메뉴 건너뛰기




Volumn 68, Issue 2, 2011, Pages 195-203

Endothelin

Author keywords

Endothelin; Endothelin receptor; Endothelin signal; Endothelin converting enzymes; Pathophysiology

Indexed keywords

ATRASENTAN; BOSENTAN; CGS 35066; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DARUSENTAN; ENALAPRIL; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME INHIBITOR; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; ENKEPHALINASE INHIBITOR; KELATORPHAN; MEMBRANE METALLOENDOPEPTIDASE; PACLITAXEL; PREPROENDOTHELIN 1; SITAXSENTAN; TAK 044; TBC 3711; TEZOSENTAN; THIORPHAN; UNCLASSIFIED DRUG; VASOCONSTRICTOR AGENT; ZIBOTENTAN;

EID: 78651375084     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0518-0     Document Type: Review
Times cited : (149)

References (105)
  • 1
    • 0030444643 scopus 로고    scopus 로고
    • The endothelin system and its potential as a therapeutic target in cardiovascular disease
    • 1:CAS:528:DyaK28XmvVClsro%3D 8981573 10.1016/S0163-7258(96)00101-5
    • GA Gray DJ Webb 1996 The endothelin system and its potential as a therapeutic target in cardiovascular disease Pharmacol Ther 72 2 109 148 1:CAS:528:DyaK28XmvVClsro%3D 8981573 10.1016/S0163-7258(96)00101-5
    • (1996) Pharmacol Ther , vol.72 , Issue.2 , pp. 109-148
    • Gray, G.A.1    Webb, D.J.2
  • 2
    • 0023859136 scopus 로고
    • A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    • 1:CAS:528:DyaL1cXlsVaks78%3D 2451132 10.1038/332411a0
    • M Yanagisawa H Kurihara S Kimura Y Tomobe M Kobayashi Y Mitsui Y Yazaki K Goto T Masaki 1988 A novel potent vasoconstrictor peptide produced by vascular endothelial cells Nature 332 6163 411 415 1:CAS:528:DyaL1cXlsVaks78%3D 2451132 10.1038/332411a0
    • (1988) Nature , vol.332 , Issue.6163 , pp. 411-415
    • Yanagisawa, M.1    Kurihara, H.2    Kimura, S.3    Tomobe, Y.4    Kobayashi, M.5    Mitsui, Y.6    Yazaki, Y.7    Goto, K.8    Masaki, T.9
  • 3
    • 0035040924 scopus 로고    scopus 로고
    • Endothelin system: The double-edged sword in health and disease
    • 1:CAS:528:DC%2BD3MXjsVaqtL0%3D 11264479 10.1146/annurev.pharmtox.41.1.851
    • RM Kedzierski M Yanagisawa 2001 Endothelin system: the double-edged sword in health and disease Annu Rev Pharmacol Toxicol 41 851 876 1:CAS:528:DC%2BD3MXjsVaqtL0%3D 11264479 10.1146/annurev.pharmtox.41.1.851
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 851-876
    • Kedzierski, R.M.1    Yanagisawa, M.2
  • 4
    • 0029017876 scopus 로고
    • Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon- sensitive metalloprotease with acidic pH optimum
    • 1:CAS:528:DyaK2MXmsFKqtLo%3D 7797512 10.1074/jbc.270.25.15262
    • N Emoto M Yanagisawa 1995 Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum J Biol Chem 270 25 15262 15268 1:CAS:528:DyaK2MXmsFKqtLo%3D 7797512 10.1074/jbc.270.25.15262
    • (1995) J Biol Chem , vol.270 , Issue.25 , pp. 15262-15268
    • Emoto, N.1    Yanagisawa, M.2
  • 5
    • 0034086055 scopus 로고    scopus 로고
    • Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development
    • 1:CAS:528:DC%2BD3cXjtlOnsL0%3D 10811845 10.1172/JCI7447
    • H Yanagisawa RE Hammer JA Richardson N Emoto SC Williams S Takeda DE Clouthier M Yanagisawa 2000 Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development J Clin Invest 105 10 1373 1382 1:CAS:528:DC%2BD3cXjtlOnsL0%3D 10811845 10.1172/JCI7447
    • (2000) J Clin Invest , vol.105 , Issue.10 , pp. 1373-1382
    • Yanagisawa, H.1    Hammer, R.E.2    Richardson, J.A.3    Emoto, N.4    Williams, S.C.5    Takeda, S.6    Clouthier, D.E.7    Yanagisawa, M.8
  • 6
    • 0030032386 scopus 로고    scopus 로고
    • Molecular pharmacology of endothelin-converting enzymes
    • 1:CAS:528:DyaK28XltFOguw%3D%3D 8615890 10.1016/0006-2952(95)02036-5
    • AJ Turner LJ Murphy 1996 Molecular pharmacology of endothelin-converting enzymes Biochem Pharmacol 51 2 91 102 1:CAS:528:DyaK28XltFOguw%3D%3D 8615890 10.1016/0006-2952(95)02036-5
    • (1996) Biochem Pharmacol , vol.51 , Issue.2 , pp. 91-102
    • Turner, A.J.1    Murphy, L.J.2
  • 7
    • 0031571260 scopus 로고    scopus 로고
    • Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cells
    • 1:CAS:528:DyaK2sXltlGitrs%3D 9257865
    • A Nakano F Kishi K Minami H Wakabayashi Y Nakaya H Kido 1997 Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cells J Immunol 159 4 1987 1992 1:CAS:528:DyaK2sXltlGitrs%3D 9257865
    • (1997) J Immunol , vol.159 , Issue.4 , pp. 1987-1992
    • Nakano, A.1    Kishi, F.2    Minami, K.3    Wakabayashi, H.4    Nakaya, Y.5    Kido, H.6
  • 8
    • 59649085140 scopus 로고    scopus 로고
    • Chymase-dependent conversion of big endothelin-1 in the mouse in vivo
    • 1:CAS:528:DC%2BD1MXhs1Khu7c%3D 18987301 10.1124/jpet.108.142992
    • E Simard D Jin S Takai M Miyazaki I Brochu P D'Orleans-Juste 2009 Chymase-dependent conversion of big endothelin-1 in the mouse in vivo J Pharmacol Exp Ther 328 2 540 548 1:CAS:528:DC%2BD1MXhs1Khu7c%3D 18987301 10.1124/jpet.108.142992
    • (2009) J Pharmacol Exp Ther , vol.328 , Issue.2 , pp. 540-548
    • Simard, E.1    Jin, D.2    Takai, S.3    Miyazaki, M.4    Brochu, I.5    D'Orleans-Juste, P.6
  • 9
    • 22144484132 scopus 로고    scopus 로고
    • Endothelin inhibition delays onset of hyperglycemia and associated vascular injury in type i diabetes: Evidence for endothelin release by pancreatic islet beta-cells
    • 1:CAS:528:DC%2BD2MXmsVOnsrw%3D 16009335 10.1016/j.bbrc.2005.06.140
    • J Ortmann PC Nett J Celeiro T Traupe L Tornillo R Hofmann-Lehmann E Haas B Frank LM Terraciano M Barton 2005 Endothelin inhibition delays onset of hyperglycemia and associated vascular injury in type I diabetes: evidence for endothelin release by pancreatic islet beta-cells Biochem Biophys Res Commun 334 2 689 695 1:CAS:528:DC%2BD2MXmsVOnsrw%3D 16009335 10.1016/j.bbrc.2005.06.140
    • (2005) Biochem Biophys Res Commun , vol.334 , Issue.2 , pp. 689-695
    • Ortmann, J.1    Nett, P.C.2    Celeiro, J.3    Traupe, T.4    Tornillo, L.5    Hofmann-Lehmann, R.6    Haas, E.7    Frank, B.8    Terraciano, L.M.9    Barton, M.10
  • 10
    • 0025312768 scopus 로고
    • Identification and characterization of endothelin converting activity in cultured bovine endothelial cells
    • 1:CAS:528:DyaK3cXktlGgtL8%3D 2189402 10.1016/0006-291X(90)91146-J
    • K Ohnaka R Takayanagi T Yamauchi H Okazaki M Ohashi F Umeda H Nawata 1990 Identification and characterization of endothelin converting activity in cultured bovine endothelial cells Biochem Biophys Res Commun 168 3 1128 1136 1:CAS:528:DyaK3cXktlGgtL8%3D 2189402 10.1016/0006-291X(90)91146-J
    • (1990) Biochem Biophys Res Commun , vol.168 , Issue.3 , pp. 1128-1136
    • Ohnaka, K.1    Takayanagi, R.2    Yamauchi, T.3    Okazaki, H.4    Ohashi, M.5    Umeda, F.6    Nawata, H.7
  • 11
    • 73949125537 scopus 로고    scopus 로고
    • Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction
    • 1:CAS:528:DC%2BC3cXnt1WmtQ%3D%3D 19962413 10.1016/j.peptides.2009.11.029
    • T Matsumoto Y Ozawa K Taguchi T Kobayashi K Kamata 2010 Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction Peptides 31 2 346 353 1:CAS:528:DC%2BC3cXnt1WmtQ%3D%3D 19962413 10.1016/j.peptides.2009.11.029
    • (2010) Peptides , vol.31 , Issue.2 , pp. 346-353
    • Matsumoto, T.1    Ozawa, Y.2    Taguchi, K.3    Kobayashi, T.4    Kamata, K.5
  • 12
    • 0027992642 scopus 로고
    • ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
    • 1:CAS:528:DyaK2MXkvV2nug%3D%3D 8062389 10.1016/0092-8674(94)90425-1
    • D Xu N Emoto A Giaid C Slaughter S Kaw D de Wit M Yanagisawa 1994 ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1 Cell 78 3 473 485 1:CAS:528:DyaK2MXkvV2nug%3D%3D 8062389 10.1016/0092-8674(94)90425-1
    • (1994) Cell , vol.78 , Issue.3 , pp. 473-485
    • Xu, D.1    Emoto, N.2    Giaid, A.3    Slaughter, C.4    Kaw, S.5    De Wit, D.6    Yanagisawa, M.7
  • 13
    • 0031627719 scopus 로고    scopus 로고
