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Volumn 57, Issue 2, 2003, Pages 395-404

Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: A gender-specific phenotype

Author keywords

Fibrosis; Gender; Gene expression; Hormones; Ventricular function

Indexed keywords

COLLAGEN; PEPTIDE HORMONE; PROCOLLAGEN; RELAXIN;

EID: 12244257489     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00663-6     Document Type: Article
Times cited : (147)

References (40)
  • 2
    • 0029819669 scopus 로고    scopus 로고
    • The effect of relaxin on collagen metabolism in the non-pregnant rat pubic symphysis: The influence of estrogen and progesterone in regulating relaxin activity
    • Samuel C.S., Butkus A., Coghlan J.P., Bateman J.F. The effect of relaxin on collagen metabolism in the non-pregnant rat pubic symphysis: the influence of estrogen and progesterone in regulating relaxin activity. Endocrinology. 137:1996;3884-3890.
    • (1996) Endocrinology , vol.137 , pp. 3884-3890
    • Samuel, C.S.1    Butkus, A.2    Coghlan, J.P.3    Bateman, J.F.4
  • 4
    • 0031782178 scopus 로고    scopus 로고
    • Effects of relaxin, pregnancy and parturition on collagen metabolism in the rat pubic symphysis
    • Samuel C.S., Coghlan J.P., Bateman J.F. Effects of relaxin, pregnancy and parturition on collagen metabolism in the rat pubic symphysis. J Endocrinol. 159:1998;117-125.
    • (1998) J Endocrinol , vol.159 , pp. 117-125
    • Samuel, C.S.1    Coghlan, J.P.2    Bateman, J.F.3
  • 5
    • 12244276385 scopus 로고    scopus 로고
    • Mechanism of relaxin action in human cervix
    • G.W. Tregear, R. Ivell, R.A.D. Bathgate, & J.D. Wade. Dordrecht: Kluwer Academic Publishers
    • Goldsmith L.T., Weiss G., Palejwala S. Mechanism of relaxin action in human cervix. Tregear G.W., Ivell R., Bathgate R.A.D., Wade J.D. Relaxin 2000. 2001;285-289 Kluwer Academic Publishers, Dordrecht.
    • (2001) Relaxin 2000 , pp. 285-289
    • Goldsmith, L.T.1    Weiss, G.2    Palejwala, S.3
  • 6
    • 0037059750 scopus 로고    scopus 로고
    • Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene: Novel members of the relaxin peptide family
    • Bathgate R.A., Samuel C.S., Burazin T.C., et al. Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene: novel members of the relaxin peptide family. J Biol Chem. 277:2002;1148-1157.
    • (2002) J Biol Chem , vol.277 , pp. 1148-1157
    • Bathgate, R.A.1    Samuel, C.S.2    Burazin, T.C.3
  • 7
    • 0027229592 scopus 로고
    • The mouse relaxin gene: Nucleotide sequence and expression
    • Evans B.A., John M., Fowler K.J., et al. The mouse relaxin gene: nucleotide sequence and expression. J Mol Endocrinol. 10:1993;15-23.
    • (1993) J Mol Endocrinol , vol.10 , pp. 15-23
    • Evans, B.A.1    John, M.2    Fowler, K.J.3
  • 8
    • 0032918829 scopus 로고    scopus 로고
    • Mice without a functional relaxin gene are unable to deliver milk to their pups
    • Zhao L., Roche P.J., Gunnersen J.M., et al. Mice without a functional relaxin gene are unable to deliver milk to their pups. Endocrinology. 140:1999;445-453.
    • (1999) Endocrinology , vol.140 , pp. 445-453
    • Zhao, L.1    Roche, P.J.2    Gunnersen, J.M.3
  • 10
    • 0009872472 scopus 로고    scopus 로고
    • Relaxin knockout mice demonstrate delayed growth and have underdeveloped male reproductive tracts
    • G.W. Tregear, R. Ivell, R.A.D. Bathgate, & J.D. Wade. Dordrecht: Kluwer Academic Publishers
    • Samuel C.S., Amento E.P. Relaxin knockout mice demonstrate delayed growth and have underdeveloped male reproductive tracts. Tregear G.W., Ivell R., Bathgate R.A.D., Wade J.D. Relaxin 2000. 2001;221-223 Kluwer Academic Publishers, Dordrecht.
    • (2001) Relaxin 2000 , pp. 221-223
    • Samuel, C.S.1    Amento, E.P.2
  • 11
    • 0032908730 scopus 로고    scopus 로고
    • Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: Characterization and effects of oestrogen treatment
    • Tan Y.Y., Wade J.D., Tregear G.W., Summers R.J. Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of oestrogen treatment. Br J Pharmacol. 127:1999;91-98.
    • (1999) Br J Pharmacol , vol.127 , pp. 91-98
    • Tan, Y.Y.1    Wade, J.D.2    Tregear, G.W.3    Summers, R.J.4
  • 12
    • 0027199629 scopus 로고
    • Expression of relaxin mRNA and relaxin receptors in postnatal and adult rat brains and hearts. Localization and developmental patterns
    • Osheroff P.L., Ho W.H. Expression of relaxin mRNA and relaxin receptors in postnatal and adult rat brains and hearts. Localization and developmental patterns. J Biol Chem. 268:1993;15193-15199.
    • (1993) J Biol Chem , vol.268 , pp. 15193-15199
    • Osheroff, P.L.1    Ho, W.H.2
  • 13
    • 0027433647 scopus 로고
    • The purely chronotropic effects of relaxin in the rat isolated heart
    • Thomas G.R., Vandlen R. The purely chronotropic effects of relaxin in the rat isolated heart. J Pharm Pharmacol. 45:1993;927-928.
    • (1993) J Pharm Pharmacol , vol.45 , pp. 927-928
    • Thomas, G.R.1    Vandlen, R.2
  • 14
    • 0026608441 scopus 로고
    • Cardiac effects of relaxin in rats
    • Kakouris H., Eddie L.W., Summers R.J. Cardiac effects of relaxin in rats. Lancet. 339:1992;1076-1078.
    • (1992) Lancet , vol.339 , pp. 1076-1078
    • Kakouris, H.1    Eddie, L.W.2    Summers, R.J.3
  • 15
    • 0025236675 scopus 로고
    • Mechanism of the haemotensive action of porcine relaxin in anaesthetized rats
    • Parry L.J., Poterski R.S., Summerlee A.J.S., Jones S.A. Mechanism of the haemotensive action of porcine relaxin in anaesthetized rats. J Neuroendocrinol. 2:1990;53-58.
    • (1990) J Neuroendocrinol , vol.2 , pp. 53-58
    • Parry, L.J.1    Poterski, R.S.2    Summerlee, A.J.S.3    Jones, S.A.4
  • 16
    • 0029761252 scopus 로고    scopus 로고
    • Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart
    • Toth M., Taskinen P., Ruskoaho H. Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart. J Endocrinol. 150:1996;487-495.
    • (1996) J Endocrinol , vol.150 , pp. 487-495
    • Toth, M.1    Taskinen, P.2    Ruskoaho, H.3
  • 17
    • 0029126464 scopus 로고
    • Relaxin-induced increased coronary flow through stimulation of nitric oxide production
    • Bani-Sacchi T., Bigazzi M., Bani D., Mannaioni P.F., Masini E. Relaxin-induced increased coronary flow through stimulation of nitric oxide production. Br J Pharmacol. 116:1995;1589-1594.
    • (1995) Br J Pharmacol , vol.116 , pp. 1589-1594
    • Bani-Sacchi, T.1    Bigazzi, M.2    Bani, D.3    Mannaioni, P.F.4    Masini, E.5
  • 18
    • 0027973395 scopus 로고
    • Evidence for a novel source of relaxin: Atrial cardiocytes
    • Taylor M.J., Clark C.L. Evidence for a novel source of relaxin: atrial cardiocytes. J Endocrinol. 143:1994;R5-R8.
    • (1994) J Endocrinol , vol.143 , pp. 5-R8
    • Taylor, M.J.1    Clark, C.L.2
  • 19
    • 0034810896 scopus 로고    scopus 로고
    • The pregnancy hormone relaxin is a player in human heart failure
    • Dschietzig T., Richter C., Bartsch C., et al. The pregnancy hormone relaxin is a player in human heart failure. FASEB J. 15:2001;2187-2195.
    • (2001) FASEB J , vol.15 , pp. 2187-2195
    • Dschietzig, T.1    Richter, C.2    Bartsch, C.3
  • 20
    • 0033984947 scopus 로고    scopus 로고
    • Serial echocardiographic assessment of left ventricular dimensions and function after myocardial infarction in mice
    • Gao X.M., Dart A.M., Dewar E., Jennings G., Du X.J. Serial echocardiographic assessment of left ventricular dimensions and function after myocardial infarction in mice. Cardiovasc Res. 45:2000;330-338.
    • (2000) Cardiovasc Res , vol.45 , pp. 330-338
    • Gao, X.M.1    Dart, A.M.2    Dewar, E.3    Jennings, G.4    Du, X.J.5
  • 21
    • 0024574077 scopus 로고
