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Volumn 174, Issue 10, 2017, Pages 933-949

Correction to: The actions of relaxin on the human cardiovascular system (Br J Pharmacol, (2017), 174, 10, (933-949), 10.1111/bph.13523);The actions of relaxin on the human cardiovascular system

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; ENDOTHELIN RECEPTOR; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RECEPTOR PROTEIN; RELAXIN; RELAXIN FAMILY PEPTIDE RECEPTOR 1; UNCLASSIFIED DRUG;

EID: 84978269177     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.14111     Document Type: Erratum
Times cited : (70)

References (169)
  • 1
    • 84866933093 scopus 로고    scopus 로고
    • Relaxin induces matrix-metalloproteinases-9 and -13 via RXFP1: induction of MMP-9 involves the PI3K, ERK, Akt and PKC-zeta pathways
    • Ahmad N, Wang W, Nair R, Kapila S (2012). Relaxin induces matrix-metalloproteinases-9 and -13 via RXFP1: induction of MMP-9 involves the PI3K, ERK, Akt and PKC-zeta pathways. Mol Cell Endocrinol 363: 46–61.
    • (2012) Mol Cell Endocrinol , vol.363 , pp. 46-61
    • Ahmad, N.1    Wang, W.2    Nair, R.3    Kapila, S.4
  • 5
    • 84884786369 scopus 로고    scopus 로고
    • Relaxin protects rat lungs from ischemia–reperfusion injury via inducible NO synthase: role of ERK-1/2, PI3K, and forkhead transcription factor FKHRL1
    • Alexiou K, Wilbring M, Matschke K, Dschietzig T (2013). Relaxin protects rat lungs from ischemia–reperfusion injury via inducible NO synthase: role of ERK-1/2, PI3K, and forkhead transcription factor FKHRL1. PLoS One 8: e75592.
    • (2013) PLoS One , vol.8
    • Alexiou, K.1    Wilbring, M.2    Matschke, K.3    Dschietzig, T.4
  • 6
    • 0035993222 scopus 로고    scopus 로고
    • Inhibitory effects of relaxin on human basophils activated by stimulation of the Fc epsilon receptor. The role of nitric oxide
    • Bani D, Baronti R, Vannacci A, Bigazzi M, Sacchi TB, Mannaioni PF et al. (2002). Inhibitory effects of relaxin on human basophils activated by stimulation of the Fc epsilon receptor. The role of nitric oxide. Int Immunopharmacol 2: 1195–1204.
    • (2002) Int Immunopharmacol , vol.2 , pp. 1195-1204
    • Bani, D.1    Baronti, R.2    Vannacci, A.3    Bigazzi, M.4    Sacchi, T.B.5    Mannaioni, P.F.6
  • 7
    • 0028820363 scopus 로고
    • Relaxin depresses platelet aggregation: in vitro studies on isolated human and rabbit platelets
    • Bani D, Bigazzi M, Masini E, Bani G, Sacchi TB (1995a). Relaxin depresses platelet aggregation: in vitro studies on isolated human and rabbit platelets. Lab Invest 73: 709–716.
    • (1995) Lab Invest , vol.73 , pp. 709-716
    • Bani, D.1    Bigazzi, M.2    Masini, E.3    Bani, G.4    Sacchi, T.B.5
  • 8
    • 0031810556 scopus 로고    scopus 로고
    • Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture
    • Bani D, Failli P, Bello MG, Thiemermann C, Bani Sacchi T, Bigazzi M et al. (1998a). Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture. Hypertension 31: 1240–1247.
    • (1998) Hypertension , vol.31 , pp. 1240-1247
    • Bani, D.1    Failli, P.2    Bello, M.G.3    Thiemermann, C.4    Bani Sacchi, T.5    Bigazzi, M.6
  • 9
    • 0028851926 scopus 로고
    • Relaxin activates the L-arginine-nitric oxide pathway in human breast cancer cells
    • Bani D, Masini E, Bello MG, Bigazzi M, Sacchi TB (1995b). Relaxin activates the L-arginine-nitric oxide pathway in human breast cancer cells. Cancer Res 55: 5272–5275.
    • (1995) Cancer Res , vol.55 , pp. 5272-5275
    • Bani, D.1    Masini, E.2    Bello, M.G.3    Bigazzi, M.4    Sacchi, T.B.5
  • 10
    • 0031945701 scopus 로고    scopus 로고
    • Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart
    • Bani D, Masini E, Bello MG, Bigazzi M, Sacchi TB (1998b). Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart. Am J Pathol 152: 1367–1376.
    • (1998) Am J Pathol , vol.152 , pp. 1367-1376
    • Bani, D.1    Masini, E.2    Bello, M.G.3    Bigazzi, M.4    Sacchi, T.B.5
  • 11
    • 0029126464 scopus 로고
    • Relaxin-induced increased coronary flow through stimulation of nitric oxide production
    • Bani-Sacchi T, Bigazzi M, Bani D, Mannaioni PF, Masini E (1995). Relaxin-induced increased coronary flow through stimulation of nitric oxide production. Br J Pharmacol 116: 1589–1594.
    • (1995) Br J Pharmacol , vol.116 , pp. 1589-1594
    • Bani-Sacchi, T.1    Bigazzi, M.2    Bani, D.3    Mannaioni, P.F.4    Masini, E.5
  • 14
    • 66949114470 scopus 로고    scopus 로고
    • Relaxin and its role in the development and treatment of fibrosis
    • Bennett RG (2009). Relaxin and its role in the development and treatment of fibrosis. Transl Res 154: 1–6.
    • (2009) Transl Res , vol.154 , pp. 1-6
    • Bennett, R.G.1
  • 15
    • 84883759083 scopus 로고    scopus 로고
    • Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice
    • Bitto A, Irrera N, Minutoli L, Calo M, Lo Cascio P, Caccia P et al. (2013). Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice. Clin Sci 125: 575–585.
    • (2013) Clin Sci , vol.125 , pp. 575-585
    • Bitto, A.1    Irrera, N.2    Minutoli, L.3    Calo, M.4    Lo Cascio, P.5    Caccia, P.6
  • 16
    • 84928704770 scopus 로고    scopus 로고
    • Relaxin protects cardiac muscle cells from hypoxia/reoxygenation injury: involvement of the Notch-1 pathway
    • Boccalini G, Sassoli C, Formigli L, Bani D, Nistri S (2015). Relaxin protects cardiac muscle cells from hypoxia/reoxygenation injury: involvement of the Notch-1 pathway. FASEB J 29: 239–249.
    • (2015) FASEB J , vol.29 , pp. 239-249
    • Boccalini, G.1    Sassoli, C.2    Formigli, L.3    Bani, D.4    Nistri, S.5
  • 17
    • 84887338159 scopus 로고    scopus 로고
    • Relaxin treatment reverses insulin resistance in mice fed a high-fat diet
    • Bonner JS, Lantier L, Hocking KM, Kang L, Owolabi M, James FD et al. (2013). Relaxin treatment reverses insulin resistance in mice fed a high-fat diet. Diabetes 62: 3251–3260.
    • (2013) Diabetes , vol.62 , pp. 3251-3260
    • Bonner, J.S.1    Lantier, L.2    Hocking, K.M.3    Kang, L.4    Owolabi, M.5    James, F.D.6
  • 18
    • 84890788174 scopus 로고    scopus 로고
    • Cardiorenal syndrome–current understanding and future perspectives
    • Braam B, Joles JA, Danishwar AH, Gaillard CA (2014). Cardiorenal syndrome–current understanding and future perspectives. Nat Rev Nephrol 10: 48–55.
    • (2014) Nat Rev Nephrol , vol.10 , pp. 48-55
    • Braam, B.1    Joles, J.A.2    Danishwar, A.H.3    Gaillard, C.A.4
  • 20
    • 0036843158 scopus 로고    scopus 로고
    • Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death
    • Bueno OF, Molkentin JD (2002). Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circ Res 91: 776–781.
    • (2002) Circ Res , vol.91 , pp. 776-781
    • Bueno, O.F.1    Molkentin, J.D.2
  • 21
    • 18244407290 scopus 로고    scopus 로고
    • Cardiovascular and renal regulation by the angiotensin type 2 receptor: the AT2 receptor comes of age
    • Carey RM (2005). Cardiovascular and renal regulation by the angiotensin type 2 receptor: the AT2 receptor comes of age. Hypertension 45: 840–844.
    • (2005) Hypertension , vol.45 , pp. 840-844
    • Carey, R.M.1
  • 22
    • 84865168929 scopus 로고    scopus 로고
    • Relaxin signals through a RXFP1–pERK–nNOS–NO–cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS
    • Chow BS, Chew EG, Zhao C, Bathgate RA, Hewitson TD, Samuel CS (2012). Relaxin signals through a RXFP1–pERK–nNOS–NO–cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS. PLoS One 7: e42714.
    • (2012) PLoS One , vol.7
    • Chow, B.S.1    Chew, E.G.2    Zhao, C.3    Bathgate, R.A.4    Hewitson, T.D.5    Samuel, C.S.6
  • 23
    • 84903773477 scopus 로고    scopus 로고
    • Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis
    • Chow BS, Kocan M, Bosnyak S, Sarwar M, Wigg B, Jones ES et al. (2014). Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis. Kidney Int 86: 75–85.