    • Big endothelin analogues with inhibitory activity on endothelin- converting enzyme-1
    • 1:CAS:528:DyaK1cXjtFaktb4%3D 9595401 10.1097/00005344-199800001-00020
    • R Takayanagi W Liu T Ito K Ohnaka H Nawata 1998 Big endothelin analogues with inhibitory activity on endothelin-converting enzyme-1 J Cardiovasc Pharmacol 31 Suppl 1 S62 S63 1:CAS:528:DyaK1cXjtFaktb4%3D 9595401 10.1097/00005344-199800001-00020
    • (1998) J Cardiovasc Pharmacol , vol.31 , Issue.SUPPL. 1
    • Takayanagi, R.1    Liu, W.2    Ito, T.3    Ohnaka, K.4    Nawata, H.5
  • 14
    • 0029585975 scopus 로고
    • Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)
    • 1:CAS:528:DyaK2MXhtVSitbrP 8530372 10.1074/jbc.270.50.29794
    • O Valdenaire E Rohrbacher MG Mattei 1995 Organization of the gene encoding the human endothelin-converting enzyme (ECE-1) J Biol Chem 270 50 29794 29798 1:CAS:528:DyaK2MXhtVSitbrP 8530372 10.1074/jbc.270.50.29794
    • (1995) J Biol Chem , vol.270 , Issue.50 , pp. 29794-29798
    • Valdenaire, O.1    Rohrbacher, E.2    Mattei, M.G.3
  • 15
    • 1842628557 scopus 로고    scopus 로고
    • Increased expression of endothelin-converting enzyme-1c isoform in response to high glucose levels in endothelial cells
    • 1:CAS:528:DC%2BD2cXjtFKqsrY%3D 15010576 10.1159/000077132
    • S Keynan M Khamaisi R Dahan K Barnes CD Jackson AJ Turner I Raz 2004 Increased expression of endothelin-converting enzyme-1c isoform in response to high glucose levels in endothelial cells J Vasc Res 41 2 131 140 1:CAS:528:DC%2BD2cXjtFKqsrY%3D 15010576 10.1159/000077132
    • (2004) J Vasc Res , vol.41 , Issue.2 , pp. 131-140
    • Keynan, S.1    Khamaisi, M.2    Dahan, R.3    Barnes, K.4    Jackson, C.D.5    Turner, A.J.6    Raz, I.7
  • 16
    • 53049107711 scopus 로고    scopus 로고
    • Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion
    • 1:CAS:528:DC%2BD1cXhtFyqt7rN 18781169 10.1038/sj.bjc.6604631
    • LA Lambert AR Whyteside AJ Turner BA Usmani 2008 Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion Br J Cancer 99 7 1114 1120 1:CAS:528:DC%2BD1cXhtFyqt7rN 18781169 10.1038/sj.bjc.6604631
    • (2008) Br J Cancer , vol.99 , Issue.7 , pp. 1114-1120
    • Lambert, L.A.1    Whyteside, A.R.2    Turner, A.J.3    Usmani, B.A.4
  • 17
    • 0029847636 scopus 로고    scopus 로고
    • Pulmonary clearance of circulating endothelin-1 in dogs in vivo: Exclusive role of ETB receptors
    • 1:CAS:528:DyaK28XmvF2nur4%3D 8904561
    • J Dupuis CA Goresky A Fournier 1996 Pulmonary clearance of circulating endothelin-1 in dogs in vivo: exclusive role of ETB receptors J Appl Physiol 81 4 1510 1515 1:CAS:528:DyaK28XmvF2nur4%3D 8904561
    • (1996) J Appl Physiol , vol.81 , Issue.4 , pp. 1510-1515
    • Dupuis, J.1    Goresky, C.A.2    Fournier, A.3
  • 18
    • 0029741347 scopus 로고    scopus 로고
    • Human pulmonary circulation is an important site for both clearance and production of endothelin-1
    • 1:CAS:528:DyaK28XmsFSntL8%3D 8840847
    • J Dupuis DJ Stewart P Cernacek G Gosselin 1996 Human pulmonary circulation is an important site for both clearance and production of endothelin-1 Circulation 94 7 1578 1584 1:CAS:528:DyaK28XmsFSntL8%3D 8840847
    • (1996) Circulation , vol.94 , Issue.7 , pp. 1578-1584
    • Dupuis, J.1    Stewart, D.J.2    Cernacek, P.3    Gosselin, G.4
  • 19
    • 0033160038 scopus 로고    scopus 로고
    • Endothelin receptor antagonists. Promising new agents in the management of cardiovascular disorders
    • 1:CAS:528:DyaK1MXmt1Sjtrs%3D 10560541 10.2165/00126839-199902010-00001
    • J Goddard DJ Webb 1999 Endothelin receptor antagonists. Promising new agents in the management of cardiovascular disorders Drugs R D 2 1 1 12 1:CAS:528:DyaK1MXmt1Sjtrs%3D 10560541 10.2165/00126839-199902010-00001
    • (1999) Drugs R D , vol.2 , Issue.1 , pp. 1-12
    • Goddard, J.1    Webb, D.J.2
  • 20
    • 0025605345 scopus 로고
    • Cloning and expression of a cDNA encoding an endothelin receptor
    • 1:CAS:528:DyaK3MXktVaisb0%3D 2175396 10.1038/348730a0
    • H Arai S Hori I Aramori H Ohkubo S Nakanishi 1990 Cloning and expression of a cDNA encoding an endothelin receptor Nature 348 6303 730 732 1:CAS:528:DyaK3MXktVaisb0%3D 2175396 10.1038/348730a0
    • (1990) Nature , vol.348 , Issue.6303 , pp. 730-732
    • Arai, H.1    Hori, S.2    Aramori, I.3    Ohkubo, H.4    Nakanishi, S.5
  • 21
    • 0025605930 scopus 로고
    • Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
    • 1:CAS:528:DyaK3MXktVaisbo%3D 2175397 10.1038/348732a0
    • T Sakurai M Yanagisawa Y Takuwa H Miyazaki S Kimura K Goto T Masaki 1990 Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor Nature 348 6303 732 735 1:CAS:528:DyaK3MXktVaisbo%3D 2175397 10.1038/348732a0
    • (1990) Nature , vol.348 , Issue.6303 , pp. 732-735
    • Sakurai, T.1    Yanagisawa, M.2    Takuwa, Y.3    Miyazaki, H.4    Kimura, S.5    Goto, K.6    Masaki, T.7
  • 23
    • 0027733802 scopus 로고
    • Human endothelin receptors characterized using reverse transcriptase-polymerase chain reaction, in situ hybridization, and subtype-selective ligands BQ123 and BQ3020: Evidence for expression of ETB receptors in human vascular smooth muscle
    • 1:CAS:528:DyaK2cXntVWrtg%3D%3D 7509950 10.1097/00005344-199322008-00008
    • AP Davenport G O'Reilly P Molenaar JJ Maguire RE Kuc A Sharkey CR Bacon A Ferro 1993 Human endothelin receptors characterized using reverse transcriptase-polymerase chain reaction, in situ hybridization, and subtype-selective ligands BQ123 and BQ3020: evidence for expression of ETB receptors in human vascular smooth muscle J Cardiovasc Pharmacol 22 Suppl 8 S22 S25 1:CAS:528:DyaK2cXntVWrtg%3D%3D 7509950 10.1097/00005344-199322008-00008
    • (1993) J Cardiovasc Pharmacol , vol.22 , Issue.SUPPL. 8
    • Davenport, A.P.1    O'Reilly, G.2    Molenaar, P.3    Maguire, J.J.4    Kuc, R.E.5    Sharkey, A.6    Bacon, C.R.7    Ferro, A.8
  • 24
    • 0025854756 scopus 로고
    • Presence of non-selective type of endothelin receptor on vascular endothelium and its linkage to vasodilation
    • 1:CAS:528:DyaK3MXisVWgt7o%3D 1851107 10.1016/0014-5793(91)80454-B
    • R Takayanagi K Kitazumi C Takasaki K Ohnaka S Aimoto K Tasaka M Ohashi H Nawata 1991 Presence of non-selective type of endothelin receptor on vascular endothelium and its linkage to vasodilation FEBS Lett 282 1 103 106 1:CAS:528:DyaK3MXisVWgt7o%3D 1851107 10.1016/0014-5793(91)80454-B
    • (1991) FEBS Lett , vol.282 , Issue.1 , pp. 103-106
    • Takayanagi, R.1    Kitazumi, K.2    Takasaki, C.3    Ohnaka, K.4    Aimoto, S.5    Tasaka, K.6    Ohashi, M.7    Nawata, H.8
  • 25
    • 0034619523 scopus 로고    scopus 로고
    • Endothelins and endothelin receptor antagonists: Therapeutic considerations for a novel class of cardiovascular drugs
    • 1:CAS:528:DC%2BD3cXptVSjtbg%3D 11067800
    • TF Luscher M Barton 2000 Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugs Circulation 102 19 2434 2440 1:CAS:528:DC%2BD3cXptVSjtbg%3D 11067800
    • (2000) Circulation , vol.102 , Issue.19 , pp. 2434-2440
    • Luscher, T.F.1    Barton, M.2
  • 26
    • 0025368480 scopus 로고
    • Endothelium-derived vasoactive factors and regulation of vascular tone in human blood vessels
    • 2166886 10.1007/BF02718110
    • TF Luscher 1990 Endothelium-derived vasoactive factors and regulation of vascular tone in human blood vessels Lung 168 Suppl 27 34 2166886 10.1007/BF02718110
    • (1990) Lung , vol.168 , Issue.SUPPL. , pp. 27-34
    • Luscher, T.F.1
  • 27
    • 0024363298 scopus 로고
    • Endothelin stimulates diacylglycerol accumulation and activates protein kinase C in cultured vascular smooth muscle cells
    • 1:CAS:528:DyaL1MXktlCitrg%3D 2656676
    • KK Griendling T Tsuda RW Alexander 1989 Endothelin stimulates diacylglycerol accumulation and activates protein kinase C in cultured vascular smooth muscle cells J Biol Chem 264 14 8237 8240 1:CAS:528:DyaL1MXktlCitrg%3D 2656676
