메뉴 건너뛰기




Volumn 12, Issue 10, 2015, Pages 584-596

Inflammation and cancer: Advances and new agents

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMG 820; ANTIINFLAMMATORY AGENT; BORTEZOMIB; CARLUMAB; CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; CP 870893; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; EMACTUZUMAB; ETANERCEPT; IMC CS 4; INFLIXIMAB; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTEROID ANTIINFLAMMATORY AGENT; PACRITINIB; PLERIXAFOR; PLX 3397; REPARIXIN; RUXOLITINIB; SILTUXIMAB; TASQUINIMOD; TOCILIZUMAB; TRABECTEDIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84942292465     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2015.105     Document Type: Review
Times cited : (961)

References (203)
  • 1
    • 47849098044 scopus 로고    scopus 로고
    • Inflammation: Gearing the journey to cancer
    • Kundu, J. K., Surh, Y. J. Inflammation: gearing the journey to cancer. Mutat. Res. 659, 15-30 (2008).
    • (2008) Mutat. Res. , vol.659 , pp. 15-30
    • Kundu, J.K.1    Surh, Y.J.2
  • 3
    • 75849117800 scopus 로고    scopus 로고
    • Inflammation and oncogenesis: A vicious connection
    • Grivennikov, S. I., Karin, M. Inflammation and oncogenesis: a vicious connection. Curr. Opin. Genet. Dev. 20, 65-71 (2010).
    • (2010) Curr. Opin. Genet. Dev. , vol.20 , pp. 65-71
    • Grivennikov, S.I.1    Karin, M.2
  • 4
    • 84872445265 scopus 로고    scopus 로고
    • Neutralizing tumor-promoting chronic inflammation: A magic bullet
    • Coussens, L. M., Zitvogel, L., Palucka, A. K. Neutralizing tumor-promoting chronic inflammation: a magic bulletScience 339, 286-291 (2013).
    • (2013) Science , vol.339 , pp. 286-291
    • Coussens, L.M.1    Zitvogel, L.2    Palucka, A.K.3
  • 5
    • 0034161878 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors
    • Masferrer, J. L. et al. Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res. 60, 1306-1311 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 1306-1311
    • Masferrer, J.L.1
  • 6
    • 0032542763 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer
    • Hwang, D., Scollard, D., Byrne, J., Levine, E. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J. Natl Cancer Inst. 90, 455-460 (1998).
    • (1998) J. Natl Cancer Inst. , vol.90 , pp. 455-460
    • Hwang, D.1    Scollard, D.2    Byrne, J.3    Levine, E.4
  • 7
    • 0033988665 scopus 로고    scopus 로고
    • Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma
    • Gupta, S., Srivastava, M., Ahmad, N., Bostwick, D. G., Mukhtar, H. Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. Prostate 42, 73-78 (2000).
    • (2000) Prostate , vol.42 , pp. 73-78
    • Gupta, S.1    Srivastava, M.2    Ahmad, N.3    Bostwick, D.G.4    Mukhtar, H.5
  • 8
    • 0033106051 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer
    • Tucker, O. N. et al. Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. Cancer Res. 59, 987-990 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 987-990
    • Tucker, O.N.1
  • 9
    • 0031843401 scopus 로고    scopus 로고
    • COX-2 expression is induced by UVB exposure in human skin: Implications for the development of skin cancer
    • Buckman, S. Y. et al. COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. Carcinogenesis 19, 723-729 (1998).
    • (1998) Carcinogenesis , vol.19 , pp. 723-729
    • Buckman, S.Y.1
  • 10
    • 0032533858 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 in human lung carcinoma
    • Wolff, H. et al. Expression of cyclooxygenase-2 in human lung carcinoma. Cancer Res. 58, 4997-5001 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 4997-5001
    • Wolff, H.1
  • 11
    • 0033571143 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder
    • Mohammed, S. I. et al. Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. Cancer Res. 59, 5647-5650 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 5647-5650
    • Mohammed, S.I.1
  • 12
    • 0033105360 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck
    • Chan, G. et al. Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. Cancer Res. 59, 991-994 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 991-994
    • Chan, G.1
  • 13
    • 0020565187 scopus 로고
    • Sulindac for polyposis of the colon
    • Waddell, W. R., Loughry, R. W. Sulindac for polyposis of the colon. J. Surg. Oncol. 24, 83-87 (1983).
    • (1983) J. Surg. Oncol. , vol.24 , pp. 83-87
    • Waddell, W.R.1    Loughry, R.W.2
  • 14
    • 84860467522 scopus 로고    scopus 로고
    • Effects of regular aspirin on long-term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials
    • Algra, A. M., Rothwell, P. M. Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol. 13, 518-527 (2012).
    • (2012) Lancet Oncol. , vol.13 , pp. 518-527
    • Algra, A.M.1    Rothwell, P.M.2
  • 15
    • 84863412124 scopus 로고    scopus 로고
    • Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the time course of risks and benefits in 51 randomised controlled trials
    • Rothwell, P. M. et al. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet 379, 1602-1612 (2012)
    • (2012) Lancet , vol.379 , pp. 1602-1612
    • Rothwell, P.M.1
  • 16
    • 84863399038 scopus 로고    scopus 로고
    • Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials
    • Rothwell, P. M. et al. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet 379, 1591-1601 (2012).
    • (2012) Lancet , vol.379 , pp. 1591-1601
    • Rothwell, P.M.1
  • 17
    • 84922532328 scopus 로고    scopus 로고
    • Estimates of benefits and harms of prophylactic use of aspirin in the general population
    • Cuzick, J. et al. Estimates of benefits and harms of prophylactic use of aspirin in the general population. Ann. Oncol. 26, 47-57 (2015).
    • (2015) Ann. Oncol. , vol.26 , pp. 47-57
    • Cuzick, J.1
  • 18
    • 79251478398 scopus 로고    scopus 로고
    • Contribution of platelets to tumour metastasis
    • Gay, L. J., Felding-Habermann, B. Contribution of platelets to tumour metastasis. Nat. Rev. Cancer 11, 123-134 (2011).
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 123-134
    • Gay, L.J.1    Felding-Habermann, B.2
  • 19
    • 0027993458 scopus 로고
    • Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
    • Eberhart, C. E. et al. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107, 1183-1188 (1994).
    • (1994) Gastroenterology , vol.107 , pp. 1183-1188
    • Eberhart, C.E.1
  • 20
    • 48949119467 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health Study
    • Gierach, G. L. et al. Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health Study. Breast Cancer Res. 10, R38 (2008).
    • (2008) Breast Cancer Res. , vol.10 , pp. R38
    • Gierach, G.L.1
  • 21
    • 77956240092 scopus 로고    scopus 로고
    • Use of aspirin and other nonsteroidal antiinflammatory medications in relation to prostate cancer risk
    • Salinas, C. A. et al. Use of aspirin and other nonsteroidal antiinflammatory medications in relation to prostate cancer risk. Am. J. Epidemiol. 172, 578-590 (2010).
