The pregnancy hormone relaxin is a player in human heart failure

FASEB Journal

Volumn 15, Issue 12, 2001, Pages 2187-2195

  Dschietzig, Thomas ^a   Richter, Christoph ^a   Bartsch, Cornelia ^a   Laule, Michael ^a   Armbruster, Franz Paul ^b   Baumann, Gert ^a   Stangl, Karl ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b IMMUNDIAGNOSTIK AG   (Germany)

Author keywords

Angiotensin II; Congestive; Endothelin 1; Gene expression; RLX

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENDOTHELIN 1; FUROSEMIDE; NITRATE; NITROPRUSSIDE SODIUM; RELAXIN;

ADULT; AGED; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE SEVERITY; FEMALE; HEART FAILURE; HEART MUSCLE; HEART MUSCLE CELL; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ANIMALS; ASPARTIC ENDOPEPTIDASES; CATTLE; CELLS, CULTURED; ENDOTHELIN-1; FEMALE; HEART FAILURE, CONGESTIVE; HEMODYNAMIC PROCESSES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MYOCARDIUM; ORGAN CULTURE TECHNIQUES; PROPROTEIN CONVERTASES; PROTEIN PRECURSORS; RATS; RATS, WISTAR; RELAXIN; RNA, MESSENGER; UP-REGULATION; VENTRICULAR PRESSURE;

ANIMALIA; DIGITALIS;

EID: 0034810896     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0070com     Document Type: Article

References (26)

1. Human relaxins: Chemistry and biology
2. Structure of a genomic clone encoding biologically active human relaxin
3. Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones
4. Relaxin: A pleiotropic hormone
5. Urinary excretion of relaxin after estradiol treatment of postmenopausal women
6. Experimental relaxation of the pubic ligament of guinea pig
7. Influence of relaxin on mammary development in sexually immature female rats
8. The emerging concept of relaxin as a centrally acting peptide hormone with hemodynamic actions
9. Mechanical and neuroendocrine regulation of the endocrine heart
10. Pulmonary release and coronary and peripheral consumption of big endothelin and endothelin-1 in severe heart failure: Acute effects of vasodilator therapy
11. Prohormone convertase-1 will process prorelaxin, a member of the insulin family of hormones
12. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
13. Expression of human relaxin genes: Characterization of a novel alternatively-spliced human relaxin mRNA species
14. Molecular cloning and characterization of cDNA sequences coding for rat relaxin
15. Shear stress-induced stimulation of mammalian cell metabolism
16. A simple sequentially rejective multiple test procedure
17. Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in atT-20 cells and islets of Langerhans
18. Evidence for a dual source of relaxin in the pregnant rat: Immunolocalization in the corpora lutea and endometrium
19. Endothelin in human congestive heart failure
20. Interactions between endothelin-1 and the renin-angiotensinaldosterone system
21. Signal transduction mechanisms mediating the vascular actions of endothelin
22. Relaxin is a potent renal vasodilator in conscious rats
23. Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart
24. Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo
25. Relaxin stimulates plasminogen activator secretion by rat granulosa cells in vitro