메뉴 건너뛰기




Volumn 21, Issue 3, 2011, Pages 264-275

Molecular pathways in cancer-related inflammation;Molekularni putovi u upali povezanoj s karcinomom

Author keywords

Cancer related inflammation; Chemokines; Cytokines; Macrophages

Indexed keywords

CHEMOKINE; CYTOKINE; HYPOXIA INDUCIBLE FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 23; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR SUPPRESSOR PROTEIN; VON HIPPEL LINDAU PROTEIN;

EID: 80054751308     PISSN: 13300962     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (154)

References (120)
  • 1
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001;357:539-5.
    • (2001) Lancet , vol.357 , pp. 535-539
    • Balkwill, F.1    Mantovani, A.2
  • 3
    • 77950825019 scopus 로고    scopus 로고
    • Molecular pathways and targets in cancer-related inflammation
    • Mantovani A, Garlanda C, Allavena P. Molecular pathways and targets in cancer-related inflammation. Ann Med 2010;42:161-70.
    • (2010) Ann Med , vol.42 , pp. 161-170
    • Mantovani, A.1    Garlanda, C.2    Allavena, P.3
  • 4
    • 78650825618 scopus 로고    scopus 로고
    • Effect of daily aspirin on long-term risk of death due to cancer: Analysis of individual patient data from randomised trials
    • Rothwell PM, Fowkes FG, Belch JF, Ogawa H, Warlow CP, Meade TW. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 2011;377:31-41.
    • (2011) Lancet , vol.377 , pp. 31-41
    • Rothwell, P.M.1    Fowkes, F.G.2    Belch, J.F.3    Ogawa, H.4    Warlow, C.P.5    Meade, T.W.6
  • 5
    • 77649090075 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and cancer treatment: Understanding the risk should be worth the reward
    • Menter DG, Schilsky RL, DuBois RN. Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward. Clin Cancer Res 2010;16:1384-90.
    • (2010) Clin Cancer Res , vol.16 , pp. 1384-1390
    • Menter, D.G.1    Schilsky, R.L.2    Dubois, R.N.3
  • 6
    • 70450218687 scopus 로고    scopus 로고
    • Colorectal carcinoma: Importance of colonic environment for anti-cancer response and systemic immunity
    • Vannucci L, Stepankova R, Grobarova V, Kozakova H, Ros-smann P, Klimesova K, et al. Colorectal carcinoma: Importance of colonic environment for anti-cancer response and systemic immunity. J Immunotoxicol 2009;6:217-26.
    • (2009) J Immunotoxicol , vol.6 , pp. 217-226
    • Vannucci, L.1    Stepankova, R.2    Grobarova, V.3    Kozakova, H.4    Ros-Smann, P.5    Klimesova, K.6
  • 7
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation ofHI-F-1alpha
    • Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation ofHI-F-1alpha. Nature 2008;453:807-11.
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1    Guma, M.2    Schachtrup, C.3    Akassoglou, K.4    Zinkernagel, A.S.5    Nizet, V.6
  • 8
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009;9:798-09.
    • (2009) Nat Rev Cancer , vol.9 , pp. 709-798
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 10
    • 58149231380 scopus 로고    scopus 로고
    • Cancer: Inflaming metastasis
    • Mantovani A. Cancer: Inflaming metastasis. Nature 2009;457:36-7.
    • (2009) Nature , vol.457 , pp. 36-37
    • Mantovani, A.1
  • 11
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 1642320337 scopus 로고    scopus 로고
    • Proinflammatory mediators and genetic background in oncogene mediated tumor progression
    • Russell JP, Engiles JB, Rothstein JL. Proinflammatory mediators and genetic background in oncogene mediated tumor progression. J Immunol 2004;172:4059-67.
    • (2004) J Immunol , vol.172 , pp. 4059-4067
    • Russell, J.P.1    Engiles, J.B.2    Rothstein, J.L.3
  • 14
    • 0043170839 scopus 로고    scopus 로고
    • Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic fac to rs
    • Russell JP, Shinohara S, Melillo RM, Castellone MD, Santo-ro M, Rothstein JL. Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic fac to rs. Oncoge ne 2003;22:4569-77.
    • (2003) Oncoge Ne , vol.22 , pp. 4569-4577
    • Russell, J.P.1    Shinohara, S.2    Melillo, R.M.3    Castellone, M.D.4    Santo-Ro, M.5    Rothstein, J.L.6
  • 15
    • 34548028445 scopus 로고    scopus 로고
    • Molecular profiling of matched samples identifies biomarkers of papillary thyroid carcinoma lymph node metastasis
    • Cerutti JM, Oler G, Michaluart P, Delcelo R, Beaty RM, Shoemaker J, Riggins GJ. Molecular profiling of matched samples identifies biomarkers of papillary thyroid carcinoma lymph node metastasis. Cancer Res 2007;67:7885-92.
