-
1
-
-
34247478090
-
State of diabetes care in the United States
-
Blonde L 2007 State of diabetes care in the United States. Am J Manag Care 13(Suppl 2):S36-S40
-
(2007)
Am J Manag Care
, vol.13
, Issue.SUPPL. 2
-
-
Blonde, L.1
-
2
-
-
32644448320
-
The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy
-
Asbun J, Villarreal FJ 2006 The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy. J Am Coll Cardiol 47:693-700
-
(2006)
J Am Coll Cardiol
, vol.47
, pp. 693-700
-
-
Asbun, J.1
Villarreal, F.J.2
-
3
-
-
0036998109
-
Myocardial fibrosis in transforming growth factor-β(1) (TGF-β(1)) transgenic mice is associated with inhibition of interstitial collagenase
-
Seeland U, Haeuseler C, Hinrichs R, Rosenkranz S, Pfitzner T, Scharffetter-Kochanek K, Böhm M 2002 Myocardial fibrosis in transforming growth factor-β(1) (TGF-β(1)) transgenic mice is associated with inhibition of interstitial collagenase. Eur J Clin Invest 32:295-303
-
(2002)
Eur J Clin Invest
, vol.32
, pp. 295-303
-
-
Seeland, U.1
Haeuseler, C.2
Hinrichs, R.3
Rosenkranz, S.4
Pfitzner, T.5
Scharffetter-Kochanek, K.6
Böhm, M.7
-
4
-
-
10744223859
-
Signs of nephropathy may occur early in young adults with diabetes despite modern diabetes management: Results from the nationwide population-based Diabetes Incidence Study in Sweden (DISS)
-
Svensson M, Sundkvist G, Arnqvist HJ, Björk E, Blohmé G, Bolinder J, Henricsson M, Nyström L, Torffvit O, Waernbaum I, Ostman J, Eriksson JW 2003 Signs of nephropathy may occur early in young adults with diabetes despite modern diabetes management: results from the nationwide population-based Diabetes Incidence Study in Sweden (DISS). Diabetes Care 26:2903-2909
-
(2003)
Diabetes Care
, vol.26
, pp. 2903-2909
-
-
Svensson, M.1
Sundkvist, G.2
Arnqvist, H.J.3
Björk, E.4
Blohmé, G.5
Bolinder, J.6
Henricsson, M.7
Nyström, L.8
Torffvit, O.9
Waernbaum, I.10
Ostman, J.11
Eriksson, J.W.12
-
5
-
-
3042610399
-
Relaxin's physiological roles and other diverse actions
-
Sherwood OD 2004 Relaxin's physiological roles and other diverse actions. Endocr Rev 25:205-234
-
(2004)
Endocr Rev
, vol.25
, pp. 205-234
-
-
Sherwood, O.D.1
-
6
-
-
84884002531
-
Physiology and molecular biology of the relaxin peptide family
-
Knobil E, Neill JD, eds, 3rd ed. San Diego: Elsevier;
-
Bathgate RAD, Hsueh AJ, Sherwood OD 2006 Physiology and molecular biology of the relaxin peptide family. In: Knobil E, Neill JD, eds. Physiology of reproduction, 3rd ed. San Diego: Elsevier; 679-770
-
(2006)
Physiology of reproduction
, pp. 679-770
-
-
Bathgate, R.A.D.1
Hsueh, A.J.2
Sherwood, O.D.3
-
7
-
-
0031021409
-
Relaxin: A pleiotropic hormone
-
Bani D 1997 Relaxin: a pleiotropic hormone. Gen Pharmacol 28:13-22
-
(1997)
Gen Pharmacol
, vol.28
, pp. 13-22
-
-
Bani, D.1
-
8
-
-
34548062188
-
Relaxin: Antifibrotic properties and effects in models of disease
-
Samuel CS 2005 Relaxin: antifibrotic properties and effects in models of disease. Clin Med Res 3:241-249
-
(2005)
Clin Med Res
, vol.3
, pp. 241-249
-
-
Samuel, C.S.1
-
9
-
-
33646522213
-
Relaxin in cardiovascular and renal disease
-
Samuel CS, Hewitson TD 2006 Relaxin in cardiovascular and renal disease. Kidney Int 69:1498-1502
-
(2006)
Kidney Int
, vol.69
, pp. 1498-1502
-
-
Samuel, C.S.1
Hewitson, T.D.2
-
10
-
-
0035095220
-
Relaxin and renal fibrosis
