.J.Yang, C.E.Chee, S.Huang, and F.A.Sinicrope: The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther 10, 1533–1541, 2011.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1533-1541
    • Yang, Z.J.1    Chee, C.E.2    Huang, S.3    Sinicrope, F.A.4
  • 41
    • 84859609587 scopus 로고    scopus 로고
    • Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells
    • X.L.Guo, D.Li, F.Hu, J.R.Song, S.S.Zhang, et al.: Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Cancer Lett 320, 171–179, 2012.
    • (2012) Cancer Lett , vol.320 , pp. 171-179
    • Guo, X.L.1    Li, D.2    Hu, F.3    Song, J.R.4    Zhang, S.S.5
  • 42
    • 84863098088 scopus 로고    scopus 로고
    • Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde?
    • S.Zhou, L.Zhao, M.Kuang, B.Zhang, Z.Liang, et al.: Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde?. Cancer Lett 323, 115–127, 2012.
    • (2012) Cancer Lett , vol.323 , pp. 115-127
    • Zhou, S.1    Zhao, L.2    Kuang, M.3    Zhang, B.4    Liang, Z.5
  • 43
    • 84856857494 scopus 로고    scopus 로고
    • Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells
    • G.M.Ajabnoor, T.Crook, and H.M.Coley: Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells. Cell Death Dis 3, e260, 2012.
    • (2012) Cell Death Dis , vol.3 , pp. e260
    • Ajabnoor, G.M.1    Crook, T.2    Coley, H.M.3
  • 44
    • 79959693771 scopus 로고    scopus 로고
    • The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells
    • S.A.Rushworth and D.J.Macewan: The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells. Cancers (Basel) 3, 1605–1621, 2011.
    • (2011) Cancers (Basel) , vol.3 , pp. 1605-1621
    • Rushworth, S.A.1    Macewan, D.J.2
  • 45
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • discussion 3080
    • I.B.Weinstein and A.Joe: Oncogene addiction. Cancer Res 68, 3077–3080; discussion 3080, 2008.
    • (2008) Cancer Res , vol.68 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 46
    • 37249003928 scopus 로고    scopus 로고
    • Oncogene addiction: setting the stage for molecularly targeted cancer therapy
    • S.V.Sharma and J.Settleman: Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev 21, 3214–3231, 2007.
    • (2007) Genes Dev , vol.21 , pp. 3214-3231
    • Sharma, S.V.1    Settleman, J.2
  • 47
    • 80052749408 scopus 로고    scopus 로고
    • Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer
    • D.Gioeli, W.Wunderlich, J.Sebolt-Leopold, S.Bekiranov, J.D.Wulfkuhle, et al.: Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer. Mol Cancer Ther 10, 1581–1590, 2011.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1581-1590
    • Gioeli, D.1    Wunderlich, W.2    Sebolt-Leopold, J.3    Bekiranov, S.4    Wulfkuhle, J.D.5
  • 48
    • 47249123747 scopus 로고    scopus 로고
    • Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy
    • E.Jabbour, H.Kantarjian, D.Jones, M.Breeden, G.Garcia-Manero, et al.: Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy. Blood 112, 53–55, 2008.
    • (2008) Blood , vol.112 , pp. 53-55
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3    Breeden, M.4    Garcia-Manero, G.5
  • 49
    • 35648949422 scopus 로고    scopus 로고
    • BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
    • discussion 1680
    • D.B.Costa, B.Halmos, A.Kumar, S.T.Schumer, M.S.Huberman, et al.: BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS Med 4, 1669–1679; discussion 1680, 2007.
    • (2007) PLoS Med , vol.4 , pp. 1669-1679
    • Costa, D.B.1    Halmos, B.2    Kumar, A.3    Schumer, S.T.4    Huberman, M.S.5
  • 50
    • 33847237571 scopus 로고    scopus 로고
    • Darwinian medicine: a case for cancer
    • M.Greaves: Darwinian medicine: a case for cancer. Nat Rev Cancer 7, 213–221, 2007.
    • (2007) Nat Rev Cancer , vol.7 , pp. 213-221
    • Greaves, M.1
  • 51
    • 84899797571 scopus 로고    scopus 로고
    • Drug resistance and the role of combination chemotherapy in improving patient outcomes
    • D.A.Yardley: Drug resistance and the role of combination chemotherapy in improving patient outcomes. Int J Breast Cancer 2013, 137414, 2013.
    • (2013) Int J Breast Cancer , vol.2013 , pp. 137414
    • Yardley, D.A.1
  • 52
    • 84925664415 scopus 로고    scopus 로고
    • ATM and ATR as therapeutic targets in cancer
    • A.M.Weber and A.J.Ryan: ATM and ATR as therapeutic targets in cancer. Pharmacol Ther 149, 124–138, 2015.
    • (2015) Pharmacol Ther , vol.149 , pp. 124-138
    • Weber, A.M.1    Ryan, A.J.2
  • 53
    • 58349102840 scopus 로고    scopus 로고
    • Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy
    • M.F.Ullah: Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy. Asian Pac J Cancer Prev 9, 1–6, 2008.
    • (2008) Asian Pac J Cancer Prev , vol.9 , pp. 1-6
    • Ullah, M.F.1
  • 54
    • 0026051296 scopus 로고
    • P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil
    • T.P.Miller, T.M.Grogan, W.S.Dalton, C.M.Spier, R.J.Scheper, et al.: P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil. J Clin Oncol 9, 17–24, 1991.
    • (1991) J Clin Oncol , vol.9 , pp. 17-24
    • Miller, T.P.1    Grogan, T.M.2    Dalton, W.S.3    Spier, C.M.4    Scheper, R.J.5
  • 55
    • 0037122701 scopus 로고    scopus 로고
    • C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump
    • F.Leonessa, J.H.Kim, A.Ghiorghis, R.J.Kulawiec, C.Hammer, et al.: C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump. J Med Chem 45, 390–398, 2002.