    • (2007) Cancer Res , vol.67 , pp. 7885-7892
    • Cerutti, J.M.1    Oler, G.2    Michaluart, P.3    Delcelo, R.4    Beaty, R.M.5    Shoemaker, J.6    Riggins, G.J.7
  • 16
    • 37549044300 scopus 로고    scopus 로고
    • Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferen-tiated thyroid cancer
    • De Falco V, Guarino V, Avilla E, Castellone MD, Salerno P, Salvatore G, et al. Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferen-tiated thyroid cancer. Cancer Res 2007;67:11821-9.
    • (2007) Cancer Res , vol.67 , pp. 11821-11829
    • de Falco, V.1    Guarino, V.2    Avilla, E.3    Castellone, M.D.4    Salerno, P.5    Salvatore, G.6
  • 17
    • 34447121976 scopus 로고    scopus 로고
    • EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-ac-tivated protein kinase-dependent activation of the Sp1/ Sp3 tran scrip tion facto rs in hu man glio mas
    • Xu K, Shu HK. EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-ac-tivated protein kinase-dependent activation of the Sp1/ Sp3 tran scrip tion facto rs in hu man glio mas. Can cer Res 2007;67:6121-9.
    • (2007) Can Cer Res , vol.67 , pp. 6121-6129
    • Xu, K.1    Shu, H.K.2
  • 18
    • 33751196812 scopus 로고    scopus 로고
    • MIP-1alpha (CCL3) is a downstream target of FG-FR3 and RAS-MAPK signaling in multiple myeloma
    • Masih-Khan E, Trudel S, Heise C, Li Z, Paterson J, Nadeem V, et al. MIP-1alpha (CCL3) is a downstream target of FG-FR3 and RAS-MAPK signaling in multiple myeloma. Blood 2006;108:3465-71.
    • (2006) Blood , vol.108 , pp. 3465-3471
    • Masih-Khan, E.1    Trudel, S.2    Heise, C.3    Li, Z.4    Paterson, J.5    Nadeem, V.6
  • 19
    • 33645850713 scopus 로고    scopus 로고
    • CXCL1 induced by prostaglandin E2 promotes angiogene-sis in colorectal cancer
    • Wang D, Wang H, Brown J, Daikoku T, Ning W, Shi Q, et al. CXCL1 induced by prostaglandin E2 promotes angiogene-sis in colorectal cancer. J Exp Med 2006;203:941-51.
    • (2006) J Exp Med , vol.203 , pp. 941-951
    • Wang, D.1    Wang, H.2    Brown, J.3    Daikoku, T.4    Ning, W.5    Shi, Q.6
  • 20
    • 33847419143 scopus 로고    scopus 로고
    • Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    • Guerra C, Schuhmacher AJ, Canamero M, Grippo PJ, Verda-guer L, Perez-Gallego L, et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 2007;11:291-02.
    • (2007) Cancer Cell , vol.11 , pp. 202-291
    • Guerra, C.1    Schuhmacher, A.J.2    Canamero, M.3    Grippo, P.J.4    Verda-Guer, L.5    Perez-Gallego, L.6
  • 21
    • 33745859743 scopus 로고    scopus 로고
    • The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
    • Sumimoto H, Imabayashi F, Iwata T, Kawakami Y. The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J Exp Med 2006;203:1651-6.
    • (2006) J Exp Med , vol.203 , pp. 1651-1656
    • Sumimoto, H.1    Imabayashi, F.2    Iwata, T.3    Kawakami, Y.4
  • 22
    • 34948852371 scopus 로고    scopus 로고
    • Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
    • Soucek L, Lawlor ER, Soto D, Shchors K, Swigart LB, Evan GI. Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med 2007;13:1211-8.
    • (2007) Nat Med , vol.13 , pp. 1211-1218
    • Soucek, L.1    Lawlor, E.R.2    Soto, D.3    Shchors, K.4    Swigart, L.B.5    Evan, G.I.6
  • 23
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005;7:211-7.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 25
    • 37349100945 scopus 로고    scopus 로고
    • Abrogation ofTGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
    • Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, et al. Abrogation ofTGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 2008;13:23-35.
    • (2008) Cancer Cell , vol.13 , pp. 23-35
    • Yang, L.1    Huang, J.2    Ren, X.3    Gorska, A.E.4    Chytil, A.5    Aakre, M.6
  • 26
    • 33144490246 scopus 로고    scopus 로고
    • Links between alpha-catenin, NF-kap-paB, and squamous cell carcinoma in skin
    • Kobielak A, Fuchs E. Links between alpha-catenin, NF-kap-paB, and squamous cell carcinoma in skin. Proc Natl Acad Sci U S A 2006;103:2322-7.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2322-2327
    • Kobielak, A.1    Fuchs, E.2
  • 27
    • 43549109264 scopus 로고    scopus 로고
    • The tumor suppressor semapho-rin 3B triggers a prometastatic program mediated by in-terleukin 8 and the tumor microenvironment
    • Rolny C, Capparuccia L, Casazza A, Mazzone M, Valla-rio A, Cignetli A, et al. The tumor suppressor semapho-rin 3B triggers a prometastatic program mediated by in-terleukin 8 and the tumor microenvironment. J Exp Med 2008;205:1155-71.