    • (2014) Kidney Int , vol.86 , pp. 75-85
    • Chow, B.S.1    Kocan, M.2    Bosnyak, S.3    Sarwar, M.4    Wigg, B.5    Jones, E.S.6
  • 24
    • 84891160261 scopus 로고    scopus 로고
    • Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury
    • Collino M, Rogazzo M, Pini A, Benetti E, Rosa AC, Chiazza F et al. (2013). Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury. J Cell Mol Med 17: 1494–1505.
    • (2013) J Cell Mol Med , vol.17 , pp. 1494-1505
    • Collino, M.1    Rogazzo, M.2    Pini, A.3    Benetti, E.4    Rosa, A.C.5    Chiazza, F.6
  • 25
    • 3042685353 scopus 로고    scopus 로고
    • Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats
    • Conrad KP, Debrah DO, Novak J, Danielson LA, Shroff SG (2004). Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats. Endocrinology 145: 3289–3296.
    • (2004) Endocrinology , vol.145 , pp. 3289-3296
    • Conrad, K.P.1    Debrah, D.O.2    Novak, J.3    Danielson, L.A.4    Shroff, S.G.5
  • 26
    • 3242794260 scopus 로고    scopus 로고
    • Emerging role of relaxin in renal and cardiovascular function
    • Conrad KP, Novak J (2004). Emerging role of relaxin in renal and cardiovascular function. Am J Physiol Regul Integr Comp Physiol 287: R250–R261.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287 , pp. R250-R261
    • Conrad, K.P.1    Novak, J.2
  • 27
    • 81255152083 scopus 로고    scopus 로고
    • Effects of relaxin on arterial dilation, remodeling, and mechanical properties
    • Conrad KP, Shroff SG (2011). Effects of relaxin on arterial dilation, remodeling, and mechanical properties. Curr Hypertens Rep 13: 409–420.
    • (2011) Curr Hypertens Rep , vol.13 , pp. 409-420
    • Conrad, K.P.1    Shroff, S.G.2
  • 28
    • 77957139942 scopus 로고    scopus 로고
    • Acute heart failure clinical drug development: from planning to proof of activity to phase III
    • Cotter G, Voors AA, Weatherley BD, Pang PS, Teerlink JR, Filippatos G et al. (2010). Acute heart failure clinical drug development: from planning to proof of activity to phase III. Cardiology 116: 292–301.
    • (2010) Cardiology , vol.116 , pp. 292-301
    • Cotter, G.1    Voors, A.A.2    Weatherley, B.D.3    Pang, P.S.4    Teerlink, J.R.5    Filippatos, G.6
  • 29
    • 0029878304 scopus 로고    scopus 로고
    • Central hemodynamic effects of recombinant human relaxin in the isolated, perfused rat heart model
    • Coulson CC, Thorp JM Jr, Mayer DC, Cefalo RC (1996). Central hemodynamic effects of recombinant human relaxin in the isolated, perfused rat heart model. Obstet Gynecol 87: 610–612.
    • (1996) Obstet Gynecol , vol.87 , pp. 610-612
    • Coulson, C.C.1    Thorp, J.M.2    Mayer, D.C.3    Cefalo, R.C.4
  • 30
    • 0033557269 scopus 로고    scopus 로고
    • Relaxin is a potent renal vasodilator in conscious rats
    • Danielson LA, Sherwood OD, Conrad KP (1999). Relaxin is a potent renal vasodilator in conscious rats. J Clin Invest 103: 525–533.
    • (1999) J Clin Invest , vol.103 , pp. 525-533
    • Danielson, L.A.1    Sherwood, O.D.2    Conrad, K.P.3
  • 31
    • 55849095483 scopus 로고    scopus 로고
    • Signaling across myoendothelial gap junctions–fact or fiction?
    • de Wit C, Boettcher M, Schmidt VJ (2008). Signaling across myoendothelial gap junctions–fact or fiction? Cell Commun Adhes 15: 231–245.
    • (2008) Cell Commun Adhes , vol.15 , pp. 231-245
    • de Wit, C.1    Boettcher, M.2    Schmidt, V.J.3
  • 32
    • 14144250653 scopus 로고    scopus 로고
    • Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: sex dependency and dose response
    • Debrah DO, Conrad KP, Danielson LA, Shroff SG (2005a). Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: sex dependency and dose response. J Appl Physiol 98: 1013–1020.
    • (2005) J Appl Physiol , vol.98 , pp. 1013-1020
    • Debrah, D.O.1    Conrad, K.P.2    Danielson, L.A.3    Shroff, S.G.4
  • 33
    • 31944449600 scopus 로고    scopus 로고
    • Relaxin increases cardiac output and reduces systemic arterial load in hypertensive rats
    • Debrah DO, Conrad KP, Jeyabalan A, Danielson LA, Shroff SG (2005b). Relaxin increases cardiac output and reduces systemic arterial load in hypertensive rats. Hypertension 46: 745–750.
    • (2005) Hypertension , vol.46 , pp. 745-750
    • Debrah, D.O.1    Conrad, K.P.2    Jeyabalan, A.3    Danielson, L.A.4    Shroff, S.G.5
  • 34
    • 33751243624 scopus 로고    scopus 로고
    • Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats
    • Debrah DO, Novak J, Matthews JE, Ramirez RJ, Shroff SG, Conrad KP (2006). Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats. Endocrinology 147: 5126–5131.
    • (2006) Endocrinology , vol.147 , pp. 5126-5131
    • Debrah, D.O.1    Novak, J.2    Matthews, J.E.3    Ramirez, R.J.4    Shroff, S.G.5    Conrad, K.P.6
  • 35
    • 79551684089 scopus 로고    scopus 로고
    • The positive inotropic effect of relaxin-2 in human atrial myocardium is preserved in end-stage heart failure: role of G(i)-phosphoinositide-3 kinase signaling
    • Dschietzig T, Alexiou K, Kinkel HT, Baumann G, Matschke K, Stangl K (2011). The positive inotropic effect of relaxin-2 in human atrial myocardium is preserved in end-stage heart failure: role of G(i)-phosphoinositide-3 kinase signaling. J Card Fail 17: 158–166.
    • (2011) J Card Fail , vol.17 , pp. 158-166
    • Dschietzig, T.1    Alexiou, K.2    Kinkel, H.T.3    Baumann, G.4    Matschke, K.5    Stangl, K.6
  • 36
    • 63049090896 scopus 로고    scopus 로고
    • RXFP1-inactive relaxin activates human glucocorticoid receptor: further investigations into the relaxin-GR pathway
    • Dschietzig T, Bartsch C, Baumann G, Stangl K (2009a). RXFP1-inactive relaxin activates human glucocorticoid receptor: further investigations into the relaxin-GR pathway. Regul Pept 154: 77–84.
    • (2009) Regul Pept , vol.154 , pp. 77-84
    • Dschietzig, T.1    Bartsch, C.2    Baumann, G.3    Stangl, K.4
  • 38
    • 0037428061 scopus 로고    scopus 로고
    • Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kB
    • Dschietzig T, Bartsch C, Richter C, Laule M, Baumann G, Stangl K (2003). Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kB. Circ Res 92: 32–40.
    • (2003) Circ Res , vol.92 , pp. 32-40
    • Dschietzig, T.1    Bartsch, C.2    Richter, C.3    Laule, M.4    Baumann, G.5    Stangl, K.6
  • 39
    • 9444226989 scopus 로고    scopus 로고
    • Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist
    • Dschietzig T, Bartsch C, Stangl V, Baumann G, Stangl K (2004). Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist. FASEB J 18: 1536–1538.
    • (2004) FASEB J , vol.18 , pp. 1536-1538
    • Dschietzig, T.1    Bartsch, C.2    Stangl, V.3    Baumann, G.4    Stangl, K.5
  • 40
    • 84862876898 scopus 로고    scopus 로고
    • Relaxin improves TNF-alpha-induced endothelial dysfunction: the role of glucocorticoid receptor and phosphatidylinositol 3-kinase signalling
    • Dschietzig T, Brecht A, Bartsch C, Baumann G, Stangl K, Alexiou K (2012). Relaxin improves TNF-alpha-induced endothelial dysfunction: the role of glucocorticoid receptor and phosphatidylinositol 3-kinase signalling. Cardiovasc Res 95: 97–107.
    • (2012) Cardiovasc Res , vol.95 , pp. 97-107
    • Dschietzig, T.1    Brecht, A.2    Bartsch, C.3    Baumann, G.4    Stangl, K.5    Alexiou, K.6
  • 41
    • 0035941053 scopus 로고    scopus 로고
    • Flow-induced pressure differentially regulates endothelin-1, urotensin II, adrenomedullin, and relaxin in pulmonary vascular endothelium
    • Dschietzig T, Richter C, Bartsch C, Bohme C, Heinze D, Ott F et al. (2001a). Flow-induced pressure differentially regulates endothelin-1, urotensin II, adrenomedullin, and relaxin in pulmonary vascular endothelium. Biochem Biophys Res Commun 289: 245–251.
