메뉴 건너뛰기




Volumn 35, Issue 1, 2016, Pages

Targeting microRNAs as key modulators of tumor immune response

Author keywords

Adaptive Immunity; Anticancer Immunotherapy; Cancer; Cancer Related Immune Response; Immune System; Immune related MicroRNAs; Innate Immunity; MicroRNAs

Indexed keywords

MICRORNA; MICRORNA 106B; MICRORNA 10B; MICRORNA 124; MICRORNA 126; MICRORNA 130; MICRORNA 142 3P; MICRORNA 146A; MICRORNA 155; MICRORNA 17; MICRORNA 17 5P; MICRORNA 199A; MICRORNA 19A 3P; MICRORNA 20A; MICRORNA 21; MICRORNA 214; MICRORNA 223; MICRORNA 23A; MICRORNA 27A; MICRORNA 29; MICRORNA 29B; MICRORNA 301; MICRORNA 326; MICRORNA 342; MICRORNA 34A; MICRORNA 34C; MICRORNA 424; MICRORNA 494; MICRORNA 96; UNCLASSIFIED DRUG;

EID: 84976619894     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/s13046-016-0375-2     Document Type: Review
Times cited : (158)

References (203)
  • 1
    • 84923027892 scopus 로고    scopus 로고
    • Immune cell promotion of metastasis
    • 1:CAS:528:DC%2BC2MXhsVarsb8%3D 25614318 4470277
    • Kitamura T, Qian BZ, Pollard JW. Immune cell promotion of metastasis. Nat Rev Immunol. 2015;15:73-86.
    • (2015) Nat Rev Immunol , vol.15 , pp. 73-86
    • Kitamura, T.1    Qian, B.Z.2    Pollard, J.W.3
  • 2
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • 1:CAS:528:DC%2BD3MXhsVKltb0%3D 11229684
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357:539-45.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 3
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • 1:CAS:528:DC%2BC3cXlsVSgu7g%3D 20303878 2866629
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140:883-99.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 4
    • 40349094954 scopus 로고    scopus 로고
    • Inflammation and breast cancer. Balancing immune response: Crosstalk between adaptive and innate immune cells during breast cancer progression
    • De Nardo DG, Coussens LM. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res. 2007;9:212.
    • (2007) Breast Cancer Res , vol.9 , pp. 212
    • De Nardo, D.G.1    Coussens, L.M.2
  • 5
    • 84860324470 scopus 로고    scopus 로고
    • Roles for microRNAs in conferring robustness to biological processes
    • 1:CAS:528:DC%2BC38Xmt1Grtb0%3D 22541426 3351105
    • Ebert MS, Sharp PA. Roles for microRNAs in conferring robustness to biological processes. Cell. 2012;149:515-24.
    • (2012) Cell , vol.149 , pp. 515-524
    • Ebert, M.S.1    Sharp, P.A.2
  • 6
    • 84881276749 scopus 로고    scopus 로고
    • Role of microRNAs in the immune system, inflammation and cancer
    • 1:CAS:528:DC%2BC3sXptFygsrY%3D 23716978 3662938
    • Raisch J, Darfeuille-Michaud A, Nguyen HT. Role of microRNAs in the immune system, inflammation and cancer. World J Gastroenterol. 2013;19:2985-96.
    • (2013) World J Gastroenterol , vol.19 , pp. 2985-2996
    • Raisch, J.1    Darfeuille-Michaud, A.2    Nguyen, H.T.3
  • 7
    • 79952779639 scopus 로고    scopus 로고
    • MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases
    • 1:CAS:528:DC%2BC3MXjsV2nt7g%3D 21420027 3072681
    • Dai R, Ahmed SA. MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases. Transl Res. 2011;157:163-79.
    • (2011) Transl Res , vol.157 , pp. 163-179
    • Dai, R.1    Ahmed, S.A.2
  • 8
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • 1:CAS:528:DC%2BD2cXhtVals7o%3D 14744438
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281-97.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 10
    • 84858379476 scopus 로고    scopus 로고
    • MicroRNAs in stress signaling and human disease
    • Mendell JT, Olson EN. MicroRNAs in stress signaling and human disease. Cell. 2004;148:1172-87.
    • (2004) Cell , vol.148 , pp. 1172-1187
    • Mendell, J.T.1    Olson, E.N.2
  • 11
    • 61849137222 scopus 로고    scopus 로고
    • Many roads to maturity: MicroRNA biogenesis pathways and their regulation
    • 1:CAS:528:DC%2BD1MXisVOltrg%3D 19255566
    • Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009;11:228-24.
    • (2009) Nat Cell Biol , vol.11 , pp. 228-324
    • Winter, J.1    Jung, S.2    Keller, S.3    Gregory, R.I.4    Diederichs, S.5
  • 12
    • 84891384103 scopus 로고    scopus 로고
    • A miRNA signature associated with human metastatic medullary thyroid carcinoma
    • 1:CAS:528:DC%2BC2cXjtVCjtbo%3D 24127332
    • Santarpia L, Calin GA, Adam L, Ye L, Fusco A, Giunti S, et al. A miRNA signature associated with human metastatic medullary thyroid carcinoma. Endocr Relat Cancer. 2013;20:809-23.
    • (2013) Endocr Relat Cancer , vol.20 , pp. 809-823
    • Santarpia, L.1    Calin, G.A.2    Adam, L.3    Ye, L.4    Fusco, A.5    Giunti, S.6
  • 13
    • 84911135072 scopus 로고    scopus 로고
    • Targeting the microRNA-regulating DNA damage/repair pathways in cancer
    • 1:CAS:528:DC%2BC2cXhslGgtL7E 25190496
    • Bottai G, Pasculli B, Calin GA, Santarpia L. Targeting the microRNA-regulating DNA damage/repair pathways in cancer. Expert Opin Biol Ther. 2014;14:1667-83.
    • (2014) Expert Opin Biol Ther , vol.14 , pp. 1667-1683
    • Bottai, G.1    Pasculli, B.2    Calin, G.A.3    Santarpia, L.4
  • 14
    • 84947808033 scopus 로고    scopus 로고
    • MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients
    • 26452030 4741929
    • De Mattos-Arruda L, Bottai G, Nuciforo PG, Di Tommaso L, Giovannetti E, Peg V, et al. MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients. Oncotarget. 2015;6:37269-80.
    • (2015) Oncotarget , vol.6 , pp. 37269-37280
    • De Mattos-Arruda, L.1    Bottai, G.2    Nuciforo, P.G.3    Di Tommaso, L.4    Giovannetti, E.5    Peg, V.6
  • 15
    • 79956227111 scopus 로고    scopus 로고
    • Shielding the messenger (RNA): MicroRNA-based anticancer therapies
    • 1:CAS:528:DC%2BC3MXmsVyltbw%3D 21514318 3124007
    • Sotillo E, Thomas-Tikhonenko A. Shielding the messenger (RNA): microRNA-based anticancer therapies. Pharmacol Ther. 2011;131:18-32.
    • (2011) Pharmacol Ther , vol.131 , pp. 18-32
    • Sotillo, E.1    Thomas-Tikhonenko, A.2
  • 16
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • 1:CAS:528:DC%2BC3cXht1egsA%3D%3D 19965718
    • Lanford RE, Hildebrandt-Eriksen ES, Petri A, Persson R, Lindow M, Munk ME, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science. 2010;327:198-201.
    • (2010) Science , vol.327 , pp. 198-201
    • Lanford, R.E.1    Hildebrandt-Eriksen, E.S.2    Petri, A.3    Persson, R.4    Lindow, M.5    Munk, M.E.6
  • 17
    • 84869219338 scopus 로고    scopus 로고
    • MiR-34 - A microRNA replacement therapy is headed to the clinic
    • 1:CAS:528:DC%2BC3sXhtFSltL3I 22783274 3387671
    • Bader G. miR-34 - a microRNA replacement therapy is headed to the clinic. Front Genet. 2012;3:120.
    • (2012) Front Genet , vol.3 , pp. 120
    • Bader, G.1
  • 18
    • 84872975552 scopus 로고    scopus 로고
    • MicroRNAs in immune response and macrophage polarization
    • 23325473 3549532
    • Liu G, Abraham E. MicroRNAs in immune response and macrophage polarization. Arterioscler Thromb Vasc Biol. 2013;33:170-7.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 170-177
    • Liu, G.1    Abraham, E.2
  • 19
    • 79953197948 scopus 로고    scopus 로고
    • Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer
    • 1:CAS:528:DC%2BC3MXktVarsL4%3D 21383199 3064319
    • Tili E, Michaille JJ, Wernicke D, Alder H, Costinean S, Volinia S, et al. Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer. Proc Natl Acad Sci U S A. 2011;108:4908-13.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4908-4913
    • Tili, E.1    Michaille, J.J.2    Wernicke, D.3    Alder, H.4    Costinean, S.5    Volinia, S.6
  • 20
    • 84876717265 scopus 로고    scopus 로고
    • MiRNA-29: A microRNA family with tumor-suppressing and immune-modulating properties
    • Schmitt MJ, Margue C, Behrmann I, Kreis S. MiRNA-29: a microRNA family with tumor-suppressing and immune-modulating properties. Curr Mol Med. 2011;13:572-85.
    • (2011) Curr Mol Med , vol.13 , pp. 572-585
    • Schmitt, M.J.1    Margue, C.2    Behrmann, I.3    Kreis, S.4
  • 21
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • 1:CAS:528:DC%2BD2sXmtVSmtb8%3D 17486113
    • Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9:654-69.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-669
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 22
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • 1:CAS:528:DC%2BC3MXjsFeqtrk%3D 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 23
    • 84942292465 scopus 로고    scopus 로고
    • Inflammation and cancer: Advances and new agents
    • 1:CAS:528:DC%2BC2MXhtFOju77K 26122183
    • Crusz SM, Balkwill FR. Inflammation and cancer: advances and new agents. Nat Rev Clin Oncol. 2015;12:584-96.
    • (2015) Nat Rev Clin Oncol , vol.12 , pp. 584-596
    • Crusz, S.M.1    Balkwill, F.R.2
  • 25
    • 30144443269 scopus 로고    scopus 로고
    • Paradoxical roles of the immune system during cancer development
    • 16397525
    • de Visser KE, Eichten A, Coussens LM. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer. 2006;6:24-37.
    • (2006) Nat Rev Cancer , vol.6 , pp. 24-37
    • De Visser, K.E.1    Eichten, A.2    Coussens, L.M.3
  • 26
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting: From immunosurveillance to tumor escape
    • 1:CAS:528:DC%2BD38Xot1Chs70%3D 12407406
    • Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3:991-8.
    • (2002) Nat Immunol , vol.3 , pp. 991-998
    • Dunn, G.P.1    Bruce, A.T.2    Ikeda, H.3    Old, L.J.4    Schreiber, R.D.5
  • 28
    • 35548936833 scopus 로고    scopus 로고
    • Models, mechanisms and clinical evidence for cancer dormancy
    • 1:CAS:528:DC%2BD2sXht1Wgsb%2FO 17957189 2519109
    • Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer. 2007;7:834-46.