    • (2008) J Exp Med , vol.205 , pp. 1155-1171
    • Rolny, C.1    Capparuccia, L.2    Casazza, A.3    Mazzone, M.4    Valla-Rio, A.5    Cignetli, A.6
  • 28
    • 33845348208 scopus 로고    scopus 로고
    • Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts
    • Moskovits N, Kalinkovich A, Bar J, Lapidot T, Oren M. p53 Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts. Cancer Res 2006;66:10671-6.
    • (2006) Cancer Res , vol.66
    • Moskovits, N.1    Kalinkovich, A.2    Bar, J.3    Lapidot, T.4    Oren, M.5
  • 29
  • 30
    • 77956905415 scopus 로고    scopus 로고
    • Dual roles for immunity in gastrointestinal cancers
    • Ferrone C, Dranoff G. Dual roles for immunity in gastrointestinal cancers. J Clin Oncol 2010;28:4045-51.
    • (2010) J Clin Oncol , vol.28 , pp. 4045-4051
    • Ferrone, C.1    Dranoff, G.2
  • 31
    • 38849171267 scopus 로고    scopus 로고
    • Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
    • Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Ka-neko S, etal. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest 2008;118:560-70.
    • (2008) J Clin Invest , vol.118 , pp. 560-570
    • Popivanova, B.K.1    Kitamura, K.2    Wu, Y.3    Kondo, T.4    Kagaya, T.5    Ka-Neko, S.6
  • 32
    • 77956631799 scopus 로고    scopus 로고
    • Lung injury and cancer: Mechanistic insights into ceramide and eGfR signaling under cigarette smoke
    • Goldkorn T, Filosto S. Lung injury and cancer: Mechanistic insights into ceramide and eGfR signaling under cigarette smoke. Am J Respir Cell Mol Biol 2010;43:259-68.
    • (2010) Am J Respir Cell Mol Biol , vol.43 , pp. 259-268
    • Goldkorn, T.1    Filosto, S.2
  • 33
    • 68849111316 scopus 로고    scopus 로고
    • Current concepts on the role of inflammation in COPD and lung cancer
    • Yao H, Rahman I. Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol 2009;9:375-83.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 375-383
    • Yao, H.1    Rahman, I.2
  • 35
    • 79952712223 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species drive proinflammatory cytokine production
    • Naik E, Dixit VM. Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med 2011;208:417-20.
    • (2011) J Exp Med , vol.208 , pp. 417-420
    • Naik, E.1    Dixit, V.M.2
  • 36
    • 78651393239 scopus 로고    scopus 로고
    • A rote for mitochondria in NLRP3 inflammasome activation
    • Zhou R, Yazdi AS, Menu P, Tschopp J. A rote for mitochondria in NLRP3 inflammasome activation. Nature 2011;469:221-5.
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 37
    • 77951432631 scopus 로고    scopus 로고
    • The causes of cancer revisited: Mitochondrial malignancy and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy
    • Ralph SJ, Rodriguez-Enriquez S, Neuzil J, Saavedra E, Moreno-Sanchez R. The causes of cancer revisited: mitochondrial malignancy and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy. Mol Aspects Med 2010;31:145-70.
    • (2010) Mol Aspects Med , vol.31 , pp. 145-170
    • Ralph, S.J.1    Rodriguez-Enriquez, S.2    Neuzil, J.3    Saavedra, E.4    Moreno-Sanchez, R.5
  • 38
    • 34147180434 scopus 로고    scopus 로고
    • Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
    • Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, Mo-risawa T, et al. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med 2007;13:470-6.
    • (2007) Nat Med , vol.13 , pp. 470-476
    • Matsumoto, Y.1    Marusawa, H.2    Kinoshita, K.3    Endo, Y.4    Kou, T.5    Mo-Risawa, T.6
  • 39
    • 40949132893 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma
    • Komori J, Marusawa H, Machimoto T, Endo Y, Kinoshita K, KouT,etal. Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma. He-pa to lo gy 2008;47:888-96.
    • (2008) He-pa to Lo Gy , vol.47 , pp. 888-896
    • Komori, J.1    Marusawa, H.2    Machimoto, T.3    Endo, Y.4    Kinoshita, K.5    Kou, T.6
  • 40
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and prog res sion
    • Karin M. Nuclear factor-kappaB in cancer development and prog res sion. Na tu re 2006;441:431-6.
    • (2006) Na Tu Re , vol.441 , pp. 431-436
    • Karin, M.1
  • 43
    • 4644324186 scopus 로고    scopus 로고
    • NF-kappaB functions as a tumour promoter in inflammation-associated cancer
    • Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004;431:461-6.
    • (2004) Nature , vol.431 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3    Abramovitch, R.4    Amit, S.5    Kasem, S.6
  • 44
    • 77953908026 scopus 로고    scopus 로고
    • Inhibitor ofkappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression
    • Sakamoto K, Hikiba Y, Nakagawa H, Hayakawa Y, Yanai A, Akanuma M, et al. Inhibitor ofkappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression. Gastroenterology 2010;139:226-38.