    • (2002) J Med Chem , vol.45 , pp. 390-398
    • Leonessa, F.1    Kim, J.H.2    Ghiorghis, A.3    Kulawiec, R.J.4    Hammer, C.5
  • 56
    • 84886233028 scopus 로고    scopus 로고
    • Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity
    • N.Bluthgen, J.P.Sumpter, A.Odermatt, and K.Fent: Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity. Aquat Toxicol 144–145, 96–104, 2013.
    • (2013) Aquat Toxicol , vol.144-145 , pp. 96-104
    • Bluthgen, N.1    Sumpter, J.P.2    Odermatt, A.3    Fent, K.4
  • 57
    • 84897092972 scopus 로고    scopus 로고
    • Tamoxifen reduces P-gp-mediated multidrug resistance via inhibiting the PI3K/Akt signaling pathway in ER-negative human gastric cancer cells
    • Z.Mao, J.Zhou, J.Luan, W.Sheng, X.Shen, et al.: Tamoxifen reduces P-gp-mediated multidrug resistance via inhibiting the PI3K/Akt signaling pathway in ER-negative human gastric cancer cells. Biomed Pharmacother 68, 179–183, 2014.
    • (2014) Biomed Pharmacother , vol.68 , pp. 179-183
    • Mao, Z.1    Zhou, J.2    Luan, J.3    Sheng, W.4    Shen, X.5
  • 58
    • 0030589989 scopus 로고    scopus 로고
    • Steroid treatment, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells
    • K.M.Barnes, B.Dickstein, G.B.Cutler, Jr., T.Fojo, and S.E.Bates: Steroid treatment, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells. Biochemistry 35, 4820–4827, 1996.
    • (1996) Biochemistry , vol.35 , pp. 4820-4827
    • Barnes, K.M.1    Dickstein, B.2    Cutler, G.B.3    Fojo, T.4    Bates, S.E.5
  • 59
    • 0032833582 scopus 로고    scopus 로고
    • Malignant endometrial polyps in postmenopausal breast cancer tamoxifen-treated patients
    • I.Cohen, J.Bernheim, R.Azaria, R.Tepper, R.Sharony, et al.: Malignant endometrial polyps in postmenopausal breast cancer tamoxifen-treated patients. Gynecol Oncol 75, 136–141, 1999.
    • (1999) Gynecol Oncol , vol.75 , pp. 136-141
    • Cohen, I.1    Bernheim, J.2    Azaria, R.3    Tepper, R.4    Sharony, R.5
  • 60
    • 84896712232 scopus 로고    scopus 로고
    • Inhibition of protein kinase C/Twist1 signaling augments anticancer effects of androgen deprivation and enzalutamide in prostate cancer
    • M.Shiota, A.Yokomizo, A.Takeuchi, K.Imada, E.Kashiwagi, et al.: Inhibition of protein kinase C/Twist1 signaling augments anticancer effects of androgen deprivation and enzalutamide in prostate cancer. Clin Cancer Res 20, 951–961, 2014.
    • (2014) Clin Cancer Res , vol.20 , pp. 951-961
    • Shiota, M.1    Yokomizo, A.2    Takeuchi, A.3    Imada, K.4    Kashiwagi, E.5
  • 61
    • 84923130724 scopus 로고    scopus 로고
    • Characterization and comparison of phenolic composition, antioxidant capacity and instrumental taste profile of juices from different botanical origins
    • D.Granato, A.R.Karnopp, and S.M.van Ruth: Characterization and comparison of phenolic composition, antioxidant capacity and instrumental taste profile of juices from different botanical origins. J Sci Food Agric, 2014.
    • (2014) J Sci Food Agric
    • Granato, D.1    Karnopp, A.R.2    van Ruth, S.M.3
  • 62
    • 84929464325 scopus 로고    scopus 로고
    • The effects of soy supplementation on gene expression in breast cancer: a randomized placebo-controlled study
    • M.Shike, A.S.Doane, L.Russo, R.Cabal, J.Reis-Filo, et al.: The effects of soy supplementation on gene expression in breast cancer: a randomized placebo-controlled study. J Natl Cancer Inst 106, 2014.
    • (2014) J Natl Cancer Inst , vol.106
    • Shike, M.1    Doane, A.S.2    Russo, L.3    Cabal, R.4    Reis-Filo, J.5
  • 63
    • 77956304287 scopus 로고    scopus 로고
    • A quantitative structure-activity relationship for the modulation effects of flavonoids on p-glycoprotein-mediated transport
    • M.T.Sheu, Y.B.Liou, Y.H.Kao, Y.K.Lin, and H.O.Ho: A quantitative structure-activity relationship for the modulation effects of flavonoids on p-glycoprotein-mediated transport. Chem Pharm Bull 58, 1187–1194, 2010.
    • (2010) Chem Pharm Bull , vol.58 , pp. 1187-1194
    • Sheu, M.T.1    Liou, Y.B.2    Kao, Y.H.3    Lin, Y.K.4    Ho, H.O.5
  • 64
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: bioavailability, metabolic effects, and safety
    • J.A.Ross and C.M.Kasum: Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22, 19–34, 2002.
    • (2002) Annu Rev Nutr , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 65
    • 44149088311 scopus 로고    scopus 로고
    • Cancer phytotherapeutics: role for flavonoids at the cellular level
    • A.Kale, S.Gawande, and S.Kotwal: Cancer phytotherapeutics: role for flavonoids at the cellular level. Phytother Res 22, 567–577, 2008.
    • (2008) Phytother Res , vol.22 , pp. 567-577
    • Kale, A.1    Gawande, S.2    Kotwal, S.3
  • 66
    • 69949106198 scopus 로고    scopus 로고
    • Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy
    • T.Bansal, M.Jaggi, R.K.Khar, and S.Talegaonkar: Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy. J Pharm Pharm Sci 12, 46–78, 2009.
    • (2009) J Pharm Pharm Sci , vol.12 , pp. 46-78
    • Bansal, T.1    Jaggi, M.2    Khar, R.K.3    Talegaonkar, S.4
  • 67
    • 33644914487 scopus 로고    scopus 로고
    • Flavonoid-drug interactions: effects of flavonoids on ABC transporters
    • M.E.Morris and S.Zhang: Flavonoid-drug interactions: effects of flavonoids on ABC transporters. Life Sci 78, 2116–2130, 2006.