    • (2010) Am. J. Epidemiol. , vol.172 , pp. 578-590
    • Salinas, C.A.1
  • 22
    • 84867817838 scopus 로고    scopus 로고
    • Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
    • Liao, X. et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N. Engl. J. Med. 367, 1596-1606 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 1596-1606
    • Liao, X.1
  • 23
    • 84905225509 scopus 로고    scopus 로고
    • Aspirin use and survival after the diagnosis of breast cancer: A population-based cohort study
    • Fraser, D. M., Sullivan, F. M., Thompson, A. M., McCowan, C. Aspirin use and survival after the diagnosis of breast cancer: a population-based cohort study. Br. J. Cancer 111, 623-627 (2014).
    • (2014) Br. J. Cancer , vol.111 , pp. 623-627
    • Fraser, D.M.1    Sullivan, F.M.2    Thompson, A.M.3    McCowan, C.4
  • 24
    • 84942299351 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00003835?term=NCT00003835=1 (2013).
    • (2013)
  • 25
    • 84926518325 scopus 로고    scopus 로고
    • Aspirin and COX-2 inhibitor use in patients with stage III colon cancer
    • Ng, K. et al. Aspirin and COX-2 inhibitor use in patients with stage III colon cancer. J. Natl Cancer Inst. 107, 345 (2015).
    • (2015) J. Natl Cancer Inst. , vol.107 , pp. 345
    • Ng, K.1
  • 26
    • 84942299352 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01150045 (2013).
    • (2013)
  • 27
    • 84942299353 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00565708?term=NCT00565708&rank=1 (2015).
    • (2015)
  • 28
    • 84942299354 scopus 로고    scopus 로고
    • The Add Aspirin trial. addaspirintrial.org [online]
    • The Add Aspirin trial. addaspirintrial.org [online], http://www.addaspirintrial.org/(2015).
    • (2015)
  • 29
    • 29044440878 scopus 로고    scopus 로고
    • Anti-angiogenic and anti inflammatory effects of statins: Relevance to anti-cancer therapy
    • Dulak, J., Jozkowicz, A. Anti-angiogenic and anti inflammatory effects of statins: relevance to anti-cancer therapy. Curr. Cancer Drug Targets 5, 579-594 (2005).
    • (2005) Curr. Cancer Drug Targets , vol.5 , pp. 579-594
    • Dulak, J.1    Jozkowicz, A.2
  • 30
    • 77953764199 scopus 로고    scopus 로고
    • Statin use and cancer risk: A comprehensive review
    • Boudreau, D. M., Yu, O., Johnson, J. Statin use and cancer risk: a comprehensive review. Expert Opin. Drug Saf. 9, 603-621 (2010).
    • (2010) Expert Opin. Drug Saf. , vol.9 , pp. 603-621
    • Boudreau, D.M.1    Yu, O.2    Johnson, J.3
  • 31
    • 84942299355 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02161822?term=NCT02161822&rank=1 (2014).
    • (2014)
  • 32
    • 84942299356 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01821404?term=NCT01821404&rank=1 (2015).
    • (2015)
  • 34
    • 84866521035 scopus 로고    scopus 로고
    • Symptoms tell it all: A systematic review of the value of symptom assessment to predict survival in advanced cancer patients
    • Trajkovic-Vidakovic, M., de Graeff, A., Voest, E. E., Teunissen, S. C. Symptoms tell it all: a systematic review of the value of symptom assessment to predict survival in advanced cancer patients. Crit. Rev. Oncol. Hematol. 84, 130-148 (2012).
    • (2012) Crit. Rev. Oncol. Hematol. , vol.84 , pp. 130-148
    • Trajkovic-Vidakovic, M.1    De Graeff, A.2    Voest, E.E.3    Teunissen, S.C.4
  • 35
    • 58949087703 scopus 로고    scopus 로고
    • Intensive anti-inflammatory therapy with dexamethasone in patients with non-small cell lung cancer: Effect on chemotherapy toxicity and efficacy
    • Leggas, M. et al. Intensive anti-inflammatory therapy with dexamethasone in patients with non-small cell lung cancer: effect on chemotherapy toxicity and efficacy. Cancer Chemother. Pharmacol. 63, 731-743 (2009).
    • (2009) Cancer Chemother. Pharmacol. , vol.63 , pp. 731-743
    • Leggas, M.1
  • 36
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D., Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 37
    • 51349098155 scopus 로고    scopus 로고
    • Cytokines as a key component of cancer-related inflammation
    • Germano, G., Allavena, P., Mantovani, A. Cytokines as a key component of cancer-related inflammation. Cytokine 43, 374-379, (2008).
    • (2008) Cytokine , vol.43 , pp. 374-379
    • Germano, G.1    Allavena, P.2    Mantovani, A.3
  • 38
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan, D., Coussens, L. M. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21, 309-322 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 40
    • 33646472252 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha as a tumour promoter
    • Szlosarek, P., Charles, K. A., Balkwill, F. R. Tumour necrosis factor-alpha as a tumour promoter. Eur. J. Cancer 42, 745-750 (2006).
    • (2006) Eur. J. Cancer , vol.42 , pp. 745-750
    • Szlosarek, P.1    Charles, K.A.2    Balkwill, F.R.3
  • 41
    • 77955489317 scopus 로고    scopus 로고
    • Anti-TNF therapy, from rationale to standard of care: What lessons has it taught us
    • Feldmann, M., Maini, R. N. Anti-TNF therapy, from rationale to standard of care: what lessons has it taught usJ. Immunol. 185, 791-794 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 791-794
    • Feldmann, M.1    Maini, R.N.2
  • 42
    • 0033125226 scopus 로고    scopus 로고
    • Antitumor necrosis factor therapy for inflammatory bowel disease: A review of agents, pharmacology, clinical results, and safety
    • Sandborn, W. J., Hanauer, S. B. Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety. Inflamm. Bowel Dis. 5, 119-133 (1999).
    • (1999) Inflamm. Bowel Dis. , vol.5 , pp. 119-133
    • Sandborn, W.J.1    Hanauer, S.B.2
  • 43
    • 0027361432 scopus 로고
    • Construction and initial characterization of a mouse-human chimeric anti-TNF antibody
    • Knight, D. M. et al. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol. Immunol. 30, 1443-1453 (1993).
    • (1993) Mol. Immunol. , vol.30 , pp. 1443-1453
    • Knight, D.M.1
  • 44
    • 0027198002 scopus 로고
    • Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists
    • Mohler, K. M. et al. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J. Immunol. 151, 1548-1561 (1993).
    • (1993) J. Immunol. , vol.151 , pp. 1548-1561
    • Mohler, K.M.1
  • 45
    • 77954425185 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of the efficacy and safety of adalimumab for treating rheumatoid arthritis
    • Wiens, A., Correr, C. J., Venson, R., Otuki, M. F., Pontarolo, R. A systematic review and meta-analysis of the efficacy and safety of adalimumab for treating rheumatoid arthritis. Rheumatol. Int. 30, 1063-1070 (2010).
    • (2010) Rheumatol. Int. , vol.30 , pp. 1063-1070
    • Wiens, A.1    Correr, C.J.2    Venson, R.3    Otuki, M.F.4    Pontarolo, R.5
  • 46
    • 0016723594 scopus 로고
    • An endotoxin-induced serum factor that causes necrosis of tumors
    • Carswell, E. A. et al. An endotoxin-induced serum factor that causes necrosis of tumors. Proc. Natl Acad. Sci. USA 72, 3666-3670 (1975).