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 245-251
    • Dschietzig, T.1    Richter, C.2    Bartsch, C.3    Bohme, C.4    Heinze, D.5    Ott, F.6
  • 43
    • 62649155715 scopus 로고    scopus 로고
    • Intravenous recombinant human relaxin in compensated heart failure: a safety, tolerability, and pharmacodynamic trial
    • Dschietzig T, Teichman S, Unemori E, Wood S, Boehmer J, Richter C et al. (2009b). Intravenous recombinant human relaxin in compensated heart failure: a safety, tolerability, and pharmacodynamic trial. J Card Fail 15: 182–190.
    • (2009) J Card Fail , vol.15 , pp. 182-190
    • Dschietzig, T.1    Teichman, S.2    Unemori, E.3    Wood, S.4    Boehmer, J.5    Richter, C.6
  • 44
    • 84894492958 scopus 로고    scopus 로고
    • Therapeutic effects of serelaxin in acute heart failure
    • Du XJ, Hewitson TD, Nguyen MN, Samuel CS (2014). Therapeutic effects of serelaxin in acute heart failure. Circ J 78: 542–552.
    • (2014) Circ J , vol.78 , pp. 542-552
    • Du, X.J.1    Hewitson, T.D.2    Nguyen, M.N.3    Samuel, C.S.4
  • 45
    • 12244257489 scopus 로고    scopus 로고
    • Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype
    • Du XJ, Samuel CS, Gao XM, Zhao L, Parry LJ, Tregear GW (2003). Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype. Cardiovasc Res 57: 395–404.
    • (2003) Cardiovasc Res , vol.57 , pp. 395-404
    • Du, X.J.1    Samuel, C.S.2    Gao, X.M.3    Zhao, L.4    Parry, L.J.5    Tregear, G.W.6
  • 48
    • 0026557823 scopus 로고
    • Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure
    • Eschenhagen T, Mende U, Nose M, Schmitz W, Scholz H, Haverich A et al. (1992). Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure. Circ Res 70: 688–696.
    • (1992) Circ Res , vol.70 , pp. 688-696
    • Eschenhagen, T.1    Mende, U.2    Nose, M.3    Schmitz, W.4    Scholz, H.5    Haverich, A.6
  • 49
    • 0036484303 scopus 로고    scopus 로고
    • Relaxin up-regulates inducible nitric oxide synthase expression and nitric oxide generation in rat coronary endothelial cells
    • Failli P, Nistri S, Quattrone S, Mazzetti L, Bigazzi M, Sacchi TB et al. (2002). Relaxin up-regulates inducible nitric oxide synthase expression and nitric oxide generation in rat coronary endothelial cells. FASEB J 16: 252–254.
    • (2002) FASEB J , vol.16 , pp. 252-254
    • Failli, P.1    Nistri, S.2    Quattrone, S.3    Mazzetti, L.4    Bigazzi, M.5    Sacchi, T.B.6
  • 51
    • 0032719798 scopus 로고    scopus 로고
    • Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor
    • Fernandez-Patron C, Radomski MW, Davidge ST (1999). Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. Circ Res 85: 906–911.
    • (1999) Circ Res , vol.85 , pp. 906-911
    • Fernandez-Patron, C.1    Radomski, M.W.2    Davidge, S.T.3
  • 52
    • 0034644582 scopus 로고    scopus 로고
    • Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction
    • Fernandez-Patron C, Stewart KG, Zhang Y, Koivunen E, Radomski MW, Davidge ST (2000). Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction. Circ Res 87: 670–676.
    • (2000) Circ Res , vol.87 , pp. 670-676
    • Fernandez-Patron, C.1    Stewart, K.G.2    Zhang, Y.3    Koivunen, E.4    Radomski, M.W.5    Davidge, S.T.6
  • 53
    • 0037118672 scopus 로고    scopus 로고
    • Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart?
    • Fisher C, MacLean M, Morecroft I, Seed A, Johnston F, Hillier C et al. (2002). Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart? Circulation 106: 292–295.
    • (2002) Circulation , vol.106 , pp. 292-295
    • Fisher, C.1    MacLean, M.2    Morecroft, I.3    Seed, A.4    Johnston, F.5    Hillier, C.6
  • 55
    • 20144383129 scopus 로고    scopus 로고
    • Morphofunctional integration between skeletal myoblasts and adult cardiomyocytes in coculture is favored by direct cell–cell contacts and relaxin treatment
    • Formigli L, Francini F, Tani A, Squecco R, Nosi D, Polidori L et al. (2005). Morphofunctional integration between skeletal myoblasts and adult cardiomyocytes in coculture is favored by direct cell–cell contacts and relaxin treatment. Am J Physiol Cell Physiol 288: C795–C804.
    • (2005) Am J Physiol Cell Physiol , vol.288 , pp. C795-C804
    • Formigli, L.1    Francini, F.2    Tani, A.3    Squecco, R.4    Nosi, D.5    Polidori, L.6
  • 56
    • 35649009903 scopus 로고    scopus 로고
    • Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling
    • Formigli L, Perna AM, Meacci E, Cinci L, Margheri M, Nistri S et al. (2007). Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling. J Cell Mol Med 11: 1087–1100.
    • (2007) J Cell Mol Med , vol.11 , pp. 1087-1100
    • Formigli, L.1    Perna, A.M.2    Meacci, E.3    Cinci, L.4    Margheri, M.5    Nistri, S.6
  • 59
    • 41149154296 scopus 로고    scopus 로고
    • Venous function and central venous pressure: a physiologic story
    • Gelman S (2008). Venous function and central venous pressure: a physiologic story. Anesthesiology 108: 735–748.
    • (2008) Anesthesiology , vol.108 , pp. 735-748
    • Gelman, S.1
  • 60
    • 33750731595 scopus 로고    scopus 로고
    • Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure
    • Gheorghiade M, Abraham WT, Albert NM, Greenberg BH, O'Connor CM, She L et al. (2006). Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure. JAMA 296: 2217–2226.
    • (2006) JAMA , vol.296 , pp. 2217-2226
    • Gheorghiade, M.1    Abraham, W.T.2    Albert, N.M.3    Greenberg, B.H.4    O'Connor, C.M.5    She, L.6
  • 61
    • 84889011225 scopus 로고    scopus 로고
    • Enhanced uterine artery stiffness in aged pregnant relaxin mutant mice is reversed with exogenous relaxin treatment
    • Gooi JH, Richardson ML, Jelinic M, Girling JE, Wlodek ME, Tare M et al. (2013). Enhanced uterine artery stiffness in aged pregnant relaxin mutant mice is reversed with exogenous relaxin treatment. Biol Reprod 89: 18.
    • (2013) Biol Reprod , vol.89 , pp. 18
    • Gooi, J.H.1    Richardson, M.L.2    Jelinic, M.3    Girling, J.E.4    Wlodek, M.E.5    Tare, M.6
  • 62
    • 84908118812 scopus 로고    scopus 로고
    • Matching mechanism of death with mechanism of action: considerations for drug development for hospitalized heart failure
    • Greene SJ, Gheorghiade M (2014). Matching mechanism of death with mechanism of action: considerations for drug development for hospitalized heart failure. J Am Coll Cardiol 64: 1599–1601.
    • (2014) J Am Coll Cardiol , vol.64 , pp. 1599-1601
    • Greene, S.J.1    Gheorghiade, M.2
  • 63
    • 84864383682 scopus 로고    scopus 로고
    • Up-regulating relaxin expression by G-quadruplex interactive ligand to achieve antifibrotic action
    • Gu HP, Lin S, Xu M, Yu HY, Du XJ, Zhang YY et al. (2012). Up-regulating relaxin expression by G-quadruplex interactive ligand to achieve antifibrotic action. Endocrinology 153: 3692–3700.
    • (2012) Endocrinology , vol.153 , pp. 3692-3700
    • Gu, H.P.1    Lin, S.2    Xu, M.3    Yu, H.Y.4    Du, X.J.5    Zhang, Y.Y.6
  • 65
    • 33745226248 scopus 로고    scopus 로고
    • Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms
    • Halls ML, Bathgate RA, Summers RJ (2006). Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms. Mol Pharmacol 70: 214–226.
    • (2006) Mol Pharmacol , vol.70 , pp. 214-226
    • Halls, M.L.1    Bathgate, R.A.2    Summers, R.J.3
  • 66
    • 84924630339 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1–4, the receptors for relaxin family peptides
    • Halls ML, Bathgate RA, Sutton SW, Dschietzig TB, Summers RJ (2015). International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1–4, the receptors for relaxin family peptides. Pharmacol Rev 67: 389–440.
    • (2015) Pharmacol Rev , vol.67 , pp. 389-440
    • Halls, M.L.1    Bathgate, R.A.2    Sutton, S.W.3    Dschietzig, T.B.4    Summers, R.J.5
  • 68
    • 0028082029 scopus 로고
    • Relaxin increases heart rate by modulating calcium current in cardiac pacemaker cells
    • Han X, Habuchi Y, Giles WR (1994). Relaxin increases heart rate by modulating calcium current in cardiac pacemaker cells. Circ Res 74: 537–541.