    • (2010) Gastroenterology , vol.139 , pp. 226-238
    • Sakamoto, K.1    Hikiba, Y.2    Nakagawa, H.3    Hayakawa, Y.4    Yanai, A.5    Akanuma, M.6
  • 45
    • 35348904953 scopus 로고    scopus 로고
    • RSUME, a small RWD-con-taining protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia
    • Carbia-Nagashima A, Gerez J, Perez-Castro C, Paez-Pereda M, Silberstein S, Stalla GK, et al. RSUME, a small RWD-con-taining protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell 2007;131:309-23.
    • (2007) Cell , vol.131 , pp. 309-323
    • Carbia-Nagashima, A.1    Gerez, J.2    Perez-Castro, C.3    Paez-Pereda, M.4    Silberstein, S.5    Stalla, G.K.6
  • 46
    • 0347334750 scopus 로고    scopus 로고
    • IL-1beta-media-ted up-regutation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
    • Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. IL-1beta-media-ted up-regutation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 2003;17:2115-7.
    • (2003) FASEB J , vol.17 , pp. 2115-2117
    • Jung, Y.J.1    Isaacs, J.S.2    Lee, S.3    Trepel, J.4    Neckers, L.5
  • 47
    • 34447118220 scopus 로고    scopus 로고
    • Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family
    • Garlanda C, Riva F, Veliz T, Polentarutti N, Pasqualini F, Ra-daelli E, et al. Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family. Cancer Res 2007; 67:6017-21.
    • (2007) Cancer Res , vol.67 , pp. 6017-6021
    • Garlanda, C.1    Riva, F.2    Veliz, T.3    Polentarutti, N.4    Pasqualini, F.5    Ra-Daelli, E.6
  • 48
    • 34247175428 scopus 로고    scopus 로고
    • The To-ll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis
    • Xiao H, Gulen F, Qin J, Yao J, Bulek K, Kish D, et al. The To-ll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis. Immuni ty 2007;26:461-75.
    • (2007) Immuni Ty , vol.26 , pp. 461-475
    • Xiao, H.1    Gulen, F.2    Qin, J.3    Yao, J.4    Bulek, K.5    Kish, D.6
  • 49
    • 49249109576 scopus 로고    scopus 로고
    • Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens
    • Lech M, Kulkarni OP, Pfeiffer S, Savarese E, Krug A, Garlanda C, et al. Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. J Exp Med 2008;205:1879-88.
    • (2008) J Exp Med , vol.205 , pp. 1879-1888
    • Lech, M.1    Kulkarni, O.P.2    Pfeiffer, S.3    Savarese, E.4    Krug, A.5    Garlanda, C.6
  • 52
    • 33344460032 scopus 로고    scopus 로고
    • A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation)
    • Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Siro-ni M, et al. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood 2006;107:2112-22.
    • (2006) Blood , vol.107 , pp. 2112-2122
    • Biswas, S.K.1    Gangi, L.2    Paul, S.3    Schioppa, T.4    Saccani, A.5    Siro-Ni, M.6
  • 53
    • 77957735624 scopus 로고    scopus 로고
    • Role of tumour-associated macrophages in cancer-related inflammation
    • Sica A. Role of tumour-associated macrophages in cancer-related inflammation. Exp Oncol 2010;32:153-8.
    • (2010) Exp Oncol , vol.32 , pp. 153-158
    • Sica, A.1
  • 55
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005;11:1314-21.
    • (2005) Nat Med , vol.11 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3    Wei, S.4    Zhang, S.5    Pilon-Thomas, S.6
  • 56
    • 0032983865 scopus 로고    scopus 로고
    • Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis
    • Moore RJ, Owens DM, Stamp G, Arnott C, Burke F, East N, et al. Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat Med 1999;5:828-31.
    • (1999) Nat Med , vol.5 , pp. 828-831
    • Moore, R.J.1    Owens, D.M.2    Stamp, G.3    Arnott, C.4    Burke, F.5    East, N.6
  • 57
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer 2009;9:361-71.
    • (2009) Nat Rev Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 58
    • 23244451640 scopus 로고    scopus 로고
    • Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK
    • Hagemann T, Wilson J, Kulbe H, Li NF, Leinster DA, Charles K, et al. Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK. J Immunol 2005;175:1197-05.
    • (2005) J Immunol , vol.175 , pp. 1105-1197
    • Hagemann, T.1    Wilson, J.2    Kulbe, H.3    Li, N.F.4    Leinster, D.A.5    Charles, K.6
  • 59
    • 70349668946 scopus 로고    scopus 로고
    • The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans
    • Charles KA, Kulbe H, Soper R, Escorcio-Correia M, Lawrence T, Schultheis A, et al. The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans. J Clin Invest 2009;119:3011-23.
    • (2009) J Clin Invest , vol.119 , pp. 3011-3023
    • Charles, K.A.1    Kulbe, H.2    Soper, R.3    Escorcio-Correia, M.4    Lawrence, T.5    Schultheis, A.6
  • 60
    • 33846682591 scopus 로고    scopus 로고
    • The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells
    • Kulbe H, Thompson R, Wilson JL, Robinson S, Hagemann T, Fatah R, et al. The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. Cancer Res 2007;67:585-92.
