Acute intravenous injection of serelaxin (recombinant human relaxin-2) causes rapid and sustained bradykinin-mediated vasorelaxation.

Journal of the American Heart Association

Volumn 3, Issue 1, 2014, Pages

  Leo, Chen Huei ^a   Jelinic, Maria ^b   Parkington, Helena C ^b   Tare, Marianne ^b   Parry, Laura J ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NOS2 PROTEIN, RAT; NOS3 PROTEIN, RAT; PROSTACYCLIN; PROTEIN KINASE B; RECOMBINANT PROTEIN; RELAXIN; SERELAXIN; SERELAXIN PROTEIN, HUMAN; SERINE; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL; ARTICLE; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIUM; ENDOTHELIUM-DERIVED HYPERPOLARIZATION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MESENTERIC ARTERY; METABOLISM; PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TIME; VASOCONSTRICTION; VASODILATATION; WISTAR RAT;

ENDOTHELIUM; ENDOTHELIUM-DERIVED HYPERPOLARIZATION; NITRIC OXIDE; PROSTACYCLIN; SERELAXIN;

ANIMALS; BRADYKININ; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOPROSTENOL; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MESENTERIC ARTERIES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; RELAXIN; SERINE; SIGNAL TRANSDUCTION; TIME FACTORS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 84898657150     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.113.000493     Document Type: Article

References (0)