    • (1994) Circ Res , vol.74 , pp. 537-541
    • Han, X.1    Habuchi, Y.2    Giles, W.R.3
  • 69
    • 24944542890 scopus 로고    scopus 로고
    • The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway
    • Heeg MHJ, Koziolek MJ, Vasko R, Schaefer L, Sharma K, Muller GA et al. (2005). The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway. Kidney Int 68: 96–109.
    • (2005) Kidney Int , vol.68 , pp. 96-109
    • Heeg, M.H.J.1    Koziolek, M.J.2    Vasko, R.3    Schaefer, L.4    Sharma, K.5    Muller, G.A.6
  • 70
    • 34247884253 scopus 로고    scopus 로고
    • Relaxin-induced matrix metalloproteinase-9 expression is associated with activation of the NF-kB pathway in human THP-1 cells
    • Ho TY, Yan W, Bagnell CA (2007). Relaxin-induced matrix metalloproteinase-9 expression is associated with activation of the NF-kB pathway in human THP-1 cells. J Leukoc Biol 81: 1303–1310.
    • (2007) J Leukoc Biol , vol.81 , pp. 1303-1310
    • Ho, T.Y.1    Yan, W.2    Bagnell, C.A.3
  • 71
    • 84863208612 scopus 로고    scopus 로고
    • Sublingual tissue perfusion improves during emergency treatment of acute decompensated heart failure
    • Hogan CJ, Ward KR, Franzen DS, Rajendran B, Thacker LR (2012a). Sublingual tissue perfusion improves during emergency treatment of acute decompensated heart failure. Am J Emerg Med 30: 872–880.
    • (2012) Am J Emerg Med , vol.30 , pp. 872-880
    • Hogan, C.J.1    Ward, K.R.2    Franzen, D.S.3    Rajendran, B.4    Thacker, L.R.5
  • 72
    • 81755167290 scopus 로고    scopus 로고
    • Peripheral tissue oxygenation improves during ED treatment of acute heart failure
    • Hogan CJ, Ward KR, Kontos MC, Thacker LR, Pittman R (2012b). Peripheral tissue oxygenation improves during ED treatment of acute heart failure. Am J Emerg Med 30: 196–202.
    • (2012) Am J Emerg Med , vol.30 , pp. 196-202
    • Hogan, C.J.1    Ward, K.R.2    Kontos, M.C.3    Thacker, L.R.4    Pittman, R.5
  • 73
    • 80955136632 scopus 로고    scopus 로고
    • Relaxin modulates proinflammatory cytokine secretion from human decidual macrophages
    • Horton JS, Yamamoto SY, Bryant-Greenwood GD (2011). Relaxin modulates proinflammatory cytokine secretion from human decidual macrophages. Biol Reprod 85: 788–797.
    • (2011) Biol Reprod , vol.85 , pp. 788-797
    • Horton, J.S.1    Yamamoto, S.Y.2    Bryant-Greenwood, G.D.3
  • 74
    • 79951939642 scopus 로고    scopus 로고
    • H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor
    • Hossain MA, Man BC, Zhao C, Xu Q, Du XJ, Wade JD et al. (2011). H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor. Biochemistry 50: 1368–1375.
    • (2011) Biochemistry , vol.50 , pp. 1368-1375
    • Hossain, M.A.1    Man, B.C.2    Zhao, C.3    Xu, Q.4    Du, X.J.5    Wade, J.D.6
  • 75
    • 34247105883 scopus 로고    scopus 로고
    • cAMP-specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling
    • Houslay MD, Baillie GS, Maurice DH (2007). cAMP-specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling. Circ Res 100: 950–966.
    • (2007) Circ Res , vol.100 , pp. 950-966
    • Houslay, M.D.1    Baillie, G.S.2    Maurice, D.H.3
  • 77
    • 0011282350 scopus 로고    scopus 로고
    • Systemic administration of recombinant human relaxin (RHRLX) ameliorates the acute cyclosporine nephrotoxicity in rats
    • Huang X, Cheng Z, Sunga J, Unemori E, Zsebo K (2001). Systemic administration of recombinant human relaxin (RHRLX) ameliorates the acute cyclosporine nephrotoxicity in rats. J Heart Lung Transplant 20: 253.
    • (2001) J Heart Lung Transplant , vol.20 , pp. 253
    • Huang, X.1    Cheng, Z.2    Sunga, J.3    Unemori, E.4    Zsebo, K.5
  • 78
    • 81255157548 scopus 로고    scopus 로고
    • Relaxin regulates myofibroblast contractility and protects against lung fibrosis
    • Huang X, Gai Y, Yang N, Lu B, Samuel CS, Thannickal VJ et al. (2011). Relaxin regulates myofibroblast contractility and protects against lung fibrosis. Am J Pathol 179: 2751–2765.
    • (2011) Am J Pathol , vol.179 , pp. 2751-2765
    • Huang, X.1    Gai, Y.2    Yang, N.3    Lu, B.4    Samuel, C.S.5    Thannickal, V.J.6
  • 79
    • 84866400461 scopus 로고    scopus 로고
    • Troponin elevation in patients with heart failure: on behalf of the third Universal Definition of Myocardial Infarction Global Task Force: Heart Failure Section
    • Januzzi JL Jr, Filippatos G, Nieminen M, Gheorghiade M (2012). Troponin elevation in patients with heart failure: on behalf of the third Universal Definition of Myocardial Infarction Global Task Force: Heart Failure Section. Eur Heart J 33: 2265–2271.
    • (2012) Eur Heart J , vol.33 , pp. 2265-2271
    • Januzzi, J.L.1    Filippatos, G.2    Nieminen, M.3    Gheorghiade, M.4
  • 80
    • 84894575631 scopus 로고    scopus 로고
    • Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment
    • Jelinic M, Leo CH, Post Uiterweer ED, Sandow SL, Gooi JH, Wlodek ME et al. (2014). Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment. FASEB J 28: 275–287.
    • (2014) FASEB J , vol.28 , pp. 275-287
    • Jelinic, M.1    Leo, C.H.2    Post Uiterweer, E.D.3    Sandow, S.L.4    Gooi, J.H.5    Wlodek, M.E.6
  • 81
    • 84934980842 scopus 로고    scopus 로고
    • Differential effects of relaxin deficiency on vascular aging in arteries of male mice
    • Jelinic M, Tare M, Conrad KP, Parry LJ (2015). Differential effects of relaxin deficiency on vascular aging in arteries of male mice. Age 37: 9803.
    • (2015) Age , vol.37 , pp. 9803
    • Jelinic, M.1    Tare, M.2    Conrad, K.P.3    Parry, L.J.4
  • 82
    • 0346120209 scopus 로고    scopus 로고
    • Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries
    • Jeyabalan A, Novak J, Danielson LA, Kerchner LJ, Opett SL, Conrad KP (2003). Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries. Circ Res 93: 1249–1257.
    • (2003) Circ Res , vol.93 , pp. 1249-1257
    • Jeyabalan, A.1    Novak, J.2    Danielson, L.A.3    Kerchner, L.J.4    Opett, S.L.5    Conrad, K.P.6
  • 83
    • 84930592013 scopus 로고    scopus 로고
    • Conditional deletion of the relaxin receptor gene in cells of smooth muscle lineage affects lower reproductive tract in pregnant mice
    • Kaftanovskaya EM, Huang Z, Lopez C, Conrad K, Agoulnik AI (2015). Conditional deletion of the relaxin receptor gene in cells of smooth muscle lineage affects lower reproductive tract in pregnant mice. Biol Reprod 92: 91.
    • (2015) Biol Reprod , vol.92 , pp. 91
    • Kaftanovskaya, E.M.1    Huang, Z.2    Lopez, C.3    Conrad, K.4    Agoulnik, A.I.5
  • 84
    • 0026608441 scopus 로고
    • Cardiac effects of relaxin in rats
    • Kakouris H, Eddie LW, Summers RJ (1992). Cardiac effects of relaxin in rats. Lancet 339: 1076–1078.
    • (1992) Lancet , vol.339 , pp. 1076-1078
    • Kakouris, H.1    Eddie, L.W.2    Summers, R.J.3
  • 85
    • 70350344952 scopus 로고    scopus 로고
    • Induction of MMP-1 (collagenase-1) by relaxin in fibrocartilaginous cells requires both the AP-1 and PEA-3 promoter sites
    • Kapila S, Xie Y, Wang W (2009). Induction of MMP-1 (collagenase-1) by relaxin in fibrocartilaginous cells requires both the AP-1 and PEA-3 promoter sites. Orthod Craniofac Res 12: 178–186.
    • (2009) Orthod Craniofac Res , vol.12 , pp. 178-186
    • Kapila, S.1    Xie, Y.2    Wang, W.3
  • 87
    • 18844369874 scopus 로고    scopus 로고
    • Evidence against the hypothesis that endothelial endothelin B receptor expression is regulated by relaxin and pregnancy
    • Kerchner LJ, Novak J, Hanley-Yanez K, Doty KD, Danielson LA, Conrad KP (2005). Evidence against the hypothesis that endothelial endothelin B receptor expression is regulated by relaxin and pregnancy. Endocrinology 146: 2791–2797.