    • (2007) Nat Rev Cancer , vol.7 , pp. 834-846
    • Aguirre-Ghiso, J.A.1
  • 29
    • 33748987908 scopus 로고    scopus 로고
    • Cancer despite immunosurveillance: Immunoselection and immunosubversion
    • 1:CAS:528:DC%2BD28XhtVSgurnM 16977338
    • Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol. 2006;6:715-27.
    • (2006) Nat Rev Immunol , vol.6 , pp. 715-727
    • Zitvogel, L.1    Tesniere, A.2    Kroemer, G.3
  • 30
    • 4143141823 scopus 로고    scopus 로고
    • The immunobiology of cancer immunosurveillance and immunoediting
    • 1:CAS:528:DC%2BD2cXnsVKltrY%3D 15308095
    • Dunn GP, Old LJ, Schreiber RD. The immunobiology of cancer immunosurveillance and immunoediting. Immunity. 2004;21:137-48.
    • (2004) Immunity , vol.21 , pp. 137-148
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 31
    • 2542430341 scopus 로고    scopus 로고
    • The three Es of cancer immunoediting
    • 1:CAS:528:DC%2BD2cXktlOgs7k%3D 15032581
    • Dunn GP, Old LJ, Schreiber RD. The three Es of cancer immunoediting. Annu Rev Immunol. 2004;22:329-60.
    • (2004) Annu Rev Immunol , vol.22 , pp. 329-360
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 32
    • 33646755569 scopus 로고    scopus 로고
    • Cancer immunosurveillance and immunoediting: The roles of immunity in suppressing tumor development and shaping tumor immunogenicity
    • 1:CAS:528:DC%2BD1cXhsVCjtbc%3D 16730260
    • Smyth MJ, Dunn GP, Schreiber RD. Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity. Adv Immunol. 2006;90:1-50.
    • (2006) Adv Immunol , vol.90 , pp. 1-50
    • Smyth, M.J.1    Dunn, G.P.2    Schreiber, R.D.3
  • 33
    • 0036852191 scopus 로고    scopus 로고
    • Natural selection of tumor variants in the generation of "tumor escape" phenotypes
    • 1:CAS:528:DC%2BD38Xot1Chs7o%3D 12407407 1508168
    • Khong HT, Restifo NP. Natural selection of tumor variants in the generation of "tumor escape" phenotypes. Nat Immunol. 2002;3:999-1005.
    • (2002) Nat Immunol , vol.3 , pp. 999-1005
    • Khong, H.T.1    Restifo, N.P.2
  • 34
    • 24344436369 scopus 로고    scopus 로고
    • Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
    • 1:CAS:528:DC%2BD2MXpslalsLg%3D 16136144
    • Willimsky G, Blankenstein T. Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance. Nature. 2005;437:141-6.
    • (2005) Nature , vol.437 , pp. 141-146
    • Willimsky, G.1    Blankenstein, T.2
  • 35
    • 0034212634 scopus 로고    scopus 로고
    • Sequential loss of cytotoxic T lymphocyte responses to simian virus 40 large T antigen epitopes in T antigen transgenic mice developing osteosarcomas
    • 1:CAS:528:DC%2BD3cXjvFOlt7s%3D 10850449
    • Schell TD, Knowles BB, Tevethia SS. Sequential loss of cytotoxic T lymphocyte responses to simian virus 40 large T antigen epitopes in T antigen transgenic mice developing osteosarcomas. Cancer Res. 2000;60:3002-12.
    • (2000) Cancer Res , vol.60 , pp. 3002-3012
    • Schell, T.D.1    Knowles, B.B.2    Tevethia, S.S.3
  • 36
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • 1:CAS:528:DC%2BC3sXhslCmsrjL 24202395 3954707
    • Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19:1423-37.
    • (2013) Nat Med , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 37
    • 79959745851 scopus 로고    scopus 로고
    • The prognostic influence of tumour-infiltrating lymphocytes in cancer: A systematic review with meta-analysis
    • 1:STN:280:DC%2BC3MnktVGisA%3D%3D 21629244 3137407
    • Gooden MJ, de Bock GH, Leffers N, Daemen T, Nijman HW. The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis. Br J Cancer. 2011;105:93-103.
    • (2011) Br J Cancer , vol.105 , pp. 93-103
    • Gooden, M.J.1    De Bock, G.H.2    Leffers, N.3    Daemen, T.4    Nijman, H.W.5
  • 38
    • 0029925375 scopus 로고    scopus 로고
    • Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma
    • 1:STN:280:DyaK287pslChtA%3D%3D 8608507
    • Clemente CG, Mihm Jr MC, Bufalino R, Zurrida S, Collini P, Cascinelli N. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer. 1996;77:1303-10.
    • (1996) Cancer , vol.77 , pp. 1303-1310
    • Clemente, C.G.1    Mihm, M.C.2    Bufalino, R.3    Zurrida, S.4    Collini, P.5    Cascinelli, N.6
  • 39
    • 0035872423 scopus 로고    scopus 로고
    • Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas
    • 1:CAS:528:DC%2BD3MXktVWqsLo%3D 11358808
    • Schumacher K, Haensch W, Roefzaad C, Schlag PM. Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas. Cancer Res. 2001;61:3932-6.
    • (2001) Cancer Res , vol.61 , pp. 3932-3936
    • Schumacher, K.1    Haensch, W.2    Roefzaad, C.3    Schlag, P.M.4
  • 40
  • 41
    • 29444442811 scopus 로고    scopus 로고
    • Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    • 1:CAS:528:DC%2BD28Xpt1Om 16344461 1311741
    • Sato E, Olson SH, Ahn J, Bundy B, Nishikawa H, Qian F, et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A. 2005;102:18538-43.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18538-18543
    • Sato, E.1    Olson, S.H.2    Ahn, J.3    Bundy, B.4    Nishikawa, H.5    Qian, F.6
  • 42
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • 1:CAS:528:DC%2BD28XhtVSnsrnK 17008531
    • Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313:1960-4.
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3    Kirilovsky, A.4    Mlecnik, B.5    Lagorce-Pages, C.6
  • 43
    • 84908116528 scopus 로고    scopus 로고
    • Prognostic significance of FOXP3+ tumor-infiltrating lymphocytes in breast cancer depends on estrogen receptor and human epidermal growth factor receptor-2 expression status and concurrent cytotoxic T-cell infiltration
    • 25193543 4303113
    • Liu S, Foulkes WD, Leung S, Gao D, Lau S, Kos Z, et al. Prognostic significance of FOXP3+ tumor-infiltrating lymphocytes in breast cancer depends on estrogen receptor and human epidermal growth factor receptor-2 expression status and concurrent cytotoxic T-cell infiltration. Breast Cancer Res. 2014;16:432.
    • (2014) Breast Cancer Res , vol.16 , pp. 432
    • Liu, S.1    Foulkes, W.D.2    Leung, S.3    Gao, D.4    Lau, S.5    Kos, Z.6
  • 44
    • 84941660341 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer: An eternal fight between good and evil
    • 26325032
    • Shalapour S, Karin M. Immunity, inflammation, and cancer: an eternal fight between good and evil. J Clin Invest. 2015;125:3347-55.
    • (2015) J Clin Invest , vol.125 , pp. 3347-3355
    • Shalapour, S.1    Karin, M.2
  • 47
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • 1:CAS:528:DC%2BC3MXhtlWltb%2FE 21997792 3422549
    • Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011;11:723-37.
    • (2011) Nat Rev Immunol , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 48
    • 84928077532 scopus 로고    scopus 로고
    • Macrophages and therapeutic resistance in cancer
    • 1:CAS:528:DC%2BC2MXmtVaku7g%3D 25858805 4400235
    • Ruffell B, Coussens LM. Macrophages and therapeutic resistance in cancer. Cancer Cell. 2015;27:462-72.
    • (2015) Cancer Cell , vol.27 , pp. 462-472
    • Ruffell, B.1    Coussens, L.M.2
  • 49
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • 1:CAS:528:DC%2BD28XlsFOmtw%3D%3D 16423985
    • Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res. 2006;66:605-12.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 50
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
    • 1:CAS:528:DC%2BC3cXhtFyhtrrL 20856220
    • Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol. 2010;11:889-96.
    • (2010) Nat Immunol , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 51
    • 84892865013 scopus 로고    scopus 로고
    • Clinical significance of macrophage heterogeneity in human malignant tumors
    • 1:CAS:528:DC%2BC2cXht1emtL0%3D 24168081
    • Komohara Y, Jinushi M, Takeya M. Clinical significance of macrophage heterogeneity in human malignant tumors. Cancer Sci. 2014;105:1-8.
    • (2014) Cancer Sci , vol.105 , pp. 1-8
    • Komohara, Y.1    Jinushi, M.2    Takeya, M.3
  • 52
    • 84867052186 scopus 로고    scopus 로고
    • Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma
    • 1:CAS:528:DC%2BC38XhslSks77M 22927533 3675667
    • Asgharzadeh S, Salo JA, Ji L, Oberthuer A, Fischer M, Berthold F, et al. Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma. J Clin Oncol. 2012;30:3525-32.
    • (2012) J Clin Oncol , vol.30 , pp. 3525-3532
    • Asgharzadeh, S.1    Salo, J.A.2    Ji, L.3    Oberthuer, A.4    Fischer, M.5    Berthold, F.6
  • 53
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • 1:CAS:528:DC%2BD1MXhsFeqsbw%3D 19197294 2828349
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9:162-74.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 54
    • 80355136945 scopus 로고    scopus 로고
    • Host type i IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha} + dendritic cells
    • 1:CAS:528:DC%2BC3MXht1KjsbnE 21930765 3182064
    • Fuertes MB, Kacha AK, Kline J, Woo SR, Kranz DM, Murphy KM, et al. Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha} + dendritic cells. J Exp Med. 2011;208:2005-16.
    • (2011) J Exp Med , vol.208 , pp. 2005-2016
    • Fuertes, M.B.1    Kacha, A.K.2    Kline, J.3    Woo, S.R.4    Kranz, D.M.5    Murphy, K.M.6
  • 55
    • 84911937777 scopus 로고    scopus 로고
    • Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity
    • 1:CAS:528:DC%2BC2cXhslOrtL%2FO 25446897 4254577
    • Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, et al. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014;26:638-52.
    • (2014) Cancer Cell , vol.26 , pp. 638-652
    • Broz, M.L.1    Binnewies, M.2    Boldajipour, B.3    Nelson, A.E.4    Pollack, J.L.5    Erle, D.J.6
  • 56
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joice JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer. 2009;9:239-52.
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joice, J.A.1    Pollard, J.W.2
  • 57
    • 70349145414 scopus 로고    scopus 로고
    • MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer
    • 1:CAS:528:DC%2BD1MXht1ersbrF 19759263 2751988
    • Olson P, Lu J, Zhang H, Shai A, Chun MG, Wang Y, et al. MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Genes Dev. 2009;23:2152-65.
