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Volumn 148, Issue 4, 2007, Pages 1582-1589

Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes

Author keywords

[No Author keywords available]

Indexed keywords

ATRIAL NATRIURETIC FACTOR; DNA; HYDROGEN PEROXIDE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PHENYLEPHRINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; RELAXIN; RELAXIN 2; UNCLASSIFIED DRUG;

EID: 33947379636     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-1324     Document Type: Article
Times cited : (73)

References (55)
  • 1
    • 0003412980 scopus 로고
    • Experimental relaxation of the pubic ligament of the guinea pig
    • Hisaw FL 1926 Experimental relaxation of the pubic ligament of the guinea pig. Proc Soc Exp Biol Med 23:661-663
    • (1926) Proc Soc Exp Biol Med , vol.23 , pp. 661-663
    • Hisaw, F.L.1
  • 2
    • 3042610399 scopus 로고    scopus 로고
    • Relaxin's physiological roles and other diverse actions
    • Sherwood OD 2004 Relaxin's physiological roles and other diverse actions. Endocr Rev 25:205-234
    • (2004) Endocr Rev , vol.25 , pp. 205-234
    • Sherwood, O.D.1
  • 4
    • 33749265164 scopus 로고    scopus 로고
    • Relaxin' the stiffened heart and arteries: The therapeutic potential for relaxin in the treatment of cardiovascular disease
    • Samuel CS, Du XJ, Bathgate RA, Summers RJ 2006 'Relaxin' the stiffened heart and arteries: the therapeutic potential for relaxin in the treatment of cardiovascular disease. Pharmacol Ther 121:529-552
    • (2006) Pharmacol Ther , vol.121 , pp. 529-552
    • Samuel, C.S.1    Du, X.J.2    Bathgate, R.A.3    Summers, R.J.4
  • 5
    • 12244257489 scopus 로고    scopus 로고
    • Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: A gender-specific phenotype
    • Du XJ, Samuel CS, Gao XM, Zhao L, Parry LJ, Tregear GW 2003 Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype. Cardiovasc Res 57:395-404
    • (2003) Cardiovasc Res , vol.57 , pp. 395-404
    • XJ, D.1    Samuel, C.S.2    Gao, X.M.3    Zhao, L.4    Parry, L.J.5    Tregear, G.W.6
  • 7
    • 4344606223 scopus 로고    scopus 로고
    • Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo
    • Samuel CS, Unemori EN, Mookerjee I, Bathgate RA, Layfield SL, Mak J, Tregear GW, Du XJ 2004 Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo. Endocrinology 145:4125-4133
    • (2004) Endocrinology , vol.145 , pp. 4125-4133
    • Samuel, C.S.1    Unemori, E.N.2    Mookerjee, I.3    Bathgate, R.A.4    Layfield, S.L.5    Mak, J.6    Tregear, G.W.7    Du, X.J.8
  • 8
    • 0031945701 scopus 로고    scopus 로고
    • Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart
    • Bani D, Masini E, Bello MG, Bigazzi M, Sacchi TB 1998 Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart. Am J Pathol 152:1367-1376
    • (1998) Am J Pathol , vol.152 , pp. 1367-1376
    • Bani, D.1    Masini, E.2    Bello, M.G.3    Bigazzi, M.4    Sacchi, T.B.5
  • 10
    • 0043169460 scopus 로고    scopus 로고
    • N-terminal pro B type natriuretic peptide, but not the new putative cardiac hormone relaxin, predicts prognosis in patients with chronic heart failure
    • Fisher C, Berry C, Blue L, Morton JJ, McMurray J 2003 N-terminal pro B type natriuretic peptide, but not the new putative cardiac hormone relaxin, predicts prognosis in patients with chronic heart failure. Heart 89:879-881
    • (2003) Heart , vol.89 , pp. 879-881
    • Fisher, C.1    Berry, C.2    Blue, L.3    Morton, J.J.4    McMurray, J.5
  • 12
    • 13444280326 scopus 로고    scopus 로고
    • Is the pregnancy hormone relaxin an important player in human heart failure?
    • Kupari M, Mikkola TS, Turto H, Lommi J 2005 Is the pregnancy hormone relaxin an important player in human heart failure? Eur J Heart Fail 7:195-198
    • (2005) Eur J Heart Fail , vol.7 , pp. 195-198
    • Kupari, M.1    Mikkola, T.S.2    Turto, H.3    Lommi, J.4
  • 14
    • 2442704145 scopus 로고    scopus 로고
    • Relaxin is an independent risk factor predicting death in male patients with end-stage kidney disease
