Relaxin inhibits early steps in vascular inflammation

Regulatory Peptides

Volumn 166, Issue 1-3, 2011, Pages 76-82

  Brecht, Anna ^a   Bartsch, Cornelia ^a   Baumann, Gert ^a   Stangl, Karl ^a   Dschietzig, Thomas ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Endothelial adhesion molecules; MCP 1; Relaxin; TNF ; Vascular inflammation

Indexed keywords

CD31 ANTIGEN; CHEMOKINE RECEPTOR CCR2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; RELAXIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; AORTA; ARTICLE; CELL ADHESION; CONTROLLED STUDY; ENDOTHELIUM CELL; HORMONE ACTION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULITIS;

AORTA; CELL ADHESION; CHEMOKINE CCL2; DOWN-REGULATION; E-SELECTIN; ENDOTHELIUM, VASCULAR; HUMANS; INFLAMMATION; INTEGRIN ALPHA4; MUSCLE, SMOOTH, VASCULAR; RECEPTORS, CCR2; RELAXIN; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 78650175034     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2010.09.001     Document Type: Article

References (40)

1. Samuel C.S., Du X.J., Bathgate R.A., Summers R.J. 'Relaxin' the stiffened heart and arteries: the therapeutic potential for relaxin in the treatment of cardiovascular disease. Pharmacol Ther 2006, 112:529-552.
2. Schwabe C., Steinetz B., Weiss G., Segaloff A., McDonald J.K., O'Byrne E., Hochman J., Carriere B., Goldsmith L. Relaxin. Recent Prog Horm Res 1978, 34:123-211.
3. Hsu S.Y., Nakabayashi K., Nishi S., Kumagai J., Kudo M., Sherwood O.D., Hsueh A.J. Activation of orphan receptors by the hormone relaxin. Science 2002, 295:671-674.
4. Masini E., Bani D., Bigazzi M., Mannaioni P.F., Bani-Sacchi T. Effects of relaxin on mast cells. In vitro and in vivo studies in rats and guinea pigs. J Clin Invest 1994, 94:1974-1980.
5. Nistri S., Bani D. Relaxin receptors and nitric oxide synthases: search for the missing link. Reprod Biol Endocrinol 2003, 1:5.
6. Dschietzig T., Bartsch C., Richter C., Laule M., Baumann G., Stangl K. Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB. Circ Res 2003, 92:32-40.
7. Dschietzig T., Bartsch C., Stangl V., Baumann G., Stangl K. Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist. FASEB J 2004, 18:1536-1538.
8. Du X.J., Samuel C.S., Gao X.M., Zhao L., Parry L.J., Tregear G.W. Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype. Cardiovasc Res 2003, 57:395-404.
9. Samuel C.S., Unemori E.N., Mookerjee I., Bathgate R.A., Layfield S.L., Mak J., Tregear G.W., Du X.J. Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo. Endocrinology 2004, 145:4125-4133.
10. Bani-Sacchi T., Bigazzi M., Bani D., Mannaioni P.F., Masini E. Relaxin-induced increased coronary flow through stimulation of nitric oxide production. Br J Pharmacol 1995, 116:1589-1594.
11. Fisher C., MacLean M., Morecroft I., Seed A., Johnston F., Hillier C., McMurray J. Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart?. Circulation 2002, 106:292-295.
12. Kakouris H., Eddie L.W., Summers R.J. Cardiac effects of relaxin in rats. Lancet 1992, 339:1076-1078.
13. Zhang H., Park Y., Wu J., Chen X., Lee S., Yang J., Dellsperger K.C., Zhang C. Role of TNF-alpha in vascular dysfunction. Clin Sci (Lond) 2009, 116:219-230. Review.
14. Ohlsson S., Bakoush O., Tencer J., Torffvit O., Segelmark M. Monocyte chemoattractant protein 1 is a prognostic marker in ANCA-associated small vessel vasculitis. Mediat Inflamm 2009, 2009:584916.
15. Conti P., DiGioacchino M. MCP-1 and RANTES are mediators of acute and chronic inflammation. Allergy Asthma Proc 2001, 22:133-137.
16. Rovin B.H., Rumancik M., Tan L., Dickerson J. Glomerular expression of monocyte chemoattractant protein-1 in experimental and human glomerulonephritis. Lab Invest 1994, 71:536-542.
17. Mestas J., Ley K. Monocyte-endothelial cell interactions in the development of atherosclerosis. Trends Cardiovasc Med 2008, 18:228-232.
18. Stangl V., Günther C., Jarrin A., Bramlage P., Moobed M., Staudt A., Baumann G., Stangl K., Felix S.B. Homocysteine inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion via nuclear factor-kappaB dependent pathway. Biochem Biophys Res Commun 2001, 280:1093-1100.
19. Auwerx J. The human leukemia cell line, THP-1: a multifaceted model for the study of monocyte-macrophage differentiation. Experientia 1991, 47:22-31.