    • (1989) J Biol Chem , vol.264 , Issue.14 , pp. 8237-8240
    • Griendling, K.K.1    Tsuda, T.2    Alexander, R.W.3
  • 28
    • 0025265191 scopus 로고
    • Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells
    • 1:CAS:528:DyaK3cXhsFanur0%3D 2155922 10.1172/JCI114488
    • Y Takuwa Y Kasuya N Takuwa M Kudo M Yanagisawa K Goto T Masaki K Yamashita 1990 Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells J Clin Invest 85 3 653 658 1:CAS:528:DyaK3cXhsFanur0%3D 2155922 10.1172/JCI114488
    • (1990) J Clin Invest , vol.85 , Issue.3 , pp. 653-658
    • Takuwa, Y.1    Kasuya, Y.2    Takuwa, N.3    Kudo, M.4    Yanagisawa, M.5    Goto, K.6    Masaki, T.7    Yamashita, K.8
  • 29
    • 0027395989 scopus 로고
    • Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature
    • 1:CAS:528:DyaK3sXhsVSltLs%3D 7678793 10.1210/en.132.2.524
    • S Eguchi Y Hirata T Imai F Marumo 1993 Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature Endocrinology 132 2 524 529 1:CAS:528:DyaK3sXhsVSltLs%3D 7678793 10.1210/en.132.2.524
    • (1993) Endocrinology , vol.132 , Issue.2 , pp. 524-529
    • Eguchi, S.1    Hirata, Y.2    Imai, T.3    Marumo, F.4
  • 30
    • 0027716834 scopus 로고
    • Endothelin subtype B receptors are coupled to adenylate cyclase via inhibitory G protein in cultured bovine endothelial cells
    • Eguchi S, Hirata Y, Marumo F 1993 Endothelin subtype B receptors are coupled to adenylate cyclase via inhibitory G protein in cultured bovine endothelial cells. J Cardiovasc Pharmacol 22 (Suppl) 8: S161-3
    • (1993) J Cardiovasc Pharmacol , vol.22 , Issue.8 SUPPL.
    • Eguchi, S.1    Hirata, Y.2    Marumo, F.3
  • 31
    • 11144318785 scopus 로고    scopus 로고
    • Molecular mechanisms for activation of voltage-independent Ca2 + channels by endothelin-1/endothelin-A receptors
    • 1:CAS:528:DC%2BD2MXjvVCltA%3D%3D 15838284 10.1097/01.fjc.0000166252. 66486.06
    • Y Kawanabe Y Okamoto N Hashimoto T Masaki 2004 Molecular mechanisms for activation of voltage-independent Ca2 + channels by endothelin-1/endothelin-A receptors J Cardiovasc Pharmacol 44 Suppl 1 S219 S223 1:CAS:528: DC%2BD2MXjvVCltA%3D%3D 15838284 10.1097/01.fjc.0000166252.66486.06
    • (2004) J Cardiovasc Pharmacol , vol.44 , Issue.SUPPL. 1
    • Kawanabe, Y.1    Okamoto, Y.2    Hashimoto, N.3    Masaki, T.4
  • 32
    • 0033580697 scopus 로고    scopus 로고
    • Differential involvement of Galpha12 and Galpha13 in receptor-mediated stress fiber formation
    • 1:CAS:528:DyaK1MXktVylsLg%3D 10364236 10.1074/jbc.274.25.17901
    • A Gohla S Offermanns TM Wilkie G Schultz 1999 Differential involvement of Galpha12 and Galpha13 in receptor-mediated stress fiber formation J Biol Chem 274 25 17901 17907 1:CAS:528:DyaK1MXktVylsLg%3D 10364236 10.1074/jbc.274.25. 17901
    • (1999) J Biol Chem , vol.274 , Issue.25 , pp. 17901-17907
    • Gohla, A.1    Offermanns, S.2    Wilkie, T.M.3    Schultz, G.4
  • 33
    • 0026715834 scopus 로고
    • Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells
    • 1:CAS:528:DyaK38XkvVCiur8%3D 1319997
    • I Aramori S Nakanishi 1992 Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells J Biol Chem 267 18 12468 12474 1:CAS:528:DyaK38XkvVCiur8%3D 1319997
    • (1992) J Biol Chem , vol.267 , Issue.18 , pp. 12468-12474
    • Aramori, I.1    Nakanishi, S.2
  • 34
    • 0027525889 scopus 로고
    • Subtype selectivity of a novel endothelin antagonist, FR139317, for the two endothelin receptors in transfected Chinese hamster ovary cells
    • 1:CAS:528:DyaK3sXit1Knurs%3D 8429819
    • I Aramori H Nirei M Shoubo K Sogabe K Nakamura H Kojo Y Notsu T Ono S Nakanishi 1993 Subtype selectivity of a novel endothelin antagonist, FR139317, for the two endothelin receptors in transfected Chinese hamster ovary cells Mol Pharmacol 43 2 127 131 1:CAS:528:DyaK3sXit1Knurs%3D 8429819
    • (1993) Mol Pharmacol , vol.43 , Issue.2 , pp. 127-131
    • Aramori, I.1    Nirei, H.2    Shoubo, M.3    Sogabe, K.4    Nakamura, K.5    Kojo, H.6    Notsu, Y.7    Ono, T.8    Nakanishi, S.9
  • 35
    • 0036085650 scopus 로고    scopus 로고
    • Molecular mechanisms for the activation of voltage-independent Ca2 + channels by endothelin-1 in Chinese hamster ovary cells stably expressing human endothelin(A) receptors
    • 1:CAS:528:DC%2BD38Xlt1Kqtb8%3D 12065757 10.1124/mol.62.1.75
    • Y Kawanabe Y Okamoto S Miwa N Hashimoto T Masaki 2002 Molecular mechanisms for the activation of voltage-independent Ca2 + channels by endothelin-1 in Chinese hamster ovary cells stably expressing human endothelin(A) receptors Mol Pharmacol 62 1 75 80 1:CAS:528:DC%2BD38Xlt1Kqtb8%3D 12065757 10.1124/mol.62.1.75
    • (2002) Mol Pharmacol , vol.62 , Issue.1 , pp. 75-80
    • Kawanabe, Y.1    Okamoto, Y.2    Miwa, S.3    Hashimoto, N.4    Masaki, T.5
  • 36
    • 0032980752 scopus 로고    scopus 로고
    • Subcellular mechanisms of endothelin action in vascular system
    • 1:CAS:528:DyaK1MXks1CrsrY%3D 10443571 10.1016/S0014-2999(99)00252-6
    • T Masaki S Miwa T Sawamura H Ninomiya Y Okamoto 1999 Subcellular mechanisms of endothelin action in vascular system Eur J Pharmacol 375 1-3 133 138 1:CAS:528:DyaK1MXks1CrsrY%3D 10443571 10.1016/S0014-2999(99)00252-6
    • (1999) Eur J Pharmacol , vol.375 , Issue.13 , pp. 133-138
    • Masaki, T.1    Miwa, S.2    Sawamura, T.3    Ninomiya, H.4    Okamoto, Y.5
  • 37
    • 0028809230 scopus 로고
    • Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors
    • 1:CAS:528:DyaK2MXjvFKksLg%3D 7882989 10.1111/j.1432-1033.1995.tb20236.x
    • M Takigawa T Sakurai Y Kasuya Y Abe T Masaki K Goto 1995 Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors Eur J Biochem 228 1 102 108 1:CAS:528:DyaK2MXjvFKksLg%3D 7882989 10.1111/j.1432-1033.1995.tb20236.x
    • (1995) Eur J Biochem , vol.228 , Issue.1 , pp. 102-108
    • Takigawa, M.1    Sakurai, T.2    Kasuya, Y.3    Abe, Y.4    Masaki, T.5    Goto, K.6
  • 38
    • 0036156350 scopus 로고    scopus 로고
    • Molecular mechanism for endothelin-1-induced stress-fiber formation: Analysis of G proteins using a mutant endothelin(A) receptor
    • 1:CAS:528:DC%2BD38Xos1Oiuw%3D%3D 11809851 10.1124/mol.61.2.277
    • Y Kawanabe Y Okamoto K Nozaki N Hashimoto S Miwa T Masaki 2002 Molecular mechanism for endothelin-1-induced stress-fiber formation: analysis of G proteins using a mutant endothelin(A) receptor Mol Pharmacol 61 2 277 284 1:CAS:528:DC%2BD38Xos1Oiuw%3D%3D 11809851 10.1124/mol.61.2.277
    • (2002) Mol Pharmacol , vol.61 , Issue.2 , pp. 277-284
    • Kawanabe, Y.1    Okamoto, Y.2    Nozaki, K.3    Hashimoto, N.4    Miwa, S.5    Masaki, T.6
  • 40
    • 0028845687 scopus 로고
    • Cytokine regulation of endothelin-1 release from bovine aortic endothelial cells
    • 1:CAS:528:DyaK2MXps1Kiurs%3D 8587467
    • R Corder M Carrier N Khan P Klemm JR Vane 1995 Cytokine regulation of endothelin-1 release from bovine aortic endothelial cells J Cardiovasc Pharmacol 26 Suppl 3 S56 S58 1:CAS:528:DyaK2MXps1Kiurs%3D 8587467
    • (1995) J Cardiovasc Pharmacol , vol.26 , Issue.SUPPL. 3
    • Corder, R.1    Carrier, M.2    Khan, N.3    Klemm, P.4    Vane, J.R.5
  • 41
    • 0028788150 scopus 로고
    • Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: Relation to hemodynamic variables and endothelin levels
    • 1:CAS:528:DyaK28XlvFCquw%3D%3D 7594089 10.1016/0735-1097(95)00399-1
    • M Nootens E Kaufmann T Rector C Toher D Judd GS Francis S Rich 1995 Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: relation to hemodynamic variables and endothelin levels J Am Coll Cardiol 26 7 1581 1585 1:CAS:528:DyaK28XlvFCquw%3D%3D 7594089 10.1016/0735-1097(95)00399-1
    • (1995) J Am Coll Cardiol , vol.26 , Issue.7 , pp. 1581-1585
    • Nootens, M.1    Kaufmann, E.2    Rector, T.3    Toher, C.4    Judd, D.5    Francis, G.S.6    Rich, S.7
  • 42
    • 0026034713 scopus 로고
    • Increased plasma endothelin-1 in pulmonary hypertension: Marker or mediator of disease?