    • Hocher B, Ziebig R, Krause R, Asmus G, Neumayer HH, Liefeldt L, Stasch JP 2004 Relaxin is an independent risk factor predicting death in male patients with end-stage kidney disease. Circulation 109:2266-2268
    • (2004) Circulation , vol.109 , pp. 2266-2268
    • Hocher, B.1    Ziebig, R.2    Krause, R.3    Asmus, G.4    Neumayer, H.H.5    Liefeldt, L.6    Stasch, J.P.7
  • 17
    • 18444381423 scopus 로고    scopus 로고
    • Left ventricular hypertrophy as a predictor of cardiovascular risk
    • Gosse P 2005 Left ventricular hypertrophy as a predictor of cardiovascular risk. J Hypertens Suppl 23:S27-S33
    • (2005) J Hypertens , Issue.SUPPL. 23
    • Gosse, P.1
  • 18
    • 11144248392 scopus 로고    scopus 로고
    • The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy in rats
    • Lee HY, Zhao S, Fields PA, Sherwood OD 2005 The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy in rats. Endocrinology 146:511-518
    • (2005) Endocrinology , vol.146 , pp. 511-518
    • Lee, H.Y.1    Zhao, S.2    Fields, P.A.3    Sherwood, O.D.4
  • 21
    • 33745226248 scopus 로고    scopus 로고
    • Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms
    • Halls ML, Bathgate RA, Summers RJ 2006 Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms. Mol Pharmacol 70:214-226
    • (2006) Mol Pharmacol , vol.70 , pp. 214-226
    • Halls, M.L.1    Bathgate, R.A.2    Summers, R.J.3
  • 22
    • 0036950082 scopus 로고    scopus 로고
    • Gene expression in fibroblasts and fibrosis: Involvement in cardiac hypertrophy
    • Manabe I, Shindo T, Nagai R 2002 Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy. Circ Res 91:1103-1113
    • (2002) Circ Res , vol.91 , pp. 1103-1113
    • Manabe, I.1    Shindo, T.2    Nagai, R.3
  • 23
    • 11144338216 scopus 로고    scopus 로고
    • Apoptosis: Measurement and technical issues
    • Rodriguez M, Schaper J 2005 Apoptosis: measurement and technical issues. J Mol Cell Cardiol 38:15-20
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 15-20
    • Rodriguez, M.1    Schaper, J.2
  • 25
    • 0029761252 scopus 로고    scopus 로고
    • Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart
    • Toth M, Taskinen P, Ruskoaho H 1996 Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart. J Endocrinol 150:487-495
    • (1996) J Endocrinol , vol.150 , pp. 487-495
    • Toth, M.1    Taskinen, P.2    Ruskoaho, H.3
  • 26
    • 0037306002 scopus 로고    scopus 로고
    • Antihypertrophic actions of the natriuretic peptides in adult rat cardiomyocytes: Importance of cyclic GMP
    • Rosenkranz AC, Woods RL, Dusting GJ, Ritchie RH 2003 Antihypertrophic actions of the natriuretic peptides in adult rat cardiomyocytes: importance of cyclic GMP. Cardiovasc Res 57:515-522
    • (2003) Cardiovasc Res , vol.57 , pp. 515-522
    • Rosenkranz, A.C.1    Woods, R.L.2    Dusting, G.J.3    Ritchie, R.H.4
  • 27
    • 0032213728 scopus 로고    scopus 로고
    • Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts
    • Gray MO, Long CS, Kalinyak JE, Li HT, Karliner JS 1998 Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts. Cardiovasc Res 40:352-363
    • (1998) Cardiovasc Res , vol.40 , pp. 352-363
    • Gray, M.O.1    Long, C.S.2    Kalinyak, J.E.3    Li, H.T.4    Karliner, J.S.5
  • 29
    • 0028816225 scopus 로고
    • Trophic effects of angiotensin II on neonatal rat cardiac myocytes are mediated by cardiac fibroblasts
    • Kim NN, Villarreal FJ, Printz MP, Lee AA, Dillmann WH 1995 Trophic effects of angiotensin II on neonatal rat cardiac myocytes are mediated by cardiac fibroblasts. Am J Physiol 269:E426-E437
    • (1995) Am J Physiol , vol.269
    • Kim, N.N.1    Villarreal, F.J.2    Printz, M.P.3    Lee, A.A.4    Dillmann, W.H.5
  • 30
  • 31
    • 0035017179 scopus 로고    scopus 로고
    • Evidence that relaxin inhibits apoptosis in the cervix and the vagina during the second half of pregnancy in the rat
    • Zhao S, Fields PA, Sherwood OD 2001 Evidence that relaxin inhibits apoptosis in the cervix and the vagina during the second half of pregnancy in the rat. Endocrinology 142:2221-2229
