Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart?

Circulation

Volumn 106, Issue 3, 2002, Pages 292-295

  Fisher, Carol ^a   MacLean, Margaret ^a   Morecroft, Ian ^a   Seed, Alison ^a   Johnston, Fiona ^b   Hillier, Christopher ^b   McMurray, John ^a,c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Arteries; Endothelium; Peptides; Vasodilation

Indexed keywords

ATRIAL NATRIURETIC FACTOR; PROSTACYCLIN; RELAXIN; SUBSTANCE P;

ARTICLE; BIOPSY; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM; HEART; HUMAN; LEISURE; LUNG CIRCULATION; PREGNANCY; PRIORITY JOURNAL; PULMONARY ARTERY; SYSTEMIC CIRCULATION;

AGED; ARTERIES; CULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; PEPTIDES; PULMONARY ARTERY; RELAXIN; VASCULAR RESISTANCE; VASODILATION; VASODILATOR AGENTS;

EID: 0037118672     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000025630.05387.45     Document Type: Article

References (17)

1. Relaxin: A pleiotropic hormone
2. Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene: Novel members of the relaxin peptide family
3. Activation of orphan receptors by the hormone relaxin
4. The pregnancy hormone relaxin is a player in human heart failure
5. Effects of urotensin II in human arteries and veins of varying calibre
6. 2 adrenoceptormediated contractile responses in human skeletal muscle resistance arteries in chronic limb ischaemia
7. Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries
8. Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart
9. Vasodilator therapy after heart transplantation: Effects of inhaled nitric oxide and intravenous prostacyclin, prostaglandin E1, and sodium nitroprusside
10. Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture
11. Relaxin is a potent renal vasodilator in conscious rats
12. Effects of human relaxin on isolated rat and human myometrium and uteroplacental arteries
13. Effect of porcine relaxin on the human umbilical artery
14. Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women
15. Blunted responses to vasoconstrictors in mesenteric vasculature but not in portal vein of spontaneously hypertensive rates treated with relaxin
16. An autocrine/paracrine role of human decidual relaxin. II. Stromelysin-1 (MMP-3) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1)
17. Vasodilatory action of endogenous atrial natriuretic factor in a rat model of chronic heart failure as determined by monoclonal ANF antibody