    • 1:STN:280:DyaK3M7js1SmsA%3D%3D 1994793
    • DJ Stewart RD Levy P Cernacek D Langleben 1991 Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann Intern Med 114 6 464 469 1:STN:280:DyaK3M7js1SmsA%3D%3D 1994793
    • (1991) Ann Intern Med , vol.114 , Issue.6 , pp. 464-469
    • Stewart, D.J.1    Levy, R.D.2    Cernacek, P.3    Langleben, D.4
  • 43
    • 0037022927 scopus 로고    scopus 로고
    • Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension
    • 1:CAS:528:DC%2BD38XislWit7w%3D 11877350 10.1161/hc0902.105719
    • M Bauer H Wilkens F Langer SO Schneider H Lausberg HJ Schafers 2002 Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension Circulation 105 9 1034 1036 1:CAS:528: DC%2BD38XislWit7w%3D 11877350 10.1161/hc0902.105719
    • (2002) Circulation , vol.105 , Issue.9 , pp. 1034-1036
    • Bauer, M.1    Wilkens, H.2    Langer, F.3    Schneider, S.O.4    Lausberg, H.5    Schafers, H.J.6
  • 44
    • 0034895433 scopus 로고    scopus 로고
    • Discrepant distribution of big endothelin (ET)-1 and et receptors in the pulmonary artery
    • 1:CAS:528:DC%2BD3MXmtlGhu7s%3D 11510805 10.1183/09031936.01.00075501
    • H Takahashi S Soma M Muramatsu M Oka H Ienaga Y Fukuchi 2001 Discrepant distribution of big endothelin (ET)-1 and ET receptors in the pulmonary artery Eur Respir J 18 1 5 14 1:CAS:528:DC%2BD3MXmtlGhu7s%3D 11510805 10.1183/09031936.01.00075501
    • (2001) Eur Respir J , vol.18 , Issue.1 , pp. 5-14
    • Takahashi, H.1    Soma, S.2    Muramatsu, M.3    Oka, M.4    Ienaga, H.5    Fukuchi, Y.6
  • 45
    • 0035818316 scopus 로고    scopus 로고
    • Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: A randomised placebo-controlled study
    • 1:CAS:528:DC%2BD3MXntlOrurs%3D 11597664 10.1016/S0140-6736(01)06250-X
    • RN Channick G Simonneau O Sitbon IM Robbins A Frost VF Tapson DB Badesch S Roux M Rainisio F Bodin LJ Rubin 2001 Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study Lancet 358 9288 1119 1123 1:CAS:528: DC%2BD3MXntlOrurs%3D 11597664 10.1016/S0140-6736(01)06250-X
    • (2001) Lancet , vol.358 , Issue.9288 , pp. 1119-1123
    • Channick, R.N.1    Simonneau, G.2    Sitbon, O.3    Robbins, I.M.4    Frost, A.5    Tapson, V.F.6    Badesch, D.B.7    Roux, S.8    Rainisio, M.9    Bodin, F.10    Rubin, L.J.11
  • 48
    • 0026544193 scopus 로고
    • Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure
    • 1:STN:280:DyaK387js1Giuw%3D%3D 1735147
    • RJ Cody GJ Haas PF Binkley Q Capers R Kelley 1992 Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure Circulation 85 2 504 509 1:STN:280:DyaK387js1Giuw%3D%3D 1735147
    • (1992) Circulation , vol.85 , Issue.2 , pp. 504-509
    • Cody, R.J.1    Haas, G.J.2    Binkley, P.F.3    Capers, Q.4    Kelley, R.5
  • 49
    • 0029880929 scopus 로고    scopus 로고
    • Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure
    • 1:STN:280:DyaK283gsVyitw%3D%3D 8606275 10.1016/0735-1097(95)00520-X
    • R Pacher B Stanek M Hulsmann J Koller-Strametz R Berger M Schuller E Hartter E Ogris B Frey G Heinz G Maurer 1996 Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure J Am Coll Cardiol 27 3 633 641 1:STN:280: DyaK283gsVyitw%3D%3D 8606275 10.1016/0735-1097(95)00520-X
    • (1996) J Am Coll Cardiol , vol.27 , Issue.3 , pp. 633-641
    • Pacher, R.1    Stanek, B.2    Hulsmann, M.3    Koller-Strametz, J.4    Berger, R.5    Schuller, M.6    Hartter, E.7    Ogris, E.8    Frey, B.9    Heinz, G.10    Maurer, G.11
  • 50
    • 3042835995 scopus 로고    scopus 로고
    • Value of cardiopulmonary exercise testing and big endothelin plasma levels to predict short-term prognosis of patients with chronic heart failure
    • 1:STN:280:DyaK1M%2FjslyqsA%3D%3D 9822098 10.1016/S0735-1097(98)00437-9
    • M Hulsmann B Stanek B Frey B Sturm D Putz T Kos R Berger W Woloszczuk D Putz T Kos R Berger W Woloszczuk G Maurer R Pacher 1998 Value of cardiopulmonary exercise testing and big endothelin plasma levels to predict short-term prognosis of patients with chronic heart failure J Am Coll Cardiol 32 6 1695 1700 1:STN:280:DyaK1M%2FjslyqsA%3D%3D 9822098 10.1016/S0735-1097(98)00437-9
    • (1998) J Am Coll Cardiol , vol.32 , Issue.6 , pp. 1695-1700
    • Hulsmann, M.1    Stanek, B.2    Frey, B.3    Sturm, B.4    Putz, D.5    Kos, T.6    Berger, R.7    Woloszczuk, W.8    Putz, D.9    Kos, T.10    Berger, R.11    Woloszczuk, W.12    Maurer, G.13    Pacher, R.14
  • 52
    • 0033609028 scopus 로고    scopus 로고
    • Expression of endothelin-1, endothelin-converting enzyme, and endothelin receptors in chronic heart failure
    • 1:CAS:528:DyaK1MXjtVOhur0%3D 10217651
    • O Zolk J Quattek G Sitzler T Schrader G Nickenig P Schnabel K Shimada M Takahashi M Bohm 1999 Expression of endothelin-1, endothelin-converting enzyme, and endothelin receptors in chronic heart failure Circulation 99 16 2118 2123 1:CAS:528:DyaK1MXjtVOhur0%3D 10217651
    • (1999) Circulation , vol.99 , Issue.16 , pp. 2118-2123
    • Zolk, O.1    Quattek, J.2    Sitzler, G.3    Schrader, T.4    Nickenig, G.5    Schnabel, P.6    Shimada, K.7    Takahashi, M.8    Bohm, M.9
  • 53
    • 0032543936 scopus 로고    scopus 로고
    • Short-term haemodynamic effects of BQ-123, a selective endothelin ET(A)-receptor antagonist, in chronic heart failure
    • 1:CAS:528:DyaK1cXlt1altbY%3D 9683214 10.1016/S0140-6736(05)77807-7
    • PJ Cowburn JG Cleland JD McArthur MR MacLean JJ McMurray HJ Dargie 1998 Short-term haemodynamic effects of BQ-123, a selective endothelin ET(A)-receptor antagonist, in chronic heart failure Lancet 352 9123 201 202 1:CAS:528:DyaK1cXlt1altbY%3D 9683214 10.1016/S0140-6736(05)77807-7
    • (1998) Lancet , vol.352 , Issue.9123 , pp. 201-202
    • Cowburn, P.J.1    Cleland, J.G.2    McArthur, J.D.3    MacLean, M.R.4    McMurray, J.J.5    Dargie, H.J.6
  • 54
    • 0029087262 scopus 로고
    • Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure
    • 1:STN:280:DyaK2Mzoslyhug%3D%3D 7658874 10.1016/S0140-6736(95)91504-4
    • W Kiowski G Sutsch P Hunziker P Muller J Kim E Oechslin R Schmitt R Jones O Bertel 1995 Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure Lancet 346 8977 732 736 1:STN:280:DyaK2Mzoslyhug%3D%3D 7658874 10.1016/S0140-6736(95)91504-4
    • (1995) Lancet , vol.346 , Issue.8977 , pp. 732-736
    • Kiowski, W.1    Sutsch, G.2    Hunziker, P.3    Muller, P.4    Kim, J.5    Oechslin, E.6    Schmitt, R.7    Jones, R.8    Bertel, O.9
  • 55
    • 0034075608 scopus 로고    scopus 로고
    • Acute hemodynamic and neurohumoral effects of selective ET(A) receptor blockade in patients with congestive heart failure. et 003 Investigators
    • 1:CAS:528:DC%2BD3cXktlGlt7c%3D 10841220 10.1016/S0735-1097(00)00649-5
    • LE Spieker V Mitrovic G Noll R Pacher MR Schulze J Muntwyler C Schalcher W Kiowski TF Luscher 2000 Acute hemodynamic and neurohumoral effects of selective ET(A) receptor blockade in patients with congestive heart failure. ET 003 Investigators J Am Coll Cardiol 35 7 1745 1752 1:CAS:528: DC%2BD3cXktlGlt7c%3D 10841220 10.1016/S0735-1097(00)00649-5
