Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis

Molecular and Cellular Endocrinology

Volumn 280, Issue 1-2, 2008, Pages 30-38

  Bathgate, R A D ^a   Lekgabe, E D ^a,b   McGuane, J T ^a   Su, Y ^b   Pham, T ^b   Ferraro, T ^a   Layfield, S ^a   Hannan, R D ^a,c   Thomas, W G ^b   Samuel, C S ^a   Du, X J ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

Adenovirus; Extracellular matrix; Fibrosis; Gene therapy; Relaxin; RXFP1

Indexed keywords

ADENOVIRUS VECTOR; COLLAGEN; GREEN FLUORESCENT PROTEIN; RELAXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE FIBROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CONTENT; PROTEIN EXPRESSION; SINGLE DRUG DOSE; SOMATIC GENE THERAPY; THERAPY EFFECT; TRANSGENIC MOUSE; TREATMENT OUTCOME; TREATMENT RESPONSE; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; CARDIOMYOPATHIES; COLLAGEN; DISEASE MODELS, ANIMAL; FEASIBILITY STUDIES; FEMALE; FIBROSIS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEART VENTRICLES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RATS; RECEPTORS, ADRENERGIC, BETA-2; RELAXIN;

EID: 36549032746     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2007.09.008     Document Type: Article

References (44)