-
Becker GJ, Hewitson TD 2001 Relaxin and renal fibrosis. Kidney Int 59:1184-1185
-
(2001)
Kidney Int
, vol.59
, pp. 1184-1185
-
-
Becker, G.J.1
Hewitson, T.D.2
-
12
-
-
34247639085
-
Relaxin as a cardiovascular hormone: Physiology, pathophysiology and therapeutic promises
-
Nistri S, Bigazzi M, Bani D 2007 Relaxin as a cardiovascular hormone: physiology, pathophysiology and therapeutic promises. Cardiovasc Hematol Agents Med Chem 5:101-108
-
(2007)
Cardiovasc Hematol Agents Med Chem
, vol.5
, pp. 101-108
-
-
Nistri, S.1
Bigazzi, M.2
Bani, D.3
-
13
-
-
33748091739
-
Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics
-
Dschietzig T, Bartsch C, Baumann G, Stangl K 2006 Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics. Pharmacol Ther 112:38-56
-
(2006)
Pharmacol Ther
, vol.112
, pp. 38-56
-
-
Dschietzig, T.1
Bartsch, C.2
Baumann, G.3
Stangl, K.4
-
14
-
-
0025302162
-
Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts
-
Unemori EN, Amento EP 1990 Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts. J Biol Chem 265:10681-10685
-
(1990)
J Biol Chem
, vol.265
, pp. 10681-10685
-
-
Unemori, E.N.1
Amento, E.P.2
-
15
-
-
0030453783
-
Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo
-
Unemori EN, Pickford LB, Salles AL, Piercy CE, Grove BH, Erikson ME, Amento EP 1996 Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J Clin Invest 98:2739-2745
-
(1996)
J Clin Invest
, vol.98
, pp. 2739-2745
-
-
Unemori, E.N.1
Pickford, L.B.2
Salles, A.L.3
Piercy, C.E.4
Grove, B.H.5
Erikson, M.E.6
Amento, E.P.7
-
16
-
-
0034925715
-
Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway
-
Palejwala S, Stein DE, Weiss G, Monia BP, Tortoriello D, Goldsmith LT 2001 Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway. Endocrinology 142:3405-3413
-
(2001)
Endocrinology
, vol.142
, pp. 3405-3413
-
-
Palejwala, S.1
Stein, D.E.2
Weiss, G.3
Monia, B.P.4
Tortoriello, D.5
Goldsmith, L.T.6
-
17
-
-
0034878781
-
Relaxin increases secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodeling in the pig
-
Lenhart JA, Ryan PL, Ohleth KM, Palmer SS, Bagnell CA 2001 Relaxin increases secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodeling in the pig. Endocrinology 142:3941-3949
-
(2001)
Endocrinology
, vol.142
, pp. 3941-3949
-
-
Lenhart, J.A.1
Ryan, P.L.2
Ohleth, K.M.3
Palmer, S.S.4
Bagnell, C.A.5
-
18
-
-
0346120209
-
Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries
-
Jeyabalan A, Novak J, Danielson LA, Kerchner LJ, Opett SL, Conrad KP 2003 Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries. Circ Res 93:1249-1257
-
(2003)
Circ Res
, vol.93
, pp. 1249-1257
-
-
Jeyabalan, A.1
Novak, J.2
Danielson, L.A.3
Kerchner, L.J.4
Opett, S.L.5
Conrad, K.P.6
-
19
-
-
1342285008
-
Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro
-
Masterson R, Hewitson TD, Kelynack K, Martic M, Parry L, Bathgate R, Darby I, Becker G 2004 Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro. Nephrol Dial Transplant 19:544-552
-
(2004)
Nephrol Dial Transplant
, vol.19
, pp. 544-552
-
-
Masterson, R.1
Hewitson, T.D.2
Kelynack, K.3
Martic, M.4
Parry, L.5
Bathgate, R.6
Darby, I.7
Becker, G.8
-
20
-
-
4344606223
-
Relaxin modulates cardiac fibroblast proliferation, differentiation and collagen production and reverses cardiac fibrosis in vivo
-