    • (1975) Proc. Natl Acad. Sci. USA , vol.72 , pp. 3666-3670
    • Carswell, E.A.1
  • 47
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • Balkwill, F. Tumour necrosis factor and cancer. Nat. Rev. Cancer 9, 361-371 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 48
    • 33644984507 scopus 로고    scopus 로고
    • Expression and regulation of tumor necrosis factor alpha in normal and malignant ovarian epithelium
    • Szlosarek, P. W. et al. Expression and regulation of tumor necrosis factor alpha in normal and malignant ovarian epithelium. Mol. Cancer Ther. 5, 382-390 (2006).
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 382-390
    • Szlosarek, P.W.1
  • 49
    • 0028280991 scopus 로고
    • Expression of tumour necrosis factor (TNF alpha) and its receptors in benign and malignant breast tissue
    • Miles, D. W. et al. Expression of tumour necrosis factor (TNF alpha) and its receptors in benign and malignant breast tissue. Int. J. Cancer 56, 777-782 (1994).
    • (1994) Int. J. Cancer , vol.56 , pp. 777-782
    • Miles, D.W.1
  • 50
    • 33845524008 scopus 로고    scopus 로고
    • TNF-alpha in promotion and progression of cancer
    • Balkwill, F. TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev. 25, 409-416 (2006).
    • (2006) Cancer Metastasis Rev. , vol.25 , pp. 409-416
    • Balkwill, F.1
  • 51
    • 35648936526 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha as a new target for renal cell carcinoma: Two sequential phase II trials of infliximab at standard and high dose
    • Harrison, M. L. et al. Tumor necrosis factor alpha as a new target for renal cell carcinoma: two sequential phase II trials of infliximab at standard and high dose. J. Clin. Oncol. 25, 4542-4549 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , pp. 4542-4549
    • Harrison, M.L.1
  • 52
    • 77958007059 scopus 로고    scopus 로고
    • A phase I/II trial of sorafenib and infliximab in advanced renal cell carcinoma
    • Larkin, J. M. et al. A phase I/II trial of sorafenib and infliximab in advanced renal cell carcinoma. Br. J. Cancer 103, 1149-1153 (2010).
    • (2010) Br. J. Cancer , vol.103 , pp. 1149-1153
    • Larkin, J.M.1
  • 53
    • 84880055051 scopus 로고    scopus 로고
    • Disrupting cytokine signaling in pancreatic cancer: A phase I/II study of etanercept in combination with gemcitabine in patients with advanced disease
    • Wu, C. et al. Disrupting cytokine signaling in pancreatic cancer: a phase I/II study of etanercept in combination with gemcitabine in patients with advanced disease. Pancreas 42, 813-818 (2013).
    • (2013) Pancreas , vol.42 , pp. 813-818
    • Wu, C.1
  • 54
    • 0030905416 scopus 로고    scopus 로고
    • Serum concentration of tumor necrosis factor in patients with breast cancer
    • Sheen-Chen, S. M., Chen, W. J., Eng, H. L., Chou, F. F. Serum concentration of tumor necrosis factor in patients with breast cancer. Breast Cancer Res. Treat. 43, 211-215 (1997).
    • (1997) Breast Cancer Res. Treat. , vol.43 , pp. 211-215
    • Sheen-Chen, S.M.1    Chen, W.J.2    Eng, H.L.3    Chou, F.F.4
  • 55
    • 5144231121 scopus 로고    scopus 로고
    • A phase II study of etanercept (Enbrel), a tumor necrosis factor alpha inhibitor in patients with metastatic breast cancer
    • Madhusudan, S. et al. A phase II study of etanercept (Enbrel), a tumor necrosis factor alpha inhibitor in patients with metastatic breast cancer. Clin. Cancer Res. 10, 6528-6534 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6528-6534
    • Madhusudan, S.1
  • 56
    • 0027163955 scopus 로고
    • Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression
    • Naylor, M. S., Stamp, G. W., Foulkes, W. D., Eccles, D., Balkwill, F. R. Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression. J. Clin. Invest. 91, 2194-2206 (1993).
    • (1993) J. Clin. Invest. , vol.91 , pp. 2194-2206
    • Naylor, M.S.1    Stamp, G.W.2    Foulkes, W.D.3    Eccles, D.4    Balkwill, F.R.5
  • 57
    • 0033367064 scopus 로고    scopus 로고
    • Ovarian cancer-induced immunosuppression: Relationship to tumor necrosis factor-alpha (TNF-alpha) release from ovarian tissue
    • Hassan, M. I., Kassim, S. K., Saeda, L., Laban, M., Khalifa, A. Ovarian cancer-induced immunosuppression: relationship to tumor necrosis factor-alpha (TNF-alpha) release from ovarian tissue. Anticancer Res. 19, 5657-5662 (1999).
    • (1999) Anticancer Res. , vol.19 , pp. 5657-5662
    • Hassan, M.I.1    Kassim, S.K.2    Saeda, L.3    Laban, M.4    Khalifa, A.5
  • 58
    • 24944554981 scopus 로고    scopus 로고
    • Study of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancer
    • Madhusudan, S. et al. Study of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancer. J. Clin. Oncol. 23, 5950-5959 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5950-5959
    • Madhusudan, S.1
  • 59
    • 34848893989 scopus 로고    scopus 로고
    • Biologic treatment of rheumatoid arthritis and the risk of malignancy: Analyses from a large US observational study
    • Wolfe, F., Michaud, K. Biologic treatment of rheumatoid arthritis and the risk of malignancy: analyses from a large US observational study. Arthritis Rheum. 56, 2886-2895 (2007).
    • (2007) Arthritis Rheum. , vol.56 , pp. 2886-2895
    • Wolfe, F.1    Michaud, K.2
  • 60
    • 34248547187 scopus 로고    scopus 로고
    • The effect of methotrexate and anti-tumor necrosis factor therapy on the risk of lymphoma in rheumatoid arthritis in 19,562 patients during 89,710 person-years of observation
    • Wolfe, F., Michaud, K. The effect of methotrexate and anti-tumor necrosis factor therapy on the risk of lymphoma in rheumatoid arthritis in 19,562 patients during 89,710 person-years of observation. Arthritis Rheum. 56, 1433-1439 (2007).
    • (2007) Arthritis Rheum. , vol.56 , pp. 1433-1439
    • Wolfe, F.1    Michaud, K.2
  • 61
    • 27744520447 scopus 로고    scopus 로고
    • Haematopoietic malignancies in rheumatoid arthritis: Lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists
    • Askling, J. et al. Haematopoietic malignancies in rheumatoid arthritis: lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists. Ann. Rheum. Dis. 64, 1414-1420, (2005).
    • (2005) Ann. Rheum. Dis. , vol.64 , pp. 1414-1420
    • Askling, J.1
  • 62
    • 27744527575 scopus 로고    scopus 로고
    • Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonists
    • Askling, J. et al. Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonists. Ann. Rheum. Dis. 64, 1421-1426 (2005).