    • (2005) Endocrinology , vol.146 , pp. 2791-2797
    • Kerchner, L.J.1    Novak, J.2    Hanley-Yanez, K.3    Doty, K.D.4    Danielson, L.A.5    Conrad, K.P.6
  • 88
    • 33847071711 scopus 로고    scopus 로고
    • The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane
    • Kern A, Agoulnik AI, Bryant-Greenwood GD (2007). The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane. Endocrinology 148: 1181–1194.
    • (2007) Endocrinology , vol.148 , pp. 1181-1194
    • Kern, A.1    Agoulnik, A.I.2    Bryant-Greenwood, G.D.3
  • 89
    • 0037343205 scopus 로고    scopus 로고
    • Signalling specificity in GPCR-dependent Ca2+ signalling
    • Kiselyov K, Shin DM, Muallem S (2003). Signalling specificity in GPCR-dependent Ca2+ signalling. Cell Signal 15: 243–253.
    • (2003) Cell Signal , vol.15 , pp. 243-253
    • Kiselyov, K.1    Shin, D.M.2    Muallem, S.3
  • 90
    • 80051540137 scopus 로고    scopus 로고
    • No-reflow phenomenon: maintaining vascular integrity
    • Kloner RA (2011). No-reflow phenomenon: maintaining vascular integrity. J Cardiovasc Pharmacol Ther 16: 244–250.
    • (2011) J Cardiovasc Pharmacol Ther , vol.16 , pp. 244-250
    • Kloner, R.A.1
  • 91
    • 0036849160 scopus 로고    scopus 로고
    • Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin
    • Kompa AR, Samuel CS, Summers RJ (2002). Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin. Br J Pharmacol 137: 710–718.
    • (2002) Br J Pharmacol , vol.137 , pp. 710-718
    • Kompa, A.R.1    Samuel, C.S.2    Summers, R.J.3
  • 92
    • 84951192437 scopus 로고    scopus 로고
    • Atrial fibrillation in heart failure: what should we do?
    • Kotecha D, Piccini JP (2015). Atrial fibrillation in heart failure: what should we do? Eur Heart J 36: 3250–3257.
    • (2015) Eur Heart J , vol.36 , pp. 3250-3257
    • Kotecha, D.1    Piccini, J.P.2
  • 94
    • 79960027552 scopus 로고    scopus 로고
    • Microvascular tissue perfusion is impaired in acutely decompensated heart failure and improves following standard treatment
    • Lauten A, Ferrari M, Goebel B, Rademacher W, Schumm J, Uth O et al. (2011). Microvascular tissue perfusion is impaired in acutely decompensated heart failure and improves following standard treatment. Eur J Heart Fail 13: 711–717.
    • (2011) Eur J Heart Fail , vol.13 , pp. 711-717
    • Lauten, A.1    Ferrari, M.2    Goebel, B.3    Rademacher, W.4    Schumm, J.5    Uth, O.6
  • 95
    • 11144248392 scopus 로고    scopus 로고
    • The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy in rats
    • Lee HY, Zhao S, Fields PA, Sherwood OD (2005). The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy in rats. Endocrinology 146: 511–518.
    • (2005) Endocrinology , vol.146 , pp. 511-518
    • Lee, H.Y.1    Zhao, S.2    Fields, P.A.3    Sherwood, O.D.4
  • 96
    • 23244443050 scopus 로고    scopus 로고
    • Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats
    • Lekgabe ED, Kiriazis H, Zhao C, Xu Q, Moore XL, Su Y et al. (2005). Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats. Hypertension 46: 412–418.
    • (2005) Hypertension , vol.46 , pp. 412-418
    • Lekgabe, E.D.1    Kiriazis, H.2    Zhao, C.3    Xu, Q.4    Moore, X.L.5    Su, Y.6
  • 97
    • 84907266429 scopus 로고    scopus 로고
    • A vasoactive role for endogenous relaxin in mesenteric arteries of male mice
    • Leo CH, Jelinic M, Gooi JH, Tare M, Parry LJ (2014a). A vasoactive role for endogenous relaxin in mesenteric arteries of male mice. PLoS One 9: e107382.
    • (2014) PLoS One , vol.9
    • Leo, C.H.1    Jelinic, M.2    Gooi, J.H.3    Tare, M.4    Parry, L.J.5
  • 98
    • 84898657150 scopus 로고    scopus 로고
    • Acute intravenous injection of serelaxin (recombinant human relaxin-2) causes rapid and sustained bradykinin-mediated vasorelaxation
    • Leo CH, Jelinic M, Parkington HC, Tare M, Parry LJ (2014b). Acute intravenous injection of serelaxin (recombinant human relaxin-2) causes rapid and sustained bradykinin-mediated vasorelaxation. J Am Heart Assoc 3: e000493.
    • (2014) J Am Heart Assoc , vol.3
    • Leo, C.H.1    Jelinic, M.2    Parkington, H.C.3    Tare, M.4    Parry, L.J.5
  • 99
    • 27744539000 scopus 로고    scopus 로고
    • Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity and compliance of the rat mesenteric arterial and venous vasculature
    • Li Y, Brookes ZL, Kaufman S (2005). Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity and compliance of the rat mesenteric arterial and venous vasculature. Regul Pept 132: 41–46.
    • (2005) Regul Pept , vol.132 , pp. 41-46
    • Li, Y.1    Brookes, Z.L.2    Kaufman, S.3
  • 101
    • 84878538995 scopus 로고    scopus 로고
    • RNAi-mediated knockdown of relaxin decreases in vitro proliferation and invasiveness of osteosarcoma MG-63 cells by inhibition of MMP-9
    • Ma JF, Liu L, Yang WJ, Zang LN, Xi YM (2013a). RNAi-mediated knockdown of relaxin decreases in vitro proliferation and invasiveness of osteosarcoma MG-63 cells by inhibition of MMP-9. Eur Rev Med Pharmacol Sci 17: 1102–1109.
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , pp. 1102-1109
    • Ma, J.F.1    Liu, L.2    Yang, W.J.3    Zang, L.N.4    Xi, Y.M.5
  • 102
    • 84878536438 scopus 로고    scopus 로고
    • Relaxin promotes in vitro tumour growth, invasion and angiogenesis of human Saos-2 osteosarcoma cells by AKT/VEGF pathway
    • Ma JF, Von Kalle M, Plautz Q, -M Xu F, Singh L, Wang L (2013b). Relaxin promotes in vitro tumour growth, invasion and angiogenesis of human Saos-2 osteosarcoma cells by AKT/VEGF pathway. Eur Rev Med Pharmacol Sci 17: 1345–1350.
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , pp. 1345-1350
    • Ma, J.F.1    Von Kalle, M.2    Plautz, Q.3    Xu, F.4    Singh, L.5    Wang, L.6
  • 103
    • 0030729675 scopus 로고    scopus 로고
    • Relaxin counteracts myocardial damage induced by ischemia–reperfusion in isolated guinea pig hearts: evidence for an involvement of nitric oxide
    • Masini E, Bani D, Bello MG, Bigazzi M, Mannaioni PF, Sacchi TB (1997). Relaxin counteracts myocardial damage induced by ischemia–reperfusion in isolated guinea pig hearts: evidence for an involvement of nitric oxide. Endocrinology 138: 4713–4720.
    • (1997) Endocrinology , vol.138 , pp. 4713-4720
    • Masini, E.1    Bani, D.2    Bello, M.G.3    Bigazzi, M.4    Mannaioni, P.F.5    Sacchi, T.B.6
  • 104
    • 0028941305 scopus 로고
    • Relaxin inhibits histamine release from mast cells: involvement of nitric oxide production
    • Masini E, Di Bello MG, Bani D, Bigazzi M, Bani Sacchi T, Mannaioni PF (1995). Relaxin inhibits histamine release from mast cells: involvement of nitric oxide production. Inflamm Res 44 (Suppl 1): S12–S13.
    • (1995) Inflamm Res , vol.44 , pp. S12-S13
    • Masini, E.1    Di Bello, M.G.2    Bani, D.3    Bigazzi, M.4    Bani Sacchi, T.5    Mannaioni, P.F.6
  • 105
    • 1442323685 scopus 로고    scopus 로고
    • Relaxin inhibits the activation of human neutrophils: involvement of the nitric oxide pathway
    • Masini E, Nistri S, Vannacci A, Bani Sacchi T, Novelli A, Bani D (2004). Relaxin inhibits the activation of human neutrophils: involvement of the nitric oxide pathway. Endocrinology 145: 1106–1112.
    • (2004) Endocrinology , vol.145 , pp. 1106-1112
    • Masini, E.1    Nistri, S.2    Vannacci, A.3    Bani Sacchi, T.4    Novelli, A.5    Bani, D.6
  • 106
    • 0036792631 scopus 로고    scopus 로고
    • Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway
    • Masini E, Zagli G, Ndisang JF, Solazzo M, Mannaioni PF, Bani D (2002). Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway. Br J Pharmacol 137: 337–344.
