메뉴 건너뛰기




Volumn 17, Issue 10, 2013, Pages 1345-1350

Relaxin promotes in vitro tumour growth, invasion and angiogenesis of human Saos-2 osteosarcoma cells by AKT/VEGF pathway

Author keywords

Angiogenesis; Invasion; Osteosarcoma; Proliferation; Relaxin

Indexed keywords

PROTEIN KINASE B; PROTEIN KINASE B BETA; RELAXIN; SERELAXIN; SMALL INTERFERING RNA; VASCULOTROPIN;

EID: 84878536438     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (19)

References (24)
  • 2
    • 65849353240 scopus 로고    scopus 로고
    • Relaxin reduces xenograft tumour growth of human MDA-MB-231 breast cancer cells
    • RADESTOCK Y, HOANG-VU C, Hombach-Klonisch S. Relaxin reduces xenograft tumour growth of human MDA-MB-231 breast cancer cells. Breast Cancer Res 2008; 10: R71.
    • (2008) Breast Cancer Res , vol.10
    • Radestock, Y.1    Hoang-Vu, C.2    Hombach-Klonisch, S.3
  • 4
    • 27944447704 scopus 로고    scopus 로고
    • H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis
    • SILVERTOWN JD, NG J, SATO T, SUMMERLEE AJ, MEDIN JA. H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis. Int J Cancer 2006; 118: 62-73.
    • (2006) Int J Cancer , vol.118 , pp. 62-73
    • Silvertown, J.D.1    Ng, J.2    Sato, T.3    Summerlee, A.J.4    Medin, J.A.5
  • 5
    • 84878529556 scopus 로고    scopus 로고
    • Relaxin enhances in-vitro invasiveness of breast cancer cell lines by upregulation of S100A4/MMPs signaling
    • CAO WH, LIU HM, LIU X, LI JG, LIANG J, LIU M, NIU ZH. Relaxin enhances in-vitro invasiveness of breast cancer cell lines by upregulation of S100A4/MMPs signaling. Eur Rev Med Pharmacol Sci 2013; 17: 609-617.
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , pp. 609-617
    • Cao, W.H.1    Liu, H.M.2    Liu, X.3    Li, J.G.4    Liang, J.5    Liu, M.6    Niu, Z.H.7
  • 8
    • 0034464024 scopus 로고    scopus 로고
    • The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): Identification of LGR6 and LGR7 and the signaling mechanism for LGR7
    • HSU SY, KUDO M, CHEN T, NAKABAYASHI K, BHALLA A, SPEK PJ VAN DER, VAN DUIN M, HSUEH AJ. The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol Endocrinol 2000; 14: 1257-1271.
    • (2000) Mol Endocrinol , vol.14 , pp. 1257-1271
    • Hsu, S.Y.1    Kudo, M.2    Chen, T.3    Nakabayashi, K.4    Bhalla, A.5    Van Der Spek, P.J.6    Van Duin, M.7    Hsueh, A.J.8
  • 11
    • 0036712077 scopus 로고    scopus 로고
    • Relaxin enhances in-vitro invasiveness of breast cancer cell lines by up-regulation of matrix metalloproteases
    • BINDER C, HAGEMANN T, HUSEN B, SCHULZ M, EINSPANIER A. Relaxin enhances in-vitro invasiveness of breast cancer cell lines by up-regulation of matrix metalloproteases. Mol Hum Reprod 2002; 8: 789-796.
    • (2002) Mol Hum Reprod , vol.8 , pp. 789-796
    • Binder, C.1    Hagemann, T.2    Husen, B.3    Schulz, M.4    Einspanier, A.5
  • 12
    • 13944269898 scopus 로고    scopus 로고
    • The AKT/IkappaB kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappaB and beta-catenin
    • AGARWAL A, DAS K, LERNER N, SATHE S, CICEK M, CASEY G, SIZEMORE N. The AKT/IkappaB kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappaB and beta-catenin. Oncogene 2005; 24: 1021-1031.
    • (2005) Oncogene , vol.24 , pp. 1021-1031
    • Agarwal, A.1    Das, K.2    Lerner, N.3    Sathe, S.4    Cicek, M.5    Casey, G.6    Sizemore, N.7
  • 15
    • 42049116924 scopus 로고    scopus 로고
    • VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro
    • MEI J, GAO Y, ZHANG L, CAI X, QIAN Z, HUANG H, HUANG W. VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro. Exp Oncol 2008; 30: 29-34.
    • (2008) Exp Oncol , vol.30 , pp. 29-34
    • Mei, J.1    Gao, Y.2    Zhang, L.3    Cai, X.4    Qian, Z.5    Huang, H.6    Huang, W.7
  • 16
    • 66249126286 scopus 로고    scopus 로고
    • Inhibitory effects of VEGF-siRNA mediated by adenovirus on osteosarcoma-bearing nude mice
    • GAO YS, MEI J, TONG TL, HU M, XUE HM, CAI XS. Inhibitory effects of VEGF-siRNA mediated by adenovirus on osteosarcoma-bearing nude mice. Cancer Biother Radiopharm 2009; 24: 243-247.
    • (2009) Cancer Biother Radiopharm , vol.24 , pp. 243-247
    • Gao, Y.S.1    Mei, J.2    Tong, T.L.3    Hu, M.4    Xue, H.M.5    Cai, X.S.6
  • 18
    • 84872246733 scopus 로고    scopus 로고
    • Protein kinase B phosphorylation correlates with vascular endothelial growth factor a and microvessel density in gastric adenocarcinoma
    • ZHOU XD, CHEN HX, GUAN RN, LEI YP, SHU X, ZHU Y, LV NH. Protein kinase B phosphorylation correlates with vascular endothelial growth factor a and microvessel density in gastric adenocarcinoma. J Int Med Res 2012; 40: 2124-2134.
    • (2012) J Int Med Res , vol.40 , pp. 2124-2134
    • Zhou, X.D.1    Chen, H.X.2    Guan, R.N.3    Lei, Y.P.4    Shu, X.5    Zhu, Y.6    Nh, L.V.7
  • 19
    • 70350227313 scopus 로고    scopus 로고
    • The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma
    • KURMASHEVA RT, DUDKIN L, BILLUPS C, DEBELENKO LV, MORTON CL, HOUGHTON PJ. The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma. Cancer Res 2009; 69: 7662-7671.
    • (2009) Cancer Res , vol.69 , pp. 7662-7671
    • Kurmasheva, R.T.1    Dudkin, L.2    Billups, C.3    Debelenko, L.V.4    Morton, C.L.5    Houghton, P.J.6
  • 22
    • 34347262496 scopus 로고    scopus 로고
    • Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation
    • QIAO M, IGLEHART JD, PARDEE AB. Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation. Cancer Res 2007; 67: 5293-5299.
    • (2007) Cancer Res , vol.67 , pp. 5293-5299
    • Qiao, M.1    Iglehart, J.D.2    Pardee, A.B.3
  • 23
    • 0035499454 scopus 로고    scopus 로고
    • Ten years of protein kinase B signalling: A hard Akt to follow
    • BRAZIL DP, HEMMINGS BA. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci 2001; 26: 657-664.
    • (2001) Trends Biochem Sci , vol.26 , pp. 657-664
    • Brazil, D.P.1    Hemmings, B.A.2
  • 24
    • 0035020950 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signaling pathways
    • CANTRELL DA. Phosphoinositide 3-kinase signaling pathways. J Cell Sci 2001; 114: 1439-1445.
    • (2001) J Cell Sci , vol.114 , pp. 1439-1445
    • Cantrell, D.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.