    • (2000) J Am Coll Cardiol , vol.35 , Issue.7 , pp. 1745-1752
    • Spieker, L.E.1    Mitrovic, V.2    Noll, G.3    Pacher, R.4    Schulze, M.R.5    Muntwyler, J.6    Schalcher, C.7    Kiowski, W.8    Luscher, T.F.9
  • 56
    • 0037868058 scopus 로고    scopus 로고
    • Hemodynamic and clinical effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients hospitalized for acute decompensated heart failure
    • 1:CAS:528:DC%2BD3sXmtVOisrk%3D 12849674 10.1016/S0735-1097(03)00556-4
    • G Torre-Amione JB Young WS Colucci BS Lewis C Pratt G Cotter K Stangl U Elkayam JR Teerlink A Frey M Rainisio I Kobrin 2003 Hemodynamic and clinical effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients hospitalized for acute decompensated heart failure J Am Coll Cardiol 42 1 140 147 1:CAS:528:DC%2BD3sXmtVOisrk%3D 12849674 10.1016/S0735-1097(03)00556-4
    • (2003) J Am Coll Cardiol , vol.42 , Issue.1 , pp. 140-147
    • Torre-Amione, G.1    Young, J.B.2    Colucci, W.S.3    Lewis, B.S.4    Pratt, C.5    Cotter, G.6    Stangl, K.7    Elkayam, U.8    Teerlink, J.R.9    Frey, A.10    Rainisio, M.11    Kobrin, I.12
  • 57
    • 0034893420 scopus 로고    scopus 로고
    • Tezosentan (an intravenous endothelin receptor A/B antagonist) reduces peripheral resistance and increases cardiac power therefore preventing a steep decrease in blood pressure in patients with congestive heart failure
    • 1:CAS:528:DC%2BD3MXntVSgt7k%3D 11511432 10.1016/S1388-9842(01)00168-4
    • G Cotter W Kiowski E Kaluski I Kobrin O Milovanov A Marmor J Jafari L Reisin R Krakover Z Vered A Caspi 2001 Tezosentan (an intravenous endothelin receptor A/B antagonist) reduces peripheral resistance and increases cardiac power therefore preventing a steep decrease in blood pressure in patients with congestive heart failure Eur J Heart Fail 3 4 457 461 1:CAS:528: DC%2BD3MXntVSgt7k%3D 11511432 10.1016/S1388-9842(01)00168-4
    • (2001) Eur J Heart Fail , vol.3 , Issue.4 , pp. 457-461
    • Cotter, G.1    Kiowski, W.2    Kaluski, E.3    Kobrin, I.4    Milovanov, O.5    Marmor, A.6    Jafari, J.7    Reisin, L.8    Krakover, R.9    Vered, Z.10    Caspi, A.11
  • 58
    • 0037438919 scopus 로고    scopus 로고
    • RITZ-5: Randomized intravenous TeZosentan (an endothelin-A/B antagonist) for the treatment of pulmonary edema: A prospective, multicenter, double-blind, placebo-controlled study
    • 1:CAS:528:DC%2BD3sXht1Srs78%3D 12535809 10.1016/S0735-1097(02)02708-0
    • E Kaluski I Kobrin R Zimlichman A Marmor O Krakov O Milo A Frey S Kaplan R Krakover A Caspi Z Vered G Cotter 2003 RITZ-5: randomized intravenous TeZosentan (an endothelin-A/B antagonist) for the treatment of pulmonary edema: a prospective, multicenter, double-blind, placebo-controlled study J Am Coll Cardiol 41 2 204 210 1:CAS:528:DC%2BD3sXht1Srs78%3D 12535809 10.1016/S0735-1097(02)02708-0
    • (2003) J Am Coll Cardiol , vol.41 , Issue.2 , pp. 204-210
    • Kaluski, E.1    Kobrin, I.2    Zimlichman, R.3    Marmor, A.4    Krakov, O.5    Milo, O.6    Frey, A.7    Kaplan, S.8    Krakover, R.9    Caspi, A.10    Vered, Z.11    Cotter, G.12
  • 59
    • 0038414660 scopus 로고    scopus 로고
    • Tezosentan in patients with acute heart failure and acute coronary syndromes: Results of the Randomized Intravenous TeZosentan Study (RITZ-4)
    • 12742280 10.1016/S0735-1097(03)00194-3 1:CAS:528:DC%2BD3sXksVWju7g%3D
    • CM O'Connor WA Gattis KF Adams Jr V Hasselblad B Chandler A Frey I Kobrin M Rainisio MR Shah J Teerlink M Gheorghiade 2003 Tezosentan in patients with acute heart failure and acute coronary syndromes: results of the Randomized Intravenous TeZosentan Study (RITZ-4) J Am Coll Cardiol 41 9 1452 1457 12742280 10.1016/S0735-1097(03)00194-3 1:CAS:528:DC%2BD3sXksVWju7g%3D
    • (2003) J Am Coll Cardiol , vol.41 , Issue.9 , pp. 1452-1457
    • O'Connor, C.M.1    Gattis, W.A.2    Adams Jr., K.F.3    Hasselblad, V.4    Chandler, B.5    Frey, A.6    Kobrin, I.7    Rainisio, M.8    Shah, M.R.9    Teerlink, J.10    Gheorghiade, M.11
  • 60
    • 0036791081 scopus 로고    scopus 로고
    • Tezosentan in patients with acute heart failure and acute coronary syndromes: Design of the Randomized Intravenous Tezosentan study (RITZ-4)
    • 12360152
    • CM O'Connor WA Gattis KF Adams Jr MR Shah I Kobrin A Frey M Gheorghiade 2002 Tezosentan in patients with acute heart failure and acute coronary syndromes: design of the Randomized Intravenous Tezosentan study (RITZ-4) Am Heart J 144 4 583 588 12360152
    • (2002) Am Heart J , vol.144 , Issue.4 , pp. 583-588
    • O'Connor, C.M.1    Gattis, W.A.2    Adams Jr., K.F.3    Shah, M.R.4    Kobrin, I.5    Frey, A.6    Gheorghiade, M.7
  • 61
    • 0034895218 scopus 로고    scopus 로고
    • The dual endothelin receptor antagonist tezosentan acutely improves hemodynamic parameters in patients with advanced heart failure
    • 1:CAS:528:DC%2BD3MXmsV2lu7o%3D 11479476 10.1067/mhj.2001.116760
    • C Schalcher G Cotter L Reisin O Bertel I Kobrin TT Guyene W Kiowski 2001 The dual endothelin receptor antagonist tezosentan acutely improves hemodynamic parameters in patients with advanced heart failure Am Heart J 142 2 340 349 1:CAS:528:DC%2BD3MXmsV2lu7o%3D 11479476 10.1067/mhj.2001.116760
    • (2001) Am Heart J , vol.142 , Issue.2 , pp. 340-349
    • Schalcher, C.1    Cotter, G.2    Reisin, L.3    Bertel, O.4    Kobrin, I.5    Guyene, T.T.6    Kiowski, W.7
  • 62
    • 0034825957 scopus 로고    scopus 로고
    • A pilot safety trial of prolonged (48 h) infusion of the dual endothelin-receptor antagonist tezosentan in patients with advanced heart failure
    • 1:CAS:528:DC%2BD3MXmsF2rtb8%3D 11502644 10.1378/chest.120.2.460
    • G Torre-Amione JB Durand S Nagueh MT Vooletich I Kobrin C Pratt 2001 A pilot safety trial of prolonged (48 h) infusion of the dual endothelin-receptor antagonist tezosentan in patients with advanced heart failure Chest 120 2 460 466 1:CAS:528:DC%2BD3MXmsF2rtb8%3D 11502644 10.1378/chest.120.2.460
    • (2001) Chest , vol.120 , Issue.2 , pp. 460-466
    • Torre-Amione, G.1    Durand, J.B.2    Nagueh, S.3    Vooletich, M.T.4    Kobrin, I.5    Pratt, C.6
  • 63
    • 0035916270 scopus 로고    scopus 로고
    • Hemodynamic effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with class III to IV congestive heart failure
    • 1:CAS:528:DC%2BD3MXit1Cqsr0%3D 11181472
    • G Torre-Amione JB Young J Durand B Bozkurt DL Mann I Kobrin CM Pratt 2001 Hemodynamic effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with class III to IV congestive heart failure Circulation 103 7 973 980 1:CAS:528:DC%2BD3MXit1Cqsr0%3D 11181472
    • (2001) Circulation , vol.103 , Issue.7 , pp. 973-980
    • Torre-Amione, G.1    Young, J.B.2    Durand, J.3    Bozkurt, B.4    Mann, D.L.5    Kobrin, I.6    Pratt, C.M.7
  • 64
    • 0036774973 scopus 로고    scopus 로고
    • Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?