    • (2002) Br J Pharmacol , vol.137 , pp. 337-344
    • Masini, E.1    Zagli, G.2    Ndisang, J.F.3    Solazzo, M.4    Mannaioni, P.F.5    Bani, D.6
  • 108
    • 0032576551 scopus 로고    scopus 로고
    • Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases
    • Matsubara H (1998). Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ Res 83: 1182–1191.
    • (1998) Circ Res , vol.83 , pp. 1182-1191
    • Matsubara, H.1
  • 109
    • 79956361338 scopus 로고    scopus 로고
    • Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans
    • McGuane JT, Danielson LA, Debrah JE, Rubin JP, Novak J, Conrad KP (2011a). Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans. Hypertension 57: 1151–1160.
    • (2011) Hypertension , vol.57 , pp. 1151-1160
    • McGuane, J.T.1    Danielson, L.A.2    Debrah, J.E.3    Rubin, J.P.4    Novak, J.5    Conrad, K.P.6
  • 110
    • 79959468302 scopus 로고    scopus 로고
    • Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide
    • McGuane JT, Debrah JE, Sautina L, Jarajapu YP, Novak J, Rubin JP et al. (2011b). Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide. Endocrinology 152: 2786–2796.
    • (2011) Endocrinology , vol.152 , pp. 2786-2796
    • McGuane, J.T.1    Debrah, J.E.2    Sautina, L.3    Jarajapu, Y.P.4    Novak, J.5    Rubin, J.P.6
  • 111
    • 84871927704 scopus 로고    scopus 로고
    • Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: correlation with outcomes
    • Metra M, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH et al. (2013a). Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: correlation with outcomes. J Am Coll Cardiol 61: 196–206.
    • (2013) J Am Coll Cardiol , vol.61 , pp. 196-206
    • Metra, M.1    Cotter, G.2    Davison, B.A.3    Felker, G.M.4    Filippatos, G.5    Greenberg, B.H.6
  • 112
    • 84890096177 scopus 로고    scopus 로고
    • Effects of serelaxin in subgroups of patients with acute heart failure: results from RELAX-AHF
    • Metra M, Ponikowski P, Cotter G, Davison BA, Felker GM, Filippatos G et al. (2013b). Effects of serelaxin in subgroups of patients with acute heart failure: results from RELAX-AHF. Eur Heart J 34: 3128–3136.
    • (2013) Eur Heart J , vol.34 , pp. 3128-3136
    • Metra, M.1    Ponikowski, P.2    Cotter, G.3    Davison, B.A.4    Felker, G.M.5    Filippatos, G.6
  • 114
    • 65349122390 scopus 로고    scopus 로고
    • Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2
    • Mookerjee I, Hewitson TD, Halls ML, Summers RJ, Mathai ML, Bathgate RA et al. (2009). Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2. FASEB J 23: 1219–1229.
    • (2009) FASEB J , vol.23 , pp. 1219-1229
    • Mookerjee, I.1    Hewitson, T.D.2    Halls, M.L.3    Summers, R.J.4    Mathai, M.L.5    Bathgate, R.A.6
  • 115
    • 84903769946 scopus 로고    scopus 로고
    • Diverse regulation of cardiac expression of relaxin receptor by α1- and β1-adrenoceptors
    • Moore XL, Su Y, Fan Y, Zhang YY, Woodcock EA, Dart AM et al. (2014). Diverse regulation of cardiac expression of relaxin receptor by α1- and β1-adrenoceptors. Cardiovasc Drugs Ther 28: 221–228.
    • (2014) Cardiovasc Drugs Ther , vol.28 , pp. 221-228
    • Moore, X.L.1    Su, Y.2    Fan, Y.3    Zhang, Y.Y.4    Woodcock, E.A.5    Dart, A.M.6
  • 116
    • 33947379636 scopus 로고    scopus 로고
    • Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes
    • Moore XL, Tan SL, Lo CY, Fang L, Su YD, Gao XM et al. (2007). Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes. Endocrinology 148: 1582–1589.
    • (2007) Endocrinology , vol.148 , pp. 1582-1589
    • Moore, X.L.1    Tan, S.L.2    Lo, C.Y.3    Fang, L.4    Su, Y.D.5    Gao, X.M.6
  • 117
    • 84937414775 scopus 로고    scopus 로고
    • Increased superoxide production and altered nitric oxide-mediated relaxation in the aorta of young but not old male relaxin-deficient mice
    • Ng HH, Jelinic M, Parry LJ, Leo CH (2015). Increased superoxide production and altered nitric oxide-mediated relaxation in the aorta of young but not old male relaxin-deficient mice. Am J Physiol Heart Circ Physiol 309: H285–H296.
    • (2015) Am J Physiol Heart Circ Physiol , vol.309 , pp. H285-H296
    • Ng, H.H.1    Jelinic, M.2    Parry, L.J.3    Leo, C.H.4
  • 118
    • 23644441514 scopus 로고    scopus 로고
    • Relaxin stimulates cAMP production in MCF-7 cells upon overexpression of type V adenylyl cyclase
    • Nguyen BT, Dessauer CW (2005a). Relaxin stimulates cAMP production in MCF-7 cells upon overexpression of type V adenylyl cyclase. Ann N Y Acad Sci 1041: 296–299.
    • (2005) Ann N Y Acad Sci , vol.1041 , pp. 296-299
    • Nguyen, B.T.1    Dessauer, C.W.2
  • 119
    • 15444366198 scopus 로고    scopus 로고
    • Relaxin stimulates protein kinase C z translocation: requirement for cyclic adenosine 3′,5′-monophosphate production
    • Nguyen BT, Dessauer CW (2005b). Relaxin stimulates protein kinase C z translocation: requirement for cyclic adenosine 3′,5′-monophosphate production. Mol Endocrinol 19: 1012–1023.
    • (2005) Mol Endocrinol , vol.19 , pp. 1012-1023
    • Nguyen, B.T.1    Dessauer, C.W.2
  • 120
    • 39149091073 scopus 로고    scopus 로고
    • Relaxin induces mast cell inhibition and reduces ventricular arrhythmias in a swine model of acute myocardial infarction
    • Nistri S, Cinci L, Perna AM, Masini E, Mastroianni R, Bani D (2008). Relaxin induces mast cell inhibition and reduces ventricular arrhythmias in a swine model of acute myocardial infarction. Pharmacol Res 57: 43–48.
    • (2008) Pharmacol Res , vol.57 , pp. 43-48
    • Nistri, S.1    Cinci, L.2    Perna, A.M.3    Masini, E.4    Mastroianni, R.5    Bani, D.6
  • 123
    • 84880771641 scopus 로고    scopus 로고
    • Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts
    • Parikh A, Patel D, McTiernan CF, Xiang W, Haney J, Yang L et al. (2013). Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts. Circ Res 113: 313–321.
    • (2013) Circ Res , vol.113 , pp. 313-321
    • Parikh, A.1    Patel, D.2    McTiernan, C.F.3    Xiang, W.4    Haney, J.5    Yang, L.6
  • 124
    • 84879748718 scopus 로고    scopus 로고
    • A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation
    • Paulus WJ, Tschope C (2013). A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol 62: 263–271.
    • (2013) J Am Coll Cardiol , vol.62 , pp. 263-271
    • Paulus, W.J.1    Tschope, C.2
  • 125
    • 0347991617 scopus 로고    scopus 로고
    • Invasive assessment of bacterial endotoxin and inflammatory cytokines in patients with acute heart failure
    • Peschel T, Schonauer M, Thiele H, Anker SD, Schuler G, Niebauer J (2003). Invasive assessment of bacterial endotoxin and inflammatory cytokines in patients with acute heart failure. Eur J Heart Fail 5: 609–614.
    • (2003) Eur J Heart Fail , vol.5 , pp. 609-614
    • Peschel, T.1    Schonauer, M.2    Thiele, H.3    Anker, S.D.4    Schuler, G.5    Niebauer, J.6
  • 126
    • 84894276127 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure
    • Ponikowski P, Mitrovic V, Ruda M, Fernandez A, Voors AA, Vishnevsky A et al. (2014). A randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure. Eur Heart J 35: 431–441.
    • (2014) Eur Heart J , vol.35 , pp. 431-441
    • Ponikowski, P.1    Mitrovic, V.2    Ruda, M.3    Fernandez, A.4    Voors, A.A.5    Vishnevsky, A.6
  • 127
    • 2642558654 scopus 로고    scopus 로고
    • Relaxin potentiates the expression of inducible nitric oxide synthase by endothelial cells from human umbilical vein in in vitro culture
    • Quattrone S, Chiappini L, Scapagnini G, Bigazzi B, Bani D (2004). Relaxin potentiates the expression of inducible nitric oxide synthase by endothelial cells from human umbilical vein in in vitro culture. Mol Hum Reprod 10: 325–330.
