Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats

Hypertension

Volumn 46, Issue 2, 2005, Pages 412-418

  Lekgabe, Edna D ^a,b   Kiriazis, Helen ^c   Zhao, Chongxin ^a   Xu, Qi ^b   Moore, Xiao Lei ^b   Su, Yidan ^b   Bathgate, Ross A D ^a   Du, Xiao Jun ^b   Samuel, Chrishan S ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c Baker Heart Research Institute ^*

Author keywords

Extracellular matrix; Fibrosis; Rats; Remodeling

Indexed keywords

ALDOSTERONE ANTAGONIST; ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; ANTIHYPERTENSIVE AGENT; ATRIAL NATRIURETIC FACTOR; CAPTOPRIL; COLLAGEN; CYCLINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MYOSIN HEAVY CHAIN; RELAXIN; RNA; SPIRONOLACTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; HEART FUNCTION; HORMONE ACTION; HYPERTENSION; KIDNEY FIBROSIS; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; ATRIAL NATRIURETIC FACTOR; BIOLOGICAL MARKERS; CARDIOMEGALY; COLLAGEN; FIBROBLASTS; FIBROSIS; HEART; HUMANS; HYPERTENSION; KIDNEY; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MYOCARDIUM; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECOMBINANT PROTEINS; RELAXIN;

EID: 23244443050     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000171930.00697.2f     Document Type: Article

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