메뉴 건너뛰기




Volumn 125, Issue 12, 2013, Pages 575-585

Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice

Author keywords

Angiogenesis; Diabetes; Matrix metalloproteinase (MMP); Relaxin; Vascular endothelial growth factor (VEGF); Wound healing

Indexed keywords

CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; MESSENGER RNA; RELAXIN; STROMAL CELL DERIVED FACTOR 1ALPHA; STROMELYSIN 3; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR 2;

EID: 84883759083     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20130105     Document Type: Article
Times cited : (37)

References (40)
  • 1
    • 27744448125 scopus 로고    scopus 로고
    • Wound healing and its impairment in the diabetic foot
    • Falanga, V. (2005) Wound healing and its impairment in the diabetic foot. Lancet 366, 1736-1743
    • (2005) Lancet , vol.366 , pp. 1736-1743
    • Falanga, V.1
  • 3
    • 27744577844 scopus 로고    scopus 로고
    • Preventing foot ulcers and amputations in diabetes
    • Reiber, G. E. and Raugi, G. J. (2005) Preventing foot ulcers and amputations in diabetes. Lancet 366, 1676-1677
    • (2005) Lancet , vol.366 , pp. 1676-1677
    • Reiber, G.E.1    Raugi, G.J.2
  • 4
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara, N., Gerber, H. P. and LeCouter, J. (2003) The biology of VEGF and its receptors. Nat. Med. 9, 669-676
    • (2003) Nat. Med. , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 6
    • 0017601198 scopus 로고
    • Studies of wound healing in experimental diabetes
    • Goodson, W. H. and Hunt, T. K. (1977) Studies of wound healing in experimental diabetes. J. Surg. Res. 22, 221-227
    • (1977) J. Surg. Res. , vol.22 , pp. 221-227
    • Goodson, W.H.1    Hunt, T.K.2
  • 7
    • 0018571270 scopus 로고
    • Adult microvascular disturbances as a result of juvenile-onset diabetes in db/db mice
    • Bohlen, H. G. and Niggl, B. A. (1979) Adult microvascular disturbances as a result of juvenile-onset diabetes in db/db mice. Blood Vessels 16, 269-276
    • (1979) Blood Vessels , vol.16 , pp. 269-276
    • Bohlen, H.G.1    Niggl, B.A.2
  • 8
    • 0035123387 scopus 로고    scopus 로고
    • Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse
    • Altavilla, D., Saitta, A., Cucinotta, D., Galeano, M., Deodato, B., Colonna, M., Torre, V., Russo, G., Sardella, A., Urna, G. et al. (2001) Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse. Diabetes 50, 667-674
    • (2001) Diabetes , vol.50 , pp. 667-674
    • Altavilla, D.1    Saitta, A.2    Cucinotta, D.3    Galeano, M.4    Deodato, B.5    Colonna, M.6    Torre, V.7    Russo, G.8    Sardella, A.9    Urna, G.10
  • 9
    • 0038293298 scopus 로고    scopus 로고
    • Adeno-associated viral vector-mediated human vascular endothelial growth factor gene transfer stimulates angiogenesis and wound healing in the genetically diabetic mouse
    • Galeano, M., Deodato, B., Altavilla, D., Cucinotta, D., Arsic, N., Marini, H., Torre, V., Giacca, M. and Squadrito, F. (2003) Adeno-associated viral vector-mediated human vascular endothelial growth factor gene transfer stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetologia 46, 546-555
    • (2003) Diabetologia , vol.46 , pp. 546-555
    • Galeano, M.1    Deodato, B.2    Altavilla, D.3    Cucinotta, D.4    Arsic, N.5    Marini, H.6    Torre, V.7    Giacca, M.8    Squadrito, F.9
  • 10
    • 12944253116 scopus 로고    scopus 로고
    • Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors
    • Peichev, M., Naiyer, A. J., Pereira, D., Zhu, Z., Lane, W. J., Williams, M., Oz, M. C., Hicklin, D. J., Witte, L., Moore, M. A. et al. (2000) Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood 95, 952-958
    • (2000) Blood , vol.95 , pp. 952-958
    • Peichev, M.1    Naiyer, A.J.2    Pereira, D.3    Zhu, Z.4    Lane, W.J.5    Williams, M.6    Oz, M.C.7    Hicklin, D.J.8    Witte, L.9    Moore, M.A.10
  • 11
    • 0033529618 scopus 로고    scopus 로고
    • Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    • Asahara, T., Masuda, H. and Takahashi, T. (1999) Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ. Res. 85, 221-228
