메뉴 건너뛰기




Volumn 89, Issue 1, 2013, Pages

Enhanced uterine artery stiffness in aged pregnant relaxin mutant mice is reversed with exogenous relaxin treatment1

Author keywords

Collagen; Extracellular matrix; Matrix metalloproteinase; Pregnancy; Relaxin gene knockout; Uterine artery

Indexed keywords

CELL ADHESION MOLECULE; ELASTIN; GELATINASE; MATRIX METALLOPROTEINASE; RECOMBINANT RELAXIN; RELAXIN;

EID: 84889011225     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.113.108118     Document Type: Article
Times cited : (24)

References (53)
  • 2
    • 59849103386 scopus 로고    scopus 로고
    • Maternal uterine vascular remodeling during pregnancy
    • Osol G, Mandala M. Maternal uterine vascular remodeling during pregnancy. Physiology (Bethesda) 2009; 24:58-71.
    • (2009) Physiology (Bethesda) , vol.24 , pp. 58-71
    • Osol, G.1    Mandala, M.2
  • 3
    • 0041834759 scopus 로고    scopus 로고
    • Placental insufficiency and its consequences
    • Gagnon R. Placental insufficiency and its consequences. Eur J Obstet Gynecol Reprod Biol 2003; 110(Suppl 1):S99-S107.
    • (2003) Eur J Obstet Gynecol Reprod Biol , vol.110 , Issue.SUPPL. 1
    • Gagnon, R.1
  • 4
    • 0036654207 scopus 로고    scopus 로고
    • Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction
    • Granger JP, Alexander BT, Llinas MT, Bennett WA, Khalil RA. Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction. Microcirculation 2002; 9:147-160.
    • (2002) Microcirculation , vol.9 , pp. 147-160
    • Granger, J.P.1    Alexander, B.T.2    Llinas, M.T.3    Bennett, W.A.4    Khalil, R.A.5
  • 5
    • 79959507759 scopus 로고    scopus 로고
    • Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease
    • Powe CE, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease. Circulation 2011; 123:2856-2869.
    • (2011) Circulation , vol.123 , pp. 2856-2869
    • Powe, C.E.1    Levine, R.J.2    Karumanchi, S.A.3
  • 6
    • 17444420761 scopus 로고    scopus 로고
    • Uterine artery remodeling and reproductive performance are impaired in endothelial nitric oxide synthase-deficient mice
    • van der Heijden OW, Essers YP, Fazzi G, Peeters LL, De Mey JG, van Eys GJ. Uterine artery remodeling and reproductive performance are impaired in endothelial nitric oxide synthase-deficient mice. Biol Reprod 2005; 72:1161-1168.
    • (2005) Biol Reprod , vol.72 , pp. 1161-1168
    • van der Heijden, O.W.1    Essers, Y.P.2    Fazzi, G.3    Peeters, L.L.4    De Mey, J.G.5    van Eys, G.J.6
  • 7
    • 0027537263 scopus 로고
    • Pregnancy-induced changes in the three-dimensional mechanical properties of pressurized rat uteroplacental (radial) arteries
    • Osol G, Cipolla M. Pregnancy-induced changes in the three-dimensional mechanical properties of pressurized rat uteroplacental (radial) arteries. Am J Obstet Gynecol 1993; 168:268-274.
    • (1993) Am J Obstet Gynecol , vol.168 , pp. 268-274
    • Osol, G.1    Cipolla, M.2
  • 8
    • 0028043589 scopus 로고
    • Hypertrophic and hyperplastic effects of pregnancy on the rat uterine arterial wall
    • Cipolla M, Osol G. Hypertrophic and hyperplastic effects of pregnancy on the rat uterine arterial wall. Am J Obstet Gynecol 1994; 171:805-811.
    • (1994) Am J Obstet Gynecol , vol.171 , pp. 805-811
    • Cipolla, M.1    Osol, G.2
  • 9
    • 0022069951 scopus 로고
    • Pregnancy-induced changes in sheep uterine and carotid arteries
    • Griendling KK, Fuller EO, Cox RH. Pregnancy-induced changes in sheep uterine and carotid arteries. Am J Physiol 1985; 248:H658-H665.