    • (2006) Life Sci , vol.78 , pp. 2116-2130
    • Morris, M.E.1    Zhang, S.2
  • 68
    • 84926254640 scopus 로고    scopus 로고
    • Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking
    • M.Saeed, O.Kadioglu, H.Khalid, Y.Sugimoto, and T.Efferth: Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking. J Nutr Biochem 26, 44–56, 2015.
    • (2015) J Nutr Biochem , vol.26 , pp. 44-56
    • Saeed, M.1    Kadioglu, O.2    Khalid, H.3    Sugimoto, Y.4    Efferth, T.5
  • 69
    • 84858039954 scopus 로고    scopus 로고
    • Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation
    • K.F.Chan, I.L.Wong, J.W.Kan, C.S.Yan, L.M.Chow, et al.: Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation. J Med Chem 55, 1999–2014, 2012.
    • (2012) J Med Chem , vol.55 , pp. 1999-2014
    • Chan, K.F.1    Wong, I.L.2    Kan, J.W.3    Yan, C.S.4    Chow, L.M.5
  • 70
    • 79957551963 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein-mediated anticancer drug accumulation, cytotoxicity, and ATPase activity by flavonoid interactions
    • V.H.Tran, D.Marks, R.K.Duke, M.Bebawy, C.C.Duke, et al.: Modulation of P-glycoprotein-mediated anticancer drug accumulation, cytotoxicity, and ATPase activity by flavonoid interactions. Nutr Cancer 63, 435–443, 2011.
    • (2011) Nutr Cancer , vol.63 , pp. 435-443
    • Tran, V.H.1    Marks, D.2    Duke, R.K.3    Bebawy, M.4    Duke, C.C.5
  • 71
    • 74049143120 scopus 로고    scopus 로고
    • Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response
    • A.I.Alvarez, R.Real, M.Perez, G.Mendoza, J.G.Prieto, et al.: Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response. J Pharm Sci 99, 598–617, 2010.
    • (2010) J Pharm Sci , vol.99 , pp. 598-617
    • Alvarez, A.I.1    Real, R.2    Perez, M.3    Mendoza, G.4    Prieto, J.G.5
  • 72
    • 84900385922 scopus 로고    scopus 로고
    • P-glycoprotein mediates the collateral sensitivity of multidrug resistant cells to steroid hormones
    • R.M.Laberge, R.Ambadipudi, and E.Georges: P-glycoprotein mediates the collateral sensitivity of multidrug resistant cells to steroid hormones. Biochem Biophys Res Commun 447, 574–579, 2014.
    • (2014) Biochem Biophys Res Commun , vol.447 , pp. 574-579
    • Laberge, R.M.1    Ambadipudi, R.2    Georges, E.3
  • 74
    • 0027981909 scopus 로고
    • Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target
    • G.Scambia, F.O.Ranelletti, P.B.Panici, R.De Vincenzo, G.Bonanno, et al.: Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target. Cancer Chemother Pharmacol 34, 459–464, 1994.
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 459-464
    • Scambia, G.1    Ranelletti, F.O.2    Panici, P.B.3    De Vincenzo, R.4    Bonanno, G.5
  • 75
    • 84874884710 scopus 로고    scopus 로고
    • Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition
    • A.B.Ke, S.Eyal, F.S.Chung, J.M.Link, D.A.Mankoff, et al.: Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition. J Nucl Med 54, 437–446, 2013.
    • (2013) J Nucl Med , vol.54 , pp. 437-446
    • Ke, A.B.1    Eyal, S.2    Chung, F.S.3    Link, J.M.4    Mankoff, D.A.5
  • 76
    • 70349881605 scopus 로고    scopus 로고
    • Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB
    • I.Murtaza, V.M.Adhami, B.B.Hafeez, M.Saleem, and H.Mukhtar: Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB. Int J Cancer 125, 2465–2473, 2009.
    • (2009) Int J Cancer , vol.125 , pp. 2465-2473
    • Murtaza, I.1    Adhami, V.M.2    Hafeez, B.B.3    Saleem, M.4    Mukhtar, H.5
  • 77
    • 28744436977 scopus 로고    scopus 로고
    • Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells
    • S.Kitagawa, T.Nabekura, T.Takahashi, Y.Nakamura, H.Sakamoto, et al.: Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells. Biol Pharm Bull 28, 2274–2278, 2005.
    • (2005) Biol Pharm Bull , vol.28 , pp. 2274-2278
    • Kitagawa, S.1    Nabekura, T.2    Takahashi, T.3    Nakamura, Y.4    Sakamoto, H.5
  • 78
    • 16244371036 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein function and expression by kaempferol and quercetin
    • P.Limtrakul, O.Khantamat, and K.Pintha: Inhibition of P-glycoprotein function and expression by kaempferol and quercetin. J Chemother 17, 86–95, 2005.
    • (2005) J Chemother , vol.17 , pp. 86-95
    • Limtrakul, P.1    Khantamat, O.2    Pintha, K.3
  • 79
    • 33645972931 scopus 로고    scopus 로고
    • In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain
    • R.Badhan and J.Penny: In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain. Eur J Med Chem 41, 285–295, 2006.
    • (2006) Eur J Med Chem , vol.41 , pp. 285-295
    • Badhan, R.1    Penny, J.2
  • 80
    • 84908679596 scopus 로고    scopus 로고
    • Upregulation of both heme oxygenase-1 and ATPase inhibitory factor 1 renders tumoricidal activity by synthetic flavonoids via depleting cellular ATP
    • P.J.Lee, I.Shin, S.Y.Seo, H.Kim, and H.P.Kim: Upregulation of both heme oxygenase-1 and ATPase inhibitory factor 1 renders tumoricidal activity by synthetic flavonoids via depleting cellular ATP. Bioorg Med Chem Lett 24, 4845–4849, 2014.