Samuel CS, Unemori EN, Mookerjee I, Bathgate RA, Layfield SL, Mak J, Tregear GW, Du XJ 2004 Relaxin modulates cardiac fibroblast proliferation, differentiation and collagen production and reverses cardiac fibrosis in vivo. Endocrinology 145:4125-4133
-
(2004)
Endocrinology
, vol.145
, pp. 4125-4133
-
-
Samuel, C.S.1
Unemori, E.N.2
Mookerjee, I.3
Bathgate, R.A.4
Layfield, S.L.5
Mak, J.6
Tregear7
GW, D.X.8
-
21
-
-
0034829351
-
Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo
-
Williams EJ, Benyon RC, Trim N, Hadwin R, Grove BH, Arthur MJ, Unemori EN, Iredale JP 2001 Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 49:577-583
-
(2001)
Gut
, vol.49
, pp. 577-583
-
-
Williams, E.J.1
Benyon, R.C.2
Trim, N.3
Hadwin, R.4
Grove, B.H.5
Arthur, M.J.6
Unemori, E.N.7
Iredale, J.P.8
-
22
-
-
23244443050
-
Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats
-
Lekgabe ED, Kiriazis H, Zhao C, Xu Q, Moore XL, Su Y, Bathgate RA, Du XJ, Samuel CS 2005 Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats. Hypertension 46:412-418
-
(2005)
Hypertension
, vol.46
, pp. 412-418
-
-
Lekgabe, E.D.1
Kiriazis, H.2
Zhao, C.3
Xu, Q.4
Moore, X.L.5
Su, Y.6
Bathgate7
RA, D.X.8
Samuel, C.S.9
-
23
-
-
0031823522
-
A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR)
-
Kelly DJ, Wilkinson-Berka JL, Allen TJ, Cooper ME, Skinner SL 1998 A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR). Kidney Int 54:343-352
-
(1998)
Kidney Int
, vol.54
, pp. 343-352
-
-
Kelly, D.J.1
Wilkinson-Berka, J.L.2
Allen, T.J.3
Cooper, M.E.4
Skinner, S.L.5
-
24
-
-
12344326842
-
Tranilast attenuates cardiac matrix deposition in experimental diabetes: Role of transforming growth factor-β
-
Martin J, Kelly DJ, Mifsud SA, Zhang Y, Cox AJ, See F, Krum H, Wilkinson-Berka J, Gilbert RE 2005 Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-β. Cardiovasc Res 65:694-701
-
(2005)
Cardiovasc Res
, vol.65
, pp. 694-701
-
-
Martin, J.1
Kelly, D.J.2
Mifsud, S.A.3
Zhang, Y.4
Cox, A.J.5
See, F.6
Krum, H.7
Wilkinson-Berka, J.8
Gilbert, R.E.9
-
25
-
-
36749008977
-
Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat
-
Connelly KA, Kelly DJ, Zhang Y, Prior DL, Martin J, Cox AJ, Thai K, Feneley MP, Tsoporis J, White KE, Krum H, Gilbert RE 2007 Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat. Cardiovasc Res 76:280-291
-
(2007)
Cardiovasc Res
, vol.76
, pp. 280-291
-
-
Connelly, K.A.1
Kelly, D.J.2
Zhang, Y.3
Prior, D.L.4
Martin, J.5
Cox, A.J.6
Thai, K.7
Feneley, M.P.8
Tsoporis, J.9
White, K.E.10
Krum, H.11
Gilbert, R.E.12
-
26
-
-
0035096195
-
Relaxin decreases renal interstitial fibrosis and slows progression of renal disease
-
Garber SL, Mirochnik Y, Brecklin CS, Unemori EN, Singh AK, Slobodskoy L, Grove BH, Arruda JA, Dunea G 2001 Relaxin decreases renal interstitial fibrosis and slows progression of renal disease. Kidney Int 59:876-882
-
(2001)
Kidney Int
, vol.59
, pp. 876-882
-
-
Garber, S.L.1
Mirochnik, Y.2
Brecklin, C.S.3
Unemori, E.N.4
Singh, A.K.5
Slobodskoy, L.6
Grove, B.H.7
Arruda, J.A.8
Dunea, G.9
-
27
-
-
0037210131
-
Effect of relaxin in two models of renal mass reduction
-
Garber SL, Mirochnik Y, Brecklin C, Slobodskoy L, Arruda JA, Dunea G 2003 Effect of relaxin in two models of renal mass reduction. Am J Nephrol 23:8-12
-
(2003)
Am J Nephrol
, vol.23
, pp. 8-12
-
-
Garber, S.L.1
Mirochnik, Y.2