    • (2009) Genes Dev , vol.23 , pp. 2152-2165
    • Olson, P.1    Lu, J.2    Zhang, H.3    Shai, A.4    Chun, M.G.5    Wang, Y.6
  • 58
    • 33144490646 scopus 로고    scopus 로고
    • A microRNA expression signature of human solid tumors defines cancer gene targets
    • 1:CAS:528:DC%2BD28XhslGjsbg%3D 16461460 1413718
    • Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A. 2006;103:2257-61.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2257-2261
    • Volinia, S.1    Calin, G.A.2    Liu, C.G.3    Ambs, S.4    Cimmino, A.5    Petrocca, F.6
  • 61
    • 79957907561 scopus 로고    scopus 로고
    • MiR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1
    • 1:CAS:528:DC%2BC3MXjt1Ghsbw%3D 20505989
    • Li H, Bian C, Liao L, Li J, Zhao RC. miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1. Breast Cancer Res Treat. 2011;126:565-75.
    • (2011) Breast Cancer Res Treat , vol.126 , pp. 565-575
    • Li, H.1    Bian, C.2    Liao, L.3    Li, J.4    Zhao, R.C.5
  • 62
    • 84862638243 scopus 로고    scopus 로고
    • Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN
    • 1:CAS:528:DC%2BC38XpsFyitbw%3D 22761812 3382593
    • Han M, Liu M, Wang Y, Chen X, Hu J, Sun Y, et al. Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN. PLoS One. 2012;7:e39520.
    • (2012) PLoS One , vol.7 , pp. e39520
    • Han, M.1    Liu, M.2    Wang, Y.3    Chen, X.4    Hu, J.5    Sun, Y.6
  • 64
    • 84857079737 scopus 로고    scopus 로고
    • The microcosmos of cancer
    • 1:CAS:528:DC%2BC38Xit12htb8%3D 22337054 3509753
    • Lujambio A, Lowe SW. The microcosmos of cancer. Nature. 2012;482:347-55.
    • (2012) Nature , vol.482 , pp. 347-355
    • Lujambio, A.1    Lowe, S.W.2
  • 65
    • 84896949069 scopus 로고    scopus 로고
    • MicroRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers
    • 24632568 4012726
    • Gasparini P, Cascione L, Fassan M, Lovat F, Guler G, Balci S, et al. microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers. Oncotarget. 2014;5:1174-84.
    • (2014) Oncotarget , vol.5 , pp. 1174-1184
    • Gasparini, P.1    Cascione, L.2    Fassan, M.3    Lovat, F.4    Guler, G.5    Balci, S.6
  • 66
    • 84928775471 scopus 로고    scopus 로고
    • A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients
    • 1:CAS:528:DC%2BC2MXjsF2iuro%3D 25547678
    • Kleivi Sahlberg K, Bottai G, Naume B, Burwinkel B, Calin GA, Børresen-Dale AL, et al. A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients. Clin Cancer Res. 2015;21:1207-14.
    • (2015) Clin Cancer Res , vol.21 , pp. 1207-1214
    • Kleivi Sahlberg, K.1    Bottai, G.2    Naume, B.3    Burwinkel, B.4    Calin, G.A.5    Børresen-Dale, A.L.6
  • 67
    • 84862109179 scopus 로고    scopus 로고
    • Global microRNA expression profiling of high-risk ER+ breast cancers from patients receiving adjuvant tamoxifen mono-therapy: A DBCG study
    • 1:CAS:528:DC%2BC38XnvFais7w%3D 22623953 3356496
    • Lyng MB, Lænkholm AV, Søkilde R, Gravgaard KH, Litman T, Ditzel HJ. Global microRNA expression profiling of high-risk ER+ breast cancers from patients receiving adjuvant tamoxifen mono-therapy: a DBCG study. PLoS One. 2012;7:e36170.
    • (2012) PLoS One , vol.7 , pp. e36170
    • Lyng, M.B.1    Lænkholm, A.V.2    Søkilde, R.3    Gravgaard, K.H.4    Litman, T.5    Ditzel, H.J.6
  • 68
    • 84892453256 scopus 로고    scopus 로고
    • Identification of intrinsic subtype-specific prognostic microRNAs in primary glioblastoma
    • 24438238 3917617
    • Li R, Gao K, Luo H, Wang X, Shi Y, Dong Q, et al. Identification of intrinsic subtype-specific prognostic microRNAs in primary glioblastoma. J Exp Clin Cancer Res. 2014;33:9.
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 9
    • Li, R.1    Gao, K.2    Luo, H.3    Wang, X.4    Shi, Y.5    Dong, Q.6
  • 69
    • 84920857648 scopus 로고    scopus 로고
    • An ER-associated miRNA signature predicts prognosis in ER-positive breast cancer
    • 1:CAS:528:DC%2BC2cXhsFOmurvP 25373603 4232612
    • Zhou X, Wang X, Huang Z, Xu L, Zhu W, Liu P. An ER-associated miRNA signature predicts prognosis in ER-positive breast cancer. J Exp Clin Cancer Res. 2014;33:94.
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 94
    • Zhou, X.1    Wang, X.2    Huang, Z.3    Xu, L.4    Zhu, W.5    Liu, P.6
  • 70
    • 84960532706 scopus 로고    scopus 로고
    • Dysregulation of microRNA biogenesis in cancer: The impact of mutant p53 on Drosha complex activity
    • 26971015 4789259
    • Gurtner A, Falcone E, Garibaldi F, Piaggio G. Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity. J Exp Clin Cancer Res. 2016;35:45.
    • (2016) J Exp Clin Cancer Res , vol.35 , pp. 45
    • Gurtner, A.1    Falcone, E.2    Garibaldi, F.3    Piaggio, G.4
  • 71
    • 84906266519 scopus 로고    scopus 로고
    • Progress and challenge of microRNA research in immunity
    • 24971086 4053854
    • Lee HM, Nguyen DT, Lu LF. Progress and challenge of microRNA research in immunity. Front Genet. 2014;5:178.
    • (2014) Front Genet , vol.5 , pp. 178
    • Lee, H.M.1    Nguyen, D.T.2    Lu, L.F.3
  • 72
    • 51649111487 scopus 로고    scopus 로고
    • Differential expression of microRNAs in hematopoietic cell lineages
    • 1:CAS:528:DC%2BD1cXht1Kru7nI 18573170
    • Merkerova M, Belickova M, Bruchova H. Differential expression of microRNAs in hematopoietic cell lineages. Eur J Haematol. 2008;81:304-10.
    • (2008) Eur J Haematol , vol.81 , pp. 304-310
    • Merkerova, M.1    Belickova, M.2    Bruchova, H.3
  • 73
    • 33750316858 scopus 로고    scopus 로고
    • The role of microRNAs in normal hematopoiesis and hematopoietic malignancies
    • 1:CAS:528:DC%2BD28XhtFWnsL3N 16990772
    • Kluiver J, Kroesen BJ, Poppema S, van den Berg A. The role of microRNAs in normal hematopoiesis and hematopoietic malignancies. Leukemia. 2006;20:1931-6.
    • (2006) Leukemia , vol.20 , pp. 1931-1936
    • Kluiver, J.1    Kroesen, B.J.2    Poppema, S.3    Van Den Berg, A.4
  • 74
    • 75749145045 scopus 로고    scopus 로고
    • MicroRNAs of the immune system: Roles in inflammation and cancer
    • 1:CAS:528:DC%2BC3cXisVehs7g%3D 20146715 2876712
    • Davidson-Moncada J, Papavasiliou FN, Tam W. MicroRNAs of the immune system: roles in inflammation and cancer. Ann N Y Acad Sci. 2010;1183:183-94.
    • (2010) Ann N y Acad Sci , vol.1183 , pp. 183-194
    • Davidson-Moncada, J.1    Papavasiliou, F.N.2    Tam, W.3
  • 75
    • 75649139134 scopus 로고    scopus 로고
    • Physiological and pathological roles for microRNAs in the immune system
    • 20098459
    • O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol. 2010;10:111-22.
    • (2010) Nat Rev Immunol , vol.10 , pp. 111-122
    • O'Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3    Baltimore, D.4
  • 76
    • 80052936529 scopus 로고    scopus 로고
    • MicroRNA function in myeloid biology
    • 21725054 3175776
    • O'Connell RM, Zhao JL, Rao DS. MicroRNA function in myeloid biology. Blood. 2011;118:2960-9.
    • (2011) Blood , vol.118 , pp. 2960-2969
    • O'Connell, R.M.1    Zhao, J.L.2    Rao, D.S.3
  • 77
    • 84875786973 scopus 로고    scopus 로고
    • MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer
    • 23550646
    • Tili E, Michaille JJ, Croce CM. MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer. Immunol Rev. 2013;253:167-84.
    • (2013) Immunol Rev , vol.253 , pp. 167-184
    • Tili, E.1    Michaille, J.J.2    Croce, C.M.3
  • 78
    • 84883477248 scopus 로고    scopus 로고
    • Dynamic nature of noncoding RNA regulation of adaptive immune response
    • 23975170 3794731
    • Curtale G, Citarella F. Dynamic nature of noncoding RNA regulation of adaptive immune response. Int J Mol Sci. 2013;14:17347-77.
    • (2013) Int J Mol Sci , vol.14 , pp. 17347-17377
    • Curtale, G.1    Citarella, F.2
  • 79
    • 84880772300 scopus 로고    scopus 로고
    • MicroRNA-mediated control of macrophages and its implications for cancer
    • 1:CAS:528:DC%2BC3sXktVOrsbo%3D 23498847 3700601
    • Squadrito ML, Etzrodt M, De Palma M, Pittet MJ. MicroRNA-mediated control of macrophages and its implications for cancer. Trends Immunol. 2013;34:350-9.
    • (2013) Trends Immunol , vol.34 , pp. 350-359
    • Squadrito, M.L.1    Etzrodt, M.2    De Palma, M.3    Pittet, M.J.4
  • 80
    • 34347383305 scopus 로고    scopus 로고
    • MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation
    • 1:CAS:528:DC%2BD2sXntFemtb4%3D 17589498
    • Fontana L, Pelosi E, Greco P, Racanicchi S, Testa U, Liuzzi F, et al. MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol. 2007;9:775-87.
    • (2007) Nat Cell Biol , vol.9 , pp. 775-787
    • Fontana, L.1    Pelosi, E.2    Greco, P.3    Racanicchi, S.4    Testa, U.5    Liuzzi, F.6
  • 81
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • 1:CAS:528:DC%2BC3cXlsVSgu74%3D 20303872
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140:805-80.
    • (2010) Cell , vol.140 , pp. 805-880
    • Takeuchi, O.1    Akira, S.2
  • 83
    • 33747608638 scopus 로고    scopus 로고
    • NFkappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    • 1:CAS:528:DC%2BD28Xos1Kqt7g%3D 16885212 1567904
    • Taganov KD, Boldin MP, Chang KJ, Baltimore D. NFkappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A. 2006;103:12481-6.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12481-12486
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.J.3    Baltimore, D.4
  • 84
    • 75649113377 scopus 로고    scopus 로고
    • Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the MicroRNA miR-21
    • 1:CAS:528:DC%2BD1MXhsVylsL3O 19946272
    • Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q, et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the MicroRNA miR-21. Nat Immunol. 2010;11:141-7.
    • (2010) Nat Immunol , vol.11 , pp. 141-147
    • Sheedy, F.J.1    Palsson-McDermott, E.2    Hennessy, E.J.3    Martin, C.4    O'Leary, J.J.5    Ruan, Q.6
  • 85
    • 68649091506 scopus 로고    scopus 로고
    • The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs
    • 1:CAS:528:DC%2BD1MXhtFOgsL7I 19699171 2865583
    • Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, et al. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity. 2009;31:220-31.