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 4845-4849
    • Lee, P.J.1    Shin, I.2    Seo, S.Y.3    Kim, H.4    Kim, H.P.5
  • 81
    • 0013016426 scopus 로고    scopus 로고
    • Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1)
    • E.M.Leslie, R.G.Deeley, and S.P.Cole: Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). Drug Metab Dispos 31, 11–15, 2003.
    • (2003) Drug Metab Dispos , vol.31 , pp. 11-15
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 82
    • 0032581075 scopus 로고    scopus 로고
    • Suppression of multidrug resistance via inhibition of heat shock factor by quercetin in MDR cells
    • S.H.Kim, G.S.Yeo, Y.S.Lim, C.D.Kang, C.M.Kim, et al.: Suppression of multidrug resistance via inhibition of heat shock factor by quercetin in MDR cells. Exp Mol Med 30, 87–92, 1998.
    • (1998) Exp Mol Med , vol.30 , pp. 87-92
    • Kim, S.H.1    Yeo, G.S.2    Lim, Y.S.3    Kang, C.D.4    Kim, C.M.5
  • 83
    • 0034599915 scopus 로고    scopus 로고
    • Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance
    • Y.Sadzuka, T.Sugiyama, and T.Sonobe: Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance. Toxicol Lett 114, 155–162, 2000.
    • (2000) Toxicol Lett , vol.114 , pp. 155-162
    • Sadzuka, Y.1    Sugiyama, T.2    Sonobe, T.3
  • 84
    • 0027482403 scopus 로고
    • Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells
    • C.H.Versantvoort, G.J.Schuurhuis, H.M.Pinedo, C.A.Eekman, C.M.Kuiper, et al.: Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells. Br J Cancer 68, 939–946, 1993.
    • (1993) Br J Cancer , vol.68 , pp. 939-946
    • Versantvoort, C.H.1    Schuurhuis, G.J.2    Pinedo, H.M.3    Eekman, C.A.4    Kuiper, C.M.5
  • 85
    • 0031060647 scopus 로고    scopus 로고
    • Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein
    • A.F.Castro and G.A.Altenberg: Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein. Biochem Pharmacol 53, 89–93, 1997.
    • (1997) Biochem Pharmacol , vol.53 , pp. 89-93
    • Castro, A.F.1    Altenberg, G.A.2
  • 86
    • 0030878058 scopus 로고    scopus 로고
    • Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein
    • J.H.Hooijberg, H.J.Broxterman, M.Heijn, D.L.Fles, J.Lankelma, et al.: Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein. FEBS Lett 413, 344–348, 1997.
    • (1997) FEBS Lett , vol.413 , pp. 344-348
    • Hooijberg, J.H.1    Broxterman, H.J.2    Heijn, M.3    Fles, D.L.4    Lankelma, J.5
  • 87
    • 0035047222 scopus 로고    scopus 로고
    • Structure-activity relationships of multidrug resistance reversers
    • M.Wiese and I.K.Pajeva: Structure-activity relationships of multidrug resistance reversers. Curr Med Chem 8, 685–713, 2001.
    • (2001) Curr Med Chem , vol.8 , pp. 685-713
    • Wiese, M.1    Pajeva, I.K.2
  • 88
    • 34548580164 scopus 로고    scopus 로고
    • Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structure-activity relationship
    • K.Katayama, K.Masuyama, S.Yoshioka, H.Hasegawa, J.Mitsuhashi, et al.: Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structure-activity relationship. Cancer Chemother Pharmacol 60, 789–797, 2007.
    • (2007) Cancer Chemother Pharmacol , vol.60 , pp. 789-797
    • Katayama, K.1    Masuyama, K.2    Yoshioka, S.3    Hasegawa, H.4    Mitsuhashi, J.5
  • 89
    • 79960407129 scopus 로고    scopus 로고
    • Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin
    • J.S.Choi, Y.J.Piao, and K.W.Kang: Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin. Arch Pharm Res 34, 607–613, 2011.
    • (2011) Arch Pharm Res , vol.34 , pp. 607-613
    • Choi, J.S.1    Piao, Y.J.2    Kang, K.W.3
  • 90
    • 84864360535 scopus 로고    scopus 로고
    • In vitro effect of quercetin on human gastric carcinoma: targeting cancer cells death and MDR
    • S.Borska, M.Chmielewska, T.Wysocka, M.Drag-Zalesinska, M.Zabel, et al.: In vitro effect of quercetin on human gastric carcinoma: targeting cancer cells death and MDR. Food Chem Toxicol 50, 3375–3383, 2012.
    • (2012) Food Chem Toxicol , vol.50 , pp. 3375-3383
    • Borska, S.1    Chmielewska, M.2    Wysocka, T.3    Drag-Zalesinska, M.4    Zabel, M.5
  • 91
    • 84864399172 scopus 로고    scopus 로고
    • Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells
    • J.Yuan, I.L.Wong, T.Jiang, S.W.Wang, T.Liu, et al.: Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells. Eur J Med Chem 54, 413–422, 2012.
    • (2012) Eur J Med Chem , vol.54 , pp. 413-422
    • Yuan, J.1    Wong, I.L.2    Jiang, T.3    Wang, S.W.4    Liu, T.5
  • 93
    • 25844443754 scopus 로고    scopus 로고
    • Breast cancer resistance protein: molecular target for anticancer drug resistance and pharmacokinetics/pharmacodynamics
    • Y.Sugimoto, S.Tsukahara, E.Ishikawa, and J.Mitsuhashi: Breast cancer resistance protein: molecular target for anticancer drug resistance and pharmacokinetics/pharmacodynamics. Cancer Sci 96, 457–465, 2005.
    • (2005) Cancer Sci , vol.96 , pp. 457-465
    • Sugimoto, Y.1    Tsukahara, S.2    Ishikawa, E.3    Mitsuhashi, J.4
  • 94
    • 59049104003 scopus 로고    scopus 로고
    • Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy
    • K.Noguchi, K.Katayama, J.Mitsuhashi, and Y.Sugimoto: Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy. Adv Drug Deliv Rev 61, 26–33, 2009.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 26-33
    • Noguchi, K.1    Katayama, K.2    Mitsuhashi, J.3    Sugimoto, Y.4
  • 95
    • 84910142657 scopus 로고    scopus 로고
    • Polyphenols and the human brain: plant “secondary metabolite” ecologic roles and endogenous signaling functions drive benefits
    • D.O.Kennedy: Polyphenols and the human brain: plant “secondary metabolite” ecologic roles and endogenous signaling functions drive benefits. Adv Nutr 5, 515–533, 2014.