    • (2005) Ann. Rheum. Dis. , vol.64 , pp. 1421-1426
    • Askling, J.1
  • 63
    • 80053565309 scopus 로고    scopus 로고
    • Malignancies associated with tumour necrosis factor inhibitors in registries and prospective observational studies: A systematic review and meta-analysis
    • Mariette, X. et al. Malignancies associated with tumour necrosis factor inhibitors in registries and prospective observational studies: a systematic review and meta-analysis. Ann. Rheum. Dis. 70, 1895-1904 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 1895-1904
    • Mariette, X.1
  • 64
    • 67549117204 scopus 로고    scopus 로고
    • The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: Meta and exposure-adjusted pooled analyses of serious adverse events
    • Leombruno, J. P., Einarson, T. R., Keystone, E. C. The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events. Ann. Rheum. Dis. 68, 1136-1145 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 1136-1145
    • Leombruno, J.P.1    Einarson, T.R.2    Keystone, E.C.3
  • 65
    • 78751685797 scopus 로고    scopus 로고
    • Cancer risk with tumor necrosis factor alpha (TNF) inhibitors: Meta-analysis of randomized controlled trials of adalimumab, etanercept, and infliximab using patient level data
    • Askling, J. et al. Cancer risk with tumor necrosis factor alpha (TNF) inhibitors: meta-analysis of randomized controlled trials of adalimumab, etanercept, and infliximab using patient level data. Pharmacoepidemiol. Drug Saf. 20, 119-130 (2011).
    • (2011) Pharmacoepidemiol. Drug Saf. , vol.20 , pp. 119-130
    • Askling, J.1
  • 66
    • 84869104402 scopus 로고    scopus 로고
    • Cancer risk of anti-TNF-alpha at recommended doses in adult rheumatoid arthritis: A meta-analysis with intention to treat and per protocol analyses
    • Moulis, G. et al. Cancer risk of anti-TNF-alpha at recommended doses in adult rheumatoid arthritis: a meta-analysis with intention to treat and per protocol analyses. PLoS ONE 7, e48991 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e48991
    • Moulis, G.1
  • 67
    • 84896494013 scopus 로고    scopus 로고
    • IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
    • Taniguchi, K., Karin, M. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin. Immunol. 26, 54-74 (2014).
    • (2014) Semin. Immunol. , vol.26 , pp. 54-74
    • Taniguchi, K.1    Karin, M.2
  • 68
    • 34447506658 scopus 로고    scopus 로고
    • Oncogenic RAS-induced secretion of IL6 is required for tumorigenesis
    • Ancrile, B., Lim, K. H., Counter, C. M. Oncogenic RAS-induced secretion of IL6 is required for tumorigenesis. Genes Dev. 21, 1714-1719 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 1714-1719
    • Ancrile, B.1    Lim, K.H.2    Counter, C.M.3
  • 69
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
    • Yonish-Rouach, E. et al. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352, 345-347 (1991).
    • (1991) Nature , vol.352 , pp. 345-347
    • Yonish-Rouach, E.1
  • 70
    • 84863115303 scopus 로고    scopus 로고
    • Paraneoplastic thrombocytosis in ovarian cancer
    • Stone, R. L. et al. Paraneoplastic thrombocytosis in ovarian cancer. N. Engl. J. Med. 366, 610-618 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 610-618
    • Stone, R.L.1
  • 71
    • 33846682591 scopus 로고    scopus 로고
    • The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells
    • Kulbe, H. et al. The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. Cancer Res. 67, 585-592 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 585-592
    • Kulbe, H.1
  • 72
    • 79954570471 scopus 로고    scopus 로고
    • IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer
    • Anglesio, M. S. et al. IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer. Clin. Cancer Res. 17, 2538-2548 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2538-2548
    • Anglesio, M.S.1
  • 73
    • 59149083547 scopus 로고    scopus 로고
    • 1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: Implications for microenvironment influence on tumor survival and proliferation
    • Shain, K. H. et al. ?1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation. Cancer Res. 69, 1009-1015 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 1009-1015
    • Shain, K.H.1
  • 74
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler, W. E. et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317, 121-124 (2007).
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1
  • 75
    • 0031811798 scopus 로고    scopus 로고
    • Chimaeric anti-interleukin 6 monoclonal antibodies in the treatment of advanced multiple myeloma: A phase i dose-escalating study
    • van Zaanen, H. C. et al. Chimaeric anti-interleukin 6 monoclonal antibodies in the treatment of advanced multiple myeloma: a phase I dose-escalating study. Br. J. Haematol. 102, 783-790 (1998).
    • (1998) Br. J. Haematol. , vol.102 , pp. 783-790
    • Van Zaanen, H.C.1
  • 76
    • 84879849025 scopus 로고    scopus 로고
    • A phase I, open-label study of siltuximab, an anti-IL-6 monoclonal antibody, in patients with B-cell non-Hodgkin lymphoma, multiple myeloma, or Castleman disease
    • Kurzrock, R. et al. A phase I, open-label study of siltuximab, an anti-IL-6 monoclonal antibody, in patients with B-cell non-Hodgkin lymphoma, multiple myeloma, or Castleman disease. Clin. Cancer Res. 19, 3659-3670 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 3659-3670
    • Kurzrock, R.1
  • 77
    • 84919683208 scopus 로고    scopus 로고
    • A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma
    • Orlowski, R. Z. et al. A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma. Am. J. Hematol. 90, 42-49 (2015).
    • (2015) Am. J. Hematol. , vol.90 , pp. 42-49
    • Orlowski, R.Z.1
  • 78
    • 80052855899 scopus 로고    scopus 로고
    • Interleukin-6 as a therapeutic target in human ovarian cancer
    • Coward, J. et al. Interleukin-6 as a therapeutic target in human ovarian cancer. Clin. Cancer Res. 17, 6083-6096 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6083-6096
    • Coward, J.1
  • 79
    • 77953091816 scopus 로고    scopus 로고
    • Clinical and correlative results of SWOG S0354: A phase II trial of CNTO328 (siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancer
    • Dorff, T. B. et al. Clinical and correlative results of SWOG S0354: a phase II trial of CNTO328 (siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancer. Clin. Cancer Res. 16, 3028-3034 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3028-3034
    • Dorff, T.B.1
  • 80
    • 0028880675 scopus 로고
    • Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines
    • Borsellino, N., Belldegrun, A., Bonavida, B. Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines. Cancer Res. 55, 4633-4639 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 4633-4639
    • Borsellino, N.1    Belldegrun, A.2    Bonavida, B.3
  • 81
    • 84879099298 scopus 로고    scopus 로고
    • A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer
    • Hudes, G. et al. A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer. Invest. New Drugs 31, 669-676 (2013).
    • (2013) Invest. New Drugs , vol.31 , pp. 669-676
    • Hudes, G.1
  • 82
    • 83255176682 scopus 로고    scopus 로고
    • Randomised phase II study of siltuximab (CNTO 328), an anti-IL-6 monoclonal antibody, in combination with mitoxantrone/prednisone versus mitoxantrone/prednisone alone in metastatic castration-resistant prostate cancer
    • Fizazi, K. et al. Randomised phase II study of siltuximab (CNTO 328), an anti-IL-6 monoclonal antibody, in combination with mitoxantrone/prednisone versus mitoxantrone/prednisone alone in metastatic castration-resistant prostate cancer. Eur. J. Cancer 48, 85-93 (2012).
    • (2012) Eur. J. Cancer , vol.48 , pp. 85-93
    • Fizazi, K.1
  • 83
    • 77957995258 scopus 로고    scopus 로고
    • A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer
    • Rossi, J. F. et al. A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer. Br. J. Cancer 103, 1154-1162 (2010).
