Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2

FEBS Letters

Volumn 586, Issue 16, 2012, Pages 2459-2467

  Wu, Zhongwen ^a   Lu, Haifeng ^a   Sheng, Jifang ^a   Li, Lanjuan ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Bcl2; Dendritic cell; IL 12; miR 21; Mycobacterium; Th1

Indexed keywords

BCG VACCINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P35; MICRORNA 21; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; BACTERIAL IMMUNITY; BCG VACCINATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG EFFICACY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INDUCTION; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; LUNG TUBERCULOSIS; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TH1 CELL; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; BONE MARROW CELLS; CYTOKINES; DENDRITIC CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERLEUKIN-12; MACROPHAGES; MICE; MICE, INBRED C57BL; MICRORNAS; MYCOBACTERIUM TUBERCULOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; TH1 CELLS;

MYCOBACTERIUM; MYCOBACTERIUM BOVIS BCG;

EID: 84864279381     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.06.004     Document Type: Article

References (50)

1. P. Glaziou, K. Floyd, and M. Raviglione Global burden and epidemiology of tuberculosis Clin. Chest Med. 30 2009 621 636 vii
2. C. Dye Global epidemiology of tuberculosis Lancet 367 2006 938 940
3. WHO global tuberculosis control report 2010. Summary. Cent. Eur. J. Public Health (2010) 18, 237.
4. E.L. Corbett, C.J. Watt, N. Walker, D. Maher, B.G. Williams, M.C. Raviglione, and C. Dye The growing burden of tuberculosis: global trends and interactions with the HIV epidemic Arch. Intern. Med. 163 2003 1009 1021 (Pubitemid 36548927)
5. M.A. Chambers A single dose of killed Mycobacterium bovis BCG in a novel class of adjuvant (Novasome) protects guinea pigs from lethal tuberculosis Vaccine 22 2004 1063 1071 (Pubitemid 38221100)
6. M. Haile, U. Schroder, B. Hamasur, A. Pawlowski, T. Jaxmar, G. Kallenius, and S.B. Svenson Immunization with heat-killed Mycobacterium bovis bacille Calmette-Guerin (BCG) in Eurocine L3 adjuvant protects against tuberculosis Vaccine 22 2004 1498 1508 (Pubitemid 38446928)
7. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
8. J. Lu MicroRNA expression profiles classify human cancers Nature 435 2005 834 838 (Pubitemid 40839735)
9. K.D. Taganov, M.P. Boldin, and D. Baltimore MicroRNAs and immunity: tiny players in a big field Immunity 26 2007 133 137 (Pubitemid 46329443)
10. R.M. O'Connell, D.S. Rao, A.A. Chaudhuri, and D. Baltimore Physiological and pathological roles for microRNAs in the immune system Nat. Rev. Immunol. 10 2010 111 122
11. S. Zhu, H. Wu, F. Wu, D. Nie, S. Sheng, and Y.Y. Mo MicroRNA-21 targets tumor suppressor genes in invasion and metastasis Cell Res. 18 2008 350 359 (Pubitemid 351333899)
12. X. Pan, Z.X. Wang, and R. Wang MicroRNA-21: a novel therapeutic target in human cancer Cancer Biol. Ther. 10 2011 1224 1232
13. E. Sonkoly MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? PLoS One 2 2007 e610
14. F.J. Sheedy Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 Nat. Immunol. 11 2010 141 147
15. T.X. Lu MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity J. Immunol. 187 2011 3362 3373
16. T.X. Lu, A. Munitz, and M.E. Rothenberg MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression J. Immunol. 182 2009 4994 5002
17. O. Gross, A. Gewies, K. Finger, M. Schafer, T. Sparwasser, C. Peschel, I. Forster, and J. Ruland Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity Nature 442 2006 651 656 (Pubitemid 44215314)
18. C. Song IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma J. Immunol. 181 2008 6117 6124
19. A. Bafica, C.A. Scanga, C.G. Feng, C. Leifer, A. Cheever, and A. Sher TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis J. Exp. Med. 202 2005 1715 1724 (Pubitemid 41815877)
20. L. Pompei, S. Jang, B. Zamlynny, S. Ravikumar, A. McBride, S.P. Hickman, and P. Salgame Disparity in IL-12 release in dendritic cells and macrophages in response to Mycobacterium tuberculosis is due to use of distinct TLRs J. Immunol. 178 2007 5192 5199 (Pubitemid 46595303)
21. C.V. Harding, and W.H. Boom Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors Nat. Rev. Microbiol. 8 2010 296 307
22. W.R. Berrington, and T.R. Hawn Mycobacterium tuberculosis, macrophages, and the innate immune response: does common variation matter? Immunol. Rev. 219 2007 167 186 (Pubitemid 47390000)
23. K.D. Mayer-Barber Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo J. Immunol. 184 2010 3326 3330