    • (2014) Adv Nutr , vol.5 , pp. 515-533
    • Kennedy, D.O.1
  • 96
    • 3042569646 scopus 로고    scopus 로고
    • Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance
    • Y.Imai, S.Tsukahara, S.Asada, and Y.Sugimoto: Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Cancer Res 64, 4346–4352, 2004.
    • (2004) Cancer Res , vol.64 , pp. 4346-4352
    • Imai, Y.1    Tsukahara, S.2    Asada, S.3    Sugimoto, Y.4
  • 97
    • 84897538348 scopus 로고    scopus 로고
    • Protective effect of tea polyphenols on renal ischemia/reperfusion injury via suppressing the activation of TLR4/NF-kappaB p65 signal pathway
    • Y.W.Li, Y.Zhang, L.Zhang, X.Li, J.B.Yu, et al.: Protective effect of tea polyphenols on renal ischemia/reperfusion injury via suppressing the activation of TLR4/NF-kappaB p65 signal pathway. Gene 542, 46–51, 2014.
    • (2014) Gene , vol.542 , pp. 46-51
    • Li, Y.W.1    Zhang, Y.2    Zhang, L.3    Li, X.4    Yu, J.B.5
  • 98
    • 84896891873 scopus 로고    scopus 로고
    • Dietary polyphenols and their effects on cell biochemistry and pathophysiology 2013
    • T.Maraldi, D.Vauzour, and C.Angeloni: Dietary polyphenols and their effects on cell biochemistry and pathophysiology 2013. Oxid Med Cell Longev 2014, 576363, 2014.
    • (2014) Oxid Med Cell Longev , vol.2014 , pp. 576363
    • Maraldi, T.1    Vauzour, D.2    Angeloni, C.3
  • 99
    • 76449110705 scopus 로고    scopus 로고
    • Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation
    • J.N.Lin, V.C.Lin, K.M.Rau, P.C.Shieh, D.H.Kuo, et al.: Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation. J Agric Food Chem 58, 1584–1592, 2010.
    • (2010) J Agric Food Chem , vol.58 , pp. 1584-1592
    • Lin, J.N.1    Lin, V.C.2    Rau, K.M.3    Shieh, P.C.4    Kuo, D.H.5
  • 100
    • 11144222544 scopus 로고    scopus 로고
    • Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance
    • R.P.Singh, G.U.Mallikarjuna, G.Sharma, S.Dhanalakshmi, A.K.Tyagi, et al.: Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance. Clin Cancer Res 10, 8641–8647, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 8641-8647
    • Singh, R.P.1    Mallikarjuna, G.U.2    Sharma, G.3    Dhanalakshmi, S.4    Tyagi, A.K.5
  • 101
    • 84866174563 scopus 로고    scopus 로고
    • Silibinin modulates TNF-alpha and IFN-gamma mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells
    • A.Tyagi, C.Agarwal, L.D.Dwyer-Nield, R.P.Singh, A.M.Malkinson, et al.: Silibinin modulates TNF-alpha and IFN-gamma mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells. Mol Carcinog 51, 832–842, 2012.
    • (2012) Mol Carcinog , vol.51 , pp. 832-842
    • Tyagi, A.1    Agarwal, C.2    Dwyer-Nield, L.D.3    Singh, R.P.4    Malkinson, A.M.5
  • 102
    • 84859203593 scopus 로고    scopus 로고
    • Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-kappaB and NF-kappaB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis
    • J.H.Kim, S.C.Gupta, B.Park, V.R.Yadav, and B.B.Aggarwal: Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-kappaB and NF-kappaB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis. Mol Nutr Food Res 56, 454–465, 2012.
    • (2012) Mol Nutr Food Res , vol.56 , pp. 454-465
    • Kim, J.H.1    Gupta, S.C.2    Park, B.3    Yadav, V.R.4    Aggarwal, B.B.5
  • 103
    • 5644283296 scopus 로고    scopus 로고
    • Role of chemopreventive agents in cancer therapy
    • T.Dorai and B.B.Aggarwal: Role of chemopreventive agents in cancer therapy. Cancer Lett 215, 129–140, 2004.
    • (2004) Cancer Lett , vol.215 , pp. 129-140
    • Dorai, T.1    Aggarwal, B.B.2
  • 104
    • 1642576201 scopus 로고    scopus 로고
    • Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol
    • S.Fulda and K.M.Debatin: Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res 64, 337–346, 2004.
    • (2004) Cancer Res , vol.64 , pp. 337-346
    • Fulda, S.1    Debatin, K.M.2
  • 105
    • 35848933017 scopus 로고    scopus 로고
    • Epigallocatechin-3 gallate induces growth inhibition and apoptosis in human breast cancer cells through survivin suppression
    • Y.Tang, D.Y.Zhao, S.Elliott, W.Zhao, T.J.Curiel, et al.: Epigallocatechin-3 gallate induces growth inhibition and apoptosis in human breast cancer cells through survivin suppression. Int J Oncol 31, 705–711, 2007.
    • (2007) Int J Oncol , vol.31 , pp. 705-711
    • Tang, Y.1    Zhao, D.Y.2    Elliott, S.3    Zhao, W.4    Curiel, T.J.5
  • 106
    • 84883465250 scopus 로고    scopus 로고
    • Silibinin reverses drug resistance in human small-cell lung carcinoma cells
    • D.Sadava and S.E.Kane: Silibinin reverses drug resistance in human small-cell lung carcinoma cells. Cancer Lett 339, 102–106, 2013.