1. Bathgate R.A., Siebel A.L., Tovote P., Claasz A., Macris M., Tregear G.W., and Parry L.J. Purification and characterization of relaxin from the tammar wallaby (Macropus eugenii): bioactivity and expression in the corpus luteum. Biol. Reprod. 67 (2002) 293-300
2. Bathgate R., Hsueh A.J., and Sherwood O.D. Physiology and molecular biology of the relaxin peptide family. In: Neill J. (Ed). Physiology of Reproduction (2006), Elsevier, San Diego 679-768
3. Beck C., Uramoto H., Boren J., and Akyurek L.M. Tissue-specific targeting for cardiovascular gene transfer. Potential vectors and future challenges. Curr. Gene Ther. 4 (2004) 457-467
4. Blomer U., Naldini L., Kafri T., Trono D., Verma I.M., and Gage F.H. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J. Virol. 71 (1997) 6641-6649
5. Brandenburger Y., Jenkins A., Autelitano D.J., and Hannan R.D. Increased expression of UBF is a critical determinant for rRNA synthesis and hypertrophic growth of cardiac myocytes. FASEB J. 15 (2001) 2051-2053
6. Burcin M.M., Schiedner G., Kochanek S., Tsai S.Y., and O'Malley B.W. Adenovirus-mediated regulable target gene expression in vivo. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 355-360
7. Du X.J., Autelitano D.J., Dilley R.J., Wang B., Dart A.M., and Woodcock E.A. Beta(2)-adrenergic receptor overexpression exacerbates development of heart failure after aortic stenosis. Circulation 101 (2000) 71-77
8. Du X.J., Gao X.M., Jennings G.L., Dart A.M., and Woodcock E.A. Preserved ventricular contractility in infarcted mouse heart overexpressing beta(2)-adrenergic receptors. Am. J. Physiol. Heart Circ. Physiol. 279 (2000) H2456-H2463
9. Du X.J., Gao X.M., Wang B., Jennings G.L., Woodcock E.A., and Dart A.M. Age-dependent cardiomyopathy and heart failure phenotype in mice overexpressing beta(2)-adrenergic receptors in the heart. Cardiovasc. Res. 48 (2000) 448-454
10. Du X.J., Samuel C.S., Gao X.M., Zhao L., Parry L.J., and Tregear G.W. Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype. Cardiovasc. Res. 57 (2003) 395-404
11. Gao X.M., Agrotis A., Autelitano D.J., Percy E., Woodcock E.A., Jennings G.L., Dart A.M., and Du X.J. Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpression. Endocrinology 144 (2003) 4097-4105
12. Garber S.L., Mirochnik Y., Brecklin C.S., Unemori E.N., Singh A.K., Slobodskoy L., Grove B.H., Arruda J.A., and Dunea G. Relaxin decreases renal interstitial fibrosis and slows progression of renal disease. Kidney Int. 59 (2001) 876-882
13. Golos T.G., and Sherwood O.D. Control of corpus luteum function during the second half of pregnancy in the rat: a direct relationship between conceptus number and both serum and ovarian relaxin levels. Endocrinology 111 (1982) 872-878
14. Gunnersen J.M., Crawford R.J., and Tregear G.W. Expression of the relaxin gene in rat tissues. Mol. Cell Endocrinol. 110 (1995) 55-64
15. Hajjar R.J., del Monte F., Matsui T., and Rosenzweig A. Prospects for gene therapy for heart failure. Circ. Res. 86 (2000) 616-621
16. Halls M.L., Bond C.P., Sudo S., Kumagai J., Ferraro T., Layfield S., Bathgate R.A., and Summers R.J. Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8). J. Pharmacol. Exp. Ther. 313 (2005) 677-687
17. Hammond H.K., and McKirnan M.D. Angiogenic gene therapy for heart disease: a review of animal studies and clinical trials. Cardiovasc. Res. 49 (2001) 561-567
18. He T.C., Zhou S., da Costa L.T., Yu J., Kinzler K.W., and Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 2509-2514
19. Herrmann J., Abriss B., van de Leur E., Weiskirchen S., Gressner A.M., and Weiskirchen R. Comparative analysis of adenoviral transgene delivery via tail or portal vein into rat liver. Arch. Virol. 149 (2004) 1611-1617
20. Jones J.M., and Koch W.J. Gene therapy approaches to cardiovascular disease. Methods Mol. Med. 112 (2005) 15-35
21. Lekgabe E.D., Kiriazis H., Zhao C., Xu Q., Moore X.L., Su Y., Bathgate R.A., Du X.J., and Samuel C.S. Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats. Hypertension 46 (2005) 412-418
22. Liggett S.B., Tepe N.M., Lorenz J.N., Canning A.M., Jantz T.D., Mitarai S., Yatani A., and Dorn II G.W. Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. Circulation 101 (2000) 1707-1714
23. Lijnen P.J., and Petrov V.V. Role of intracardiac renin-angiotensin-aldosterone system in extracellular matrix remodeling. Methods Find. Exp. Clin. Pharmacol. 25 (2003) 541-564
24. Mandarim-de-Lacerda C.A., and Pereira L.M. The effects of spironolactone monotherapy on blood pressure and myocardial remodeling in spontaneously hypertensive rats: a stereological study. J. Biomed. Sci. 10 (2003) 50-57
25. Masterson R., Hewitson T.D., Kelynack K., Martic M., Parry L., Bathgate R., Darby I., and Becker G. Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro. Nephrol. Dial. Transplant. 19 (2004) 544-552
26. Milano C.A., Allen L.F., Rockman H.A., Dolber P.C., McMinn T.R., Chien K.R., Johnson T.D., Bond R.A., and Lefkowitz R.J. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science 264 (1994) 582-586
27. Munch G., Rosport K., Bultmann A., Baumgartner C., Li Z., Laacke L., and Ungerer M. Cardiac overexpression of the norepinephrine transporter uptake-1 results in marked improvement of heart failure. Circ. Res. 97 (2005) 928-936
28. O'Byrne E.M., and Steinetz B.G. Radioimmunoassay (RIA) of relaxin in sera of various species using an antiserum to porcine relaxin. Proc. Soc. Exp. Biol. Med. 152 (1976) 272-276
29. Relph K.L., Harrington K.J., and Pandha H. Adenoviral strategies for the gene therapy of cancer. Semin. Oncol. 32 (2005) 573-582
30. Rivera V.M., Ye X., Courage N.L., Sachar J., Cerasoli Jr. F., Wilson J.M., and Gilman M. Long-term regulated expression of growth hormone in mice after intramuscular gene transfer. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 8657-8662
31. Samuel C.S., Butkus A., Coghlan J.P., and Bateman J.F. The effect of relaxin on collagen metabolism in the nonpregnant rat pubic symphysis: the influence of estrogen and progesterone in regulating relaxin activity. Endocrinology 137 (1996) 3884-3890
32. Samuel C.S., Zhao C., Bathgate R.A., Bond C.P., Burton M.D., Parry L.J., Summers R.J., Tang M.L., Amento E.P., and Tregear G.W. Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis. FASEB J. 17 (2003) 121-123
33. Samuel C.S., Unemori E.N., Mookerjee I., Bathgate R.A., Layfield S.L., Mak J., Tregear G.W., and Du X.J. Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo. Endocrinology 145 (2004) 4125-4133
34. Samuel C.S., Zhao C., Bond C.P., Hewitson T.D., Amento E.P., and Summers R.J. Relaxin-1-deficient mice develop an age-related progression of renal fibrosis. Kidney Int. 65 (2004) 2054-2064
35. Scott D.J., Layfield S., Yan Y., Sudo S., Hsueh A.J., Tregear G.W., and Bathgate R.A. Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique LDLa modules. J. Biol. Chem. 281 (2006) 34942-34954
36. Silvertown J.D., Geddes B.J., and Summerlee A.J. Adenovirus-mediated expression of human prorelaxin promotes the invasive potential of canine mammary cancer cells. Endocrinology 144 (2003) 3683-3691
37. Stone D., David A., Bolognani F., Lowenstein P.R., and Castro M.G. Viral vectors for gene delivery and gene therapy within the endocrine system. J. Endocrinol. 164 (2000) 103-118
38. Tyagi S.C., Kumar S.G., Alla S.R., Reddy H.K., Voelker D.J., and Janicki J.S. Extracellular matrix regulation of metalloproteinase and antiproteinase in human heart fibroblast cells. J. Cell Physiol. 167 (1996) 137-147
39. Unemori E.N., and Amento E.P. Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts. J. Biol. Chem. 265 (1990) 10681-10685
40. Unemori E.N., Pickford L.B., Salles A.L., Piercy C.E., Grove B.H., Erikson M.E., and Amento E.P. Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J. Clin. Invest. 98 (1996) 2739-2745
41. van der Eb M.M., Cramer S.J., Vergouwe Y., Schagen F.H., van Krieken J.H., van der Eb A.J., Borel Rinkes I.H., van de Velde C.J., and Hoeben R.C. Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration. Gene Ther. 5 (1998) 451-458
42. Wade J.D., Lin F., Talbo G., Otvos Jr. L., Tan Y.Y., and Tregear G.W. Solid phase synthesis and biological activity of rat relaxin. Biomed. Pept. Proteins Nucleic Acids 2 (1996) 89-92
43. Weber K.T. Fibrosis and hypertensive heart disease. Curr. Opin. Cardiol. 15 (2000) 264-272
44. Williams E.J., Benyon R.C., Trim N., Hadwin R., Grove B.H., Arthur M.J., Unemori E.N., and Iredale J.P. Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 49 (2001) 577-583