    • Assessment of diastolic function of the heart: Background and current applications of Doppler echocardiography
    • Nishmura R.A., Abel M.D., Hatle L.K., Tajik A.J. Assessment of diastolic function of the heart: background and current applications of Doppler echocardiography. Mayo Clin Proc. 64:1989;181-204.
    • (1989) Mayo Clin Proc , vol.64 , pp. 181-204
    • Nishmura, R.A.1    Abel, M.D.2    Hatle, L.K.3    Tajik, A.J.4
  • 22
    • 0035971216 scopus 로고    scopus 로고
    • Inotropic stimulation induces cardiac dysfunction in transgenic mice expressing a troponin T (I79N) mutation liked to familial hypertrophic cardiomyopathy
    • Knollmann B.C., Blatt S.A., Horton K., et al. Inotropic stimulation induces cardiac dysfunction in transgenic mice expressing a troponin T (I79N) mutation liked to familial hypertrophic cardiomyopathy. J Biol Chem. 276:2001;10039-10048.
    • (2001) J Biol Chem , vol.276 , pp. 10039-10048
    • Knollmann, B.C.1    Blatt, S.A.2    Horton, K.3
  • 24
    • 0028290539 scopus 로고
    • Mineralocorticoids, hypertension, and cardiac fibrosis
    • Young M., Fullerton M., Dilley R., Funder J. Mineralocorticoids, hypertension, and cardiac fibrosis. J Clin Invest. 93:1994;2578-2583.
    • (1994) J Clin Invest , vol.93 , pp. 2578-2583
    • Young, M.1    Fullerton, M.2    Dilley, R.3    Funder, J.4
  • 25
    • 0036241982 scopus 로고    scopus 로고
    • The upregulation of mesotocin receptors in the tammar wallaby myometrium is pregnancy-specific and independent of estrogen
    • Siebel A.L., Gehring H.M., Nave C.D., Bathgate R.A.D., Borchers C.E., Parry L.J. The upregulation of mesotocin receptors in the tammar wallaby myometrium is pregnancy-specific and independent of estrogen. Biol Reprod. 66:2002;1237-1243.
    • (2002) Biol Reprod , vol.66 , pp. 1237-1243
    • Siebel, A.L.1    Gehring, H.M.2    Nave, C.D.3    Bathgate, R.A.D.4    Borchers, C.E.5    Parry, L.J.6
  • 26
    • 0037118672 scopus 로고    scopus 로고
    • Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart?
    • Fisher C., MacLean M., Morecroft I., et al. Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart? Circulation. 106:2002;292-295.
    • (2002) Circulation , vol.106 , pp. 292-295
    • Fisher, C.1    MacLean, M.2    Morecroft, I.3
  • 27
    • 0033680477 scopus 로고    scopus 로고
    • Impact of gender and endothelin on renal vasodilation and hyperfiltration induced by relaxin in conscious rats
    • Danielson L.A., Kercher L.J., Conrad K.P. Impact of gender and endothelin on renal vasodilation and hyperfiltration induced by relaxin in conscious rats. Am J Physiol. 279:2000;R1298-R1304.
    • (2000) Am J Physiol , vol.279 , pp. 1298-R1304
    • Danielson, L.A.1    Kercher, L.J.2    Conrad, K.P.3
  • 28
    • 0028197422 scopus 로고
    • Brain angiotensin-II partially mediates the effects of relaxin on vasopressin and oxytocin release in anesthetized rats
    • Geddes B.J., Parry L.J., Summerlee A.J.S. Brain angiotensin-II partially mediates the effects of relaxin on vasopressin and oxytocin release in anesthetized rats. Endocrinology. 134:1994;1188-1192.
    • (1994) Endocrinology , vol.134 , pp. 1188-1192
    • Geddes, B.J.1    Parry, L.J.2    Summerlee, A.J.S.3
  • 29
    • 0036484303 scopus 로고    scopus 로고
    • Relaxin up-regulates inducible nitric oxide synthase expression and nitric oxide generation in rat coronary endothelial cells
    • Failli P., Nistri S., Quattrone S., et al. Relaxin up-regulates inducible nitric oxide synthase expression and nitric oxide generation in rat coronary endothelial cells. FASEB J. 16:2002;252-254.
    • (2002) FASEB J , vol.16 , pp. 252-254
    • Failli, P.1    Nistri, S.2    Quattrone, S.3
  • 30
    • 12244301842 scopus 로고    scopus 로고
    • Relaxin deficient mice are associated with an age-related progression of pulmonary fibrosis
