Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo

Endocrinology

Volumn 145, Issue 9, 2004, Pages 4125-4133

  Samuel, Chrishan S ^a   Unemori, Elaine N ^b   Mookerjee, Ishanee ^a   Bathgate, Ross A D ^a   Layfield, Sharon L ^a   Mak, John ^b   Tregear, Geoffrey W ^a   Du, Xiao Jun ^c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b Bradley Pharmaceuticals Inc   (United States)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; ANGIOTENSIN; BETA 2 ADRENERGIC RECEPTOR; COLLAGEN; GELATINASE A; RELAXIN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; FIBROBLAST; GENE OVEREXPRESSION; HEART; HEART ATRIUM; HEART MUSCLE FIBROSIS; HEART VENTRICLE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RODENT; SMOOTH MUSCLE;

AMINO ACID SEQUENCE; ANGIOTENSIN II; ANIMALS; CARDIOMYOPATHIES; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; COLLAGEN; CYCLIC AMP; DISEASE MODELS, ANIMAL; FIBROBLASTS; FIBROSIS; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, CARDIAC; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RELAXIN; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; VASOCONSTRICTOR AGENTS;

EID: 4344606223     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0209     Document Type: Article

References (42)

1. Sherwood OD 1994 Relaxin. In: Knobil E, Neill JD, eds. Physiology of reproduction. 2nd ed. New York: Raven Press; 861-1009
2. Unemori EN, Amento EP 1990 Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts. J Biol Chem 265: 10681-10685
3. Unemori EN, Pickford LB, Salles AL, Piercy CE, Grove BH, Erikson ME, Amento EP 1996 Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J Clin Invest 98:2739-2745
4. Garber SL, Mirochnik Y, Brecklin CS, Unemori EN, Singh AK, Slobodskoy L, Grove BH, Arruda JA, Dunea G 2001 Relaxin decreases renal interstitial fibrosis and slows progression of renal disease. Kidney Int 59:876-882
5. Willams EJ, Benyon RC, Trim N, Hadwin R, Grove BH, Arthur MJ, Unemori EN, Iredale JP 2001 Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 49:577-583
6. Samuel CS, Zhao C, Bathgate RAD, Bond CP, Burton MD, Parry LJ, Summers RJ, Tang MLK, Amento EP, Tregear GW 2003 Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis. FASEB J 17:121-123
7. Erikson MS, Unemori EN 2001 Relaxin clinical trials in systemic sclerosis. In: Tregear GW, Ivell R, Bathgate RA, Wade JD, eds, Relaxin 2000: proceedings of the 3rd international conference on relaxin and related peptides. The Netherlands: Kluwer Academic Publishers; 373-381
8. Judgutt BI 2003 Remodeling of the myocardium and potential targets in the collagen degradation and synthesis pathways. Curr Drug Targets Cardiovasc Haematol Disord 3:1-30
9. Weber KT 1989 Cardiac interstitium in health and disease: the fibrillar collagen network. J Am Coll Cardiol 13:1637-1652
10. Bishop JE, Lindahl G 1999 Regulation of cardiovascular collagen synthesis by mechanical load. Cardiovasc Res 42:27-44
11. Lijnen PJ, Petrov VV, Fagard RH 2000 Induction of cardiac fibrosis by transforming growth factor-β(1). Mol Genet Metab 71:418-435
12. Lijnen PJ, Petrov VV, Fagard RH 2000 Induction of cardiac fibrosis by angiotensin II. Methods Find Exp Clin Pharmacol 22:709-723
13. Chua CC, Diglio CA, Siu BB, Chua BH 1994 Angiotensin II induces TGF-β1 production in rat heart endothelial cells. Biochim Biophys Acta 1223:141-147
14. Lee AA, Dillmann WH, McCulloch AD, Villarreal FJ 1995 Angiotensin II stimulates the autocrine production of transforming growth factor-β1 in adult rat cardiac fibroblasts. J Mol Cell Cardiol 27:2347-2357
15. Campbell SE, Katwa LC 1997 Angiotensin II stimulated expression of transforming growth factor-β1 in cardiac fibroblasts and myofibroblasts. J Mol Cell Cardiol 29:1947-1958
16. Du XJ, Samuel CS, Gao XM, Zhao L, Parry LJ, Tregear GW 2003 Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype. Cardiovasc Res 57:395-404
17. Dschietzig T, Richter C, Bartsch C, Laule M, Ambruster FP, Baumann G, Stangl K 2001 The pregnancy hormone relaxin is a player in human heart failure. FASEB J 15:2187-2195
18. Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ 2002 Activation of orphan receptors by the hormone relaxin. Science 295:671-674
19. Gao XM, Agrotis A, Autelitano DJ, Percy E, Woodcock EA, Jennings GL, Dart AM, Du XJ 2003 Sex hormones and cardiomyopathic phenotype induced by cardiac β2-adrenergic receptor overexpression. Endocrinology 144:4097-4105
20. Gray MO, Long CS, Kalinyak JE, Li H-T, Karlinet JS 1998 Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-β1 and endothelin-1 from fibroblasts. Cardiovasc Res 40:352-363
21. Masur SK, Dewal HS, Dinh TT, Erenburg I, Petridou S 1996 Myofibroblasts differentiate from fibroblasts when plated at low density. Proc Natl Acad Sci USA 93:4219-4223
22. Sherwood OD, Crnekovic VE, Gordon WL, Rutherford JE 1980 Radioimrminoassay of relaxin throughout pregnancy and during parturition in the rat. Endocrinology 107:691-698
23. Samuel CS, Butkus A, Coghlan JP, Bateman JF 1996 The effect of relaxin on collagen metabolism in the nonpregnant rat pubic symphysis: the influence of estrogen and progesterone in regulating relaxin activity. Endocrinology 137: 3884-3890
24. Gallop PM, Paz MA 1975 Posttranslational protein modifications, with special attention to collagen and elastin. Physiol Rev 55:418-487
25. Talhouk RS, Chin JR, Unemori EN, Werb Z, Bissell MJ 1991 Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture. Development 112:439-449
26. McEwan PE, Gray GA, Sherry L, Webb DJ, Kenyon CJ 1998 Differential effects of angiotensin II on cardiac proliferation and intramyocardial perivascular fibrosis in vivo. Circulation 98:2765-2773
27. Van Eickels M, Vetter H, Grohe C 2000 Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol 131:1592-1596
28. Samuel CS, Sakai LY, Amento EP 2003 Relaxin regulates fibrillin-2, but not fibrillin-1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin. Arch Biochem Biophys 411:47-55
29. Kompa AR, Samuel CS, Summers RJ 2002 Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin. Br J Pharmacol 137:710-718
30. Bathgate RAD, Samuel CS, Burazin TCD, Layfield S, Claasz AA, Reytomas IGT, Dawson NF, Zhao C, Bond C, Summers RJ, Parry LJ, Wade JD, Tregear GW 2002 Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. J Biol Chem 277:1148-1157
31. Eghbali M 1998 Cardiac fibroblasts: function, regulation of gene expression, and phenotypic modulation. Basic Res Cardiol 87(Suppl 2):183-189
32. Bouzegrhane F, Thibault G 2002 Is angiotensin II a proliferative factor of cardiac fibroblasts? Cardiovasc Res 53:304-312
33. 1 during differentiation of cardiac fibroblasts to myofibroblasts. Hypertension 39:258-263
34. Eddy AA 1996 Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 7:2495-2508
35. Dschietzig T, Bartsch C, Richter C, Laule M, Baumann G, Stangl K 2003 Relaxin, a pregnancy hormone, is a functional antagonist of endothelin-1- mediated vasoconstriction by stimulation of endothelin type-B-receptor expression via ERK-1/2 and nuclear factor-κB. Circ Res 92:32-40
36. Aimes RT, Quigley JP 1995 Matrix metalloproteinase-2 is an interstitial collagenase. J Biol Chem 270:5872-5876
37. Palejwala S, Stein D, Wojtczuk A, Weiss G, Goldsmith LT 1998 Demonstration of a relaxin receptor and relaxin-stimulated tyrosine phosphorylation in human lower uterine segment fibroblasts. Endocrinology 139:1208-1212
38. Bartsch O, Bartlick B, Ivell R 2001 Relaxin signalling links tyrosine phophorylation to phosphodiesterases and adenylyl cyclase activity. Mol Hum Reprod 7:799-809
39. Zhang Q, Liu SH, Erikson M, Lewis M, Unemori E 2002 Relaxin activates the MAP kinase pathway in human endometrial stromal cells. J Cell Biochem 85:536-544
40. Tharaux PL, Chatziantoniou C, Fakhouri F, Dussaule JC 2000 Angiotensin II activates collagen I gene through a mechanism involving the MAP/ER kinase pathway. Hypertension 36:330-336
41. Funaba M, Zimmerman CM, Matthews LS 2002 Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. J Biol Chem 277: 41361-41368
42. Lijnen PJ, Petrov VV 2003 Role of intracardiac renin-angiotensin- aldosterone system in extracellular matrix remodeling. Methods Find Exp Clin Pharmacol 25:541-564