    • (1999) Circ. Res. , vol.85 , pp. 221-228
    • Asahara, T.1    Masuda, H.2    Takahashi, T.3
  • 12
    • 18744362545 scopus 로고    scopus 로고
    • Endothelial progenitor cells functional characterization
    • Urbich, C. and Dimmeler, S. (2004) Endothelial progenitor cells functional characterization. Trends Cardiovasc. Med. 14, 318-322
    • (2004) Trends Cardiovasc. Med. , vol.14 , pp. 318-322
    • Urbich, C.1    Dimmeler, S.2
  • 13
    • 0033894983 scopus 로고    scopus 로고
    • Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair
    • Wetzler, C., Kampfer, H., Stallmeyer, B., Pfeilschifter, J. and Frank, S. (2000) Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair. J. Invest. Dermatol. 115, 245-253
    • (2000) J. Invest. Dermatol. , vol.115 , pp. 245-253
    • Wetzler, C.1    Kampfer, H.2    Stallmeyer, B.3    Pfeilschifter, J.4    Frank, S.5
  • 14
    • 34248225758 scopus 로고    scopus 로고
    • Cellular and molecular basis of wound healing in diabetes
    • Brem, H. and Tomic-Canic, M. (2007) Cellular and molecular basis of wound healing in diabetes. J. Clin. Invest. 117, 1219-1222
    • (2007) J. Clin. Invest. , vol.117 , pp. 1219-1222
    • Brem, H.1    Tomic-Canic, M.2
  • 15
  • 17
    • 23644458767 scopus 로고    scopus 로고
    • Relaxin modulates fibroblast function, collagen production, and matrix metalloproteinase-2 expression by cardiac fibroblasts
    • Mookerjee, I., Unemori, E. N., Du, X. J., Tregear, G. W. and Samuel, C. S. (2005) Relaxin modulates fibroblast function, collagen production, and matrix metalloproteinase-2 expression by cardiac fibroblasts. Ann. N.Y. Acad. Sci. 1041, 190-193
    • (2005) Ann. N.Y. Acad. Sci. , vol.1041 , pp. 190-193
    • Mookerjee, I.1    Unemori, E.N.2    Du, X.J.3    Tregear, G.W.4    Samuel, C.S.5
  • 19
    • 64549162386 scopus 로고    scopus 로고
    • Scar prevention and cosmetically enhanced wound healing usingrelaxin
    • Stewart, D. R. (2009) Scar prevention and cosmetically enhanced wound healing usingrelaxin. Ann. N.Y. Acad. Sci. 1160, 336-341
    • (2009) Ann. N.Y. Acad. Sci. , vol.1160 , pp. 336-341
    • Stewart, D.R.1
  • 20
    • 78751575958 scopus 로고    scopus 로고
    • Activation of adenosine A2A receptors restores the altered cell-cycle machinery during impaired wound healing in genetically diabetic mice
    • Altavilla, D., Squadrito, F., Polito, F., Irrera, N., Caló, M., Lo Cascio, P., Galeano, M., La Cava, L., Minutoli, L., Marini, H. et al. (2011) Activation of adenosine A2A receptors restores the altered cell-cycle machinery during impaired wound healing in genetically diabetic mice. Surgery 149, 253-261
    • (2011) Surgery , vol.149 , pp. 253-261
    • Altavilla, D.1    Squadrito, F.2    Polito, F.3    Irrera, N.4    Caló, M.5    Lo Cascio, P.6    Galeano, M.7    La Cava, L.8    Minutoli, L.9    Marini, H.10
  • 25
    • 47849084197 scopus 로고    scopus 로고
    • Relaxin as a natural agent for vascular health
    • Bani, D. (2008) Relaxin as a natural agent for vascular health. Vasc. Health Risk Manag. 4, 515-524
    • (2008) Vasc. Health Risk Manag. , vol.4 , pp. 515-524
    • Bani, D.1
  • 26
    • 0033037935 scopus 로고    scopus 로고
    • Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women
    • Unemori, E. N., Erikson, M. E., Rocco, S. E., Sutherland, K. M., Parsell, D. A., Mak, J. and Grove, B. H. (1999) Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women. Hum. Reprod. 14, 800-806
    • (1999) Hum. Reprod. , vol.14 , pp. 800-806
    • Unemori, E.N.1    Erikson, M.E.2    Rocco, S.E.3    Sutherland, K.M.4    Parsell, D.A.5    Mak, J.6    Grove, B.H.7
  • 28
    • 1442323685 scopus 로고    scopus 로고
    • Relaxin inhibits the activation of human neutrophils: involvement of the nitric oxide pathway
    • Masini, E., Nistri, S., Vannacci, A., Bani Sacchi, T., Novelli, A. and Bani, D. (2004) Relaxin inhibits the activation of human neutrophils: involvement of the nitric oxide pathway. Endocrinology 145, 1106-1112