    • in press
    • Samuel CS, Zhao C, Bathgate RAD et al., Relaxin deficient mice are associated with an age-related progression of pulmonary fibrosis. FASEB J (in press).
    • FASEB J
    • Samuel, C.S.1    Zhao, C.2    Bathgate, R.A.D.3
  • 31
    • 0025302162 scopus 로고
    • Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts
    • Unemori E.N., Amento E.P. Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts. J Biol Chem. 265:1990;10681-10685.
    • (1990) J Biol Chem , vol.265 , pp. 10681-10685
    • Unemori, E.N.1    Amento, E.P.2
  • 32
    • 0030453783 scopus 로고    scopus 로고
    • Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo
    • Unemori E.N., Pickford L.B., Salles A.L., et al. Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J Clin Invest. 98:1996;2739-2745.
    • (1996) J Clin Invest , vol.98 , pp. 2739-2745
    • Unemori, E.N.1    Pickford, L.B.2    Salles, A.L.3
  • 33
    • 0034878781 scopus 로고    scopus 로고
    • Relaxin increases secretion of matrix-metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodelling in the pig
    • Lenhart J.A., Ryan P.L., Ohleth K.M., Palmer S.S., Bagnell C.A. Relaxin increases secretion of matrix-metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodelling in the pig. Endocrinology. 142:2001;3941-3949.
    • (2001) Endocrinology , vol.142 , pp. 3941-3949
    • Lenhart, J.A.1    Ryan, P.L.2    Ohleth, K.M.3    Palmer, S.S.4    Bagnell, C.A.5
  • 34
    • 0034829351 scopus 로고    scopus 로고
    • Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo
    • Williams E.J., Benyon R.C., Trim N., et al. Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut. 49:2001;577-583.
    • (2001) Gut , vol.49 , pp. 577-583
    • Williams, E.J.1    Benyon, R.C.2    Trim, N.3
  • 35
    • 0035096195 scopus 로고    scopus 로고
    • Relaxin decreases renal interstitial fibrosis and slows progression of renal disease
    • Garber S.L., Mirochnik Y., Brecklin C.S., et al. Relaxin decreases renal interstitial fibrosis and slows progression of renal disease. Kidney Int. 59:2001;876-882.
    • (2001) Kidney Int , vol.59 , pp. 876-882
    • Garber, S.L.1    Mirochnik, Y.2    Brecklin, C.S.3
  • 36
    • 0031945701 scopus 로고    scopus 로고
    • Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart
    • Bani D., Masini E., Bello M.G., Bigazzi M., Sacchi T.B. Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart. Am J Pathol. 152:1998;1367-1376.
    • (1998) Am J Pathol , vol.152 , pp. 1367-1376
    • Bani, D.1    Masini, E.2    Bello, M.G.3    Bigazzi, M.4    Sacchi, T.B.5
  • 37
    • 0033856283 scopus 로고    scopus 로고
    • Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression
    • Kadokami T., McTiernan C.F., Kubota T., Frye C.S., Feldman A.M. Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression. J Clin Invest. 106:2000;589-597.
    • (2000) J Clin Invest , vol.106 , pp. 589-597
    • Kadokami, T.1    McTiernan, C.F.2    Kubota, T.3    Frye, C.S.4    Feldman, A.M.5
  • 39
    • 0032576615 scopus 로고    scopus 로고
    • 2+ exchanger increases susceptibility to ischemia/reperfusion injury in male, but not female, transgenic mice
    • 2+ exchanger increases susceptibility to ischemia/reperfusion injury in male, but not female, transgenic mice. Circ Res. 83:1998;1215-1223.
    • (1998) Circ Res , vol.83 , pp. 1215-1223
    • Cross, H.R.1    Lu, L.2    Steenbergen, C.3    Philipson, K.D.4    Murphy, E.5
  • 40
    • 0030067394 scopus 로고    scopus 로고
    • A mouse model of familial hypertrophic cardiomyopathy
    • Geisterfer-Lowrance A.A., Christe M., Conner D.A., et al. A mouse model of familial hypertrophic cardiomyopathy. Science. 272:1996;731-734.
    • (1996) Science , vol.272 , pp. 731-734
    • Geisterfer-Lowrance, A.A.1    Christe, M.2    Conner, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.