    • (2010) Br. J. Cancer , vol.103 , pp. 1154-1162
    • Rossi, J.F.1
  • 84
    • 84875713812 scopus 로고    scopus 로고
    • Possible role for tocilizumab, an anti-interleukin-6 receptor antibody, in treating cancer cachexia
    • Ando, K. et al. Possible role for tocilizumab, an anti-interleukin-6 receptor antibody, in treating cancer cachexia. J. Clin. Oncol. 31, e69-e72 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. e69-e72
    • Ando, K.1
  • 85
    • 84941653574 scopus 로고    scopus 로고
    • Adaptive upregulation of EGFR limits attenuation of tumor growth by neutralizing IL-6 antibodies with implications for combined therapy in ovarian cancer
    • Milagre, C. S. et al. Adaptive upregulation of EGFR limits attenuation of tumor growth by neutralizing IL-6 antibodies with implications for combined therapy in ovarian cancer. Cancer Res. 75, 1255-1264 (2015).
    • (2015) Cancer Res. , vol.75 , pp. 1255-1264
    • Milagre, C.S.1
  • 86
    • 78649291412 scopus 로고    scopus 로고
    • Targeting chemokine (C-C motif) ligand 2 (CCL2) as an example of translation of cancer molecular biology to the clinic
    • Zhang, J., Patel, L., Pienta, K. J. Targeting chemokine (C-C motif) ligand 2 (CCL2) as an example of translation of cancer molecular biology to the clinic. Prog. Mol. Biol. Transl. Sci. 95, 31-53 (2010).
    • (2010) Prog. Mol. Biol. Transl. Sci. , vol.95 , pp. 31-53
    • Zhang, J.1    Patel, L.2    Pienta, K.J.3
  • 87
    • 84878849941 scopus 로고    scopus 로고
    • A first-in-human, first-in-class, phase i study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors
    • Sandhu, S. K. et al. A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors. Cancer Chemother. Pharmacol. 71, 1041-1050 (2013).
    • (2013) Cancer Chemother. Pharmacol. , vol.71 , pp. 1041-1050
    • Sandhu, S.K.1
  • 88
    • 84879085632 scopus 로고    scopus 로고
    • Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer
    • Pienta, K. J. et al. Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer. Invest. New Drugs 31, 760-768 (2013).
    • (2013) Invest. New Drugs , vol.31 , pp. 760-768
    • Pienta, K.J.1
  • 89
    • 84915793974 scopus 로고    scopus 로고
    • Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis
    • Bonapace, L. et al. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature 515, 130-133 (2014).
    • (2014) Nature , vol.515 , pp. 130-133
    • Bonapace, L.1
  • 90
    • 0035312891 scopus 로고    scopus 로고
    • Significant correlation between expression of interleukin-1and liver metastasis in gastric carcinoma
    • Tomimatsu, S., Ichikura, T., Mochizuki, H. Significant correlation between expression of interleukin-1and liver metastasis in gastric carcinoma. Cancer 91, 1272-1276 (2001).
    • (2001) Cancer , vol.91 , pp. 1272-1276
    • Tomimatsu, S.1    Ichikura, T.2    Mochizuki, H.3
  • 91
    • 10744223635 scopus 로고    scopus 로고
    • Interleukin 1 system and sex steroid receptor expression in human breast cancer: Interleukin 1protein secretion is correlated with malignant phenotype
    • Singer, C. F. et al. Interleukin 1 system and sex steroid receptor expression in human breast cancer: interleukin 1protein secretion is correlated with malignant phenotype. Clin. Cancer Res. 9, 4877-4883 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4877-4883
    • Singer, C.F.1
  • 92
    • 84855946746 scopus 로고    scopus 로고
    • KrasG12D-induced IKK2/?/NF-?B activation by IL-1and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma
    • Ling, J. et al. KrasG12D-induced IKK2/?/NF-?B activation by IL-1and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell 21, 105-120 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 105-120
    • Ling, J.1
  • 93
    • 84899989426 scopus 로고    scopus 로고
    • MABp1, a first-in-class true human antibody targeting interleukin-1in refractory cancers: An open-label, phase 1 dose-escalation and expansion study
    • Hong, D. S. et al. MABp1, a first-in-class true human antibody targeting interleukin-1in refractory cancers: an open-label, phase 1 dose-escalation and expansion study. Lancet Oncol. 15, 656-666 (2014).
    • (2014) Lancet Oncol. , vol.15 , pp. 656-666
    • Hong, D.S.1
  • 94
    • 0025735630 scopus 로고
    • Properties of the novel proinflammatory supergene intercrine" cytokine family
    • Oppenheim, J. J., Zachariae, C. O., Mukaida, N., Matsushima, K. Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu. Rev. Immunol. 9, 617-648 (1991).
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 617-648
    • Oppenheim, J.J.1    Zachariae, C.O.2    Mukaida, N.3    Matsushima, K.4
  • 95
    • 0024573776 scopus 로고
    • The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes
    • Larsen, C. G., Anderson, A. O., Appella, E., Oppenheim, J. J., Matsushima, K. The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes. Science 243, 1464-1466 (1989).
    • (1989) Science , vol.243 , pp. 1464-1466
    • Larsen, C.G.1    Anderson, A.O.2    Appella, E.3    Oppenheim, J.J.4    Matsushima, K.5
  • 96
    • 0025264320 scopus 로고
    • IL-1 alpha or tumor necrosis factor-alpha stimulate release of three NAP-1/IL-8-related neutrophil chemotactic proteins in human dermal fibroblasts
    • Schroder, J. M., Sticherling, M., Henneicke, H. H., Preissner, W. C., Christophers, E. IL-1 alpha or tumor necrosis factor-alpha stimulate release of three NAP-1/IL-8-related neutrophil chemotactic proteins in human dermal fibroblasts. J. Immunol. 144, 2223-2232 (1990).
    • (1990) J. Immunol. , vol.144 , pp. 2223-2232
    • Schroder, J.M.1    Sticherling, M.2    Henneicke, H.H.3    Preissner, W.C.4    Christophers, E.5
  • 97
    • 0026730106 scopus 로고
    • Activation of human basophils through the IL-8 receptor
    • Krieger, M. et al. Activation of human basophils through the IL-8 receptor. J. Immunol. 149, 2662-2667 (1992).
    • (1992) J. Immunol. , vol.149 , pp. 2662-2667
    • Krieger, M.1
  • 99
    • 0027052607 scopus 로고
    • Interleukin-8. A corneal factor that induces neovascularization
    • Strieter, R. M. et al. Interleukin-8. A corneal factor that induces neovascularization. Am. J. Pathol. 141, 1279-1284 (1992).
    • (1992) Am. J. Pathol. , vol.141 , pp. 1279-1284
    • Strieter, R.M.1
  • 100
    • 0027097806 scopus 로고
    • Interleukin-8 as a macrophage-derived mediator of angiogenesis
    • Koch, A. E. et al. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258, 1798-1801 (1992).
    • (1992) Science , vol.258 , pp. 1798-1801
    • Koch, A.E.1
  • 101
    • 0027279450 scopus 로고
    • IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor
    • Schadendorf, D. et al. IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor. J. Immunol. 151, 2667-2675 (1993).