    • (2009) Immunity , vol.31 , pp. 220-231
    • Androulidaki, A.1    Iliopoulos, D.2    Arranz, A.3    Doxaki, C.4    Schworer, S.5    Zacharioudaki, V.6
  • 88
    • 34247584465 scopus 로고    scopus 로고
    • Requirement of bic/microRNA-155 for normal immune function
    • 1:CAS:528:DC%2BD2sXksFeksbg%3D 17463290 2610435
    • Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, et al. Requirement of bic/microRNA-155 for normal immune function. Science. 2007;316:608-11.
    • (2007) Science , vol.316 , pp. 608-611
    • Rodriguez, A.1    Vigorito, E.2    Clare, S.3    Warren, M.V.4    Couttet, P.5    Soond, D.R.6
  • 89
    • 70449716915 scopus 로고    scopus 로고
    • MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
    • 1:CAS:528:DC%2BD1MXht1Ogsr3F 19838199
    • Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, et al. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol. 2009;10:1252-9.
    • (2009) Nat Immunol , vol.10 , pp. 1252-1259
    • Du, C.1    Liu, C.2    Kang, J.3    Zhao, G.4    Ye, Z.5    Huang, S.6
  • 90
    • 84880778954 scopus 로고    scopus 로고
    • The microRNA cluster miR-17 approximately 92 promotes TFH cell differentiation and represses subset-inappropriate gene expression
    • 1:CAS:528:DC%2BC3sXhtVakur%2FN 23812098 3720769
    • Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, et al. The microRNA cluster miR-17 approximately 92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol. 2013;14:840-8.
    • (2013) Nat Immunol , vol.14 , pp. 840-848
    • Baumjohann, D.1    Kageyama, R.2    Clingan, J.M.3    Morar, M.M.4    Patel, S.5    De Kouchkovsky, D.6
  • 91
    • 84928774817 scopus 로고    scopus 로고
    • MicroRNAs function in CD8 + T cell biology
    • 1:CAS:528:DC%2BC2MXkvV2gu7w%3D 25560605
    • Liang Y, Pan HF, Ye DQ. microRNAs function in CD8 + T cell biology. J Leukoc Biol. 2015;97:487-97.
    • (2015) J Leukoc Biol , vol.97 , pp. 487-497
    • Liang, Y.1    Pan, H.F.2    Ye, D.Q.3
  • 92
    • 77956632634 scopus 로고    scopus 로고
    • Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses
    • 1:CAS:528:DC%2BC3cXhtFyitbzK 20850013 3049116
    • Lu LF, Boldin MP, Chaudhry A, Lin LL, Taganov KD, Hanada T, et al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010;142:914-29.
    • (2010) Cell , vol.142 , pp. 914-929
    • Lu, L.F.1    Boldin, M.P.2    Chaudhry, A.3    Lin, L.L.4    Taganov, K.D.5    Hanada, T.6
  • 93
    • 58149268107 scopus 로고    scopus 로고
    • Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein
    • 1:CAS:528:DC%2BD1MXhtlCnsLs%3D 19144316 2654249
    • Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, et al. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009;30:80-91.
    • (2009) Immunity , vol.30 , pp. 80-91
    • Lu, L.F.1    Thai, T.H.2    Calado, D.P.3    Chaudhry, A.4    Kubo, M.5    Tanaka, K.6
  • 94
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in humantumours: Impact on clinical outcome
    • 1:CAS:528:DC%2BC38Xjslersb4%3D 22419253
    • Fridman WH, Pagès F, Sautès-Fridman C, Galon J. The immune contexture in humantumours: impact on clinical outcome. Nat Rev Cancer. 2012;12:298-306.
    • (2012) Nat Rev Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pagès, F.2    Sautès-Fridman, C.3    Galon, J.4
  • 95
    • 84902129290 scopus 로고    scopus 로고
    • MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene
    • 1:CAS:528:DC%2BC3sXhtVKhu77P 23831570
    • Yang J, Zhang Z, Chen C, Liu Y, Si Q, Chuang TH, et al. MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene. Oncogene. 2014;33:3014-23.
    • (2014) Oncogene , vol.33 , pp. 3014-3023
    • Yang, J.1    Zhang, Z.2    Chen, C.3    Liu, Y.4    Si, Q.5    Chuang, T.H.6
  • 96
    • 77953284681 scopus 로고    scopus 로고
    • Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages
    • 1:CAS:528:DC%2BC3cXmvFeqt78%3D 20386569
    • Wang Q, Ni H, Lan L, Wei X, Xiang R, Wang Y. Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages. Cell Res. 2010;20:701-12.
    • (2010) Cell Res , vol.20 , pp. 701-712
    • Wang, Q.1    Ni, H.2    Lan, L.3    Wei, X.4    Xiang, R.5    Wang, Y.6
  • 97
    • 84971646937 scopus 로고    scopus 로고
    • A double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression
    • Ma S, Liu M, Xu Z, Li Y, Guo H, Ge Y, et al. A double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression. Oncotarget. 2015;7:13502-19.
    • (2015) Oncotarget , vol.7 , pp. 13502-13519
    • Ma, S.1    Liu, M.2    Xu, Z.3    Li, Y.4    Guo, H.5    Ge, Y.6
  • 98
    • 84884478648 scopus 로고    scopus 로고
    • A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice
    • 1:CAS:528:DC%2BC3sXhtFejsb7P 23487026
    • Zonari E, Pucci F, Saini M, Mazzieri R, Politi LS, Gentner B, et al. A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice. Blood. 2013;122:243-522.
    • (2013) Blood , vol.122 , pp. 243-522
    • Zonari, E.1    Pucci, F.2    Saini, M.3    Mazzieri, R.4    Politi, L.S.5    Gentner, B.6
  • 99
    • 84859417595 scopus 로고    scopus 로고
    • Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion
    • 1:CAS:528:DC%2BC38XlvFSrurY%3D 22323291 3315799
    • Mondal S, Subramanian KK, Sakai J, Bajrami B, Luo HR. Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion. Mol Biol Cell. 2012;23:1219-30.
    • (2012) Mol Biol Cell , vol.23 , pp. 1219-1230
    • Mondal, S.1    Subramanian, K.K.2    Sakai, J.3    Bajrami, B.4    Luo, H.R.5
  • 100
    • 84874629992 scopus 로고    scopus 로고
    • MiR-126 and miR-126 repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis
    • 1:CAS:528:DC%2BC3sXit1ansrk%3D 23396050 3672398
    • Zhang Y, Yang P, Sun T, Li D, Xu X, Rui Y, et al. miR-126 and miR-126 repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol. 2013;15:284-94.
    • (2013) Nat Cell Biol , vol.15 , pp. 284-294
    • Zhang, Y.1    Yang, P.2    Sun, T.3    Li, D.4    Xu, X.5    Rui, Y.6
  • 101
    • 34948896045 scopus 로고    scopus 로고
    • Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    • 1:CAS:528:DC%2BD2sXhtFagt7fI 17914389
    • Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007;449:557-63.
    • (2007) Nature , vol.449 , pp. 557-563
    • Karnoub, A.E.1    Dash, A.B.2    Vo, A.P.3    Sullivan, A.4    Brooks, M.W.5    Bell, G.W.6
  • 102
    • 79960411324 scopus 로고    scopus 로고
    • CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    • 1:CAS:528:DC%2BC3MXntFKrsb0%3D 21654748 3208506
    • Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature. 2011;475:222-5.
    • (2011) Nature , vol.475 , pp. 222-225
    • Qian, B.Z.1    Li, J.2    Zhang, H.3    Kitamura, T.4    Zhang, J.5    Campion, L.R.6
  • 103
    • 38049115129 scopus 로고    scopus 로고
    • Endogenous human microRNAs that suppress breast cancer metastasis
    • 1:CAS:528:DC%2BD1cXksVGhuw%3D%3D 18185580 2782491
    • Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, et al. Endogenous human microRNAs that suppress breast cancer metastasis. Nature. 2008;451:147-3.
    • (2008) Nature , vol.451 , pp. 147-153
    • Tavazoie, S.F.1    Alarcón, C.2    Oskarsson, T.3    Padua, D.4    Wang, Q.5    Bos, P.D.6
  • 104
    • 84906851359 scopus 로고    scopus 로고
    • Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression
    • 1:CAS:528:DC%2BC2cXhsVCrtb%2FL
    • Xie J, Liu M, Li Y, Nie Y, Mi Q, Zhao S. Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression. Cell Mol Biol. 2014;11:495-502.
    • (2014) Cell Mol Biol , vol.11 , pp. 495-502
    • Xie, J.1    Liu, M.2    Li, Y.3    Nie, Y.4    Mi, Q.5    Zhao, S.6
  • 105
    • 24944500112 scopus 로고    scopus 로고
    • Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
    • 1:CAS:528:DC%2BD2MXos1eqtL0%3D 16116470
    • Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, Tigelaar RE, et al. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nat Immunol. 2005;6:928-37.
    • (2005) Nat Immunol , vol.6 , pp. 928-937
    • Oppenheim, D.E.1    Roberts, S.J.2    Clarke, S.L.3    Filler, R.4    Lewis, J.M.5    Tigelaar, R.E.6
  • 106
    • 65349147075 scopus 로고    scopus 로고
    • Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA libraries
    • 19390579 2668797
    • Wyman SK, Parkin RK, Mitchell PS, Fritz BR, O'Briant K, Godwin AK, et al. Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA libraries. PLoS ONE. 2009;4:e5311.
    • (2009) PLoS ONE , vol.4 , pp. e5311
    • Wyman, S.K.1    Parkin, R.K.2    Mitchell, P.S.3    Fritz, B.R.4    O'Briant, K.5    Godwin, A.K.6
  • 107
    • 84868246872 scopus 로고    scopus 로고
    • MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells
    • 1:CAS:528:DC%2BC38XhsF2jsLrO 22915757
    • Tsukerman P, Stern-Ginossar N, Gur C, Glasner A, Nachmani D, Bauman Y, et al. MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells. Cancer Res. 2012;72:5463-72.
    • (2012) Cancer Res , vol.72 , pp. 5463-5472
    • Tsukerman, P.1    Stern-Ginossar, N.2    Gur, C.3    Glasner, A.4    Nachmani, D.5    Bauman, Y.6
  • 108
    • 84920690806 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma
    • 1:CAS:528:DC%2BC2MXjvFGitw%3D%3D 25393367
    • Yang H, Lan P, Hou Z, Guan Y, Zhang J, Xu W, et al. Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma. Br J Cancer. 2015;112:112-21.
    • (2015) Br J Cancer , vol.112 , pp. 112-121
    • Yang, H.1    Lan, P.2    Hou, Z.3    Guan, Y.4    Zhang, J.5    Xu, W.6
  • 109
    • 0036229870 scopus 로고    scopus 로고
    • Expression of stress-induced MHC class i related chain molecules on human melanoma
    • 1:CAS:528:DC%2BD38Xjt1Cju7g%3D 11918705
    • Vetter CS, Groh V, Thor Straten P, Spies T, Brocker EB, Becker JC. Expression of stress-induced MHC class I related chain molecules on human melanoma. J Invest Dermatol. 2002;118:600-5.