    • (2007) Cancer Res , vol.67 , pp. 585-592
    • Kulbe, H.1    Thompson, R.2    Wilson, J.L.3    Robinson, S.4    Hagemann, T.5    Fatah, R.6
  • 61
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002;23:549-55.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 62
    • 33645991795 scopus 로고    scopus 로고
    • Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy
    • Sica A, Schioppa T, Mantovani A, Allavena A. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 2006;42:717-27.
    • (2006) Eur J Cancer , vol.42 , pp. 717-727
    • Sica, A.1    Schioppa, T.2    Mantovani, A.3    Allavena, A.4
  • 63
    • 47049116663 scopus 로고    scopus 로고
    • Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells
    • Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamu-ra S, et al. Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells. EMBO J 2008;27:1671-81.
    • (2008) EMBO J , vol.27 , pp. 1671-1681
    • Oguma, K.1    Oshima, H.2    Aoki, M.3    Uchio, R.4    Naka, K.5    Nakamu-Ra, S.6
  • 64
    • 35648936526 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha as a new target for renal cetl carcinoma: Two sequential phase II trials of infliximab at standard and high dose
    • Harrison ML, Obermuelter E, Maisey NR, Hoare S, Edmonds K, Li NF, et al. Tumor necrosis factor alpha as a new target for renal cetl carcinoma: two sequential phase II trials of infliximab at standard and high dose. J Clin Oncol 2007;25:4542-9.
    • (2007) J Clin Oncol , vol.25 , pp. 4542-4549
    • Harrison, M.L.1    Obermuelter, E.2    Maisey, N.R.3    Hoare, S.4    Edmonds, K.5    Li, N.F.6
  • 65
    • 46749137580 scopus 로고    scopus 로고
    • Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3
    • Chang YC, Chen TC, Lee CT, Yang CY, Wang HW, Wang CC, Hsieh SL. Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3. Blood 2008;111:5054-63.
    • (2008) Blood , vol.111 , pp. 5054-5063
    • Chang, Y.C.1    Chen, T.C.2    Lee, C.T.3    Yang, C.Y.4    Wang, H.W.5    Wang, C.C.6    Hsieh, S.L.7
  • 66
    • 0025311435 scopus 로고
    • Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice
    • Giavazzi R, Garofalo A, Bani MR, Abbate M, Ghezzi P, Boras-chi D, et al. Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice. Cancer Res 1990;50:4771-5.
    • (1990) Cancer Res , vol.50 , pp. 4771-4775
    • Giavazzi, R.1    Garofalo, A.2    Bani, M.R.3    Abbate, M.4    Ghezzi, P.5    Boras-Chi, D.6
  • 67
    • 34247274248 scopus 로고    scopus 로고
    • Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin
    • Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Go-nias SL, et al. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature 2007;446:690-4.
    • (2007) Nature , vol.446 , pp. 690-694
    • Luo, J.L.1    Tan, W.2    Ricono, J.M.3    Korchynskyi, O.4    Zhang, M.5    Go-Nias, S.L.6
  • 68
    • 34047246527 scopus 로고    scopus 로고
    • Direct visualization of macrophage-assisted tumor cell in tra vasa tion in mam ma ry tu mo rs
    • Wyckoff JB, Wang Y, Lin EY, Li JF, Goswami S, Stanley ER, et al. Direct visualization of macrophage-assisted tumor cell in tra vasa tion in mam ma ry tu mo rs. Can cer Res 2007;67:2649-56.
    • (2007) Can Cer Res , vol.67 , pp. 2649-2656
    • Wyckoff, J.B.1    Wang, Y.2    Lin, E.Y.3    Li, J.F.4    Goswami, S.5    Stanley, E.R.6
  • 70
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006;124:263-6.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 71
    • 58149269348 scopus 로고    scopus 로고
    • Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
    • Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Luo JL, et al. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 2009;457:102-6.
    • (2009) Nature , vol.457 , pp. 102-106
    • Kim, S.1    Takahashi, H.2    Lin, W.W.3    Descargues, P.4    Grivennikov, S.5    Luo, J.L.6
  • 72
    • 78649631703 scopus 로고    scopus 로고
    • Interleukin-1beta regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1alpha
    • Naldini A, Filippi I, Miglietta D, Moschetta M, Giavazzi R, Carraro F. Interleukin-1beta regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1alpha. Eur J Cancer 2010;46:3400-8.
    • (2010) Eur J Cancer , vol.46 , pp. 3400-3408
    • Naldini, A.1    Filippi, I.2    Miglietta, D.3    Moschetta, M.4    Giavazzi, R.5    Carraro, F.6
  • 73
    • 33845532359 scopus 로고    scopus 로고
    • The paradox of pro-inflammatory cytokines in cancer
    • Dinarello CA. The paradox of pro-inflammatory cytokines in cancer. Cancer Metastasis Rev 2006;25:307-13.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 307-313
    • Dinarello, C.A.1
  • 75
    • 70449732756 scopus 로고    scopus 로고
    • The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis
    • Carmi Y, Voronov E, Dotan S, Lahat N, Rahat MA, Fogel M, et al. The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis. J Immunol 2009;183:4705-14.