    • (1993) J. Immunol. , vol.151 , pp. 2667-2675
    • Schadendorf, D.1
  • 102
    • 84918550680 scopus 로고    scopus 로고
    • Serum interleukin-8 reflects tumor burden and treatment response across malignancies of multiple tissue origins
    • Sanmamed, M. F. et al. Serum interleukin-8 reflects tumor burden and treatment response across malignancies of multiple tissue origins. Clin. Cancer Res. 20, 5697-5707 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 5697-5707
    • Sanmamed, M.F.1
  • 103
    • 0034163318 scopus 로고    scopus 로고
    • IL-8 reduced tumorigenicity of human ovarian cancer in vivo due to neutrophil infiltration
    • Lee, L. F. et al. IL-8 reduced tumorigenicity of human ovarian cancer in vivo due to neutrophil infiltration. J. Immunol. 164, 2769-2775 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 2769-2775
    • Lee, L.F.1
  • 104
    • 0029987940 scopus 로고    scopus 로고
    • Taxol-dependent transcriptional activation of IL-8 expression in a subset of human ovarian cancer
    • Lee, L. F. et al. Taxol-dependent transcriptional activation of IL-8 expression in a subset of human ovarian cancer. Cancer Res. 56, 1303-1308 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 1303-1308
    • Lee, L.F.1
  • 105
    • 80052869906 scopus 로고    scopus 로고
    • Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation
    • Bekes, E. M. et al. Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation. Am. J. Pathol. 179, 1455-1470 (2011).
    • (2011) Am. J. Pathol. , vol.179 , pp. 1455-1470
    • Bekes, E.M.1
  • 106
    • 0036310021 scopus 로고    scopus 로고
    • Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma
    • Huang, S. et al. Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am. J. Pathol. 161, 125-134 (2002).
    • (2002) Am. J. Pathol. , vol.161 , pp. 125-134
    • Huang, S.1
  • 107
    • 11244328119 scopus 로고    scopus 로고
    • Interleukin-8/CXCL8 is a growth factor for human lung cancer cells
    • Zhu, Y. M., Webster, S. J., Flower, D., Woll, P. J. Interleukin-8/CXCL8 is a growth factor for human lung cancer cells. Br. J. Cancer 91, 1970-1976 (2004).
    • (2004) Br. J. Cancer , vol.91 , pp. 1970-1976
    • Zhu, Y.M.1    Webster, S.J.2    Flower, D.3    Woll, P.J.4
  • 108
    • 67650034624 scopus 로고    scopus 로고
    • CXC-chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer
    • Matsuo, Y. et al. CXC-chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer. Int. J. Cancer 125, 1027-1037 (2009).
    • (2009) Int. J. Cancer , vol.125 , pp. 1027-1037
    • Matsuo, Y.1
  • 109
    • 84942299357 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00003835?term=NCT00003835&rank=1 (2013).
    • (2013)
  • 110
    • 84942299358 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02001974 (2015).
    • (2015)
  • 111
    • 76649113726 scopus 로고    scopus 로고
    • CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    • Ginestier, C. et al. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J. Clin. Invest. 120, 485-497 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 485-497
    • Ginestier, C.1
  • 112
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Müller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-56 (2001).
    • (2001) Nature , vol.410 , pp. 50-56
    • Müller, A.1
  • 113
    • 0038636392 scopus 로고    scopus 로고
    • Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells
    • Hall, J. M., Korach, K. S. Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. Mol. Endocrinol. 17, 792-803 (2003).
    • (2003) Mol. Endocrinol. , vol.17 , pp. 792-803
    • Hall, J.M.1    Korach, K.S.2
  • 114
    • 0037085938 scopus 로고    scopus 로고
    • Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    • Taichman, R. S. et al. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res. 62, 1832-1837 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 1832-1837
    • Taichman, R.S.1
  • 115
    • 22244470409 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: Von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor
    • Zagzag, D. et al. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res. 65, 6178-6188 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 6178-6188
    • Zagzag, D.1
  • 116
    • 42449111736 scopus 로고    scopus 로고
    • Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases
    • Kim, S. Y. et al. Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases. Clin. Exp. Metastases 25, 201-211 (2008).
    • (2008) Clin. Exp. Metastases , vol.25 , pp. 201-211
    • Kim, S.Y.1
  • 117
    • 0035887626 scopus 로고    scopus 로고
    • A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma
    • Geminder, H. et al. A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma. J. Immunol. 167, 4747-4757 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 4747-4757
    • Geminder, H.1
  • 118
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo, A. et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121, 335-348 (2005).
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1
  • 119
    • 21044440756 scopus 로고    scopus 로고
    • Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-and TGF
    • Stuelten, C. H. et al. Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-and TGF-?. J. Cell Sci. 118, 2143-2153 (2005).
    • (2005) J. Cell Sci. , vol.118 , pp. 2143-2153
    • Stuelten, C.H.1
  • 120
    • 84877724314 scopus 로고    scopus 로고
    • Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis
    • Jung, Y. et al. Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nat. Commun. 4, 1795 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 1795
    • Jung, Y.1
  • 121
    • 9244234390 scopus 로고    scopus 로고
    • CXCR4 regulates growth of-both primary and metastatic breast cancer
    • Smith, M. C. et al. CXCR4 regulates growth of-both primary and metastatic breast cancer. Cancer Res. 64, 8604-8612 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 8604-8612
    • Smith, M.C.1
  • 122
    • 78650315639 scopus 로고    scopus 로고
    • CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche
    • Kim, M. et al. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer Res. 70, 10411-10421 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 10411-10421
    • Kim, M.1
  • 123
    • 84867582756 scopus 로고    scopus 로고
    • Inhibition of stromal CXCR4 impairs development of lung metastases
    • D'Alterio, C. et al. Inhibition of stromal CXCR4 impairs development of lung metastases. Cancer Immunol. Immunother. 61, 1713-1720 (2012).
    • (2012) Cancer Immunol. Immunother. , vol.61 , pp. 1713-1720
    • D'Alterio, C.1
  • 124
    • 79251599039 scopus 로고    scopus 로고
    • Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases
    • Uchida, D. et al. Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases. Eur. J. Cancer 47, 452-459 (2011).
    • (2011) Eur. J. Cancer , vol.47 , pp. 452-459
    • Uchida, D.1
  • 125
    • 36749003738 scopus 로고    scopus 로고
    • Involvement of SDF-1?/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma
    • Kajiyama, H. et al. Involvement of SDF-1?/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma. Int. J. Cancer 122, 91-99 (2008).
    • (2008) Int. J. Cancer , vol.122 , pp. 91-99
    • Kajiyama, H.1
  • 126
    • 84890281217 scopus 로고    scopus 로고
    • Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
    • Feig, C. et al. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc. Natl Acad. Sci. USA 110, 20212-20217 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 20212-20217
    • Feig, C.1
  • 127
    • 84942299359 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02179970 (2015).