    • (1985) Am J Physiol , vol.248
    • Griendling, K.K.1    Fuller, E.O.2    Cox, R.H.3
  • 10
    • 0024199450 scopus 로고
    • Structural and mechanical changes of uterine arteries during pregnancy in the pig
    • Guenther AE, Conley AJ, Van Orden DE, Farley DB, Ford SP. Structural and mechanical changes of uterine arteries during pregnancy in the pig. J Anim Sci 1988; 66:3144-3152.
    • (1988) J Anim Sci , vol.66 , pp. 3144-3152
    • Guenther, A.E.1    Conley, A.J.2    Van Orden, D.E.3    Farley, D.B.4    Ford, S.P.5
  • 13
    • 0038648808 scopus 로고    scopus 로고
    • Gestational profile of matrix metalloproteinases in rat uterine artery
    • Kelly BA, Bond BC, Poston L. Gestational profile of matrix metalloproteinases in rat uterine artery. Mol Hum Reprod 2003; 9:351-358.
    • (2003) Mol Hum Reprod , vol.9 , pp. 351-358
    • Kelly, B.A.1    Bond, B.C.2    Poston, L.3
  • 14
    • 80053292702 scopus 로고    scopus 로고
    • Reduced NO signaling during pregnancy attenuates outward uterine artery remodeling by altering MMP expression and collagen and elastin deposition
    • Hale SA, Weger L, Mandala M, Osol G. Reduced NO signaling during pregnancy attenuates outward uterine artery remodeling by altering MMP expression and collagen and elastin deposition. Am J Physiol Heart Circ Physiol 2011; 301:H1266-H1275.
    • (2011) Am J Physiol Heart Circ Physiol , vol.301
    • Hale, S.A.1    Weger, L.2    Mandala, M.3    Osol, G.4
  • 15
    • 83455185431 scopus 로고    scopus 로고
    • Physiological remodelling of the maternal uterine circulation during pregnancy
    • Mandala M, Osol G. Physiological remodelling of the maternal uterine circulation during pregnancy. Basic Clin Pharmacol Toxicol 2012; 110: 12-18.
    • (2012) Basic Clin Pharmacol Toxicol , vol.110 , pp. 12-18
    • Mandala, M.1    Osol, G.2
  • 16
    • 64749097486 scopus 로고    scopus 로고
    • Predominance of local over systemic factors in uterine arterial remodeling during pregnancy
    • Fuller R, Barron C, Mandala M, Gokina N, Osol G. Predominance of local over systemic factors in uterine arterial remodeling during pregnancy. Reprod Sci 2009; 16:489-500.
    • (2009) Reprod Sci , vol.16 , pp. 489-500
    • Fuller, R.1    Barron, C.2    Mandala, M.3    Gokina, N.4    Osol, G.5
  • 17
    • 84863793577 scopus 로고    scopus 로고
    • Uterine distension differentially affects remodelling and distensibility of the uterine vasculature in non-pregnant rats
    • Osol G, Barron C, Mandala M. Uterine distension differentially affects remodelling and distensibility of the uterine vasculature in non-pregnant rats. Reprod Fertil Dev 2012; 24:835-842.
    • (2012) Reprod Fertil Dev , vol.24 , pp. 835-842
    • Osol, G.1    Barron, C.2    Mandala, M.3
  • 18
    • 67650116682 scopus 로고    scopus 로고
    • The effects of the ovarian cycle and pregnancy on uterine vascular impedance and uterine artery mechanics
    • Sprague BJ, Phernetton TM, Magness RR, Chesler NC. The effects of the ovarian cycle and pregnancy on uterine vascular impedance and uterine artery mechanics. Eur J Obstet Gynecol Reprod Biol 2009; 144(Suppl 1): S170-S178.
    • (2009) Eur J Obstet Gynecol Reprod Biol , vol.144 , Issue.SUPPL. 1
    • Sprague, B.J.1    Phernetton, T.M.2    Magness, R.R.3    Chesler, N.C.4
  • 20
    • 59549085141 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthases abrogates pregnancy-induced uterine vascular expansive remodeling
    • Osol G, Barron C, Gokina N, Mandala M. Inhibition of nitric oxide synthases abrogates pregnancy-induced uterine vascular expansive remodeling. J Vasc Res 2009; 46:478-486.