    • (2002) J Invest Dermatol , vol.118 , pp. 600-605
    • Vetter, C.S.1    Groh, V.2    Thor Straten, P.3    Spies, T.4    Brocker, E.B.5    Becker, J.C.6
  • 110
    • 69349104067 scopus 로고    scopus 로고
    • Differential clinical significance of individual NKG2D ligands in melanoma: Soluble ULBP2 as an indicator of poor prognosis superior to S100B
    • 1:CAS:528:DC%2BD1MXpvFeitrs%3D 19671853
    • Paschen A, Sucker A, Hill B, Moll I, Zapatka M, Nguyen XD, et al. Differential clinical significance of individual NKG2D ligands in melanoma: soluble ULBP2 as an indicator of poor prognosis superior to S100B. Clin Cancer Res. 2009;15:5208-15.
    • (2009) Clin Cancer Res , vol.15 , pp. 5208-5215
    • Paschen, A.1    Sucker, A.2    Hill, B.3    Moll, I.4    Zapatka, M.5    Nguyen, X.D.6
  • 111
    • 84855906694 scopus 로고    scopus 로고
    • Cell Receptor NKG2D Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Tumor Suppressive MicroRNAs miR-34a/c
    • 1:CAS:528:DC%2BC38Xos1Kksw%3D%3D 22102694
    • Heinemann A, Zhao F, Pechlivanis S, Eberle J, Steinle A, Diederichs S, et al. Cell Receptor NKG2D Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Tumor Suppressive MicroRNAs miR-34a/c. Cancer Res. 2012;72:460-71.
    • (2012) Cancer Res , vol.72 , pp. 460-471
    • Heinemann, A.1    Zhao, F.2    Pechlivanis, S.3    Eberle, J.4    Steinle, A.5    Diederichs, S.6
  • 112
    • 49749126791 scopus 로고    scopus 로고
    • Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
    • 1:CAS:528:DC%2BD1cXht1elsbnO 18719384
    • Lodygin D, Tarasov V, Epanchintsev A, Berking C, Knyazeva T, Körner H, et al. Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle. 2008;7:2591-600.
    • (2008) Cell Cycle , vol.7 , pp. 2591-2600
    • Lodygin, D.1    Tarasov, V.2    Epanchintsev, A.3    Berking, C.4    Knyazeva, T.5    Körner, H.6
  • 113
    • 84866018690 scopus 로고    scopus 로고
    • TGF-b-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma
    • 1:CAS:528:DC%2BC38XhtlCjtb%2FP 22975373 3443566
    • Yang P, Li QJ, Feng Y, Zhang Y, Markowitz GJ, Ning S, et al. TGF-b-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell. 2012;22:291-303.
    • (2012) Cancer Cell , vol.22 , pp. 291-303
    • Yang, P.1    Li, Q.J.2    Feng, Y.3    Zhang, Y.4    Markowitz, G.J.5    Ning, S.6
  • 114
    • 68049117231 scopus 로고    scopus 로고
    • MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: Potential implications for immune based therapy of human solid tumors
    • 1:CAS:528:DC%2BD1MXpt1Cgur0%3D 19584290 2719680
    • Xu H, Cheung IY, Guo HF, Cheung NK. MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors. Cancer Res. 2009;69:6275-81.
    • (2009) Cancer Res , vol.69 , pp. 6275-6281
    • Xu, H.1    Cheung, I.Y.2    Guo, H.F.3    Cheung, N.K.4
  • 115
    • 84875381512 scopus 로고    scopus 로고
    • The role of miRNA-29 family in cancer
    • 1:CAS:528:DC%2BC3sXhsFCrtrg%3D 23357522
    • Wang Y, Zhang X, Li H, Yu J, Ren X. The role of miRNA-29 family in cancer. Eur J Cell Biol. 2013;92:123-8.
    • (2013) Eur J Cell Biol , vol.92 , pp. 123-128
    • Wang, Y.1    Zhang, X.2    Li, H.3    Yu, J.4    Ren, X.5
  • 116
    • 84856706929 scopus 로고    scopus 로고
    • Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients
    • 1:CAS:528:DC%2BC38XhsVWmuro%3D 22120756
    • Filipazzi P, Huber V, Rivoltini L. Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients. Cancer Immunol Immunother. 2012;61:255-63.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 255-263
    • Filipazzi, P.1    Huber, V.2    Rivoltini, L.3
  • 117
    • 84862074482 scopus 로고    scopus 로고
    • MicroRNA-494 is required for the accumulation and functions of tumor-expanded myeloid-derived suppressor cells via targeting of PTEN
    • 1:CAS:528:DC%2BC38Xnt1aisLc%3D 22544933
    • Liu Y, Lai L, Chen Q, Song Y, Xu S, Ma F, et al. MicroRNA-494 is required for the accumulation and functions of tumor-expanded myeloid-derived suppressor cells via targeting of PTEN. J Immunol. 2012;188:5500-10.
    • (2012) J Immunol , vol.188 , pp. 5500-5510
    • Liu, Y.1    Lai, L.2    Chen, Q.3    Song, Y.4    Xu, S.5    Ma, F.6
  • 118
    • 84961289224 scopus 로고    scopus 로고
    • MicroRNA-155 deficiency enhances the recruitment and functions of myeloid-derived suppressor cells in tumor microenvironment and promotes solid tumor growth
    • 1:CAS:528:DC%2BC2cXhsVCru7vL 25143000
    • Wang J, Yu F, Jia X, Iwanowycz S, Wang Y, Huang S, et al. MicroRNA-155 deficiency enhances the recruitment and functions of myeloid-derived suppressor cells in tumor microenvironment and promotes solid tumor growth. Int J Cancer. 2015;136:E602-13.
    • (2015) Int J Cancer , vol.136 , pp. E602-E613
    • Wang, J.1    Yu, F.2    Jia, X.3    Iwanowycz, S.4    Wang, Y.5    Huang, S.6
  • 119
    • 79960122931 scopus 로고    scopus 로고
    • Dual roles of immune cells and their factors in cancer development and progression
    • 1:CAS:528:DC%2BC3MXmsl2lsrg%3D 21647333 3107473
    • Zamarron BF, Chen W. Dual roles of immune cells and their factors in cancer development and progression. Int J Biol Sci. 2011;7:651-8.
    • (2011) Int J Biol Sci , vol.7 , pp. 651-658
    • Zamarron, B.F.1    Chen, W.2
  • 120
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • 1:CAS:528:DC%2BD1cXhtF2msbbK 18836471 3689267
    • Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene. 2008;27:5904-12.
    • (2008) Oncogene , vol.27 , pp. 5904-5912
    • Whiteside, T.L.1
  • 121
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
    • 1:CAS:528:DC%2BD1cXmvVGmsL8%3D 18432192 2669289
    • Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008;453:807-11.
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1    Guma, M.2    Schachtrup, C.3    Akassoglou, K.4    Zinkernagel, A.S.5    Nizet, V.6
  • 122
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2008;9:361-71.
    • (2008) Nat Rev Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 123
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • 18662538 3512574
    • Massagué J. TGFbeta in Cancer. Cell. 2008;134:215-30.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagué, J.1
  • 124
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • 1:CAS:528:DC%2BD28XkvVyrsrw%3D 16724054
    • Karin M. Nuclear factor-kappaB in cancer development and progression. Nature. 2006;441:431-6.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 125
    • 4644324186 scopus 로고    scopus 로고
    • NF-kB functions as a tumour promoter in inflammation-associated cancer
    • 1:CAS:528:DC%2BD2cXnslelsrc%3D 15329734
    • Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-kB functions as a tumour promoter in inflammation-associated cancer. Nature. 2004;431:461-4.
    • (2004) Nature , vol.431 , pp. 461-464
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3    Abramovitch, R.4    Amit, S.5    Kasem, S.6
  • 126
    • 62849116942 scopus 로고    scopus 로고
    • Integration of cytokine and heterologous receptor signaling pathways
    • 1:CAS:528:DC%2BD1MXjtlyntb8%3D 19295629
    • Bezbradica JS, Medzhitov R. Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol. 2009;10:333-9.
    • (2009) Nat Immunol , vol.10 , pp. 333-339
    • Bezbradica, J.S.1    Medzhitov, R.2
  • 127
    • 14044261093 scopus 로고    scopus 로고
    • Tumor necrosis factor, cancer and anticancer therapy
    • 1:CAS:528:DC%2BD2MXhslChsr0%3D 15733831
    • Mocellin S, Rossi CR, Pilati P, Nitti D. Tumor necrosis factor, cancer and anticancer therapy. Cytokine Growth Factor Rev. 2005;16:35-53.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 35-53
    • Mocellin, S.1    Rossi, C.R.2    Pilati, P.3    Nitti, D.4
  • 128
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • 1:CAS:528:DC%2BD2MXht1yisr3I 16288283
    • Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med. 2005;11:1314-21.
    • (2005) Nat Med , vol.11 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3    Wei, S.4    Zhang, S.5    Pilon-Thomas, S.6
  • 129
    • 33645532055 scopus 로고    scopus 로고
    • Activation of stat3 in human melanoma promotes brain metastasis
    • 1:CAS:528:DC%2BD28Xitlert7w%3D 16540670
    • Xie TX, Huang FJ, Aldape KD, Kang SH, Liu M, Gershenwald JE, et al. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res. 2006;66:3188-96.
    • (2006) Cancer Res , vol.66 , pp. 3188-3196
    • Xie, T.X.1    Huang, F.J.2    Aldape, K.D.3    Kang, S.H.4    Liu, M.5    Gershenwald, J.E.6
  • 130
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • 1:CAS:528:DC%2BD28XhtlCht7fE 17186030
    • Yu H, Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol. 2007;7:41-51.
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Yu, H.2    Kortylewski, M.3    Pardoll, D.4
  • 131
    • 11144357779 scopus 로고    scopus 로고
    • Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
    • 14702634
    • Burdelya L, Shain K, Zhang S, Bhattacharya R, Gabrilovich D, Heller R, et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med. 2004;10:48-54.
    • (2004) Nat Med , vol.10 , pp. 48-54
    • Burdelya, L.1    Shain, K.2    Zhang, S.3    Bhattacharya, R.4    Gabrilovich, D.5    Heller, R.6
  • 132
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-beta/Smad signaling system
    • 10775259 302010
    • Massagué J, Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J. 2000;19:1745-54.
    • (2000) EMBO J , vol.19 , pp. 1745-1754
    • Massagué, J.1    Wotton, D.2
  • 133
    • 0022373618 scopus 로고
    • Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells
    • 1:CAS:528:DyaL2MXlsFGit7s%3D 3861940
    • Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, et al. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature. 1985;316:701-5.
    • (1985) Nature , vol.316 , pp. 701-705
    • Derynck, R.1    Jarrett, J.A.2    Chen, E.Y.3    Eaton, D.H.4    Bell, J.R.5    Assoian, R.K.6
  • 134
    • 0027136296 scopus 로고
    • Production of multiple cytokines by cultured human melanomas
    • 1:CAS:528:DyaK2cXisVaitbY%3D 7512880
    • Bennicelli JL, Guerry D. Production of multiple cytokines by cultured human melanomas. Exp Dermatol. 1993;2:186-90.