    • (2013) Cancer Lett , vol.339 , pp. 102-106
    • Sadava, D.1    Kane, S.E.2
  • 107
    • 3242786628 scopus 로고    scopus 로고
    • Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells
    • A.K.Tyagi, C.Agarwal, D.C.Chan, and R.Agarwal: Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncol Rep 11, 493–499, 2004.
    • (2004) Oncol Rep , vol.11 , pp. 493-499
    • Tyagi, A.K.1    Agarwal, C.2    Chan, D.C.3    Agarwal, R.4
  • 108
    • 42549155669 scopus 로고    scopus 로고
    • Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cells
    • L.Zhou, P.Liu, B.Chen, Y.Wang, X.Wang, et al.: Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cells. Anticancer Res 28, 1119–1127, 2008.
    • (2008) Anticancer Res , vol.28 , pp. 1119-1127
    • Zhou, L.1    Liu, P.2    Chen, B.3    Wang, Y.4    Wang, X.5
  • 109
    • 0043025262 scopus 로고    scopus 로고
    • Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death
    • S.Dhanalakshmi, P.Agarwal, L.M.Glode, and R.Agarwal: Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death. Int J Cancer 106, 699–705, 2003.
    • (2003) Int J Cancer , vol.106 , pp. 699-705
    • Dhanalakshmi, S.1    Agarwal, P.2    Glode, L.M.3    Agarwal, R.4
  • 110
    • 84888878711 scopus 로고    scopus 로고
    • Silibinin improves the cytotoxicity of methotrexate in chemo resistant human rhabdomyosarcoma cell lines
    • S.A.Hussain and B.H.Marouf: Silibinin improves the cytotoxicity of methotrexate in chemo resistant human rhabdomyosarcoma cell lines. Saudi Med J 34, 1145–1150, 2013.
    • (2013) Saudi Med J , vol.34 , pp. 1145-1150
    • Hussain, S.A.1    Marouf, B.H.2
  • 111
    • 84978809439 scopus 로고    scopus 로고
    • Predictive markers of chemoresistance in advanced stages epithelial ovarian carcinoma
    • C.Bonneau, R.Rouzier, C.Geyl, A.Cortez, M.Castela, et al.: Predictive markers of chemoresistance in advanced stages epithelial ovarian carcinoma. Gynecol Oncol, 2014.
    • (2014) Gynecol Oncol
    • Bonneau, C.1    Rouzier, R.2    Geyl, C.3    Cortez, A.4    Castela, M.5
  • 112
    • 83555164705 scopus 로고    scopus 로고
    • The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells
    • J.J.Lu, Y.J.Cai, and J.Ding: The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells. Mol Cell Biochem 360, 253–260, 2012.
    • (2012) Mol Cell Biochem , vol.360 , pp. 253-260
    • Lu, J.J.1    Cai, Y.J.2    Ding, J.3
  • 113
    • 84902664217 scopus 로고    scopus 로고
    • Cecal succinate elevated by some dietary polyphenols may inhibit colon cancer cell proliferation and angiogenesis
    • T.Haraguchi, T.Kayashima, Y.Okazaki, J.Inoue, S.Mineo, et al.: Cecal succinate elevated by some dietary polyphenols may inhibit colon cancer cell proliferation and angiogenesis. J Agric Food Chem 62, 5589–5594, 2014.
    • (2014) J Agric Food Chem , vol.62 , pp. 5589-5594
    • Haraguchi, T.1    Kayashima, T.2    Okazaki, Y.3    Inoue, J.4    Mineo, S.5
  • 114
    • 50349096718 scopus 로고    scopus 로고
    • Angiotensin II induces the vascular expression of VEGF and MMP-2 in vivo: preventive effect of red wine polyphenols
    • A.Walter, N.Etienne-Selloum, M.Sarr, M.O.Kane, A.Beretz, et al.: Angiotensin II induces the vascular expression of VEGF and MMP-2 in vivo: preventive effect of red wine polyphenols. J Vasc Res 45, 386–394, 2008.
    • (2008) J Vasc Res , vol.45 , pp. 386-394
    • Walter, A.1    Etienne-Selloum, N.2    Sarr, M.3    Kane, M.O.4    Beretz, A.5
  • 115
    • 33750958329 scopus 로고    scopus 로고
    • New insights on the anticancer properties of dietary polyphenols
    • P.Fresco, F.Borges, C.Diniz, and M.P.Marques: New insights on the anticancer properties of dietary polyphenols. Med Res Rev 26, 747–766, 2006.
    • (2006) Med Res Rev , vol.26 , pp. 747-766
    • Fresco, P.1    Borges, F.2    Diniz, C.3    Marques, M.P.4
  • 116
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • B.B.Aggarwal and S.Shishodia: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71, 1397–1421, 2006.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 117
    • 84855857731 scopus 로고    scopus 로고
    • Mechanisms underlying the anti-proliferative effects of berry components in in vitro models of colon cancer
    • E.M.Brown, C.I.Gill, G.J.McDougall, and D.Stewart: Mechanisms underlying the anti-proliferative effects of berry components in in vitro models of colon cancer. Curr Pharm Biotechnol 13, 200–209, 2012.
    • (2012) Curr Pharm Biotechnol , vol.13 , pp. 200-209
    • Brown, E.M.1    Gill, C.I.2    McDougall, G.J.3    Stewart, D.4
  • 118
    • 84891456992 scopus 로고    scopus 로고
    • Effect of berry extracts and bioactive compounds on fulvestrant (ICI 182,780) sensitive and resistant cell lines
    • D.R.Woode, H.S.Aiyer, N.Sie, A.L.Zwart, L.Li, et al.: Effect of berry extracts and bioactive compounds on fulvestrant (ICI 182,780) sensitive and resistant cell lines. Int J Breast Cancer 2012, 147828, 2012.
    • (2012) Int J Breast Cancer , vol.2012 , pp. 147828
    • Woode, D.R.1    Aiyer, H.S.2    Sie, N.3    Zwart, A.L.4    Li, L.5
  • 119
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • D.Hanahan and R.A.Weinberg: Hallmarks of cancer: the next generation. Cell 144, 646–674, 2011.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 120
    • 57449087215 scopus 로고    scopus 로고
    • Is cancer a disease of abnormal cellular metabolism? New angles on an old idea
    • R.J.DeBerardinis: Is cancer a disease of abnormal cellular metabolism? New angles on an old idea. Genet Med 10, 767–777, 2008.