    • (2015)
  • 128
    • 0036251154 scopus 로고    scopus 로고
    • STAT proteins and oncogenesis
    • Bromberg, J. STAT proteins and oncogenesis. J. Clin. Invest. 109, 1139-1142 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 1139-1142
    • Bromberg, J.1
  • 129
    • 84863393110 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
    • Verstovsek, S. et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N. Engl. J. Med. 366, 799-807 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 799-807
    • Verstovsek, S.1
  • 130
    • 84857837774 scopus 로고    scopus 로고
    • JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
    • Harrison, C. et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N. Engl. J. Med. 366, 787-798 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 787-798
    • Harrison, C.1
  • 131
    • 84869401524 scopus 로고    scopus 로고
    • Phase i study of a novel oral Janus kinase 2 inhibitor, SB1518, in patients with relapsed lymphoma: Evidence of clinical and biologic activity in multiple lymphoma subtypes
    • Younes, A. et al. Phase I study of a novel oral Janus kinase 2 inhibitor, SB1518, in patients with relapsed lymphoma: evidence of clinical and biologic activity in multiple lymphoma subtypes. J. Clin. Oncol. 30, 4161-4167 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 4161-4167
    • Younes, A.1
  • 132
    • 84942299360 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02055781?term=pacritinib&rank=3 (2015).
    • (2015)
  • 133
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao, S. P. et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J. Clin. Invest. 117, 3846-3856 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 3846-3856
    • Gao, S.P.1
  • 134
    • 79955780881 scopus 로고    scopus 로고
    • JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling
    • Song, L., Rawal, B., Nemeth, J. A., Haura, E. B. JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling. Mol. Cancer Ther. 10, 481-494 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 481-494
    • Song, L.1    Rawal, B.2    Nemeth, J.A.3    Haura, E.B.4
  • 135
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Karin, M. Nuclear factor-kappaB in cancer development and progression. Nature 441, 431-436 (2006).
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 136
    • 84858718448 scopus 로고    scopus 로고
    • NF-kappaB and the link between inflammation and cancer
    • DiDonato, J. A., Mercurio, F., Karin, M. NF-kappaB and the link between inflammation and cancer. Immunol. Rev. 246, 379-400 (2012).
    • (2012) Immunol. Rev. , vol.246 , pp. 379-400
    • DiDonato, J.A.1    Mercurio, F.2    Karin, M.3
  • 137
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • San Miguel, J. F. et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N. Engl. J. Med. 359, 906-917 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 906-917
    • San Miguel, J.F.1
  • 138
    • 84874768399 scopus 로고    scopus 로고
    • Persistent overall survival benefit and no increased risk of second malignancies with bortezomib-melphalan-prednisone versus melphalan-prednisone in-patients with previously untreated multiple myeloma
    • San Miguel, J. F. et al. Persistent overall survival benefit and no increased risk of second malignancies with bortezomib-melphalan-prednisone versus melphalan-prednisone in-patients with previously untreated multiple myeloma. J. Clin. Oncol. 31, 448-455 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 448-455
    • San Miguel, J.F.1
  • 139
    • 61649094981 scopus 로고    scopus 로고
    • Bortezomib in patients with relapsed or refractory mantle cell lymphoma: Updated time-to-event analyses of the multicenter phase 2 PINNACLE study
    • Goy, A. et al. Bortezomib in patients with relapsed or refractory mantle cell lymphoma: updated time-to-event analyses of the multicenter phase 2 PINNACLE study. Ann. Oncol. 20, 520-525 (2009).
    • (2009) Ann. Oncol. , vol.20 , pp. 520-525
    • Goy, A.1
  • 140
    • 0027302498 scopus 로고
    • Interleukin-6 gene expression in multiple myeloma: A characteristic of immature tumor cells
    • Hata, H. et al. Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells. Blood 81, 3357-3364 (1993).
    • (1993) Blood , vol.81 , pp. 3357-3364
    • Hata, H.1
  • 141
    • 84875243259 scopus 로고    scopus 로고
    • Phase II randomized double blind placebo-controlled study comparing siltuximab plus bortezomib versus bortezomib alone in pts with relapsed/refractory multiple myeloma [abstract]
    • Orlowski, R. Z. et al. Phase II, randomized, double blind, placebo-controlled study comparing siltuximab plus bortezomib versus bortezomib alone in pts with relapsed/refractory multiple myeloma [abstract]. J. Clin. Oncol. 30 (Suppl.), a8018 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. a8018
    • Orlowski, R.Z.1
  • 142
    • 84903642514 scopus 로고    scopus 로고
    • Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma
    • San-Miguel, J. et al. Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma. Blood 123, 4136-4142 (2014).
    • (2014) Blood , vol.123 , pp. 4136-4142
    • San-Miguel, J.1
  • 143
    • 84885724091 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
    • Bindea, G. et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39, 782-795 (2013).
    • (2013) Immunity , vol.39 , pp. 782-795
    • Bindea, G.1
  • 144
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: Impact on clinical outcome
    • Fridman, W. H., Pages, F., Sautes-Fridman, C., Galon, J. The immune contexture in human tumours: impact on clinical outcome. Nat. Rev. Cancer 12, 298-306 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pages, F.2    Sautes-Fridman, C.3    Galon, J.4
  • 145
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer, J. R. et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28, 3167-3175 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1
  • 146
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 147
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok, J. D. et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369, 122-133 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 122-133
    • Wolchok, J.D.1
  • 148
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles, T. et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 515, 558-562 (2014).
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1
  • 149
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
    • Bingle, L., Brown, N. J., Lewis, C. E. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 196, 254-265 (2002).
    • (2002) J. Pathol. , vol.196 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 150
    • 84904394690 scopus 로고    scopus 로고
    • Macrophage activation and polarization: Nomenclature and experimental guidelines
    • Murray, P. J. et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14-20 (2014).
    • (2014) Immunity , vol.41 , pp. 14-20
    • Murray, P.J.1
  • 151
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis, J., Pollard, J. W. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124, 263-266 (2006).
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 152
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard, J. W. Tumour-educated macrophages promote tumour progression and metastasis. Nat. Rev Cancer 4, 71-78 (2004).
    • (2004) Nat. Rev Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 154
    • 18444404938 scopus 로고    scopus 로고
    • Unique features of the mode of action of ET-743
    • D'Incalci, M. et al. Unique features of the mode of action of ET-743. Oncologist 7, 210-216 (2002).
    • (2002) Oncologist , vol.7 , pp. 210-216
    • D'Incalci, M.1
  • 155
    • 81055124701 scopus 로고    scopus 로고
    • Multicenter phase II study of trabectedin in patients with metastatic castration-resistant prostate cancer
    • Michaelson, M. D. et al. Multicenter phase II study of trabectedin in patients with metastatic castration-resistant prostate cancer. Ann. Oncol. 23, 1234-1240 (2012).
    • (2012) Ann. Oncol. , vol.23 , pp. 1234-1240
    • Michaelson, M.D.1
  • 156
    • 84942299361 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00050427?term=NCT00050427&rank=1 (2011).
    • (2011)
  • 157
    • 84942299362 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01339754?term=NCT01339754&rank=1 (2014).
    • (2014)
  • 158
    • 84942299363 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02194231?term=NCT02194231&rank=1 (2015).