20. Braun M., Pietsch P., Zepp A., Schrör K., Baumann G., Felix S.B. Regulation of tumor necrosis factor alpha- and interleukin-1-beta-induced induced adhesion molecule expression in human vascular smooth muscle cells by cAMP. Arterioscler Thromb Vasc Biol 1997, 17:2568-2575.
21. Ludwig A., Lorenz M., Grimbo N., Steinle F., Meiners S., Bartsch C., Stangl K., Baumann G., Stangl V. The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells. Biochem Biophys Res Commun 2004, 316:659-665.
22. Stangl V., Lorenz M., Meiners S., Ludwig A., Bartsch C., Moobed M., Vietzke A., Kinkel H.T., Baumann G., Stangl K. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J 2004, 18:272-279.
23. Dschietzig T., Bartsch C., Baumann G., Stangl K. Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics. Pharmacol Ther 2006, 112:38-56.
24. Dschietzig T., Richter C., Bartsch C., Böhme C., Heinze D., Ott F., Zartnack F., Baumann G., Stangl K. Flow-induced pressure differentially regulates endothelin-1, urotensin II, adrenomedullin, and relaxin in pulmonary vascular endothelium. Biochem Biophys Res Commun 2001, 289(1):245-251.
25. Huo Y., Ley K. Adhesion molecules and atherogenesis. Acta Physiol Scand 2001, 173:35-43.
26. Kumar P., Shen Q., Pivetti C.D., Lee E.S., Wu M.H., Yuan S.Y. Molecular mechanisms of endothelial hyperpermeability: implications in inflammation. Expert Rev Mol Med 2009, 11:e19.
27. Cybulsky M.I., Iiyama K., Li H., Zhu S., Chen M., Iiyama M., Davis V., Gutierrez-Ramos J.C., Connelly P.W., Milstone D.S. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001, 107:1255-1262.
28. Huo Y., Weber C., Forlow S.B., Sperandio M., Thatte J., Mack M., Jung S., Littman D.R., Ley K. The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium. J Clin Invest 2001, 108:1307-1314.
29. Orr A.W., Hastings N.E., Blackman B.R., Wamhoff B.R. Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis. J Vasc Res 2009, 47:168-180.
30. Chatzizisis Y.S., Coskun A.U., Jonas M., Edelman E.R., Feldman C.L., Stone P.H. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol 2007, 49:2379-2393.
31. Namiki M., Kawashima S., Yamashita T., Ozaki M., Hirase T., Ishida T., Inoue N., Hirata K., Matsukawa A., Morishita R., Kaneda Y., Yokoyama M. Local overexpression of monocyte chemoattractant protein-1 at vessel wall induces infiltration of macrophages and formation of atherosclerotic lesion: synergism with hypercholesterolemia. Arterioscler Thromb Vasc Biol 2002, 22:115-120.
32. Niu J., Kolattukudy P.E. Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications. Clin Sci (Lond) 2009, 117:95-109. Review.
33. Ip W.K., Wong C.K., Lam C.W. Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-Jun NH2-terminal kinase 1/2 signalling pathways. Clin Exp Immunol 2006, 145:162-172.
34. Spoettl T., Hausmann M., Herlyn M., Gunckel M., Dirmeier A., Falk W., Herfarth H., Schoelmerich J., Rogler G. Monocyte chemoattractant protein-1 (MCP-1) inhibits the intestinal-like differentiation of monocytes. Clin Exp Immunol 2006, 145:190-199.
35. Rantapää-Dahlqvist S., Boman K., Tarkowski A., Hallmans G. Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis. Ann Rheum Dis 2007, 66:121-123.
36. Nistri S., Chiappini L., Sassoli C., Bani D. Relaxin inhibits lipopolysaccharide-induced adhesion of neutrophils to coronary endothelial cells by a nitric oxide-mediated mechanism. FASEB J 2003, 17:2109-2111.
37. Bani D., Masini E., Bello M.G., Bigazzi M., Sacchi T.B. Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart. Am J Pathol 1998, 152:1367-1376.
38. Alexiou K., Matschke K., Westphal A., Stangl K., Dschietzig T. Relaxin is a candidate drug for lung preservation: relaxin-induced protection of rat lungs from ischemia-reperfusion injury. J Heart Lung Transplant 2010, 29:454-460.
39. Muller W.A. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol 2003, 24:327-334. Review.
40. Chan J.R., Hyduk S.J., Cybulsky M.I. Chemoattractants induce a rapid and transient upregulation of monocyte alpha4 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: an early step in the process of emigration. J Exp Med 2001, 193:1149-1158.