    • (2004) Endocrinology , vol.145 , pp. 1106-1112
    • Masini, E.1    Nistri, S.2    Vannacci, A.3    Bani Sacchi, T.4    Novelli, A.5    Bani, D.6
  • 29
    • 58149492762 scopus 로고    scopus 로고
    • Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player
    • Vestweber, D., Winderlich, M., Cagna, G. and Nottebaum, A. F. (2009) Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol. 19, 8-15
    • (2009) Trends Cell Biol. , vol.19 , pp. 8-15
    • Vestweber, D.1    Winderlich, M.2    Cagna, G.3    Nottebaum, A.F.4
  • 31
    • 77949697909 scopus 로고    scopus 로고
    • Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
    • Kioi, M., Vogel, H., Schultz, G., Hoffman, R. M., Harsh, G. R. and Brown, J. M. (2010) Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J. Clin. Invest. 120, 694-705
    • (2010) J. Clin. Invest. , vol.120 , pp. 694-705
    • Kioi, M.1    Vogel, H.2    Schultz, G.3    Hoffman, R.M.4    Harsh, G.R.5    Brown, J.M.6
  • 33
    • 28344434182 scopus 로고    scopus 로고
    • The effect of relaxin treatment on skeletal muscle injuries
    • Negishi, S., Li, Y., Usas, A., Fu, F. H. and Huard, J. (2005) The effect of relaxin treatment on skeletal muscle injuries. Am. J. Sports Med. 33, 1816-1824
    • (2005) Am. J. Sports Med. , vol.33 , pp. 1816-1824
    • Negishi, S.1    Li, Y.2    Usas, A.3    Fu, F.H.4    Huard, J.5
  • 34
    • 0034829351 scopus 로고    scopus 로고
    • Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo
    • Williams, E. J., Benyon, R. C., Trim, N., Hadwin, R., Grove, B. H., Arthur, M. J., Unemori, E. N. and Iredale, J. P. (2001) Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 49, 577-583
    • (2001) Gut , vol.49 , pp. 577-583
    • Williams, E.J.1    Benyon, R.C.2    Trim, N.3    Hadwin, R.4    Grove, B.H.5    Arthur, M.J.6    Unemori, E.N.7    Iredale, J.P.8
  • 36
    • 0025302162 scopus 로고
    • Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts
    • Unemori, E. N. and Amento, E. P. (1990) Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts. J. Biol. Chem. 265, 10681-10685
    • (1990) J. Biol. Chem. , vol.265 , pp. 10681-10685
    • Unemori, E.N.1    Amento, E.P.2
  • 37
    • 34548062188 scopus 로고    scopus 로고
    • Relaxin: antifibrotic properties and effects in models of disease
    • Samuel, C. S. (2005) Relaxin: antifibrotic properties and effects in models of disease. Clin. Med. Res. 3, 241-249
    • (2005) Clin. Med. Res. , vol.3 , pp. 241-249
    • Samuel, C.S.1
  • 38
    • 65249190276 scopus 로고    scopus 로고
    • Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study
    • Teerlink, J. R., Metra, M., Felker, G. M., Ponikowski, P., Voors, A. A., Weatherley, B. D., Marmor, A., Katz, A., Grzybowski, J., Unemori, E. et al. (2009) Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study. Lancet 373, 1429-1439
    • (2009) Lancet , vol.373 , pp. 1429-1439
    • Teerlink, J.R.1    Metra, M.2    Felker, G.M.3    Ponikowski, P.4    Voors, A.A.5    Weatherley, B.D.6    Marmor, A.7    Katz, A.8    Grzybowski, J.9    Unemori, E.10
  • 39
    • 79960959816 scopus 로고    scopus 로고
    • Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials
    • Boussageon, R., Bejan-Angoulvant, T., Saadatian-Elahi, M., Lafont, S., Bergeonneau, C., Kassaïi, B., Erpeldinger, S., Wright, J. M., Gueyffier, F. and Cornu, C. (2011) Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ. 343, d4169
    • (2011) BMJ. , vol.343
    • Boussageon, R.1    Bejan-Angoulvant, T.2    Saadatian-Elahi, M.3    Lafont, S.4    Bergeonneau, C.5    Kassaïi, B.6    Erpeldinger, S.7    Wright, J.M.8    Gueyffier, F.9    Cornu, C.10
  • 40
    • 79953850301 scopus 로고    scopus 로고
    • Diabetes: a driver for heart failure
    • Voors, A. A. and van der Horst, I. C. (2011) Diabetes: a driver for heart failure. Heart 97, 774-780
    • (2011) Heart , vol.97 , pp. 774-780
    • Voors, A.A.1    van der Horst, I.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.