    • 12208583 10.1016/S0167-5273(02)00182-1
    • PR Kalra JC Moon AJ Coats 2002 Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure? Int J Cardiol 85 2-3 195 197 12208583 10.1016/S0167-5273(02)00182-1
    • (2002) Int J Cardiol , vol.85 , Issue.23 , pp. 195-197
    • Kalra, P.R.1    Moon, J.C.2    Coats, A.J.3
  • 65
    • 0033510665 scopus 로고    scopus 로고
    • Update of REACH-1 and MERIT-HF clinical trials in heart failure Cardio.net Editorial Team
    • 1:STN:280:DC%2BD3cvgtlKjsw%3D%3D 10937931 10.1016/S1388-9842(99)00022-7
    • P Mylona JG Cleland 1999 Update of REACH-1 and MERIT-HF clinical trials in heart failure Cardio.net Editorial Team Eur J Heart Fail 1 2 197 200 1:STN:280:DC%2BD3cvgtlKjsw%3D%3D 10937931 10.1016/S1388-9842(99)00022-7
    • (1999) Eur J Heart Fail , vol.1 , Issue.2 , pp. 197-200
    • Mylona, P.1    Cleland, J.G.2
  • 66
    • 0034780445 scopus 로고    scopus 로고
    • Blockade of endothelin receptors reduces diet-induced hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice
    • 1:CAS:528:DC%2BD3MXns1ait7w%3D 11641611 10.1159/000048751
    • S Iwasa J Fan T Miyauchi T Watanabe 2001 Blockade of endothelin receptors reduces diet-induced hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice Pathobiology 69 1 1 10 1:CAS:528:DC%2BD3MXns1ait7w%3D 11641611 10.1159/000048751
    • (2001) Pathobiology , vol.69 , Issue.1 , pp. 1-10
    • Iwasa, S.1    Fan, J.2    Miyauchi, T.3    Watanabe, T.4
  • 68
    • 0031590298 scopus 로고    scopus 로고
    • Angiotensin II increases vascular and renal endothelin-1 and functional endothelin converting enzyme activity in vivo: Role of ETA receptors for endothelin regulation
    • 1:CAS:528:DyaK2sXmsFCnsL8%3D 9325182 10.1006/bbrc.1997.7394
    • M Barton S Shaw LV d'Uscio P Moreau TF Luscher 1997 Angiotensin II increases vascular and renal endothelin-1 and functional endothelin converting enzyme activity in vivo: role of ETA receptors for endothelin regulation Biochem Biophys Res Commun 238 3 861 865 1:CAS:528:DyaK2sXmsFCnsL8%3D 9325182 10.1006/bbrc.1997.7394
    • (1997) Biochem Biophys Res Commun , vol.238 , Issue.3 , pp. 861-865
    • Barton, M.1    Shaw, S.2    D'Uscio, L.V.3    Moreau, P.4    Luscher, T.F.5
  • 69
    • 0034993096 scopus 로고    scopus 로고
    • Role of endothelin-1 in hypertension and vascular disease
    • Schiffrin EL (2001) Role of endothelin-1 in hypertension and vascular disease. Am J Hypertens 14(6 Pt 2):83S-89S
    • (2001) Am J Hypertens , vol.14 , Issue.6 PART 2
    • Schiffrin, E.L.1
  • 70
    • 50249165289 scopus 로고    scopus 로고
    • Reversal of proteinuric renal disease and the emerging role of endothelin
    • 1:CAS:528:DC%2BD1cXhtVamtr3E 18648345 10.1038/ncpneph0891
    • M Barton 2008 Reversal of proteinuric renal disease and the emerging role of endothelin Nat Clin Pract Nephrol 4 9 490 501 1:CAS:528:DC%2BD1cXhtVamtr3E 18648345 10.1038/ncpneph0891
    • (2008) Nat Clin Pract Nephrol , vol.4 , Issue.9 , pp. 490-501
    • Barton, M.1
  • 71
    • 0033535945 scopus 로고    scopus 로고
    • Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice
    • 1:CAS:528:DyaK1MXks1Wkt78%3D 10359814 10.1073/pnas.96.12.6920
    • G Caligiuri B Levy J Pernow P Thoren GK Hansson 1999 Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice Proc Natl Acad Sci USA 96 12 6920 6924 1:CAS:528:DyaK1MXks1Wkt78%3D 10359814 10.1073/pnas.96.12.6920
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.12 , pp. 6920-6924
    • Caligiuri, G.1    Levy, B.2    Pernow, J.3    Thoren, P.4    Hansson, G.K.5
  • 72
    • 0034137623 scopus 로고    scopus 로고
    • Endothelial dysfunction and atherosclerosis: Endothelin receptor antagonists as novel therapeutics
    • 1:STN:280:DC%2BD3M%2FhsFagtw%3D%3D 10981133 10.1007/s11906-000-0064-5
    • M Barton 2000 Endothelial dysfunction and atherosclerosis: endothelin receptor antagonists as novel therapeutics Curr Hypertens Rep 2 1 84 91 1:STN:280:DC%2BD3M%2FhsFagtw%3D%3D 10981133 10.1007/s11906-000-0064-5
    • (2000) Curr Hypertens Rep , vol.2 , Issue.1 , pp. 84-91
    • Barton, M.1
  • 73
    • 0033584711 scopus 로고    scopus 로고
    • Vasoconstriction to endogenous endothelin-1 is increased in the peripheral circulation of patients with essential hypertension
    • 1:CAS:528:DyaK1MXntlSqsbg%3D 10525485
    • S Taddei A Virdis L Ghiadoni I Sudano M Notari A Salvetti 1999 Vasoconstriction to endogenous endothelin-1 is increased in the peripheral circulation of patients with essential hypertension Circulation 100 16 1680 1683 1:CAS:528:DyaK1MXntlSqsbg%3D 10525485
    • (1999) Circulation , vol.100 , Issue.16 , pp. 1680-1683
    • Taddei, S.1    Virdis, A.2    Ghiadoni, L.3    Sudano, I.4    Notari, M.5    Salvetti, A.6
  • 74
    • 0036004052 scopus 로고    scopus 로고
    • Role of endothelin in cardiovascular disease
    • 1:CAS:528:DC%2BD38Xjs1Knu7c%3D 10.3317/jraas.2002.001
    • AV Agapitov WG Haynes 2002 Role of endothelin in cardiovascular disease J Renin Angiotensin Aldosterone Sys 3 1 1 15 1:CAS:528:DC%2BD38Xjs1Knu7c%3D 10.3317/jraas.2002.001
    • (2002) J Renin Angiotensin Aldosterone Sys , vol.3 , Issue.1 , pp. 1-15
    • Agapitov, A.V.1    Haynes, W.G.2
  • 75
    • 0030776737 scopus 로고    scopus 로고
    • Angiotensin II increases tissue endothelin and induces vascular hypertrophy: Reversal by ET(A)-receptor antagonist
    • 1:CAS:528:DyaK2sXmtFeisLs%3D 9315552
    • P Moreau LV d'Uscio S Shaw H Takase M Barton TF Luscher 1997 Angiotensin II increases tissue endothelin and induces vascular hypertrophy: reversal by ET(A)-receptor antagonist Circulation 96 5 1593 1597 1:CAS:528: DyaK2sXmtFeisLs%3D 9315552
    • (1997) Circulation , vol.96 , Issue.5 , pp. 1593-1597
    • Moreau, P.1    D'Uscio, L.V.2    Shaw, S.3    Takase, H.4    Barton, M.5    Luscher, T.F.6
  • 77
    • 0032898757 scopus 로고    scopus 로고
    • Systemic blockade of the endothelin-B receptor increases peripheral vascular resistance in healthy men
    • Strachan FE, Spratt JC, Wilkinson IB, Johnston NR, Gray GA, Webb DJ (1999) Systemic blockade of the endothelin-B receptor increases peripheral vascular resistance in healthy men. Hypertension 33(1 Pt 2):581-585
    • (1999) Hypertension , vol.33 , Issue.1 PART 2 , pp. 581-585
    • Strachan, F.E.1    Spratt, J.C.2    Wilkinson, I.B.3    Johnston, N.R.4    Gray, G.A.5    Webb, D.J.6
  • 78
    • 0029886596 scopus 로고    scopus 로고
    • Systemic endothelin receptor blockade decreases peripheral vascular resistance and blood pressure in humans
    • 1:CAS:528:DyaK28Xjs1Sku70%3D 8635265
    • WG Haynes CJ Ferro KP O'Kane D Somerville CC Lomax DJ Webb 1996 Systemic endothelin receptor blockade decreases peripheral vascular resistance and blood pressure in humans Circulation 93 10 1860 1870 1:CAS:528:DyaK28Xjs1Sku70%3D 8635265
    • (1996) Circulation , vol.93 , Issue.10 , pp. 1860-1870
    • Haynes, W.G.1    Ferro, C.J.2    O'Kane, K.P.3    Somerville, D.4    Lomax, C.C.5    Webb, D.J.6
  • 79
    • 0027983753 scopus 로고
    • Contribution of endogenous generation of endothelin-1 to basal vascular tone
    • 1:STN:280:DyaK2czns1Gnsg%3D%3D 7916401 10.1016/S0140-6736(94)92827-4
    • WG Haynes DJ Webb 1994 Contribution of endogenous generation of endothelin-1 to basal vascular tone Lancet 344 8926 852 854 1:STN:280: DyaK2czns1Gnsg%3D%3D 7916401 10.1016/S0140-6736(94)92827-4