    • (1993) Exp Dermatol , vol.2 , pp. 186-190
    • Bennicelli, J.L.1    Guerry, D.2
  • 137
    • 84884593828 scopus 로고    scopus 로고
    • MiRNA-21 inhibition enhances RANTES and IP-10 release in MCF-7 via PIAS3 and STAT3 signalling and causes increased lymphocyte migration
    • 1:CAS:528:DC%2BC3sXhsVOlu73I 23998932
    • Wang Z, Han J, Cui Y, Zhou X, Fan K. miRNA-21 inhibition enhances RANTES and IP-10 release in MCF-7 via PIAS3 and STAT3 signalling and causes increased lymphocyte migration. Biochem Biophys Res Commun. 2013;439:384-9.
    • (2013) Biochem Biophys Res Commun , vol.439 , pp. 384-389
    • Wang, Z.1    Han, J.2    Cui, Y.3    Zhou, X.4    Fan, K.5
  • 138
    • 84859594480 scopus 로고    scopus 로고
    • Identification of novel miR-21 target proteins in multiple myeloma cells by quantitative proteomics
    • 1:CAS:528:DC%2BC38XhvFKmtr4%3D 22316494
    • Xiong Q, Zhong Q, Zhang J, Yang M, Li C, Zheng P, et al. Identification of novel miR-21 target proteins in multiple myeloma cells by quantitative proteomics. J Proteome Res. 2012;11:2078-90.
    • (2012) J Proteome Res , vol.11 , pp. 2078-2090
    • Xiong, Q.1    Zhong, Q.2    Zhang, J.3    Yang, M.4    Li, C.5    Zheng, P.6
  • 139
    • 78049285751 scopus 로고    scopus 로고
    • IFN induces miR-21 through a signal transducer and activator transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis
    • 1:CAS:528:DC%2BC3cXht1yqs7fN 20813833 3014825
    • Yang CH, Yue J, Fan M, Pfeffer LM. IFN induces miR-21 through a signal transducer and activator transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis. Cancer Res. 2010;70:8108-16.
    • (2010) Cancer Res , vol.70 , pp. 8108-8116
    • Yang, C.H.1    Yue, J.2    Fan, M.3    Pfeffer, L.M.4
  • 140
    • 80052810971 scopus 로고    scopus 로고
    • Regulation and function of miRNA-21 in health and disease
    • 1:CAS:528:DC%2BC38XhsV2lsLY%3D 21712654 3256347
    • Kumarswamy R, Volkmann I, Thum T. Regulation and function of miRNA-21 in health and disease. RNA Biol. 2011;8:706-13.
    • (2011) RNA Biol , vol.8 , pp. 706-713
    • Kumarswamy, R.1    Volkmann, I.2    Thum, T.3
  • 141
    • 77951026718 scopus 로고    scopus 로고
    • MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene
    • 1:CAS:528:DC%2BC3cXkslShtrw%3D 20354188
    • Jiang S, Zhang HW, Lu MH, He XH, Li Y, Gu H, et al. MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res. 2010;70:3119-27.
    • (2010) Cancer Res , vol.70 , pp. 3119-3127
    • Jiang, S.1    Zhang, H.W.2    Lu, M.H.3    He, X.H.4    Li, Y.5    Gu, H.6
  • 142
    • 84928733650 scopus 로고    scopus 로고
    • MicroRNA-17 inhibits tumor growth by stimulating T cell mediated host immune response
    • 25594054 4278315
    • Li H, Gupta S, Du WW, Yang BB. MicroRNA-17 inhibits tumor growth by stimulating T cell mediated host immune response. Oncoscience. 2014;1:531-9.
    • (2014) Oncoscience , vol.1 , pp. 531-539
    • Li, H.1    Gupta, S.2    Du, W.W.3    Yang, B.B.4
  • 143
    • 84880062228 scopus 로고    scopus 로고
    • MiR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma
    • 1:CAS:528:DC%2BC3sXhtValurbO 23636127 3780786
    • Wei J, Wang F, Kong LY, Xu S, Doucette T, Ferguson SD, et al. miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma. Cancer Res. 2013;73:3913-26.
    • (2013) Cancer Res , vol.73 , pp. 3913-3926
    • Wei, J.1    Wang, F.2    Kong, L.Y.3    Xu, S.4    Doucette, T.5    Ferguson, S.D.6
  • 144
    • 79955022118 scopus 로고    scopus 로고
    • Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression
    • 1:CAS:528:DC%2BC3MXkt1Gqsbs%3D 21383238
    • Zhang M, Liu Q, Mi S, Liang X, Zhang Z, Su X, et al. Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression. J Immunol. 2011;186:4716-24.
    • (2011) J Immunol , vol.186 , pp. 4716-4724
    • Zhang, M.1    Liu, Q.2    Mi, S.3    Liang, X.4    Zhang, Z.5    Su, X.6
  • 145
    • 84915748802 scopus 로고    scopus 로고
    • Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression
    • 25347474 4348954
    • Lin R, Chen L, Chen G, Hu C, Jiang S, Sevilla J, et al. Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression. J Clin Invest. 2014;124:5352-67.
    • (2014) J Clin Invest , vol.124 , pp. 5352-5367
    • Lin, R.1    Chen, L.2    Chen, G.3    Hu, C.4    Jiang, S.5    Sevilla, J.6
  • 146
    • 84863004855 scopus 로고    scopus 로고
    • H. Pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells
    • 21947847
    • Li N, Xu X, Xiao B, Zhu ED, Li BS, Liu Z, et al. H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells. Mol Biol Rep. 2011;39:4655-661.
    • (2011) Mol Biol Rep , vol.39 , pp. 4655-4661
    • Li, N.1    Xu, X.2    Xiao, B.3    Zhu, E.D.4    Li, B.S.5    Liu, Z.6
  • 147
    • 52149102044 scopus 로고    scopus 로고
    • Expression of micro-RNA 146 suppresses NF-kB activity with reduction of metastatic potential in breast cancer cells
    • 1:CAS:528:DC%2BD1cXhtFant7%2FE 18504431 2811234
    • Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J, Benz CC. Expression of micro-RNA 146 suppresses NF-kB activity with reduction of metastatic potential in breast cancer cells. Oncogene. 2008;27:5643-7.
    • (2008) Oncogene , vol.27 , pp. 5643-5647
    • Bhaumik, D.1    Scott, G.K.2    Schokrpur, S.3    Patil, C.K.4    Campisi, J.5    Benz, C.C.6
  • 148
    • 49149091917 scopus 로고    scopus 로고
    • Regulation of IKKbeta by miR-199a affects NF-kB activity in ovarian cancer cells
    • 1:CAS:528:DC%2BD1cXptlKntrg%3D 18408758 3041589
    • Chen R, Alvero AB, Silasi DA, Kelly MG, Fest S, Visintin I, et al. Regulation of IKKbeta by miR-199a affects NF-kB activity in ovarian cancer cells. Oncogene. 2008;27:4712-23.
    • (2008) Oncogene , vol.27 , pp. 4712-4723
    • Chen, R.1    Alvero, A.B.2    Silasi, D.A.3    Kelly, M.G.4    Fest, S.5    Visintin, I.6
  • 149
    • 1542328234 scopus 로고    scopus 로고
    • The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer
    • 1:CAS:528:DC%2BD2cXhvFahsr0%3D 15013524
    • Greten FR, Karin M. The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett. 2004;206:193-9.
    • (2004) Cancer Lett , vol.206 , pp. 193-199
    • Greten, F.R.1    Karin, M.2
  • 150
    • 20244372724 scopus 로고    scopus 로고
    • Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis
    • 1:CAS:528:DC%2BD2MXktlSntr4%3D 15826931
    • Fukata M, Michelsen KS, Eri R, Thomas LS, Hu B, Lukasek K, et al. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol. 2005;288:G1055-65.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288 , pp. G1055-G1065
    • Fukata, M.1    Michelsen, K.S.2    Eri, R.3    Thomas, L.S.4    Hu, B.5    Lukasek, K.6
  • 151
    • 84966270957 scopus 로고    scopus 로고
    • MiR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
    • 1:CAS:528:DC%2BC28XnsVertrs%3D 27147225 4858750
    • Xu S, Tao Z, Hai B, Liang H, Shi Y, Wang T, et al. miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint. Nat Commun. 2016;7:11406.
    • (2016) Nat Commun , vol.7 , pp. 11406
    • Xu, S.1    Tao, Z.2    Hai, B.3    Liang, H.4    Shi, Y.5    Wang, T.6
  • 152
    • 84886443752 scopus 로고    scopus 로고
    • MicroRNAs in the tumour microenvironment: Big role for small players
    • 1:CAS:528:DC%2BC2cXnslKhsrk%3D 23878074
    • Soon P, Kiaris H. MicroRNAs in the tumour microenvironment: big role for small players. Endocr Relat Cancer. 2013;20:R257-67.
    • (2013) Endocr Relat Cancer , vol.20 , pp. R257-R267
    • Soon, P.1    Kiaris, H.2
  • 153
    • 84860218631 scopus 로고    scopus 로고
    • Intercellular communication: Diverse structures for exchange of genetic information
    • 1:CAS:528:DC%2BC38Xls1Wgtbk%3D 22510790 3738855
    • Mittelbrunn M, Sánchez-Madrid F. Intercellular communication: diverse structures for exchange of genetic information. Nat Rev Mol Cell Biol. 2012;13:328-35.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 328-335
    • Mittelbrunn, M.1    Sánchez-Madrid, F.2
  • 155
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • 1:CAS:528:DC%2BD1cXhsVentbfI 19011622 3423894
    • Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008;10:1470-6.
    • (2008) Nat Cell Biol , vol.10 , pp. 1470-1476
    • Skog, J.1    Würdinger, T.2    Van Rijn, S.3    Meijer, D.H.4    Gainche, L.5    Sena-Esteves, M.6
  • 157
    • 84862908547 scopus 로고    scopus 로고
    • Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
    • 1:CAS:528:DC%2BC38Xhs1Kjtb0%3D 22031862 3265200
    • Montecalvo A, Larregina AT, Shufesky WJ, Stolz DB, Sullivan ML, Karlsson JM, et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2012;119:756-66.
    • (2012) Blood , vol.119 , pp. 756-766
    • Montecalvo, A.1    Larregina, A.T.2    Shufesky, W.J.3    Stolz, D.B.4    Sullivan, M.L.5    Karlsson, J.M.6
  • 158
    • 69949117622 scopus 로고    scopus 로고
    • Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity
    • 1:CAS:528:DC%2BD1MXhtVKrsbnJ 19684575
    • Gibbings DJ, Ciaudo C, Erhardt M, Voinnet O. Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. Nat Cell Biol. 2009;11:1143-9.
    • (2009) Nat Cell Biol , vol.11 , pp. 1143-1149
    • Gibbings, D.J.1    Ciaudo, C.2    Erhardt, M.3    Voinnet, O.4
  • 159
    • 69949185018 scopus 로고    scopus 로고
    • Silencing by small RNAs is linked to endosomal trafficking
    • 1:CAS:528:DC%2BD1MXhtVKrsbjE 19684574 2737091
    • Lee YS, Pressman S, Andress AP, Kim K, White JL, Cassidy JJ, et al. Silencing by small RNAs is linked to endosomal trafficking. Nat Cell Biol. 2009;11:1150-6.