    • (2004) Mol Hum Reprod , vol.10 , pp. 325-330
    • Quattrone, S.1    Chiappini, L.2    Scapagnini, G.3    Bigazzi, B.4    Bani, D.5
  • 128
    • 84904514461 scopus 로고    scopus 로고
    • Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease
    • Samuel CS, Bodaragama H, Chew JY, Widdop RE, Royce SG, Hewitson TD (2014). Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease. Hypertension 64: 315–322.
    • (2014) Hypertension , vol.64 , pp. 315-322
    • Samuel, C.S.1    Bodaragama, H.2    Chew, J.Y.3    Widdop, R.E.4    Royce, S.G.5    Hewitson, T.D.6
  • 130
    • 46349103257 scopus 로고    scopus 로고
    • Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy
    • Samuel CS, Hewitson TD, Zhang Y, Kelly DJ (2008). Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy. Endocrinology 149: 3286–3293.
    • (2008) Endocrinology , vol.149 , pp. 3286-3293
    • Samuel, C.S.1    Hewitson, T.D.2    Zhang, Y.3    Kelly, D.J.4
  • 131
    • 38749122842 scopus 로고    scopus 로고
    • The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease
    • Samuel CS, Lekgabe ED, Mookerjee I (2007). The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease. Adv Exp Med Biol 612: 88–103.
    • (2007) Adv Exp Med Biol , vol.612 , pp. 88-103
    • Samuel, C.S.1    Lekgabe, E.D.2    Mookerjee, I.3
  • 132
    • 0037385601 scopus 로고    scopus 로고
    • Physiological or pathological–a role for relaxin in the cardiovascular system?
    • Samuel CS, Parry LJ, Summers RJ (2003). Physiological or pathological–a role for relaxin in the cardiovascular system? Curr Opin Pharmacol 3: 152–158.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 152-158
    • Samuel, C.S.1    Parry, L.J.2    Summers, R.J.3
  • 133
    • 4344606223 scopus 로고    scopus 로고
    • Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo
    • Samuel CS, Unemori EN, Mookerjee I, Bathgate RA, Layfield SL, Mak J et al. (2004a). Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo. Endocrinology 145: 4125–4133.
    • (2004) Endocrinology , vol.145 , pp. 4125-4133
    • Samuel, C.S.1    Unemori, E.N.2    Mookerjee, I.3    Bathgate, R.A.4    Layfield, S.L.5    Mak, J.6
  • 135
    • 84956752656 scopus 로고    scopus 로고
    • Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells
    • Sarwar M, Samuel CS, Bathgate RA, Stewart DR, Summers RJ (2016). Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells. Br J Pharmacol 173: 484–496.
    • (2016) Br J Pharmacol , vol.173 , pp. 484-496
    • Sarwar, M.1    Samuel, C.S.2    Bathgate, R.A.3    Stewart, D.R.4    Summers, R.J.5
  • 136
    • 84921792573 scopus 로고    scopus 로고
    • Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration–response curves reflect differential coupling to G proteins
    • Sarwar M, Samuel CS, Bathgate RA, Stewart DR, Summers RJ (2015). Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration–response curves reflect differential coupling to G proteins. Br J Pharmacol 172: 1005–1019.
    • (2015) Br J Pharmacol , vol.172 , pp. 1005-1019
    • Sarwar, M.1    Samuel, C.S.2    Bathgate, R.A.3    Stewart, D.R.4    Summers, R.J.5
  • 137
    • 80051472751 scopus 로고    scopus 로고
    • Relaxin ameliorates hypertension and increases nitric oxide metabolite excretion in angiotensin II but not N(omega)-nitro-l-arginine methyl ester hypertensive rats
    • Sasser JM, Molnar M, Baylis C (2011). Relaxin ameliorates hypertension and increases nitric oxide metabolite excretion in angiotensin II but not N(omega)-nitro-l-arginine methyl ester hypertensive rats. Hypertension 58: 197–204.
    • (2011) Hypertension , vol.58 , pp. 197-204
    • Sasser, J.M.1    Molnar, M.2    Baylis, C.3
  • 138
    • 84930067739 scopus 로고    scopus 로고
    • Multicenter, randomized, double-blinded, placebo-controlled phase II study of serelaxin in Japanese patients with acute heart failure
    • Sato N, Takahashi W, Hirayama A, Ajioka M, Takahashi N, Okishige K et al. (2015). Multicenter, randomized, double-blinded, placebo-controlled phase II study of serelaxin in Japanese patients with acute heart failure. Circ J 79: 1237–1247.
    • (2015) Circ J , vol.79 , pp. 1237-1247
    • Sato, N.1    Takahashi, W.2    Hirayama, A.3    Ajioka, M.4    Takahashi, N.5    Okishige, K.6
  • 139
    • 84862907742 scopus 로고    scopus 로고
    • Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice
    • Segal MS, Sautina L, Li S, Diao Y, Agoulnik AI, Kielczewski J et al. (2012). Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice. Blood 119: 629–636.
    • (2012) Blood , vol.119 , pp. 629-636
    • Segal, M.S.1    Sautina, L.2    Li, S.3    Diao, Y.4    Agoulnik, A.I.5    Kielczewski, J.6
  • 141
    • 3042610399 scopus 로고    scopus 로고
    • Relaxin's physiological roles and other diverse actions
    • Sherwood OD (2004). Relaxin's physiological roles and other diverse actions. Endocr Rev 25: 205–234.
    • (2004) Endocr Rev , vol.25 , pp. 205-234
    • Sherwood, O.D.1
  • 142
    • 0029933870 scopus 로고    scopus 로고
    • Hemodynamic changes in early pregnancy in chronically instrumented, conscious rats
    • Slangen BF, Out IC, Verkeste CM, Peeters LL (1996). Hemodynamic changes in early pregnancy in chronically instrumented, conscious rats. Am J Physiol 270: H1779–H1784.
    • (1996) Am J Physiol , vol.270 , pp. H1779-H1784
    • Slangen, B.F.1    Out, I.C.2    Verkeste, C.M.3    Peeters, L.L.4
  • 143
    • 84976865494 scopus 로고    scopus 로고
    • The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands
    • Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SPH et al. (2016). The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucl Acids Res 44 (Database Issue): D1054–D1068.
    • (2016) Nucl Acids Res , vol.44 , Issue.Database Issue , pp. D1054-D1068
    • Southan, C.1    Sharman, J.L.2    Benson, H.E.3    Faccenda, E.4    Pawson, A.J.5    Alexander, S.P.H.6
  • 144
    • 0034609575 scopus 로고    scopus 로고
    • Pulmonary release and coronary and peripheral consumption of big endothelin and endothelin-1 in severe heart failure: acute effects of vasodilator therapy
    • Stangl K, Dschietzig T, Richter C, Laule M, Stangl V, Tanis E et al. (2000). Pulmonary release and coronary and peripheral consumption of big endothelin and endothelin-1 in severe heart failure: acute effects of vasodilator therapy. Circulation 102: 1132–1138.
    • (2000) Circulation , vol.102 , pp. 1132-1138
    • Stangl, K.1    Dschietzig, T.2    Richter, C.3    Laule, M.4    Stangl, V.5    Tanis, E.6
  • 145
    • 0032908730 scopus 로고    scopus 로고
    • Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of oestrogen treatment
    • Tan YY, Wade JD, Tregear GW, Summers RJ (1999). Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of oestrogen treatment. Br J Pharmacol 127: 91–98.
    • (1999) Br J Pharmacol , vol.127 , pp. 91-98
    • Tan, Y.Y.1    Wade, J.D.2    Tregear, G.W.3    Summers, R.J.4
  • 146
    • 84871986523 scopus 로고    scopus 로고
    • Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial
    • Teerlink JR, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH et al. (2013). Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial. Lancet 381: 29–39.
    • (2013) Lancet , vol.381 , pp. 29-39
    • Teerlink, J.R.1    Cotter, G.2    Davison, B.A.3    Felker, G.M.4    Filippatos, G.5    Greenberg, B.H.6
  • 147
    • 65249190276 scopus 로고    scopus 로고
    • Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study
    • Teerlink JR, Metra M, Felker GM, Ponikowski P, Voors AA, Weatherley BD et al. (2009). Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study. Lancet 373: 1429–1439.
    • (2009) Lancet , vol.373 , pp. 1429-1439
    • Teerlink, J.R.1    Metra, M.2    Felker, G.M.3    Ponikowski, P.4    Voors, A.A.5    Weatherley, B.D.6
  • 148
    • 0029761252 scopus 로고    scopus 로고
    • Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart
    • Toth M, Taskinen P, Ruskoaho H (1996). Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart. J Endocrinol 150: 487–495.
    • (1996) J Endocrinol , vol.150 , pp. 487-495
    • Toth, M.1    Taskinen, P.2    Ruskoaho, H.3
  • 149
    • 0033037935 scopus 로고    scopus 로고
    • Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women
    • Unemori EN, Erikson ME, Rocco SE, Sutherland KM, Parsell DA, Mak J et al. (1999). Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women. Hum Reprod 14: 800–806.
    • (1999) Hum Reprod , vol.14 , pp. 800-806
    • Unemori, E.N.1    Erikson, M.E.2    Rocco, S.E.3    Sutherland, K.M.4    Parsell, D.A.5    Mak, J.6
  • 150
    • 0026446859 scopus 로고
    • Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells
    • Unemori EN, Ferrara N, Bauer EA, Amento EP (1992). Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153: 557–562.