Brecklin, C.3
Slobodskoy, L.4
Arruda, J.A.5
Dunea, G.6
-
28
-
-
0031954084
-
Differential development of early hypertension in heterozygous transgenic TGR(mREN2)27 rats
-
Kreutz R, Fernandez-Alfonso MS, Paul M, Peters J 1998 Differential development of early hypertension in heterozygous transgenic TGR(mREN2)27 rats. Clin Exp Hypertens 20:273-282
-
(1998)
Clin Exp Hypertens
, vol.20
, pp. 273-282
-
-
Kreutz, R.1
Fernandez-Alfonso, M.S.2
Paul, M.3
Peters, J.4
-
29
-
-
22244487289
-
Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction
-
Boyle AJ, Kelly DJ, Zhang Y, Cox AJ, Gow RM, Way K, Itescu S, Krum H, Gilbert RE 2005 Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction. J Mol Cell Cardiol 39:213-221
-
(2005)
J Mol Cell Cardiol
, vol.39
, pp. 213-221
-
-
Boyle, A.J.1
Kelly, D.J.2
Zhang, Y.3
Cox, A.J.4
Gow, R.M.5
Way, K.6
Itescu, S.7
Krum, H.8
Gilbert, R.E.9
-
30
-
-
0029819669
-
The effect of relaxin on collagen metabolism in the nonpregnant rat pubic symphysis: The influence of estrogen and progesterone in regulating relaxin activity
-
Samuel CS, Butkus A, Coghlan JP, Bateman JF 1996 The effect of relaxin on collagen metabolism in the nonpregnant rat pubic symphysis: the influence of estrogen and progesterone in regulating relaxin activity. Endocrinology 137:3884-3890
-
(1996)
Endocrinology
, vol.137
, pp. 3884-3890
-
-
Samuel, C.S.1
Butkus, A.2
Coghlan, J.P.3
Bateman, J.F.4
-
31
-
-
0016795817
-
Posttranslational protein modifications, with special attention to collagen and elastin
-
Gallop PM, Paz MA 1975 Posttranslational protein modifications, with special attention to collagen and elastin. Physiol Rev 55:418-487
-
(1975)
Physiol Rev
, vol.55
, pp. 418-487
-
-
Gallop, P.M.1
Paz, M.A.2
-
32
-
-
0029001584
-
Quantification of matrix metalloproteinases in tissue samples
-
Woessner Jr JF 1995 Quantification of matrix metalloproteinases in tissue samples. Methods Enzymol 248:510-528
-
(1995)
Methods Enzymol
, vol.248
, pp. 510-528
-
-
Woessner Jr, J.F.1
-
33
-
-
33744946031
-
Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats
-
2006
-
Jeyabalan A, Kerchner LJ, Fisher MC, McGuane JT, Doty KD, Conrad KP 2006 Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats. J Appl Physiol 100:1955-1963
-
(1955)
J Appl Physiol
, vol.100
-
-
Jeyabalan, A.1
Kerchner, L.J.2
Fisher, M.C.3
McGuane, J.T.4
Doty, K.D.5
Conrad, K.P.6
-
34
-
-
33847350691
-
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
-
Wynn TA 2007 Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 117:524-529
-
(2007)
J Clin Invest
, vol.117
, pp. 524-529
-
-
Wynn, T.A.1
-
35
-
-
0036244244
-
Treatment of heart failure in patients with diabetes: Clinical update
-
Bell DS 2002 Treatment of heart failure in patients with diabetes: clinical update. Ethn Dis 12(suppl 1):S12-S18
-
(2002)
Ethn Dis
, vol.12
, Issue.SUPPL. 1
-
-
Bell, D.S.1
-
36
-
-
0027517659
-
-
Lewis EJ, Hunsicker LG, Bain RP, Rohde RD 1993 The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med [Erratum (1993) 330:152] 329:1456-1462
-
Lewis EJ, Hunsicker LG, Bain RP, Rohde RD 1993 The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med [Erratum (1993) 330:152] 329:1456-1462
-
-
-
-
37
-
-
30044439402
-
What role do extracellular matrix changes contribute to the cardiovascular disease burden of diabetes mellitus?