    • (2009) Nat Cell Biol , vol.11 , pp. 1150-1156
    • Lee, Y.S.1    Pressman, S.2    Andress, A.P.3    Kim, K.4    White, J.L.5    Cassidy, J.J.6
  • 160
    • 81055157988 scopus 로고    scopus 로고
    • Exosome secretion: Molecular mechanisms and roles in immune responses
    • 1:CAS:528:DC%2BC3MXhs1SqtrbJ 21645191
    • Bobrie A, Colombo M, Raposo G, Théry C. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic. 2011;12:1659-68.
    • (2011) Traffic , vol.12 , pp. 1659-1668
    • Bobrie, A.1    Colombo, M.2    Raposo, G.3    Théry, C.4
  • 161
    • 34548512488 scopus 로고    scopus 로고
    • Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory
    • 1:CAS:528:DC%2BD2sXpsFWksrw%3D 17591775 3636815
    • Bhatnagar S, Schorey JS. Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory. J Biol Chem. 2007;282:25779-89.
    • (2007) J Biol Chem , vol.282 , pp. 25779-25789
    • Bhatnagar, S.1    Schorey, J.S.2
  • 162
    • 84867334962 scopus 로고    scopus 로고
    • Cell-to-cell miRNA transfer: From body homeostasis to therapy Roxana
    • 1:CAS:528:DC%2BC38Xht12lsbrK 22903157
    • Redis RS, Calin S, Yang Y, You MJ, Calin GA. Cell-to-cell miRNA transfer: From body homeostasis to therapy Roxana. Pharmacol Ther. 2012;136:169-74.
    • (2012) Pharmacol Ther , vol.136 , pp. 169-174
    • Redis, R.S.1    Calin, S.2    Yang, Y.3    You, M.J.4    Calin, G.A.5
  • 163
    • 80053175966 scopus 로고    scopus 로고
    • Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells
    • 1:CAS:528:DC%2BC3MXhtleis7vM 21939504 3190352
    • Yang M, Chen J, Su F, Yu B, Su F, Lin L, et al. Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer. 2011;10:117.
    • (2011) Mol Cancer , vol.10 , pp. 117
    • Yang, M.1    Chen, J.2    Su, F.3    Yu, B.4    Su, F.5    Lin, L.6
  • 164
    • 84947073208 scopus 로고    scopus 로고
    • IL6 mediates immune and colorectal cancer cell crosstalk via miR-21 and miR-29b
    • Patel SA, Gooderham NJ. IL6 mediates immune and colorectal cancer cell crosstalk via miR-21 and miR-29b. Mol Cancer Res. 2015;3:1502-8.
    • (2015) Mol Cancer Res , vol.3 , pp. 1502-1508
    • Patel, S.A.1    Gooderham, N.J.2
  • 165
    • 84864503916 scopus 로고    scopus 로고
    • MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
    • 1:CAS:528:DC%2BC38Xhtleks7nE 22753494 3412003
    • Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A. 2012;109:E2110-16.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E2110-E2116
    • Fabbri, M.1    Paone, A.2    Calore, F.3    Galli, R.4    Gaudio, E.5    Santhanam, R.6
  • 166
    • 84926151514 scopus 로고    scopus 로고
    • Tumor-secreted miR-214 induces regulatory T cells: A major link between immune evasion and tumor growth
    • 1:CAS:528:DC%2BC2cXhsFyltr%2FO 25223704 4185347
    • Yin Y, Cai X, Chen X, Liang H, Zhang Y, Li J, et al. Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth. Cell Res. 2014;24:1164-80.
    • (2014) Cell Res , vol.24 , pp. 1164-1180
    • Yin, Y.1    Cai, X.2    Chen, X.3    Liang, H.4    Zhang, Y.5    Li, J.6
  • 167
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    • 1:CAS:528:DC%2BD1cXnvVOlu74%3D 18589210
    • Taylor DD, Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol. 2008;110:13-21.
    • (2008) Gynecol Oncol , vol.110 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 168
    • 42549128233 scopus 로고    scopus 로고
    • Circulating microparticles in breast cancer patients: A comparative analysis with established biomarkers
    • 1:CAS:528:DC%2BD1cXmt1eht7k%3D 18507061
    • Toth B, Nieuwland R, Liebhardt S, Ditsch N, Steinig K, Stieber P, et al. Circulating microparticles in breast cancer patients: a comparative analysis with established biomarkers. Anticancer Res. 2008;28:1107-12.
    • (2008) Anticancer Res , vol.28 , pp. 1107-1112
    • Toth, B.1    Nieuwland, R.2    Liebhardt, S.3    Ditsch, N.4    Steinig, K.5    Stieber, P.6
  • 169
    • 0242525678 scopus 로고    scopus 로고
    • T-cell apoptosis and suppression of T-Cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors
    • 1:CAS:528:DC%2BD3sXovVOgtbo%3D 14613988
    • Taylor DD, Gercel-Taylor C, Lyons KS, Stanson J, Whiteside TL. T-cell apoptosis and suppression of T-Cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors. Clin Cancer Res. 2003;9:5113-9.
    • (2003) Clin Cancer Res , vol.9 , pp. 5113-5119
    • Taylor, D.D.1    Gercel-Taylor, C.2    Lyons, K.S.3    Stanson, J.4    Whiteside, T.L.5
  • 170
    • 12944329896 scopus 로고    scopus 로고
    • Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes
    • 1:CAS:528:DC%2BD2MXht1ynsb0%3D 15709166
    • Kim JW, Wieckowski E, Taylor DD, Reichert TE, Watkins S, Whiteside TL. Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin Cancer Res. 2005;11:1010-20.
    • (2005) Clin Cancer Res , vol.11 , pp. 1010-1020
    • Kim, J.W.1    Wieckowski, E.2    Taylor, D.D.3    Reichert, T.E.4    Watkins, S.5    Whiteside, T.L.6
  • 171
    • 84906212452 scopus 로고    scopus 로고
    • Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma
    • 24978137 4170615
    • Ye SB, Li ZL, Luo DH, Huang BJ, Chen YS, Zhang XS, et al. Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. Oncotarget. 2014;5:5439-52.
    • (2014) Oncotarget , vol.5 , pp. 5439-5452
    • Ye, S.B.1    Li, Z.L.2    Luo, D.H.3    Huang, B.J.4    Chen, Y.S.5    Zhang, X.S.6
  • 172
    • 84890327208 scopus 로고    scopus 로고
    • MicroRNAs transfer from human macrophages to hepatocarcinoma cells and inhibit proliferation
    • 1:CAS:528:DC%2BC3sXhvV2lsb7I 24227773
    • Aucher A, Rudnicka D, Davis DM. MicroRNAs transfer from human macrophages to hepatocarcinoma cells and inhibit proliferation. J Immunol. 2013;191:6250-60.
    • (2013) J Immunol , vol.191 , pp. 6250-6260
    • Aucher, A.1    Rudnicka, D.2    Davis, D.M.3
  • 173
    • 4043127616 scopus 로고    scopus 로고
    • GATA-4 and MEF2C transcription factors control the tissue-specific expression of the alphaT-catenin gene CTNNA3
    • 1:CAS:528:DC%2BD2cXntFagur4%3D 15302915 514362
    • Vanpoucke G, Goossens S, De Craene B, Gilbert B, van Roy F, Berx G. GATA-4 and MEF2C transcription factors control the tissue-specific expression of the alphaT-catenin gene CTNNA3. Nucleic Acids Res. 2004;32:4155-65.
    • (2004) Nucleic Acids Res , vol.32 , pp. 4155-4165
    • Vanpoucke, G.1    Goossens, S.2    De Craene, B.3    Gilbert, B.4    Van Roy, F.5    Berx, G.6
  • 174
    • 0034741031 scopus 로고    scopus 로고
    • AlphaT-catenin: A novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion
    • 1:CAS:528:DC%2BD3MXnsFOhu7w%3D 11590244
    • Janssens B, Goossens S, Staes K, Gilbert B, van Hengel J, Colpaert C, et al. AlphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. J Cell Sci. 2001;114:3177-88.
    • (2001) J Cell Sci , vol.114 , pp. 3177-3188
    • Janssens, B.1    Goossens, S.2    Staes, K.3    Gilbert, B.4    Van Hengel, J.5    Colpaert, C.6
  • 175
    • 84908261279 scopus 로고    scopus 로고
    • Tumor-stromal cross talk: Direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes
    • 1:CAS:528:DC%2BC2cXhtlKrtr%2FN 24929208 4242806
    • Thayanithy V, Dickson EL, Steer C, Subramanian S, Lou E. Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes. Transl Res. 2014;164:359-65.
    • (2014) Transl Res , vol.164 , pp. 359-365
    • Thayanithy, V.1    Dickson, E.L.2    Steer, C.3    Subramanian, S.4    Lou, E.5
  • 176
    • 84919792381 scopus 로고    scopus 로고
    • MiRNA-based therapies: Strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents
    • 1:CAS:528:DC%2BC2cXitVyltr%2FP 25495987 4417715
    • Baumann V, Winkler J. miRNA-based therapies: strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents. Future Med Chem. 2014;6:1967-84.
    • (2014) Future Med Chem , vol.6 , pp. 1967-1984
    • Baumann, V.1    Winkler, J.2
  • 177
  • 178
    • 79953202455 scopus 로고    scopus 로고
    • Silencing of microRNA families by seed-targeting tiny LNAs
    • 1:CAS:528:DC%2BC3MXjsVOju7c%3D
    • Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, et al. Silencing of microRNA families by seed-targeting tiny LNAs. Nat Gen. 2011;43:371-8.
    • (2011) Nat Gen , vol.43 , pp. 371-378
    • Obad, S.1    Dos Santos, C.O.2    Petri, A.3    Heidenblad, M.4    Broom, O.5    Ruse, C.6
  • 179
    • 77649275464 scopus 로고    scopus 로고
    • MiR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
    • 1:CAS:528:DC%2BC3cXisFems7g%3D 20173740 2845545
    • Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, et al. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol. 2010;12:247-56.
    • (2010) Nat Cell Biol , vol.12 , pp. 247-256
    • Ma, L.1    Young, J.2    Prabhala, H.3    Pan, E.4    Mestdagh, P.5    Muth, D.6
  • 181
    • 77956476392 scopus 로고
    • MicroRNAs: Synthesis, mechanism, function, and recent clinical trials
    • Wahid F, Shehzad A, Khan T, Kim YY. MicroRNAs: synthesis, mechanism, function, and recent clinical trials. Biochim Biophys Acta. 1803;2010:1231-43.
    • (1803) Biochim Biophys Acta , vol.2010 , pp. 1231-1243
    • Wahid, F.1    Shehzad, A.2    Khan, T.3    Kim, Y.Y.4
  • 182
    • 67650744372 scopus 로고    scopus 로고
    • Immune therapy for cancer
    • 1:CAS:528:DC%2BD1MXlsFSlsbo%3D 19007331
    • Dougan M, Dranoff G. Immune therapy for cancer. Annu Rev Immunol. 2009;27:83-117.