    • (1992) J Cell Physiol , vol.153 , pp. 557-562
    • Unemori, E.N.1    Ferrara, N.2    Bauer, E.A.3    Amento, E.P.4
  • 151
    • 0033673465 scopus 로고    scopus 로고
    • Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites
    • Unemori EN, Lewis M, Constant J, Arnold G, Grove BH, Normand J et al. (2000). Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites. Wound Repair Regen 8: 361–370.
    • (2000) Wound Repair Regen , vol.8 , pp. 361-370
    • Unemori, E.N.1    Lewis, M.2    Constant, J.3    Arnold, G.4    Grove, B.H.5    Normand, J.6
  • 152
    • 0030453783 scopus 로고    scopus 로고
    • Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo
    • Unemori EN, Pickford LB, Salles AL, Piercy CE, Grove BH, Erikson ME et al. (1996). Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J Clin Invest 98: 2739–2745.
    • (1996) J Clin Invest , vol.98 , pp. 2739-2745
    • Unemori, E.N.1    Pickford, L.B.2    Salles, A.L.3    Piercy, C.E.4    Grove, B.H.5    Erikson, M.E.6
  • 153
    • 77958588102 scopus 로고    scopus 로고
    • Progesterone withdrawal, and not increased circulating relaxin, mediates the decrease in myometrial relaxin receptor (RXFP1) expression in late gestation in rats
    • Vodstrcil LA, Shynlova O, Westcott K, Laker R, Simpson E, Wlodek ME et al. (2010). Progesterone withdrawal, and not increased circulating relaxin, mediates the decrease in myometrial relaxin receptor (RXFP1) expression in late gestation in rats. Biol Reprod 83: 825–832.
    • (2010) Biol Reprod , vol.83 , pp. 825-832
    • Vodstrcil, L.A.1    Shynlova, O.2    Westcott, K.3    Laker, R.4    Simpson, E.5    Wlodek, M.E.6
  • 154
    • 84925721219 scopus 로고    scopus 로고
    • Renal hemodynamic effects of serelaxin in patients with chronic heart failure: a randomized, placebo-controlled study
    • Voors AA, Dahlke M, Meyer S, Stepinska J, Gottlieb SS, Jones A et al. (2014). Renal hemodynamic effects of serelaxin in patients with chronic heart failure: a randomized, placebo-controlled study. Circ Heart Fail 7: 994–1002.
    • (2014) Circ Heart Fail , vol.7 , pp. 994-1002
    • Voors, A.A.1    Dahlke, M.2    Meyer, S.3    Stepinska, J.4    Gottlieb, S.S.5    Jones, A.6
  • 155
    • 80052016600 scopus 로고    scopus 로고
    • Early drop in systolic blood pressure and worsening renal function in acute heart failure: renal results of Pre-RELAX-AHF
    • Voors AA, Davison B, Felker GM, Ponikowski P, Unemori E, Cotter G et al. (2011). Early drop in systolic blood pressure and worsening renal function in acute heart failure: renal results of Pre-RELAX-AHF. Eur J Heart Fail 13: 961–967.
    • (2011) Eur J Heart Fail , vol.13 , pp. 961-967
    • Voors, A.A.1    Davison, B.2    Felker, G.M.3    Ponikowski, P.4    Unemori, E.5    Cotter, G.6
  • 156
    • 0028800212 scopus 로고
    • Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure. Endothelin antagonism in heart failure
    • Webb DJ (1995). Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure. Endothelin antagonism in heart failure. Circulation 92: 3372.
    • (1995) Circulation , vol.92 , pp. 3372
    • Webb, D.J.1
  • 157
    • 0034829351 scopus 로고    scopus 로고
    • Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo
    • Williams EJ, Benyon RC, Trim N, Hadwin R, Grove BH, Arthur MJ et al. (2001). Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 49: 577–583.
    • (2001) Gut , vol.49 , pp. 577-583
    • Williams, E.J.1    Benyon, R.C.2    Trim, N.3    Hadwin, R.4    Grove, B.H.5    Arthur, M.J.6
  • 158
    • 29244450479 scopus 로고    scopus 로고
    • Relaxin-induced reduction of infarct size in male rats receiving MCAO is dependent on nitric oxide synthesis and not estrogenic mechanisms
    • Wilson BC, Connell B, Saleh TM (2006). Relaxin-induced reduction of infarct size in male rats receiving MCAO is dependent on nitric oxide synthesis and not estrogenic mechanisms. Neurosci Lett 393: 160–164.
    • (2006) Neurosci Lett , vol.393 , pp. 160-164
    • Wilson, B.C.1    Connell, B.2    Saleh, T.M.3
  • 159
    • 77951499083 scopus 로고    scopus 로고
    • Relaxin therapy reverses large artery remodeling and improves arterial compliance in senescent spontaneously hypertensive rats
    • Xu Q, Chakravorty A, Bathgate RA, Dart AM, Du XJ (2010). Relaxin therapy reverses large artery remodeling and improves arterial compliance in senescent spontaneously hypertensive rats. Hypertension 55: 1260–1266.
    • (2010) Hypertension , vol.55 , pp. 1260-1266
    • Xu, Q.1    Chakravorty, A.2    Bathgate, R.A.3    Dart, A.M.4    Du, X.J.5
  • 160
    • 38549084862 scopus 로고    scopus 로고
    • Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis
    • Xu Q, Lekgabe ED, Gao XM, Ming Z, Tregear GW, Dart AM et al. (2008). Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis. Endocrinology 149: 476–482.
    • (2008) Endocrinology , vol.149 , pp. 476-482
    • Xu, Q.1    Lekgabe, E.D.2    Gao, X.M.3    Ming, Z.4    Tregear, G.W.5    Dart, A.M.6
  • 161
    • 43549110730 scopus 로고    scopus 로고
    • Relaxin (RLX) and estrogen affect estrogen receptor alpha, vascular endothelial growth factor, and RLX receptor expression in the neonatal porcine uterus and cervix
    • Yan W, Chen J, Wiley AA, Crean-Harris BD, Bartol FF, Bagnell CA (2008). Relaxin (RLX) and estrogen affect estrogen receptor alpha, vascular endothelial growth factor, and RLX receptor expression in the neonatal porcine uterus and cervix. Reproduction 135: 705–712.
    • (2008) Reproduction , vol.135 , pp. 705-712
    • Yan, W.1    Chen, J.2    Wiley, A.A.3    Crean-Harris, B.D.4    Bartol, F.F.5    Bagnell, C.A.6
  • 162
    • 64549156090 scopus 로고    scopus 로고
    • Relative roles of the epithelial and stromal tissue compartment(s) in mediating the actions of relaxin and estrogen on cell proliferation and apoptosis in the mouse lower reproductive tract
    • Yao L, Agoulnik AI, Cooke PS, Meling DD, Sherwood OD (2009). Relative roles of the epithelial and stromal tissue compartment(s) in mediating the actions of relaxin and estrogen on cell proliferation and apoptosis in the mouse lower reproductive tract. Ann N Y Acad Sci 1160: 121–129.
    • (2009) Ann N Y Acad Sci , vol.1160 , pp. 121-129
    • Yao, L.1    Agoulnik, A.I.2    Cooke, P.S.3    Meling, D.D.4    Sherwood, O.D.5
  • 165
    • 23844466328 scopus 로고    scopus 로고
    • Effect of relaxin on myocardial ischemia injury induced by isoproterenol
    • Zhang J, Qi YF, Geng B, Pan CS, Zhao J, Chen L et al. (2005). Effect of relaxin on myocardial ischemia injury induced by isoproterenol. Peptides 26: 1632–1639.
    • (2005) Peptides , vol.26 , pp. 1632-1639
    • Zhang, J.1    Qi, Y.F.2    Geng, B.3    Pan, C.S.4    Zhao, J.5    Chen, L.6
  • 166
    • 0036242761 scopus 로고    scopus 로고
    • Relaxin activates the MAP kinase pathway in human endometrial stromal cells
    • Zhang Q, Liu SH, Erikson M, Lewis M, Unemori E (2002). Relaxin activates the MAP kinase pathway in human endometrial stromal cells. J Cell Biochem 85: 536–544.
    • (2002) J Cell Biochem , vol.85 , pp. 536-544
    • Zhang, Q.1    Liu, S.H.2    Erikson, M.3    Lewis, M.4    Unemori, E.5
  • 167
    • 84919399181 scopus 로고    scopus 로고
    • H2 and H3 relaxin inhibit high glucose-induced apoptosis in neonatal rat ventricular myocytes
    • Zhang X, Ma X, Zhao M, Zhang B, Chi J, Liu W et al. (2015). H2 and H3 relaxin inhibit high glucose-induced apoptosis in neonatal rat ventricular myocytes. Biochimie 108: 59–67.
    • (2015) Biochimie , vol.108 , pp. 59-67
    • Zhang, X.1    Ma, X.2    Zhao, M.3    Zhang, B.4    Chi, J.5    Liu, W.6


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