Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: Attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-κB

Circulation Research

Volumn 92, Issue 1, 2003, Pages 32-40

  Dschietzig, Thomas ^a   Bartsch, Cornelia ^a   Richter, Christoph ^a   Laule, Michael ^a   Baumann, Gert ^a   Stangl, Karl ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Endothelin; Receptors; Signal transduction; Vasoconstriction; Vasodilation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (1,3 BENZODIOXOL 5 YL) 1 [(2,6 DIETHYLPHENYL)CARBAMOYLMETHYL] 2 (4 PROPOXYPHENYL) 3 PYRROLIDINECARBOXYLIC ACID; ATRASENTAN; ENDOTHELIN 1; ENDOTHELIN 1 ANTAGONIST; ENDOTHELIN 1 DERIVATIVE; ENDOTHELIN 3; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR AGONIST; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RAF PROTEIN; RECOMBINANT RELAXIN; RELAXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME SPECIFICITY; EPITHELIUM CELL; GENETIC TRANSFECTION; HEART FAILURE; HORMONE DETERMINATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MALE; MEDIATOR RELEASE; MESENTERIC ARTERY; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION;

ANIMALS; CATTLE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATORS; EPITHELIAL CELLS; GENE EXPRESSION; GENES, REPORTER; HELA CELLS; HUMANS; MALE; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; RELAXIN; SIGNAL TRANSDUCTION; TRANSFECTION; UP-REGULATION; VASOCONSTRICTION;

EID: 0037428061     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000051884.27117.7E     Document Type: Article

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