    • (2009) Annu Rev Immunol , vol.27 , pp. 83-117
    • Dougan, M.1    Dranoff, G.2
  • 183
    • 77951614830 scopus 로고    scopus 로고
    • Monoclonal antibodies: Versatile platforms for cancer immunotherapy
    • 1:CAS:528:DC%2BC3cXltV2kurg%3D 20414205 3508064
    • Weiner LM, Surana R, Wang S. Monoclonal antibodies: versatile platforms for cancer immunotherapy. Nat Rev Immunol. 2010;10:317-27.
    • (2010) Nat Rev Immunol , vol.10 , pp. 317-327
    • Weiner, L.M.1    Surana, R.2    Wang, S.3
  • 184
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • 10430624 2195583
    • van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med. 1999;190:355-66.
    • (1999) J Exp Med , vol.190 , pp. 355-366
    • Van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 185
    • 33646794392 scopus 로고    scopus 로고
    • Checkpoint blockade in cancer immunotherapy
    • 1:CAS:528:DC%2BD1cXhsVCju74%3D 16730267 1951510
    • Korman AJ, Peggs KS, Allison JP. Checkpoint blockade in cancer immunotherapy. Adv Immunol. 2006;90:297-339.
    • (2006) Adv Immunol , vol.90 , pp. 297-339
    • Korman, A.J.1    Peggs, K.S.2    Allison, J.P.3
  • 186
    • 36849035139 scopus 로고    scopus 로고
    • Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): A novel strategy for the treatment of melanoma and other malignancies
    • 18000991
    • O'Day SJ, Hamid O, Urba WJ. Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): a novel strategy for the treatment of melanoma and other malignancies. Cancer. 2007;110:2614-27.
    • (2007) Cancer , vol.110 , pp. 2614-2627
    • O'Day, S.J.1    Hamid, O.2    Urba, W.J.3
  • 187
    • 34848900497 scopus 로고    scopus 로고
    • Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs
    • 1:CAS:528:DC%2BD2sXhtFSrtrrP 17898045
    • Wong RM, Scotland RR, Lau RL, Wang C, Korman AJ, Kast WM, et al. Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs. Int Immunol. 2007;19:1223-34.
    • (2007) Int Immunol , vol.19 , pp. 1223-1234
    • Wong, R.M.1    Scotland, R.R.2    Lau, R.L.3    Wang, C.4    Korman, A.J.5    Kast, W.M.6
  • 188
    • 49649114804 scopus 로고    scopus 로고
    • Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
    • 1:CAS:528:DC%2BD1cXmtVCmtbw%3D 18483370
    • Berger R, Rotem-Yehudar R, Slama G, Landes S, Kneller A, Leiba M, et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res. 2008;14:3044-51.
    • (2008) Clin Cancer Res , vol.14 , pp. 3044-3051
    • Berger, R.1    Rotem-Yehudar, R.2    Slama, G.3    Landes, S.4    Kneller, A.5    Leiba, M.6
  • 189
    • 84896793649 scopus 로고    scopus 로고
    • Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer
    • 1:CAS:528:DC%2BC2cXivFyitrY%3D 24565525
    • Deng X, Cao M, Zhang J, Hu K, Yin Z, Zhou Z, et al. Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer. Biomaterials. 2014;35:4333-44.
    • (2014) Biomaterials , vol.35 , pp. 4333-4344
    • Deng, X.1    Cao, M.2    Zhang, J.3    Hu, K.4    Yin, Z.5    Zhou, Z.6
  • 190
    • 84901660489 scopus 로고    scopus 로고
    • A versatile RNA-interference nanoplatform for systemic delivery of RNAs
    • 1:CAS:528:DC%2BC2cXntFOgtL0%3D 24779637 4046792
    • Choi KY, Silvestre OF, Huang X, Min KH, Howard GP, Hida N, et al. A versatile RNA-interference nanoplatform for systemic delivery of RNAs. ACS Nano. 2014;8:4559-70.
    • (2014) ACS Nano , vol.8 , pp. 4559-4570
    • Choi, K.Y.1    Silvestre, O.F.2    Huang, X.3    Min, K.H.4    Howard, G.P.5    Hida, N.6
  • 191
    • 84875140612 scopus 로고    scopus 로고
    • Functionalized graphene oxide mediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro
    • 1:CAS:528:DC%2BC3sXlt1Cru7g%3D 23527297 3603917
    • Zhi F, Dong H, Jia X, Guo W, Lu H, Yang Y, et al. Functionalized graphene oxide mediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro. PLoS One. 2013;8:e60034.
    • (2013) PLoS One , vol.8 , pp. e60034
    • Zhi, F.1    Dong, H.2    Jia, X.3    Guo, W.4    Lu, H.5    Yang, Y.6
  • 192
    • 84891372908 scopus 로고    scopus 로고
    • Star-branched amphiphilic PLA-b-PDMAEMA copolymers for co-delivery of miR-21 inhibitor and doxorubicin to treat glioma
    • 1:CAS:528:DC%2BC3sXhvFCqtL7N 24332459
    • Qian X, Long L, Shi Z, Liu C, Qiu M, Sheng J, et al. Star-branched amphiphilic PLA-b-PDMAEMA copolymers for co-delivery of miR-21 inhibitor and doxorubicin to treat glioma. Biomaterials. 2014;35:2322-35.
    • (2014) Biomaterials , vol.35 , pp. 2322-2335
    • Qian, X.1    Long, L.2    Shi, Z.3    Liu, C.4    Qiu, M.5    Sheng, J.6
  • 193
    • 84859386994 scopus 로고    scopus 로고
    • Reprogramming tumor-associated dendritic cells in vivo using microRNA mimetics triggers protective immunity against ovarian cancer
    • 1:CAS:528:DC%2BC38XkvVelsLg%3D 22307839 3319850
    • Cubillos-Ruiz JR, Baird JR, Tesone AJ, Rutkowski MR, Scarlett UK, Camposeco-Jacobs AL, et al. Reprogramming tumor-associated dendritic cells in vivo using microRNA mimetics triggers protective immunity against ovarian cancer. Cancer Res. 2012;72:1683-93.
    • (2012) Cancer Res , vol.72 , pp. 1683-1693
    • Cubillos-Ruiz, J.R.1    Baird, J.R.2    Tesone, A.J.3    Rutkowski, M.R.4    Scarlett, U.K.5    Camposeco-Jacobs, A.L.6
  • 194
    • 84871516015 scopus 로고    scopus 로고
    • MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment
    • 1:CAS:528:DC%2BC38XhvVCiu7%2FP 23230184 3531831
    • Chou J, Werb Z. MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment. Cancer Discov. 2012;2:1078-80.
    • (2012) Cancer Discov , vol.2 , pp. 1078-1080
    • Chou, J.1    Werb, Z.2
  • 195
    • 84871528926 scopus 로고    scopus 로고
    • MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer
    • 1:CAS:528:DC%2BC38XhvVCiu7zP 23171795 3685866
    • Mitra AK, Zillhardt M, Hua Y, Tiwari P, Murmann AE, Peter ME, et al. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov. 2012;2:1100-8.
    • (2012) Cancer Discov , vol.2 , pp. 1100-1108
    • Mitra, A.K.1    Zillhardt, M.2    Hua, Y.3    Tiwari, P.4    Murmann, A.E.5    Peter, M.E.6
  • 196
    • 84864279381 scopus 로고    scopus 로고
    • Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2
    • 1:CAS:528:DC%2BC38XhtVeks7%2FN 22710123
    • Wu Z, Lu H, Sheng J, Li L. Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2. FEBS Lett. 2012;586:2459-67.
    • (2012) FEBS Lett , vol.586 , pp. 2459-2467
    • Wu, Z.1    Lu, H.2    Sheng, J.3    Li, L.4
  • 197
    • 22244459917 scopus 로고    scopus 로고
    • Gene therapy: Twenty-first century medicine
    • 1:CAS:528:DC%2BD2MXpsVensLc%3D 15952901
    • Verma IM, Weitzman MD. Gene therapy: twenty-first century medicine. Annu Rev Biochem. 2005;74:711-38.
    • (2005) Annu Rev Biochem , vol.74 , pp. 711-738
    • Verma, I.M.1    Weitzman, M.D.2
  • 198
    • 84920767728 scopus 로고    scopus 로고
    • Therapeutic applications of extracellular vesicles: Clinical promise and open questions
    • 25292428
    • György B, Hung ME, Breakefield XO, Leonard JN. Therapeutic applications of extracellular vesicles: clinical promise and open questions. Annu Rev Pharmacol Toxicol. 2015;55:439-64.
    • (2015) Annu Rev Pharmacol Toxicol , vol.55 , pp. 439-464
    • György, B.1    Hung, M.E.2    Breakefield, X.O.3    Leonard, J.N.4
  • 199
    • 84871923602 scopus 로고    scopus 로고
    • Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells
    • 1:CAS:528:DC%2BC38XhsVegsb7P 23032975
    • Ohno S, Takanashi M, Sudo K, Ueda S, Ishikawa A, Matsuyama N, et al. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther. 2013;21:185-911.
    • (2013) Mol Ther , vol.21 , pp. 185-911
    • Ohno, S.1    Takanashi, M.2    Sudo, K.3    Ueda, S.4    Ishikawa, A.5    Matsuyama, N.6
  • 200
    • 84896818399 scopus 로고    scopus 로고
    • Regulation of immune responses by extracellular vesicles
    • 1:CAS:528:DC%2BC2cXivFyhtbg%3D 24566916 4350779
    • Robbins PD, Morelli AE. Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 2014;14:195-208.
    • (2014) Nat Rev Immunol , vol.14 , pp. 195-208
    • Robbins, P.D.1    Morelli, A.E.2
  • 201
    • 14844334129 scopus 로고    scopus 로고
    • Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
    • 1:CAS:528:DC%2BD2MXhtFWgsro%3D 15655551 2361848
    • Taylor DD, Gercel-Taylor C. Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br J Cancer. 2005;92:305-11.
    • (2005) Br J Cancer , vol.92 , pp. 305-311
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 202
    • 84862117665 scopus 로고    scopus 로고
    • Recent advances on the role of tumor exosomes in immunosuppression and disease progression
    • 1:CAS:528:DC%2BC38XosVKjtbc%3D 22369922
    • Filipazzi P, Burdek M, Villa A, Rivoltini L, Huber V. Recent advances on the role of tumor exosomes in immunosuppression and disease progression. Semin Cancer Biol. 2012;22:342-9.
    • (2012) Semin Cancer Biol , vol.22 , pp. 342-349
    • Filipazzi, P.1    Burdek, M.2    Villa, A.3    Rivoltini, L.4    Huber, V.5
  • 203
    • 84911966357 scopus 로고    scopus 로고
    • Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis
    • 1:CAS:528:DC%2BC2cXhvVantbbM 25446899 4254633
    • Melo SA, Sugimoto H, O'Connell JT, Kato N, Villanueva A, Vidal A. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell. 2014;26:707-21.
    • (2014) Cancer Cell , vol.26 , pp. 707-721
    • Melo, S.A.1    Sugimoto, H.2    O'Connell, J.T.3    Kato, N.4    Villanueva, A.5    Vidal, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.