-
Tayebjee MH, Lip GY, MacFadyen RJ 2005 What role do extracellular matrix changes contribute to the cardiovascular disease burden of diabetes mellitus? Diabet Med 22:1628-1635
-
(2005)
Diabet Med
, vol.22
, pp. 1628-1635
-
-
Tayebjee, M.H.1
Lip, G.Y.2
MacFadyen, R.J.3
-
39
-
-
33846000986
-
Increased circulatory MMP-2 and MMP-9 levels and activities in patients with type 1 diabetes mellitus
-
Shiau MY, Tsai ST, Tsai KJ, Haung ML, Hsu YT, Chang YH 2006 Increased circulatory MMP-2 and MMP-9 levels and activities in patients with type 1 diabetes mellitus. Mt Sinai J Med 73:1024-1028
-
(2006)
Mt Sinai J Med
, vol.73
, pp. 1024-1028
-
-
Shiau, M.Y.1
Tsai, S.T.2
Tsai, K.J.3
Haung, M.L.4
Hsu, Y.T.5
Chang, Y.H.6
-
40
-
-
29244483682
-
Expression and response to angiotensin-converting enzyme inhibition of matrix metalloproteinases 2 and 9 in renal glomerular damage in young transgenic rats with renin-dependent hypertension
-
Bolbrinker J, Markovic S, Wehland M, Melenhorst WB, van Goor H, Kreutz R 2006 Expression and response to angiotensin-converting enzyme inhibition of matrix metalloproteinases 2 and 9 in renal glomerular damage in young transgenic rats with renin-dependent hypertension. J Pharmacol Exp Ther 316:8-16
-
(2006)
J Pharmacol Exp Ther
, vol.316
, pp. 8-16
-
-
Bolbrinker, J.1
Markovic, S.2
Wehland, M.3
Melenhorst, W.B.4
van Goor, H.5
Kreutz, R.6
-
41
-
-
33847342561
-
Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: The role of angiotensin type 1 receptor antagonism
-
Westermann D, Rutschow S, Jager S, Linderer A, Anker S, Riad A, Unger T, Schultheiss HP, Pauschinger M, Tschöpe C 2007 Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism. Diabetes 56:641-646
-
(2007)
Diabetes
, vol.56
, pp. 641-646
-
-
Westermann, D.1
Rutschow, S.2
Jager, S.3
Linderer, A.4
Anker, S.5
Riad, A.6
Unger, T.7
Schultheiss, H.P.8
Pauschinger, M.9
Tschöpe, C.10
-
42
-
-
34547814720
-
Advanced glycation end products decrease mesangial cell MMP-7: A role in matrix accumulation in diabetic nephropathy?
-
McLennan SV, Kelly DJ, Schache M, Waltham M, Dy V, Langham RG, Yue DK, Gilbert R 2007 Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy? Kidney Int 72:481-488
-
(2007)
Kidney Int
, vol.72
, pp. 481-488
-
-
McLennan, S.V.1
Kelly, D.J.2
Schache, M.3
Waltham, M.4
Dy, V.5
Langham, R.G.6
Yue, D.K.7
Gilbert, R.8
-
43
-
-
0011015891
-
Relaxin clinical trials in systemic sclerosis
-
Tregear GW, Ivell R, Bathgate RA, Wade JD, eds, Amsterdam: Kluwer;
-
Erikson MS, Unemori EN 2001 Relaxin clinical trials in systemic sclerosis. In: Tregear GW, Ivell R, Bathgate RA, Wade JD, eds. Relaxin 2000: Proceedings of the Third International Conference on Relaxin and Related Peptides. Amsterdam: Kluwer; 373-381
-
(2001)
Relaxin 2000: Proceedings of the Third International Conference on Relaxin and Related Peptides
, pp. 373-381
-
-
Erikson, M.S.1
Unemori, E.N.2
-
44
-
-
6844266294
-
Safety and pharmacokinetics of recombinant human relaxin in systemic sclerosis
-
Seibold JR, Clements PJ, Furst DE, Mayes MD, McCloskey DA, Moreland LW, White B, Wigley FM, Rocco S, Erikson M, Hannigan JF, Sanders ME, Amento EP 1998 Safety and pharmacokinetics of recombinant human relaxin in systemic sclerosis. J Rheumatol 25:302-307
-
(1998)
J Rheumatol
, vol.25
, pp. 302-307
-
-
Seibold, J.R.1
Clements, P.J.2
Furst, D.E.3
Mayes, M.D.4
McCloskey, D.A.5
Moreland, L.W.6
White, B.7
Wigley, F.M.8
Rocco, S.9
Erikson, M.10
Hannigan, J.F.11
Sanders, M.E.12
Amento, E.P.13
|