    • (2008) Genet Med , vol.10 , pp. 767-777
    • DeBerardinis, R.J.1
  • 121
    • 84861975431 scopus 로고    scopus 로고
    • Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis
    • D.Daye and K.E.Wellen: Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis. Semin Cell Dev Biol 23, 362–369, 2012.
    • (2012) Semin Cell Dev Biol , vol.23 , pp. 362-369
    • Daye, D.1    Wellen, K.E.2
  • 122
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • R.J.DeBerardinis, J.J.Lum, G.Hatzivassiliou, and C.B.Thompson: The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7, 11–20, 2008.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 123
    • 84860316773 scopus 로고    scopus 로고
    • Carbon source metabolism and its regulation in cancer cells
    • C.Yin, S.Qie, and N.Sang: Carbon source metabolism and its regulation in cancer cells. Crit Rev Eukaryot Gene Exp 22, 17–35, 2012.
    • (2012) Crit Rev Eukaryot Gene Exp , vol.22 , pp. 17-35
    • Yin, C.1    Qie, S.2    Sang, N.3
  • 124
    • 77958492734 scopus 로고    scopus 로고
    • Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?
    • C.V.Dang: Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?. Cell Cycle 9, 3884–3886, 2010.
    • (2010) Cell Cycle , vol.9 , pp. 3884-3886
    • Dang, C.V.1
  • 125
    • 34447094919 scopus 로고    scopus 로고
    • Glycolysis in cancer: a potential target for therapy
    • R.A.Gatenby and R.J.Gillies: Glycolysis in cancer: a potential target for therapy. Int J Biochem Cell Biol 39, 1358–1366, 2007.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1358-1366
    • Gatenby, R.A.1    Gillies, R.J.2
  • 126
    • 77954162846 scopus 로고    scopus 로고
    • Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
    • U.E.Martinez-Outschoorn, R.M.Balliet, D.B.Rivadeneira, B.Chiavarina, S.Pavlides, et al.: Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle 9, 3256–3276, 2010.
    • (2010) Cell Cycle , vol.9 , pp. 3256-3276
    • Martinez-Outschoorn, U.E.1    Balliet, R.M.2    Rivadeneira, D.B.3    Chiavarina, B.4    Pavlides, S.5
  • 127
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: warburg and beyond
    • P.P.Hsu and D.M.Sabatini: Cancer cell metabolism: warburg and beyond. Cell 134, 703–707, 2008.
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 128
    • 61849135453 scopus 로고    scopus 로고
    • Tumor suppressors and cell metabolism: a recipe for cancer growth
    • R.G.Jones and C.B.Thompson: Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 23, 537–548, 2009.
    • (2009) Genes Dev , vol.23 , pp. 537-548
    • Jones, R.G.1    Thompson, C.B.2
  • 129
    • 79959861423 scopus 로고    scopus 로고
    • Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism
    • Y.Zhao, H.Liu, Z.Liu, Y.Ding, S.P.Ledoux, et al.: Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism. Cancer Res 71, 4585–4597, 2011.
    • (2011) Cancer Res , vol.71 , pp. 4585-4597
    • Zhao, Y.1    Liu, H.2    Liu, Z.3    Ding, Y.4    Ledoux, S.P.5
  • 130
    • 77957937428 scopus 로고    scopus 로고
    • Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
    • J.B.Wang, J.W.Erickson, R.Fuji, S.Ramachandran, P.Gao, et al.: Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18, 207–219, 2010.
    • (2010) Cancer Cell , vol.18 , pp. 207-219
    • Wang, J.B.1    Erickson, J.W.2    Fuji, R.3    Ramachandran, S.4    Gao, P.5
  • 131
    • 84890159876 scopus 로고    scopus 로고
    • Cancer cell metabolism: implications for therapeutic targets
    • M.Jang, S.S.Kim, and J.Lee: Cancer cell metabolism: implications for therapeutic targets. Exp Mol Med 45, e45, 2013.
    • (2013) Exp Mol Med , vol.45 , pp. e45
    • Jang, M.1    Kim, S.S.2    Lee, J.3
  • 132
    • 84875890762 scopus 로고    scopus 로고
    • Targeting cellular metabolism to improve cancer therapeutics
    • Y.Zhao, E.B.Butler, and M.Tan: Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis 4, e532, 2013.
    • (2013) Cell Death Dis , vol.4 , pp. e532
    • Zhao, Y.1    Butler, E.B.2    Tan, M.3
  • 134
    • 84893593461 scopus 로고    scopus 로고
    • Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract
    • F.Alzaid, H.M.Cheung, V.R.Preedy, and P.A.Sharp: Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract. PLoS One 8, e78932, 2013.
    • (2013) PLoS One , vol.8 , pp. e78932
    • Alzaid, F.1    Cheung, H.M.2    Preedy, V.R.3    Sharp, P.A.4
  • 135
    • 84881669256 scopus 로고    scopus 로고
    • Attenuation of glucose transport across Caco-2 cell monolayers by a polyphenol-rich herbal extract: interactions with SGLT1 and GLUT2 transporters
    • T.L.Farrell, S.L.Ellam, T.Forrelli, and G.Williamson: Attenuation of glucose transport across Caco-2 cell monolayers by a polyphenol-rich herbal extract: interactions with SGLT1 and GLUT2 transporters. Biofactors 39, 448–456, 2013.
    • (2013) Biofactors , vol.39 , pp. 448-456
    • Farrell, T.L.1    Ellam, S.L.2    Forrelli, T.3    Williamson, G.4
  • 136
    • 84872122319 scopus 로고    scopus 로고
    • Possible effects of dietary polyphenols on sugar absorption and digestion
    • G.Williamson: Possible effects of dietary polyphenols on sugar absorption and digestion. Mol Nutr Food Res 57, 48–57, 2013.