    • (2001) Endocrinology , vol.142 , pp. 2221-2229
    • Zhao, S.1    Fields, P.A.2    Sherwood, O.D.3
  • 32
    • 0032730499 scopus 로고    scopus 로고
    • Mechanisms of myocardial reperfusion injury
    • Park JL, Lucchesi BR 1999 Mechanisms of myocardial reperfusion injury. Ann Thorac Surg 68:1905-1912
    • (1999) Ann Thorac Surg , vol.68 , pp. 1905-1912
    • Park, J.L.1    Lucchesi, B.R.2
  • 34
    • 33747618467 scopus 로고    scopus 로고
    • Effects of a left ventricular assist device on the myocardium in ischemia-reperfusion injury
    • Unosawa S 2004 Effects of a left ventricular assist device on the myocardium in ischemia-reperfusion injury. Ann Thorac Cardiovasc Surg 10:350-356
    • (2004) Ann Thorac Cardiovasc Surg , vol.10 , pp. 350-356
    • Unosawa, S.1
  • 36
  • 37
    • 1442323685 scopus 로고    scopus 로고
    • Relaxin inhibits the activation of human neutrophils: Involvement of the nitric oxide pathway
    • Masini E, Nistri S, Vannacci A, Bani Sacchi T, Novelli A, Bani D 2004 Relaxin inhibits the activation of human neutrophils: involvement of the nitric oxide pathway. Endocrinology 145:1106-1112
    • (2004) Endocrinology , vol.145 , pp. 1106-1112
    • Masini, E.1    Nistri, S.2    Vannacci, A.3    Bani Sacchi, T.4    Novelli, A.5    Bani, D.6
  • 38
    • 0642364972 scopus 로고    scopus 로고
    • Relaxin inhibits lipopolysaccharide-induced adhesion of neutrophils to coronary endothelial cells by a nitric oxide-mediated mechanism
    • Nistri S, Chiappini L, Sassoli C, Bani D 2003 Relaxin inhibits lipopolysaccharide-induced adhesion of neutrophils to coronary endothelial cells by a nitric oxide-mediated mechanism. FASEB J 17:2109-2111
    • (2003) FASEB J , vol.17 , pp. 2109-2111
    • Nistri, S.1    Chiappini, L.2    Sassoli, C.3    Bani, D.4
  • 39
    • 0031657519 scopus 로고    scopus 로고
    • Role of relaxin and estrogen in the control of eosinophilic invasion and collagen remodeling in rat cervical tissue at term
    • Luque EH, Munoz de Toro MM, Ramos JG, Rodriguez HA, Sherwood OD 1998 Role of relaxin and estrogen in the control of eosinophilic invasion and collagen remodeling in rat cervical tissue at term. Biol Reprod 59:795-800
    • (1998) Biol Reprod , vol.59 , pp. 795-800
    • Luque, E.H.1    Munoz de Toro, M.M.2    Ramos, J.G.3    Rodriguez, H.A.4    Sherwood, O.D.5
  • 40
    • 0028143544 scopus 로고
    • Effects of relaxin on mast cells. In vitro and in vivo studies in rats and guinea pigs
    • Masini E, Bani D, Bigazzi M, Mannaioni PF, Bani-Sacchi T 1994 Effects of relaxin on mast cells. In vitro and in vivo studies in rats and guinea pigs. J Clin Invest 94:1974-1980
    • (1994) J Clin Invest , vol.94 , pp. 1974-1980
    • Masini, E.1    Bani, D.2    Bigazzi, M.3    Mannaioni, P.F.4    Bani-Sacchi, T.5
  • 41
    • 0028820363 scopus 로고
    • Relaxin depresses platelet aggregation: In vitro studies on isolated human and rabbit platelets
    • Bani D, Bigazzi M, Masini E, Bani G, Sacchi TB 1995 Relaxin depresses platelet aggregation: in vitro studies on isolated human and rabbit platelets. Lab Invest 73:709-716
    • (1995) Lab Invest , vol.73 , pp. 709-716
    • Bani, D.1    Bigazzi, M.2    Masini, E.3    Bani, G.4    Sacchi, T.B.5
  • 43
    • 1842558592 scopus 로고    scopus 로고
    • Oxidative stress-elicited myocardial apoptosis during reperfusion
    • Zhao ZQ 2004 Oxidative stress-elicited myocardial apoptosis during reperfusion. Curr Opin Pharmacol 4:159-165
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 159-165
    • Zhao, Z.Q.1
  • 44
    • 1142285456 scopus 로고    scopus 로고
    • Nitric oxide in myocardial ischemia/reperfusion injury
    • Schulz R, Kelm M, Heusch G 2004 Nitric oxide in myocardial ischemia/reperfusion injury. Cardiovasc Res 61:402-413
    • (2004) Cardiovasc Res , vol.61 , pp. 402-413
    • Schulz, R.1    Kelm, M.2    Heusch, G.3
  • 45
    • 33644589069 scopus 로고    scopus 로고
    • International Union of Pharmacology LVII: Recommendations for the nomenclature of receptors for relaxin family peptides
    • Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ 2006 International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol Rev 58:7-31
    • (2006) Pharmacol Rev , vol.58 , pp. 7-31
    • Bathgate, R.A.1    Ivell, R.2    Sanborn, B.M.3    Sherwood, O.D.4    Summers, R.J.5
  • 47
    • 11144253483 scopus 로고    scopus 로고
    • Convergent signal transduction pathways controlling cardiomyocyte survival and function: The role of PI 3-kinase and Akt
    • Matsui T, Rosenzweig A 2005 Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J Mol Cell Cardiol 38:63-71
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 63-71
    • Matsui, T.1    Rosenzweig, A.2
  • 48
    • 11144307292 scopus 로고    scopus 로고
    • STRESS signaling pathways that modulate cardiac myocyte apoptosis
    • Baines CP, Molkentin JD 2005 STRESS signaling pathways that modulate cardiac myocyte apoptosis. J Mol Cell Cardiol 38:47-62
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 47-62
    • Baines, C.P.1    Molkentin, J.D.2
  • 49
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME 1997 Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 50
    • 33745046922 scopus 로고    scopus 로고
    • Granulocyte colony stimulating factor directly inhibits myocardial ischemia-reperfusion injury through Akt-endothelial NO synthase pathway
    • Ueda K, Takano H, Hasegawa H, Niitsuma Y, Qin Y, Ohtsuka M, Komuro I 2006 Granulocyte colony stimulating factor directly inhibits myocardial ischemia-reperfusion injury through Akt-endothelial NO synthase pathway. Arterioscler Thromb Vasc Biol 26:e108-e113
    • (2006) Arterioscler Thromb Vasc Biol , vol.26
    • Ueda, K.1    Takano, H.2    Hasegawa, H.3    Niitsuma, Y.4    Qin, Y.5    Ohtsuka, M.6    Komuro, I.7
  • 51
    • 13844255495 scopus 로고    scopus 로고
    • Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes
    • Xu Z, Park SS, Mueller RA, Bagnell RC, Patterson C, Boysen PG 2005 Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes. Cardiovasc Res 65:803-812
    • (2005) Cardiovasc Res , vol.65 , pp. 803-812
    • Xu, Z.1    Park, S.S.2    Mueller, R.A.3    Bagnell, R.C.4    Patterson, C.5    Boysen, P.G.6
  • 52
    • 0036792631 scopus 로고    scopus 로고
    • Protective effect of relaxin in cardiac anaphylaxis: Involvement of the nitric oxide pathway
    • Masini E, Zagli G, Ndisang JF, Solazzo M, Mannaioni PF, Bani D 2002 Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway. Br J Pharmacol 137:337-344
    • (2002) Br J Pharmacol , vol.137 , pp. 337-344
    • Masini, E.1    Zagli, G.2    Ndisang, J.F.3    Solazzo, M.4    Mannaioni, P.F.5    Bani, D.6
  • 53
    • 0033675205 scopus 로고    scopus 로고
    • Low catecholamine concentrations protect adult rat ventricular myocytes against apoptosis through cAMP-dependent extracellular signal-regulated kinase activation
    • Henaff M, Hatem SN, Mercadier JJ 2000 Low catecholamine concentrations protect adult rat ventricular myocytes against apoptosis through cAMP-dependent extracellular signal-regulated kinase activation. Mol Pharmacol 58:1546-1553
    • (2000) Mol Pharmacol , vol.58 , pp. 1546-1553
    • Henaff, M.1    Hatem, S.N.2    Mercadier, J.J.3
  • 54
    • 0033035655 scopus 로고    scopus 로고
    • On the mechanism of relaxin action: The involvement of adenylyl cyclase signalling system
    • Kuznetsova L, Plesneva S, Derjabina N, Omeljaniuk E, Pertseva M 1999 On the mechanism of relaxin action: the involvement of adenylyl cyclase signalling system. Regul Pept 80:33-39
    • (1999) Regul Pept , vol.80 , pp. 33-39
    • Kuznetsova, L.1    Plesneva, S.2    Derjabina, N.3    Omeljaniuk, E.4    Pertseva, M.5
  • 55
    • 0036849160 scopus 로고    scopus 로고
    • Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): Effect of pertussis toxin
    • Kompa AR, Samuel CS, Summers RJ 2002 Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin. Br J Pharmacol 137:710-718
    • (2002) Br J Pharmacol , vol.137 , pp. 710-718
    • Kompa, A.R.1    Samuel, C.S.2    Summers, R.J.3


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