    • (2009) J Immunol , vol.183 , pp. 4705-4714
    • Carmi, Y.1    Voronov, E.2    Dotan, S.3    Lahat, N.4    Rahat, M.A.5    Fogel, M.6
  • 77
    • 48649109203 scopus 로고    scopus 로고
    • Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
    • Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, Hardiman G, Karin M. Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 2008;14:156-65.
    • (2008) Cancer Cell , vol.14 , pp. 156-165
    • Sakurai, T.1    He, G.2    Matsuzawa, A.3    Yu, G.Y.4    Maeda, S.5    Hardiman, G.6    Karin, M.7
  • 78
    • 43949107175 scopus 로고    scopus 로고
    • Opposing effects of fibrosarcoma cell-derived IL-1 alpha and IL-1 beta on immune response induction
    • Marhaba R, Nazarenko I, Knofler D, Reich E, Voronov E, Vi-tacolonna M, et al. Opposing effects of fibrosarcoma cell-derived IL-1 alpha and IL-1 beta on immune response induction. Int J Cancer 2008;123:134-45.
    • (2008) Int J Cancer , vol.123 , pp. 134-145
    • Marhaba, R.1    Nazarenko, I.2    Knofler, D.3    Reich, E.4    Voronov, E.5    Vi-Tacolonna, M.6
  • 79
    • 65249096761 scopus 로고    scopus 로고
    • Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylc-holantrene tumor cells
    • Elkabets M, Krelin Y, Dotan S, Cerwenka A, Porgador A, Lic-htenstein RG, et al. Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylc-holantrene tumor cells. J Immunol 2009;182:4874-81.
    • (2009) J Immunol , vol.182 , pp. 4874-4881
    • Elkabets, M.1    Krelin, Y.2    Dotan, S.3    Cerwenka, A.4    Porgador, A.5    Lic-Htenstein, R.G.6
  • 80
    • 34447116244 scopus 로고    scopus 로고
    • Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
    • Chen CJ, Kono H, Golenbock D, Reed G, Akira S, Rock KL. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 2007;13:851-6.
    • (2007) Nat Med , vol.13 , pp. 851-856
    • Chen, C.J.1    Kono, H.2    Golenbock, D.3    Reed, G.4    Akira, S.5    Rock, K.L.6
  • 81
    • 0027496949 scopus 로고
    • Interleukin 1 receptor antagonist inhibits the augmentation of metastasis induced by interleukin 1 or lipopolysac-charide in a human melanoma/nude mouse system
    • Chirivi RG, Garofalo A, Padura IM, Mantovani A, Giavazzi R. Interleukin 1 receptor antagonist inhibits the augmentation of metastasis induced by interleukin 1 or lipopolysac-charide in a human melanoma/nude mouse system. Cancer Res 1993;53:5051-4.
    • (1993) Cancer Res , vol.53 , pp. 5051-5054
    • Chirivi, R.G.1    Garofalo, A.2    Padura, I.M.3    Mantovani, A.4    Giavazzi, R.5
  • 82
    • 0028283851 scopus 로고
    • Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases
    • Vidal-Vanaclocha F, Amezaga C, Asumendi A, Kaplanski G, Dinarello CA. Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases. Cancer Res 1994;54:2667-72.
    • (1994) Cancer Res , vol.54 , pp. 2667-2672
    • Vidal-Vanaclocha, F.1    Amezaga, C.2    Asumendi, A.3    Kaplanski, G.4    Dinarello, C.A.5
  • 83
    • 61449122079 scopus 로고    scopus 로고
    • Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1{beta}-induced interleukin 6 production and the myeloma proliferative component
    • Lust JA, Lacy MQ, Zeldenrust SR, Dispenzieri A, Gertz MA, Witzig TE, et al. Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1{beta}-induced interleukin 6 production and the myeloma proliferative component. Mayo Clin Proc 2009;84:114-22.
    • (2009) Mayo Clin Proc , vol.84 , pp. 114-122
    • Lust, J.A.1    Lacy, M.Q.2    Zeldenrust, S.R.3    Dispenzieri, A.4    Gertz, M.A.5    Witzig, T.E.6
  • 84
    • 77954551165 scopus 로고    scopus 로고
    • Why not treat human cancer with interleukin-1 blockade?
    • Dinarello CA. Why not treat human cancer with interleukin-1 blockade? Cancer Metastasis Rev 2010;29:317-29.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 317-329
    • Dinarello, C.A.1
  • 85
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediat ed link bet ween innate immunity, inflammation, and cancer
    • Lin WW, Karin M. A cytokine-mediat ed link bet ween innate immunity, inflammation, and cancer. J Clin Invest 2007;117:1175-83.
    • (2007) J Clin Invest , vol.117 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 86
    • 40649109728 scopus 로고    scopus 로고
    • The wolf in sheep's clothing: The role of interleukin-6 in immunity, inflammation and cancer
    • Naugler WE, Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med 2008;14:109-19.