    • (2009) J Vasc Res , vol.46 , pp. 478-486
    • Osol, G.1    Barron, C.2    Gokina, N.3    Mandala, M.4
  • 26
    • 33748310575 scopus 로고    scopus 로고
    • Hormonal changes accompanying cigarette smoke-induced preterm births in a mouse model
    • Ng SP, Steinetz BG, Lasano SG, Zelikoff JT. Hormonal changes accompanying cigarette smoke-induced preterm births in a mouse model. Exp Biol Med (Maywood) 2006; 231:1403-1409.
    • (2006) Exp Biol Med (Maywood) , vol.231 , pp. 1403-1409
    • Ng, S.P.1    Steinetz, B.G.2    Lasano, S.G.3    Zelikoff, J.T.4
  • 27
    • 3142669073 scopus 로고    scopus 로고
    • Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase Cbeta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats
    • Wigg SJ, Tare M, Forbes J, Cooper ME, Thomas MC, Coleman HA, Parkington HC, O'Brien RC. Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase Cbeta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats. Diabetologia 2004; 47:1038-1046.
    • (2004) Diabetologia , vol.47 , pp. 1038-1046
    • Wigg, S.J.1    Tare, M.2    Forbes, J.3    Cooper, M.E.4    Thomas, M.C.5    Coleman, H.A.6    Parkington, H.C.7    O'Brien, R.C.8
  • 28
    • 84864130487 scopus 로고    scopus 로고
    • Uteroplacental insufficiency programmes vascular dysfunction in non-pregnant rats: compensatory adaptations in pregnancy
    • Mazzuca MQ, Tare M, Parkington HC, Dragomir NM, Parry LJ, Wlodek ME. Uteroplacental insufficiency programmes vascular dysfunction in non-pregnant rats: compensatory adaptations in pregnancy. J Physiol 2012; 590:3375-3388.
    • (2012) J Physiol , vol.590 , pp. 3375-3388
    • Mazzuca, M.Q.1    Tare, M.2    Parkington, H.C.3    Dragomir, N.M.4    Parry, L.J.5    Wlodek, M.E.6
  • 29
    • 79956361338 scopus 로고    scopus 로고
    • Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans
    • McGuane JT, Danielson LA, Debrah JE, Rubin JP, Novak J, Conrad KP. Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans. Hypertension 2011; 57:1151-1160.
    • (2011) Hypertension , vol.57 , pp. 1151-1160
    • McGuane, J.T.1    Danielson, L.A.2    Debrah, J.E.3    Rubin, J.P.4    Novak, J.5    Conrad, K.P.6
  • 30
    • 33744946031 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats
    • Jeyabalan A, Kerchner LJ, Fisher MC, McGuane JT, Doty KD, Conrad KP. Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats. J Appl Physiol 2006; 100:1955-1963.
    • (2006) J Appl Physiol , vol.100 , pp. 1955-1963
    • Jeyabalan, A.1    Kerchner, L.J.2    Fisher, M.C.3    McGuane, J.T.4    Doty, K.D.5    Conrad, K.P.6
  • 31
    • 3042610399 scopus 로고    scopus 로고
    • Relaxin's physiological roles and other diverse actions
    • Sherwood OD. Relaxin's physiological roles and other diverse actions. Endocr Rev 2004; 25:205-234.
    • (2004) Endocr Rev , vol.25 , pp. 205-234
    • Sherwood, O.D.1
  • 33
    • 33751243624 scopus 로고    scopus 로고
    • Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats
    • Debrah DO, Novak J, Matthews JE, Ramirez RJ, Shroff SG, Conrad KP. Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats. Endocrinology 2006; 147:5126-5131.
    • (2006) Endocrinology , vol.147 , pp. 5126-5131
    • Debrah, D.O.1    Novak, J.2    Matthews, J.E.3    Ramirez, R.J.4    Shroff, S.G.5    Conrad, K.P.6
  • 34
    • 36849093542 scopus 로고    scopus 로고
    • Vasorelaxant action of 17- estradiol in rat uterine arteries: role of nitric oxide synthases and estrogen receptors
    • Scott PA, Tremblay A, Brochu M, St-Louis J. Vasorelaxant action of 17- estradiol in rat uterine arteries: role of nitric oxide synthases and estrogen receptors. Am J Physiol Heart Circ Physiol 2007; 293:H3713-H3719.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Scott, P.A.1    Tremblay, A.2    Brochu, M.3    St-Louis, J.4
  • 35
    • 0023088537 scopus 로고
    • Estrogens as natural antioxidants of membrane phospholipid peroxidation
    • Sugioka K, Shimosegawa Y, Nakano M. Estrogens as natural antioxidants of membrane phospholipid peroxidation. FEBS Lett 1987; 210:37-39.