24. C.M. Fremond IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection J. Immunol. 179 2007 1178 1189
25. A.M. Cooper, K.D. Mayer-Barber, and A. Sher Role of innate cytokines in mycobacterial infection Mucosal Immunol. 4 2011 252 260
26. P.S. Redford, P.J. Murray, and A. O'Garra The role of IL-10 in immune regulation during M. tuberculosis infection Mucosal Immunol. 4 2011 261 270
27. K. Suzue, T. Asai, T. Takeuchi, and S. Koyasu In vivo role of IFN-gamma produced by antigen-presenting cells in early host defense against intracellular pathogens Eur. J. Immunol. 33 2003 2666 2675 (Pubitemid 37337132)
28. I. Fricke, D. Mitchell, J. Mittelstadt, N. Lehan, H. Heine, T. Goldmann, A. Bohle, and S. Brandau Mycobacteria induce IFN-gamma production in human dendritic cells via triggering of TLR2 J. Immunol. 176 2006 5173 5182
29. D.M. Frucht, T. Fukao, C. Bogdan, H. Schindler, J.J. O'Shea, and S. Koyasu IFN-gamma production by antigen-presenting cells: mechanisms emerge Trends Immunol. 22 2001 556 560 (Pubitemid 33016402)
30. C.J. Riendeau, and H. Kornfeld THP-1 cell apoptosis in response to Mycobacterial infection Infect. Immun. 71 2003 254 259 (Pubitemid 36026027)
31. K. Klingler, K.M. Tchou-Wong, O. Brandli, C. Aston, R. Kim, C. Chi, and W.N. Rom Effects of mycobacteria on regulation of apoptosis in mononuclear phagocytes Infect. Immun. 65 1997 5272 5278 (Pubitemid 27513580)
32. N.S. Wickramasinghe, T.T. Manavalan, S.M. Dougherty, K.A. Riggs, Y. Li, and C.M. Klinge Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells Nucleic Acids Res. 37 2009 2584 2595
33. J.L. Flynn, and J. Chan Immunology of tuberculosis Annu. Rev. Immunol. 19 2001 93 129 (Pubitemid 32368031)
34. A.M. Cooper Cell-mediated immune responses in tuberculosis Annu. Rev. Immunol. 27 2009 393 422
35. C. Holscher, R.A. Atkinson, B. Arendse, N. Brown, E. Myburgh, G. Alber, and F. Brombacher A protective and agonistic function of IL-12p40 in mycobacterial infection J. Immunol. 167 2001 6957 6966 (Pubitemid 33144190)
36. S.A. Khader Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection J. Exp. Med. 203 2006 1805 1815 (Pubitemid 44036285)
37. H.W. Tso, Y.L. Lau, C.M. Tam, H.S. Wong, and A.K. Chiang Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population J. Infect. Dis. 190 2004 913 919 (Pubitemid 39120968)
38. A. Iwasaki, and R. Medzhitov Toll-like receptor control of the adaptive immune responses Nat. Immunol. 5 2004 987 995 (Pubitemid 41057715)
39. A.G. Rothfuchs, A. Bafica, C.G. Feng, J.G. Egen, D.L. Williams, G.D. Brown, and A. Sher Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells J. Immunol. 179 2007 3463 3471
40. J.A. Chan, A.M. Krichevsky, and K.S. Kosik MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells Cancer Res. 65 2005 6029 6033 (Pubitemid 40994386)
41. M.L. Si, S. Zhu, H. Wu, Z. Lu, F. Wu, and Y.Y. Mo MiR-21-mediated tumor growth Oncogene 26 2007 2799 2803 (Pubitemid 46663837)
42. M. Seike MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers Proc. Natl. Acad. Sci. USA 106 2009 12085 12090
43. L.B. Frankel, N.R. Christoffersen, A. Jacobsen, M. Lindow, A. Krogh, and A.H. Lund Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells J. Biol. Chem. 283 2008 1026 1033
44. S. Zhu, M.L. Si, H. Wu, and Y.Y. Mo MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1) J. Biol. Chem. 282 2007 14328 14336 (Pubitemid 47100416)
45. F. Meng, R. Henson, H. Wehbe-Janek, K. Ghoshal, S.T. Jacob, and T. Patel MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer Gastroenterology 133 2007 647 658 (Pubitemid 47187346)
46. A.M. Cooper, J. Magram, J. Ferrante, and I.M. Orme Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis J. Exp. Med. 186 1997 39 45 (Pubitemid 27304845)
47. A.J. Wolf, L. Desvignes, B. Linas, N. Banaiee, T. Tamura, K. Takatsu, and J.D. Ernst Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs J. Exp. Med. 205 2008 105 115 (Pubitemid 351185719)
48. I.R. Humphreys, G.R. Stewart, D.J. Turner, J. Patel, D. Karamanou, R.J. Snelgrove, and D.B. Young A role for dendritic cells in the dissemination of mycobacterial infection Microbes Infect 8 2006 1339 1346 (Pubitemid 43842003)
49. J. Gercken, J. Pryjma, M. Ernst, and H.D. Flad Defective antigen presentation by Mycobacterium tuberculosis-infected monocytes Infect. Immun. 62 1994 3472 3478 (Pubitemid 24232135)
50. A.J. Wolf, B. Linas, G.J. Trevejo-Nunez, E. Kincaid, T. Tamura, K. Takatsu, and J.D. Ernst Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo J. Immunol. 179 2007 2509 2519