    • (1994) Lancet , vol.344 , Issue.8926 , pp. 852-854
    • Haynes, W.G.1    Webb, D.J.2
  • 80
    • 0032546259 scopus 로고    scopus 로고
    • The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan hypertension Investigators
    • 1:CAS:528:DyaK1cXitlChtbs%3D 9504938 10.1056/NEJM199803193381202
    • H Krum RJ Viskoper Y Lacourciere M Budde V Charlon 1998 The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan hypertension Investigators N Engl J Med 338 12 784 790 1:CAS:528:DyaK1cXitlChtbs%3D 9504938 10.1056/NEJM199803193381202
    • (1998) N Engl J Med , vol.338 , Issue.12 , pp. 784-790
    • Krum, H.1    Viskoper, R.J.2    Lacourciere, Y.3    Budde, M.4    Charlon, V.5
  • 81
    • 1542514709 scopus 로고    scopus 로고
    • Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: A comparison of selective and combined endothelin receptor blockade
    • 1:CAS:528:DC%2BD2cXhs12kt7w%3D 14981006 10.1161/01.CIR.0000118499.69469. 51
    • J Goddard NR Johnston MF Hand AD Cumming TJ Rabelink AJ Rankin DJ Webb 2004 Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade Circulation 109 9 1186 1193 1:CAS:528:DC%2BD2cXhs12kt7w%3D 14981006 10.1161/01.CIR.0000118499.69469.51
    • (2004) Circulation , vol.109 , Issue.9 , pp. 1186-1193
    • Goddard, J.1    Johnston, N.R.2    Hand, M.F.3    Cumming, A.D.4    Rabelink, T.J.5    Rankin, A.J.6    Webb, D.J.7
  • 82
    • 16644384951 scopus 로고    scopus 로고
    • Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism
    • 1:CAS:528:DC%2BD2cXnslOnu70%3D 15466264 10.1097/01.ASN.0000141313.84470. 4B
    • J Goddard C Eckhart NR Johnston AD Cumming AJ Rankin DJ Webb 2004 Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism J Am Soc Nephrol 15 10 2601 2610 1:CAS:528:DC%2BD2cXnslOnu70%3D 15466264 10.1097/01.ASN.0000141313.84470.4B
    • (2004) J Am Soc Nephrol , vol.15 , Issue.10 , pp. 2601-2610
    • Goddard, J.1    Eckhart, C.2    Johnston, N.R.3    Cumming, A.D.4    Rankin, A.J.5    Webb, D.J.6
  • 83
    • 33645472590 scopus 로고    scopus 로고
    • The endothelin system and its antagonism in chronic kidney disease
    • 1:CAS:528:DC%2BD28XjvFSqsLc%3D 16540557 10.1681/ASN.2005121256
    • N Dhaun J Goddard DJ Webb 2006 The endothelin system and its antagonism in chronic kidney disease J Am Soc Nephrol 17 4 943 955 1:CAS:528: DC%2BD28XjvFSqsLc%3D 16540557 10.1681/ASN.2005121256
    • (2006) J Am Soc Nephrol , vol.17 , Issue.4 , pp. 943-955
    • Dhaun, N.1    Goddard, J.2    Webb, D.J.3
  • 84
    • 67649859521 scopus 로고    scopus 로고
    • Blood pressure-independent reduction in proteinuria and arterial stiffness after acute endothelin-a receptor antagonism in chronic kidney disease
    • 1:CAS:528:DC%2BD1MXntVyrtL0%3D 19506099 10.1161/HYPERTENSIONAHA.109. 132670
    • N Dhaun IM Macintyre V Melville P Lilitkarntakul NR Johnston J Goddard DJ Webb 2009 Blood pressure-independent reduction in proteinuria and arterial stiffness after acute endothelin-a receptor antagonism in chronic kidney disease Hypertension 54 1 113 119 1:CAS:528:DC%2BD1MXntVyrtL0%3D 19506099 10.1161/HYPERTENSIONAHA.109.132670
    • (2009) Hypertension , vol.54 , Issue.1 , pp. 113-119
    • Dhaun, N.1    MacIntyre, I.M.2    Melville, V.3    Lilitkarntakul, P.4    Johnston, N.R.5    Goddard, J.6    Webb, D.J.7
  • 85
    • 68849110980 scopus 로고    scopus 로고
    • Endothelin receptor antagonism and cancer
    • 1:CAS:528:DC%2BD1MXmvVyiurY%3D 19335749 10.1111/j.1365-2362.2009.02123.x
    • A Bhalla S Haque I Taylor M Winslet M Loizidou 2009 Endothelin receptor antagonism and cancer Eur J Clin Invest 39 Suppl 2 74 77 1:CAS:528: DC%2BD1MXmvVyiurY%3D 19335749 10.1111/j.1365-2362.2009.02123.x
    • (2009) Eur J Clin Invest , vol.39 , Issue.SUPPL. 2 , pp. 74-77
    • Bhalla, A.1    Haque, S.2    Taylor, I.3    Winslet, M.4    Loizidou, M.5
  • 86
    • 0032213023 scopus 로고    scopus 로고
    • Endothelins as autocrine regulators of tumor cell growth
    • 1:CAS:528:DyaK1cXnsVKnsbw%3D 18406309 10.1016/S1043-2760(98)00094-0
    • A Bagnato KJ Catt 1998 Endothelins as autocrine regulators of tumor cell growth Trends Endocrinol Metab 9 9 378 383 1:CAS:528:DyaK1cXnsVKnsbw%3D 18406309 10.1016/S1043-2760(98)00094-0
    • (1998) Trends Endocrinol Metab , vol.9 , Issue.9 , pp. 378-383
    • Bagnato, A.1    Catt, K.J.2
  • 87
    • 0033083191 scopus 로고    scopus 로고
    • Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: Evidence for an autocrine role in tumor growth
    • 1:CAS:528:DyaK1MXhtFSisbo%3D 9973223
    • A Bagnato D Salani V Di Castro JR Wu-Wong R Tecce MR Nicotra A Venuti PG Natali 1999 Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth Cancer Res 59 3 720 727 1:CAS:528:DyaK1MXhtFSisbo%3D 9973223
    • (1999) Cancer Res , vol.59 , Issue.3 , pp. 720-727
    • Bagnato, A.1    Salani, D.2    Di Castro, V.3    Wu-Wong, J.R.4    Tecce, R.5    Nicotra, M.R.6    Venuti, A.7    Natali, P.G.8
  • 88
    • 0028982331 scopus 로고
    • Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells
    • 1:CAS:528:DyaK2MXoslSmtL4%3D 9816080
    • A Bagnato R Tecce C Moretti V Di Castro D Spergel KJ Catt 1995 Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells Clin Cancer Res 1 9 1059 1066 1:CAS:528:DyaK2MXoslSmtL4%3D 9816080
    • (1995) Clin Cancer Res , vol.1 , Issue.9 , pp. 1059-1066
    • Bagnato, A.1    Tecce, R.2    Moretti, C.3    Di Castro, V.4    Spergel, D.5    Catt, K.J.6
  • 89
    • 29144495415 scopus 로고    scopus 로고
    • Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells
    • 1:CAS:528:DC%2BD2MXhtlWiu7rE 16357176 10.1158/0008-5472.CAN-05-2123
    • L Rosano F Spinella V Di Castro MR Nicotra S Dedhar AG de Herreros PG Natali A Bagnato 2005 Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells Cancer Res 65 24 11649 11657 1:CAS:528: DC%2BD2MXhtlWiu7rE 16357176 10.1158/0008-5472.CAN-05-2123
    • (2005) Cancer Res , vol.65 , Issue.24 , pp. 11649-11657
    • Rosano, L.1    Spinella, F.2    Di Castro, V.3    Nicotra, M.R.4    Dedhar, S.5    De Herreros, A.G.6    Natali, P.G.7    Bagnato, A.8
  • 92
    • 0023765634 scopus 로고
    • Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells
    • 1:CAS:528:DyaL1cXmtVGksrY%3D 3139457 10.1016/0014-5793(88)80489-7
    • I Komuro H Kurihara T Sugiyama M Yoshizumi F Takaku Y Yazaki 1988 Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells FEBS Lett 238 2 249 252 1:CAS:528:DyaL1cXmtVGksrY%3D 3139457 10.1016/0014-5793(88)80489-7
    • (1988) FEBS Lett , vol.238 , Issue.2 , pp. 249-252
    • Komuro, I.1    Kurihara, H.2    Sugiyama, T.3    Yoshizumi, M.4    Takaku, F.5    Yazaki, Y.6
  • 93
    • 0034665584 scopus 로고    scopus 로고
    • Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells
    • 1:CAS:528:DC%2BD3cXntValsrw%3D 11016663
    • F Vacca A Bagnato KJ Catt R Tecce 2000 Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells Cancer Res 60 18 5310 5317 1:CAS:528: DC%2BD3cXntValsrw%3D 11016663
    • (2000) Cancer Res , vol.60 , Issue.18 , pp. 5310-5317
    • Vacca, F.1    Bagnato, A.2    Catt, K.J.3    Tecce, R.4
  • 94
    • 67749137207 scopus 로고    scopus 로고
    • Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair
    • 1:CAS:528:DC%2BD1MXhsVClt7%2FN 19477925 10.1091/mbc.E09-01-0085