    • (1987) FEBS Lett , vol.210 , pp. 37-39
    • Sugioka, K.1    Shimosegawa, Y.2    Nakano, M.3
  • 36
    • 33750690742 scopus 로고    scopus 로고
    • Endothelial vasodilator production by uterine and systemic arteries.III. Ovarian and estrogen effects on NO synthase
    • Vagnoni KE, Shaw CE, Phernetton TM, Meglin BM, Bird IM, Magness RR. Endothelial vasodilator production by uterine and systemic arteries. III. Ovarian and estrogen effects on NO synthase. Am J Physiol 1998; 275: H1845-H1856.
    • (1998) Am J Physiol , vol.275
    • Vagnoni, K.E.1    Shaw, C.E.2    Phernetton, T.M.3    Meglin, B.M.4    Bird, I.M.5    Magness, R.R.6
  • 37
    • 0033670492 scopus 로고    scopus 로고
    • Estrogen replacement reduces ageassociated remodeling in rat mesenteric arteries
    • Zhang Y, Stewart KG, Davidge ST. Estrogen replacement reduces ageassociated remodeling in rat mesenteric arteries. Hypertension 2000; 36: 970-974.
    • (2000) Hypertension , vol.36 , pp. 970-974
    • Zhang, Y.1    Stewart, K.G.2    Davidge, S.T.3
  • 39
    • 84869081780 scopus 로고    scopus 로고
    • Maternal-fetal resource allocation: co-operation and conflict
    • Fowden AL, Moore T. Maternal-fetal resource allocation: co-operation and conflict. Placenta 2012; 33(Suppl 2):e11-e15.
    • (2012) Placenta , vol.33 , Issue.SUPPL. 2
    • Fowden, A.L.1    Moore, T.2
  • 40
    • 12244257489 scopus 로고    scopus 로고
    • Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype
    • Du XJ, Samuel CS, Gao XM, Zhao L, Parry LJ, Tregear GW. Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype. Cardiovasc Res 2003; 57: 395-404.
    • (2003) Cardiovasc Res , vol.57 , pp. 395-404
    • Du, X.J.1    Samuel, C.S.2    Gao, X.M.3    Zhao, L.4    Parry, L.J.5    Tregear, G.W.6
  • 42
    • 23644458574 scopus 로고    scopus 로고
    • Mechanisms of relaxin action in the reproductive tract: studies in the relaxin-deficient (Rlx-/-) mouse
    • Parry LJ, McGuane JT, Gehring HM, Kostic IG, Siebel AL. Mechanisms of relaxin action in the reproductive tract: studies in the relaxin-deficient (Rlx-/-) mouse. Ann N Y Acad Sci 2005; 1041:91-103.
    • (2005) Ann N Y Acad Sci , vol.1041 , pp. 91-103
    • Parry, L.J.1    McGuane, J.T.2    Gehring, H.M.3    Kostic, I.G.4    Siebel, A.L.5
  • 44
    • 57349140339 scopus 로고    scopus 로고
    • Heightened aberrant deposition of hard-wearing elastin in conduit arteries of prehypertensive SHR is associated with increased stiffness and inward remodeling
    • Arribas SM, Briones AM, Bellingham C, Gonzalez MC, Salaices M, Liu K, Wang Y, Hinek A. Heightened aberrant deposition of hard-wearing elastin in conduit arteries of prehypertensive SHR is associated with increased stiffness and inward remodeling. Am J Physiol Heart Circ Physiol 2008; 295:H2299-H2307.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Arribas, S.M.1    Briones, A.M.2    Bellingham, C.3    Gonzalez, M.C.4    Salaices, M.5    Liu, K.6    Wang, Y.7    Hinek, A.8
  • 45
    • 33845909264 scopus 로고    scopus 로고
    • Vascular matrix metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxin
    • Jeyabalan A, Novak J, Doty KD, Matthews J, Fisher MC, Kerchner LJ, Conrad KP. Vascular matrix metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxin. Endocrinology 2007; 148:189-197.