    • (2008) Trends Mol Med , vol.14 , pp. 109-119
    • Naugler, W.E.1    Karin, M.2
  • 87
    • 70449717285 scopus 로고    scopus 로고
    • C/ EBPbeta regu la tes tran scrip tion fac to rs cri ti cal for proliferation and survival of multiple myeloma cells
    • Pal R, Janz M, Galson DL, Gries M, Li S, Johrens K, et al. C/ EBPbeta regu la tes tran scrip tion fac to rs cri ti cal for proliferation and survival of multiple myeloma cells. Blood 2009;114:3890-8.
    • (2009) Blood , vol.114 , pp. 3890-3898
    • Pal, R.1    Janz, M.2    Galson, D.L.3    Gries, M.4    Li, S.5    Johrens, K.6
  • 88
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007;317:121-4.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6    Karin, M.7
  • 89
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • Rakoff-Nahoum S, Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 2007;317:124-7.
    • (2007) Science , vol.317 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 90
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL, et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007;117:3846-56.
    • (2007) J Clin Invest , vol.117 , pp. 3846-3856
    • Gao, S.P.1    Mark, K.G.2    Leslie, K.3    Pao, W.4    Motoi, N.5    Gerald, W.L.6
  • 91
    • 37349098725 scopus 로고    scopus 로고
    • Autocrine IL-6 signaling: A key event in tumorigenesis?
    • Grivennikov S, Karin M. Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell 2008;13:7-9.
    • (2008) Cancer Cell , vol.13 , pp. 7-9
    • Grivennikov, S.1    Karin, M.2
  • 92
    • 36849039660 scopus 로고    scopus 로고
    • IL-6 triggers malignant features in mam-mospheres from human ductal breast carcinoma and normal mammary gland
    • Sansone P, Storci G, Tavolari S, Guarnieri T, Giovannini C, Taffurelli M, et al. IL-6 triggers malignant features in mam-mospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest 2007;117:3988-4002.
    • (2007) J Clin Invest , vol.117 , pp. 3988-4002
    • Sansone, P.1    Storci, G.2    Tavolari, S.3    Guarnieri, T.4    Giovannini, C.5    Taffurelli, M.6
  • 93
    • 58649101347 scopus 로고    scopus 로고
    • Gp130-me dia ted Sta t3 acti vation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
    • Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, et al. gp130-me dia ted Sta t3 acti vation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 2009;15:91-102.
    • (2009) Cancer Cell , vol.15 , pp. 91-102
    • Bollrath, J.1    Phesse, T.J.2    von Burstin, V.A.3    Putoczki, T.4    Bennecke, M.5    Bateman, T.6
  • 94
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabha-purapu S, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009;15:103-13.
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5    Vallabha-Purapu, S.6
  • 95
    • 58649119388 scopus 로고    scopus 로고
    • Regulation of the IL-23 and IL-12 balance byStat3 signaling in the tumor microenvironment
    • Kortylewski M, Xin H, Kujawski M, Lee H, Liu Y, Harris T, et al. Regulation of the IL-23 and IL-12 balance byStat3 signaling in the tumor microenvironment. Cancer Cell 2009;15:114-23.
    • (2009) Cancer Cell , vol.15 , pp. 114-123
    • Kortylewski, M.1    Xin, H.2    Kujawski, M.3    Lee, H.4    Liu, Y.5    Harris, T.6
  • 96
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • Balkwill F. Cancer and the chemokine network. Nat Rev Cancer 2004;4:540-50.
    • (2004) Nat Rev Cancer , vol.4 , pp. 540-550
    • Balkwill, F.1
  • 97
    • 77949329326 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors: New insights into cancer-related inflammation
    • Lazennec G, Richmond A. Chemokines and chemokine receptors: new insights into cancer-related inflammation. Trends Mol Med 2010;16:133-44.
    • (2010) Trends Mol Med , vol.16 , pp. 133-144
    • Lazennec, G.1    Richmond, A.2
  • 100
    • 47049126742 scopus 로고    scopus 로고
    • Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice
    • Sawanobori Y, Ueha S, Kurachi M, Shimaoka T, Talmad-ge JE, Abe J, et al. Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. Blood 2008;111:5457-66.
    • (2008) Blood , vol.111 , pp. 5457-5466
    • Sawanobori, Y.1    Ueha, S.2    Kurachi, M.3    Shimaoka, T.4    Talmad-Ge, J.E.5    Abe, J.6
  • 101
    • 55349148665 scopus 로고    scopus 로고
    • The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma
    • Marchesi F, Piemonti L, Fedele G, Destro A, Roncalli M, Alba-rello L, et al. The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma. Cancer Res 2008;68:9060-9.
    • (2008) Cancer Res , vol.68 , pp. 9060-9069
    • Marchesi, F.1    Piemonti, L.2    Fedele, G.3    Destro, A.4    Roncalli, M.5    Alba-Rello, L.6
  • 102
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
    • Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010;22:231-7.
    • (2010) Curr Opin Immunol , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 104
    • 39849102836 scopus 로고    scopus 로고
    • HI-F1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegue E, et al. HI-F1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008;13:206-20.
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3    Liu, P.4    Ganss, R.5    Passegue, E.6
  • 105
    • 47949097072 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice
    • Dineen SP, Lynn KD, Holloway SE, Miller AF, Sullivan JP, Shames DS, et al. Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice. Cancer Res 2008;68:4340-6.
