Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 413-422

  Yuan, Jian ^a   Wong, Iris L K ^b,c   Jiang, Tao ^a   Wang, Si Wen ^a   Liu, Tao ^a   Jin Wen, Bin ^a   Chow, Larry M C ^b,c   Wan Sheng, Biao ^a  

^a Ocean University of China   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^c State Key Laboratory in Chinese Medicine and Molecular Pharmacology   (China)

Author keywords

BCRP; Methylated quercetin derivatives; MRP1; Multidrug resistance (MDR); P gp; Quercetin

Indexed keywords

2 (3,4 DIMETHOXYPHENYL) 3 (2 HYDROXYETHOXY) 5,7 DIMETHOXY 4H CHROMEN 4 ONE; 2 (3,4 DIMETHOXYPHENYL) 3 [2 (3,4 DIMETHOXYPHENYL) 2 OXETHOXY] 5,7 DIME THOXY 4H CHROMEN 4 ONE; 2 (3,4 DIMETHOXYPHENYL) 3,5,7 TRIMETHOXY 4H CHROMEN 4 ONE; 2 (3,4 DIMETHOXYPHENYL) 5 HYDROXY 3,7 DIMETHOXY 4H CHROMEN 4 ONE; 2 (3,4 DIMETHOXYPHENYL) 5,7 DIMETHOXY 3 [(3,4,5 TRIMETHOXYBENZYL)OXY] 4H CHROMEN 4 ONE; 2 (3,4 DIMETHOXYPHENYL) 5,7 DIMETHOXY 3 [[3,4,5 TRIMETHOXY 6 [[(3,4,5 TRIMETHOXY 6 METHYLTETRAHYDRO 2H PYRAN 2 YL)OXY] METHYL]TETRAHYDRO 2H PYRAN 2 YL]OXY] 4H CHROMEN 4 ONE; 2 (3,4 DIMETHOXYPHENYL) 5,7 DIMETHOXY 4 OXO 4H CHROMEN 3 YL 3,4,5 TRIME THOXYBENZOATE; 2 [[2 (3,4 DIMETHOXYPHENYL) 5,7 DIMETHOXY 4 OXO 4H CHROMEN 3 YL]OXY]ETHYL 3 (3,4,5 TRIMETHOXYPHENYL)ACRYLATE; 2 [[2 (3,4 DIMETHOXYPHENYL) 5,7 DIMETHOXY 4 OXO 4H CHROMEN 3 YL]OXY]ETHYL 3,4 DIMETHOXYBENZOATE; 2 [[2 (3,4 DIMETHOXYPHENYL) 5,7 DIMETHOXY 4 OXO 4H CHROMEN 3 YL]OXY]ETHYL 3,4,5 TRIMETHOXYBENZOATE; 2 [[2 (3,4 DIMETHOXYPHENYL) 5,7 DIMETHOXY 4 OXO 4H CHROMEN 3 YL]OXY]ETHYL 4 METHOXYBENZOATE; 3 [2 (6 AMINO 9H PURIN 9 YL)ETHOXY] 2 (3,4 DIMETHOXYPHENYL) 5,7 DIMETHOXY 4H CHROMEN 4 ONE; 3 [2 [[4 [(3 CHLORO 4 FLUOROPHENYL)AMINO] 7 METHOXYQUINAZOLIN 6 YL]OXY]ETHOXY] 2 (3,4 DIMETHOXYPHENYL) 5,7 DIMETHOXY 4H CHROMEN 4 ONE; 3,7,3',4' TETRA O METHYLATED QUERCETIN; 9 [2 [[2 (3,4 DIMETHOXYPHENYL) 5,7 DIMETHOXY 4H CHROMEN 3 YL]OXY]ETHYL] 1,3 DIMETHYL 1H PURINE 2,6(3H,9H)DIONE; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; GLYCOPROTEIN P; QUERCETIN DERIVATIVE; RUTOSIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; METHYLATION; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG RESISTANCE, MULTIPLE; HUMANS; METHYLATION; MICE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; QUERCETIN;

EID: 84864399172     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.05.026     Document Type: Article

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