    • (2007) Endocrinology , vol.148 , pp. 189-197
    • Jeyabalan, A.1    Novak, J.2    Doty, K.D.3    Matthews, J.4    Fisher, M.C.5    Kerchner, L.J.6    Conrad, K.P.7
  • 46
    • 0026560454 scopus 로고
    • TGF-beta: regulation of extracellular matrix
    • Roberts AB, McCune BK, Sporn MB. TGF-beta: regulation of extracellular matrix. Kidney Int 1992; 41:557-559.
    • (1992) Kidney Int , vol.41 , pp. 557-559
    • Roberts, A.B.1    McCune, B.K.2    Sporn, M.B.3
  • 47
    • 0032482202 scopus 로고    scopus 로고
    • PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate
    • Hirschi KK, Rohovsky SA, D'Amore PA. PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate. J Cell Biol 1998; 141:805-814.
    • (1998) J Cell Biol , vol.141 , pp. 805-814
    • Hirschi, K.K.1    Rohovsky, S.A.2    D'Amore, P.A.3
  • 48
    • 0345035511 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 stimulates the synthesis of basement membrane proteins laminin, collagen type IV and entactin in rat liver sinusoidal endothelial cells
    • Neubauer K, Kruger M, Quondamatteo F, Knittel T, Saile B, Ramadori G. Transforming growth factor-beta1 stimulates the synthesis of basement membrane proteins laminin, collagen type IV and entactin in rat liver sinusoidal endothelial cells. J Hepatol 1999; 31:692-702.
    • (1999) J Hepatol , vol.31 , pp. 692-702
    • Neubauer, K.1    Kruger, M.2    Quondamatteo, F.3    Knittel, T.4    Saile, B.5    Ramadori, G.6
  • 49
    • 3042685353 scopus 로고    scopus 로고
    • Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats
    • Conrad KP, Debrah DO, Novak J, Danielson LA, Shroff SG. Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats. Endocrinology 2004; 145:3289-3296.
    • (2004) Endocrinology , vol.145 , pp. 3289-3296
    • Conrad, K.P.1    Debrah, D.O.2    Novak, J.3    Danielson, L.A.4    Shroff, S.G.5
  • 50
    • 77951499083 scopus 로고    scopus 로고
    • Relaxin therapy reverses large artery remodeling and improves arterial compliance in senescent spontaneously hypertensive rats
    • Xu Q, Chakravorty A, Bathgate RA, Dart AM, Du XJ. Relaxin therapy reverses large artery remodeling and improves arterial compliance in senescent spontaneously hypertensive rats. Hypertension 2010; 55: 1260-1266.
    • (2010) Hypertension , vol.55 , pp. 1260-1266
    • Xu, Q.1    Chakravorty, A.2    Bathgate, R.A.3    Dart, A.M.4    Du, X.J.5
  • 51
    • 27744539000 scopus 로고    scopus 로고
    • Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity and compliance of the rat mesenteric arterial and venous vasculature
    • Li Y, Brookes ZL, Kaufman S. Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity and compliance of the rat mesenteric arterial and venous vasculature. Regul Pept 2005; 132:41-46.
    • (2005) Regul Pept , vol.132 , pp. 41-46
    • Li, Y.1    Brookes, Z.L.2    Kaufman, S.3
  • 52
    • 80052652796 scopus 로고    scopus 로고
    • Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferatoractivated receptor-gamma
    • Chan SL, Cipolla MJ. Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferatoractivated receptor-gamma. FASEB J 2011; 25:3229-3239.
    • (2011) FASEB J , vol.25 , pp. 3229-3239
    • Chan, S.L.1    Cipolla, M.J.2
  • 53
    • 81255152083 scopus 로고    scopus 로고
    • Effects of relaxin on arterial dilation, remodeling, and mechanical properties
    • Conrad KP, Shroff SG. Effects of relaxin on arterial dilation, remodeling, and mechanical properties. Curr Hypertens Rep 2011; 13:409-420.
    • (2011) Curr Hypertens Rep , vol.13 , pp. 409-420
    • Conrad, K.P.1    Shroff, S.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.