    • (2013) Mol Nutr Food Res , vol.57 , pp. 48-57
    • Williamson, G.1
  • 137
    • 77949488872 scopus 로고    scopus 로고
    • Novel inhibitors of basal glucose transport as potential anticancer agents
    • W.Zhang, Y.Liu, X.Chen, and S.C.Bergmeier: Novel inhibitors of basal glucose transport as potential anticancer agents. Bioorg Med Chem Lett 20, 2191–2194, 2010.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 2191-2194
    • Zhang, W.1    Liu, Y.2    Chen, X.3    Bergmeier, S.C.4
  • 138
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Y.J.Surh: Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3, 768–780, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 139
    • 84885763308 scopus 로고    scopus 로고
    • Hypoxia induced multidrug resistance of laryngeal cancer cells via hypoxia-inducible factor-1alpha
    • D.W.Li, P.Dong, F.Wang, X.W.Chen, C.Z.Xu, et al.: Hypoxia induced multidrug resistance of laryngeal cancer cells via hypoxia-inducible factor-1alpha. Asian Pac J Cancer Prev 14, 4853–4858, 2013.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 4853-4858
    • Li, D.W.1    Dong, P.2    Wang, F.3    Chen, X.W.4    Xu, C.Z.5
  • 140
    • 79959955993 scopus 로고    scopus 로고
    • Cancer therapeutic agents targeting hypoxia-inducible factor-1
    • R.Wang, S.Zhou, and S.Li: Cancer therapeutic agents targeting hypoxia-inducible factor-1. Curr Med Chem 18, 3168–3189, 2011.
    • (2011) Curr Med Chem , vol.18 , pp. 3168-3189
    • Wang, R.1    Zhou, S.2    Li, S.3
  • 141
    • 84879616328 scopus 로고    scopus 로고
    • Active extracts of black tea (Camellia Sinensis) induce apoptosis of PC-3 prostate cancer cells via mitochondrial dysfunction
    • S.Sun, S.Pan, A.Miao, C.Ling, S.Pang, et al.: Active extracts of black tea (Camellia Sinensis) induce apoptosis of PC-3 prostate cancer cells via mitochondrial dysfunction. Oncol Rep 30, 763–772, 2013.
    • (2013) Oncol Rep , vol.30 , pp. 763-772
    • Sun, S.1    Pan, S.2    Miao, A.3    Ling, C.4    Pang, S.5
  • 142
    • 84867817828 scopus 로고    scopus 로고
    • 7alpha-hydroxy-beta-sitosterol from chisocheton tomentosus induces apoptosis via dysregulation of cellular Bax/Bcl-2 ratio and cell cycle arrest by downregulating ERK1/2 activation
    • M.Tasyriq, I.A.Najmuldeen, L.L.In, K.Mohamad, K.Awang, et al.: 7alpha-hydroxy-beta-sitosterol from chisocheton tomentosus induces apoptosis via dysregulation of cellular Bax/Bcl-2 ratio and cell cycle arrest by downregulating ERK1/2 activation. Evid Based Complement Alternat Med 2012, 765316, 2012.
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 765316
    • Tasyriq, M.1    Najmuldeen, I.A.2    In, L.L.3    Mohamad, K.4    Awang, K.5
  • 143
    • 80051621155 scopus 로고    scopus 로고
    • Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells
    • M.Singh, R.Singh, K.Bhui, S.Tyagi, Z.Mahmood, et al.: Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells. Oncol Res 19, 245–257, 2011.
    • (2011) Oncol Res , vol.19 , pp. 245-257
    • Singh, M.1    Singh, R.2    Bhui, K.3    Tyagi, S.4    Mahmood, Z.5
  • 144
    • 84874940235 scopus 로고    scopus 로고
    • Curcumin inhibits proliferation and induces apoptosis of human colorectal cancer cells by activating the mitochondria apoptotic pathway
    • L.D.Guo, X.J.Chen, Y.H.Hu, Z.J.Yu, D.Wang, et al.: Curcumin inhibits proliferation and induces apoptosis of human colorectal cancer cells by activating the mitochondria apoptotic pathway. Phytother Res 27, 422–430, 2013.
    • (2013) Phytother Res , vol.27 , pp. 422-430
    • Guo, L.D.1    Chen, X.J.2    Hu, Y.H.3    Yu, Z.J.4    Wang, D.5
  • 145
    • 77950817519 scopus 로고    scopus 로고
    • Curcumin induces mitochondria pathway mediated cell apoptosis in A549 lung adenocarcinoma cells
    • Q.Y.Chen, G.H.Lu, Y.Q.Wu, Y.Zheng, K.Xu, et al.: Curcumin induces mitochondria pathway mediated cell apoptosis in A549 lung adenocarcinoma cells. Oncol Rep 23, 1285–1292, 2010.
    • (2010) Oncol Rep , vol.23 , pp. 1285-1292
    • Chen, Q.Y.1    Lu, G.H.2    Wu, Y.Q.3    Zheng, Y.4    Xu, K.5
  • 146
    • 84929265637 scopus 로고    scopus 로고
    • Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signalling in women with hormone receptor-negative breast cancer
    • K.D.Crew, K.A.Ho, P.Brown, H.Greenlee, T.B.Bevers, et al.: Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signalling in women with hormone receptor-negative breast cancer. J Hum Nutr Diet 28(3), 272–282, 2014.
    • (2014) J Hum Nutr Diet , vol.28 , Issue.3 , pp. 272-282
    • Crew, K.D.1    Ho, K.A.2    Brown, P.3    Greenlee, H.4    Bevers, T.B.5
  • 147
    • 64749115451 scopus 로고    scopus 로고
    • Inhibitory effects of four plants flavonoids extracts on fatty acid synthase
    • J.Chen, D.Zhuang, W.Cai, L.Xu, E.Li, et al.: Inhibitory effects of four plants flavonoids extracts on fatty acid synthase. J Environ Sci 21 Suppl 1, S131–S134, 2009.
    • (2009) J Environ Sci , vol.21 , pp. S131-S134
    • Chen, J.1    Zhuang, D.2    Cai, W.3    Xu, L.4    Li, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.