    • A Pedram M Razandi AJ Evinger E Lee ER Levin 2009 Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair Mol Biol Cell 20 14 3374 3389 1:CAS:528:DC%2BD1MXhsVClt7%2FN 19477925 10.1091/mbc.E09-01-0085
    • (2009) Mol Biol Cell , vol.20 , Issue.14 , pp. 3374-3389
    • Pedram, A.1    Razandi, M.2    Evinger, A.J.3    Lee, E.4    Levin, E.R.5
  • 95
    • 11144308977 scopus 로고    scopus 로고
    • Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: Evidence for involvement of transactivation of the epidermal growth factor receptor
    • 1:CAS:528:DC%2BD2MXjvVCnug%3D%3D 15838264 10.1097/01.fjc.0000166255. 12229.0d
    • F Spinella L Rosano G Elia V Di Castro PG Natali A Bagnato 2004 Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor J Cardiovasc Pharmacol 44 Suppl 1 S140 S143 1:CAS:528:DC%2BD2MXjvVCnug%3D%3D 15838264 10.1097/01.fjc.0000166255.12229. 0d
    • (2004) J Cardiovasc Pharmacol , vol.44 , Issue.SUPPL. 1
    • Spinella, F.1    Rosano, L.2    Elia, G.3    Di Castro, V.4    Natali, P.G.5    Bagnato, A.6
  • 96
    • 33744902332 scopus 로고    scopus 로고
    • Antitumor effect of green tea polyphenol epigallocatechin-3-gallate in ovarian carcinoma cells: Evidence for the endothelin-1 as a potential target
    • 1:CAS:528:DC%2BD28Xlt1ertb0%3D
    • F Spinella L Rosano S Decandia V Di Castro A Albini G Elia PG Natali A Bagnato 2006 Antitumor effect of green tea polyphenol epigallocatechin-3-gallate in ovarian carcinoma cells: evidence for the endothelin-1 as a potential target Exp Biol Med (Maywood) 231 6 1123 1127 1:CAS:528:DC%2BD28Xlt1ertb0%3D
    • (2006) Exp Biol Med (Maywood) , vol.231 , Issue.6 , pp. 1123-1127
    • Spinella, F.1    Rosano, L.2    Decandia, S.3    Di Castro, V.4    Albini, A.5    Elia, G.6    Natali, P.G.7    Bagnato, A.8
  • 97
    • 21244445833 scopus 로고    scopus 로고
    • Atrasentan: A novel and rationally designed therapeutic alternative in the management of cancer
    • 1:CAS:528:DC%2BD2MXmtF2it7g%3D 16001950 10.1586/14737140.5.3.419
    • A Jimeno M Carducci 2005 Atrasentan: a novel and rationally designed therapeutic alternative in the management of cancer Expert Rev Anticancer Ther 5 3 419 427 1:CAS:528:DC%2BD2MXmtF2it7g%3D 16001950 10.1586/14737140.5.3.419
    • (2005) Expert Rev Anticancer Ther , vol.5 , Issue.3 , pp. 419-427
    • Jimeno, A.1    Carducci, M.2
  • 98
    • 33744928079 scopus 로고    scopus 로고
    • ZD4054, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma cell proliferation
    • 1:CAS:528:DC%2BD28Xlt1ertbs%3D
    • L Rosano V Di Castro F Spinella S Decandia PG Natali A Bagnato 2006 ZD4054, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma cell proliferation Exp Biol Med (Maywood) 231 6 1132 1135 1:CAS:528: DC%2BD28Xlt1ertbs%3D
    • (2006) Exp Biol Med (Maywood) , vol.231 , Issue.6 , pp. 1132-1135
    • Rosano, L.1    Di Castro, V.2    Spinella, F.3    Decandia, S.4    Natali, P.G.5    Bagnato, A.6
  • 99
    • 51449109131 scopus 로고    scopus 로고
    • ZD4054: A specific endothelin A receptor antagonist with promising activity in metastatic castration-resistant prostate cancer
    • 1:CAS:528:DC%2BD1cXos1Chs7o%3D 18616419 10.1517/13543784.17.8.1237
    • R Warren G Liu 2008 ZD4054: a specific endothelin A receptor antagonist with promising activity in metastatic castration-resistant prostate cancer Expert Opin Investig Drugs 17 8 1237 1245 1:CAS:528:DC%2BD1cXos1Chs7o%3D 18616419 10.1517/13543784.17.8.1237
    • (2008) Expert Opin Investig Drugs , vol.17 , Issue.8 , pp. 1237-1245
    • Warren, R.1    Liu, G.2
  • 100
    • 59449108669 scopus 로고    scopus 로고
    • Preclinical anticancer activity of the specific endothelin A receptor antagonist ZD4054
    • 1:CAS:528:DC%2BD1MXhvVSitLs%3D 19065106 10.1097/CAD.0b013e328320791c
    • JW Growcott 2009 Preclinical anticancer activity of the specific endothelin A receptor antagonist ZD4054 Anticancer Drugs 20 2 83 88 1:CAS:528:DC%2BD1MXhvVSitLs%3D 19065106 10.1097/CAD.0b013e328320791c
    • (2009) Anticancer Drugs , vol.20 , Issue.2 , pp. 83-88
    • Growcott, J.W.1
  • 101
    • 62449145673 scopus 로고    scopus 로고
    • Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis
    • 1:CAS:528:DC%2BD1MXislaht70%3D 19202075 10.1073/pnas.0807158106
    • L Rosano R Cianfrocca S Masi F Spinella V Di Castro A Biroccio E Salvati MR Nicotra PG Natali A Bagnato 2009 Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis Proc Natl Acad Sci USA 106 8 2806 2811 1:CAS:528:DC%2BD1MXislaht70%3D 19202075 10.1073/pnas.0807158106
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.8 , pp. 2806-2811
    • Rosano, L.1    Cianfrocca, R.2    Masi, S.3    Spinella, F.4    Di Castro, V.5    Biroccio, A.6    Salvati, E.7    Nicotra, M.R.8    Natali, P.G.9    Bagnato, A.10
  • 102
    • 34447128915 scopus 로고    scopus 로고
    • ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo
    • 1:CAS:528:DC%2BD2sXnsV2jsrg%3D 17620430 10.1158/1535-7163.MCT-07-0151
    • L Rosano V Di Castro F Spinella MR Nicotra PG Natali A Bagnato 2007 ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo Mol Cancer Ther 6 7 2003 2011 1:CAS:528:DC%2BD2sXnsV2jsrg%3D 17620430 10.1158/1535-7163.MCT-07-0151
    • (2007) Mol Cancer Ther , vol.6 , Issue.7 , pp. 2003-2011
    • Rosano, L.1    Di Castro, V.2    Spinella, F.3    Nicotra, M.R.4    Natali, P.G.5    Bagnato, A.6
  • 103
    • 11144337535 scopus 로고    scopus 로고
    • Therapeutic targeting of the endothelin-A receptor in human ovarian carcinoma: Efficacy of cytotoxic agents is markedly enhanced by co-administration with atrasentan
    • 1:CAS:528:DC%2BD2MXjvVCntA%3D%3D 15838262 10.1097/01.fjc.0000166259. 96980.6a
    • L Rosano F Spinella V Di Castro PG Natali A Bagnato 2004 Therapeutic targeting of the endothelin-A receptor in human ovarian carcinoma: efficacy of cytotoxic agents is markedly enhanced by co-administration with atrasentan J Cardiovasc Pharmacol 44 Suppl 1 S132 S135 1:CAS:528:DC%2BD2MXjvVCntA%3D%3D 15838262 10.1097/01.fjc.0000166259.96980.6a
    • (2004) J Cardiovasc Pharmacol , vol.44 , Issue.SUPPL. 1
    • Rosano, L.1    Spinella, F.2    Di Castro, V.3    Natali, P.G.4    Bagnato, A.5
  • 104
    • 0037843596 scopus 로고    scopus 로고
    • Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma
    • 1:CAS:528:DC%2BD3sXjslehsLc%3D 12750265
    • L Rosano F Spinella D Salani V Di Castro A Venuti MR Nicotra PG Natali A Bagnato 2003 Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma Cancer Res 63 10 2447 2453 1:CAS:528:DC%2BD3sXjslehsLc%3D 12750265
    • (2003) Cancer Res , vol.63 , Issue.10 , pp. 2447-2453
    • Rosano, L.1    Spinella, F.2    Salani, D.3    Di Castro, V.4    Venuti, A.5    Nicotra, M.R.6    Natali, P.G.7    Bagnato, A.8
  • 105
    • 34547556790 scopus 로고    scopus 로고
    • The endothelin axis: A novel target for pharmacotherapy of female malignancies
    • 1:CAS:528:DC%2BD2sXmsFehur8%3D 17627567 10.2174/157016107781024082
    • M Smollich P Wulfing 2007 The endothelin axis: a novel target for pharmacotherapy of female malignancies Curr Vasc Pharmacol 5 3 239 248 1:CAS:528:DC%2BD2sXmsFehur8%3D 17627567 10.2174/157016107781024082
    • (2007) Curr Vasc Pharmacol , vol.5 , Issue.3 , pp. 239-248
    • Smollich, M.1    Wulfing, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.