    • (2008) Cancer Res , vol.68 , pp. 4340-4346
    • Dineen, S.P.1    Lynn, K.D.2    Holloway, S.E.3    Miller, A.F.4    Sullivan, J.P.5    Shames, D.S.6
  • 106
    • 47949110692 scopus 로고    scopus 로고
    • Oxidative stress regulates expression ofVEGFR1 in myeloid cells: Link to tumor-induced immune suppression in renal cell carcinoma
    • Kusmartsev S, Erustanov E, Kubter H, Tseng T, Sakai Y, Su Z, etal. Oxidative stress regulates expression ofVEGFR1 in myeloid cells: link to tumor-induced immune suppression in renal cell carcinoma. J Immunol 2008;181:346-53.
    • (2008) J Immunol , vol.181 , pp. 346-353
    • Kusmartsev, S.1    Erustanov, E.2    Kubter, H.3    Tseng, T.4    Sakai, Y.5    Su, Z.6
  • 107
    • 39649120597 scopus 로고    scopus 로고
    • Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated mac-rophage-like cells
    • Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, et al. Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated mac-rophage-like cells. Blood 2007;110:4319-30.
    • (2007) Blood , vol.110 , pp. 4319-4330
    • Duluc, D.1    Delneste, Y.2    Tan, F.3    Moles, M.P.4    Grimaud, L.5    Lenoir, J.6
  • 109
    • 39149138136 scopus 로고    scopus 로고
    • A macrophage gene expression signature defines a field effect in the lung tumor microenvironment
    • Stearman RS, Dwyer-Nield L, Grady MC, Malkinson AM, Ge-raci MW. A macrophage gene expression signature defines a field effect in the lung tumor microenvironment. Cancer Res 2008;68:34-43.
    • (2008) Cancer Res , vol.68 , pp. 34-43
    • Stearman, R.S.1    Dwyer-Nield, L.2    Grady, M.C.3    Malkinson, A.M.4    Ge-Raci, M.W.5
  • 111
    • 47949090079 scopus 로고    scopus 로고
    • The rote of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch C, Muthana M, Coffett SB, Lewis CE. The rote of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer 2008;8:618-31.
    • (2008) Nat Rev Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffett, S.B.3    Lewis, C.E.4
  • 112
    • 35548982639 scopus 로고    scopus 로고
    • Anti-PlGF inhibits growth ofVEGF(R)-inhibi-tor-resistant tumors without affecting healthy vessels
    • Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pat-tarini L, et al. Anti-PlGF inhibits growth ofVEGF(R)-inhibi-tor-resistant tumors without affecting healthy vessels. Cell 2007;131:463-75.
    • (2007) Cell , vol.131 , pp. 463-475
    • Fischer, C.1    Jonckx, B.2    Mazzone, M.3    Zacchigna, S.4    Loges, S.5    Pat-Tarini, L.6
  • 113
    • 34547820876 scopus 로고    scopus 로고
    • Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myetoid celts
    • Shojaei F, Wu X, Matik AK, Zhong C, Baldwin ME, Scha-nz S, et al. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myetoid celts. Nat Biotechnol 2007;25:911-20.
    • (2007) Nat Biotechnol , vol.25 , pp. 911-920
    • Shojaei, F.1    Wu, X.2    Matik, A.K.3    Zhong, C.4    Baldwin, M.E.5    Scha-Nz, S.6
  • 114
    • 30144443269 scopus 로고    scopus 로고
    • Paradoxical roles of the immune system during cancer development
    • de Visser KE, Eichten A, Coussens LM. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 2006;6:24-37.
    • (2006) Nat Rev Cancer , vol.6 , pp. 24-37
    • de Visser, K.E.1    Eichten, A.2    Coussens, L.M.3
  • 115
    • 44349101991 scopus 로고    scopus 로고
    • Immunomodulatory mast cells: Negative, as well as positive, regulators of immunity
    • Galli SJ, Grimbaldeston M, Tsai M. Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 2008;8:478-86.
    • (2008) Nat Rev Immunol , vol.8 , pp. 478-486
    • Galli, S.J.1    Grimbaldeston, M.2    Tsai, M.3
  • 116
    • 46949110502 scopus 로고    scopus 로고
    • Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages
    • Sierra JR, Corso S, Caione L, Cepero V, Conrotto P, Cignetti A, et al. Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages. J Exp Med 2008;205:1673-85.
    • (2008) J Exp Med , vol.205 , pp. 1673-1685
    • Sierra, J.R.1    Corso, S.2    Caione, L.3    Cepero, V.4    Conrotto, P.5    Cignetti, A.6
  • 118
    • 34547184682 scopus 로고    scopus 로고
    • CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration
    • Loberg RD, Ying C, Craig M, Yan L, Snyder LA, Pienta KJ. CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration. Neoplasia 2007;9:556-62.
    • (2007) Neoplasia , vol.9 , pp. 556-562
    • Loberg, R.D.1    Ying, C.2    Craig, M.3    Yan, L.4    Snyder, L.A.5    Pienta, K.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.