    • (2015)
  • 159
    • 20144388299 scopus 로고    scopus 로고
    • Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): Inhibition of macrophage differentiation and cytokine production
    • Allavena, P. et al. Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production. Cancer Res. 65, 2964-2971 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 2964-2971
    • Allavena, P.1
  • 160
    • 84873597334 scopus 로고    scopus 로고
    • Role of macrophage targeting in the antitumor activity of trabectedin
    • Germano, G. et al. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell 23, 249-262 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 249-262
    • Germano, G.1
  • 161
    • 84873468174 scopus 로고    scopus 로고
    • Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
    • Mitchem, J. B. et al. Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res. 73, 1128-1141 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 1128-1141
    • Mitchem, J.B.1
  • 162
    • 84877738839 scopus 로고    scopus 로고
    • CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer
    • Xu, J. et al. CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer. Cancer Res. 73, 2782-2794 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 2782-2794
    • Xu, J.1
  • 163
    • 77949900433 scopus 로고    scopus 로고
    • Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1-receptor: Combating tumor evasion of antiangiogenic therapy
    • Priceman, S. J. et al. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1-receptor: combating tumor evasion of antiangiogenic therapy. Blood 115, 1461-1471 (2010).
    • (2010) Blood , vol.115 , pp. 1461-1471
    • Priceman, S.J.1
  • 164
    • 84892738557 scopus 로고    scopus 로고
    • Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy
    • Mok, S. et al. Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy. Cancer Res. 74, 153-161 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 153-161
    • Mok, S.1
  • 165
    • 84902546715 scopus 로고    scopus 로고
    • Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy
    • Ries, C. H. et al. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell 25, 846-859 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 846-859
    • Ries, C.H.1
  • 166
    • 84942299364 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01444404?term=NCT01444404&rank=1 (2014).
    • (2014)
  • 167
    • 84942299365 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01346358?term=NCT01346358&rank=1 (2014).
    • (2014)
  • 168
    • 84942299366 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01596751?term=NCT01596751&rank=1 (2015).
    • (2015)
  • 169
    • 84942299367 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02265536?term=NCT02265536&rank=1 (2015).
    • (2015)
  • 170
    • 84942299368 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01349036?term=NCT01349036&rank=1 (2015).
    • (2015)
  • 171
    • 84942299369 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01004861?term=NCT01004861&rank=1 (2015).
    • (2015)
  • 172
    • 84942299370 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01346358?term=NCT01346358&rank=1 (2014).
    • (2014)
  • 173
    • 84907484156 scopus 로고    scopus 로고
    • CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models
    • Zhu, Y. et al. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res. 74, 5057-5069 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 5057-5069
    • Zhu, Y.1
  • 174
    • 0032482356 scopus 로고    scopus 로고
    • Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    • Bennett, S. R. et al. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393, 478-480 (1998).
    • (1998) Nature , vol.393 , pp. 478-480
    • Bennett, S.R.1
  • 175
    • 0032984347 scopus 로고    scopus 로고
    • Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40
    • Sotomayor, E. M. et al. Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40. Nat. Med. 5, 780-787 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 780-787
    • Sotomayor, E.M.1
  • 176
    • 0032984496 scopus 로고    scopus 로고
    • CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
    • Diehl, L. et al. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat. Med. 5, 774-779 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 774-779
    • Diehl, L.1
  • 177
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty, G. L. et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 331, 1612-1616 (2011).
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1
  • 178
    • 84888086049 scopus 로고    scopus 로고
    • A phase i study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma
    • Beatty, G. L. et al. A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma. Clin. Cancer Res. 19, 6286-6295 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 6286-6295
    • Beatty, G.L.1
  • 179
    • 65949111512 scopus 로고    scopus 로고
    • Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides
    • Bjork, P. et al. Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides. PLoS Biol. 7, e97 (2009).
    • (2009) PLoS Biol. , vol.7 , pp. e97
    • Bjork, P.1
  • 180
    • 70349952393 scopus 로고    scopus 로고
    • Open-label, clinical phase i studies of tasquinimod in patients with castration-resistant prostate cancer
    • Bratt, O. et al. Open-label, clinical phase I studies of tasquinimod in patients with castration-resistant prostate cancer. Br. J. Cancer 101, 1233-1240 (2009).
    • (2009) Br. J. Cancer , vol.101 , pp. 1233-1240
    • Bratt, O.1
  • 181
    • 80054761310 scopus 로고    scopus 로고
    • Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancer
    • Pili, R. et al. Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancer. J. Clin. Oncol. 29, 4022-4028 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 4022-4028
    • Pili, R.1
  • 182
    • 84942299371 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01234311?term=NCT+01234311&rank=1 (2014).
    • (2014)
  • 183
    • 84942299372 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01732549?term=NCT+01732549&rank=1 (2014).
    • (2014)
  • 184
    • 84942299373 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01513733?term=NCT+01513733&rank=1 (2014).
    • (2014)
  • 185
    • 84888049920 scopus 로고    scopus 로고
    • Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
    • Iida, N. et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 342, 967-970 (2013).
    • (2013) Science , vol.342 , pp. 967-970
    • Iida, N.1
  • 186
    • 84888059687 scopus 로고    scopus 로고
    • The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
    • Viaud, S. et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 342, 971-976 (2013).
    • (2013) Science , vol.342 , pp. 971-976
    • Viaud, S.1
  • 187
    • 1242315588 scopus 로고    scopus 로고
    • Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
    • Demaria, S. et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int. J. Radiat. Oncol. Biol. Phys. 58, 862-870 (2004).
    • (2004) Int. J. Radiat. Oncol. Biol. Phys. , vol.58 , pp. 862-870
    • Demaria, S.1
  • 189
    • 84905739456 scopus 로고    scopus 로고
    • Radiation as immunomodulator: Implications for dendritic cell-based immunotherapy
    • Roses, R. E., Datta, J., Czerniecki, B. J. Radiation as immunomodulator: implications for dendritic cell-based immunotherapy. Radiat. Res. 182, 211-218, (2014).
    • (2014) Radiat. Res. , vol.182 , pp. 211-218
    • Roses, R.E.1    Datta, J.2    Czerniecki, B.J.3
  • 190
    • 3442879246 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotide enhances tumor response to radiation
    • Milas, L. et al. CpG oligodeoxynucleotide enhances tumor response to radiation. Cancer Res. 64, 5074-5077 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 5074-5077
    • Milas, L.1
  • 191
    • 11344265206 scopus 로고    scopus 로고
    • Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances tumor response to fractionated radiotherapy
    • Mason, K. A. et al. Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances tumor response to fractionated radiotherapy. Clin. Cancer Res. 11, 361-369 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 361-369
    • Mason, K.A.1
  • 192
    • 84942299374 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01637532?term=NCT01637532&rank=1 (2014).
    • (2014)
  • 193
    • 84942299375 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01767857?term=NCT01767857&rank=1 (2015).
    • (2015)
  • 194
    • 84942299376 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02001974?term=NCT02001974&rank=1 (2015).
    • (2015)
  • 195
    • 84942299377 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02179970?term=NCT02179970&rank=1 (2015).
    • (2015)
  • 196
    • 84942299378 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02055781?term=NCT02055781&rank=1 (2015).
    • (2015)
  • 197
    • 84942299379 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02277093?term=NCT02277093&rank=1 (2015).
    • (2015)
  • 198
    • 70249101414 scopus 로고    scopus 로고
    • Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized phase II study of two different schedules
    • Demetri, G. D. et al. Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules. J. Clin. Oncol. 27, 4188-4196 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4188-4196
    • Demetri, G.D.1
  • 199
    • 84942299380 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00002904?term=NCT00002904&rank=1 (2012).
    • (2012)
  • 200
    • 84942299381 scopus 로고    scopus 로고
    • US National Library Medicine ClinicalTrials.gov [online]
    • US National Library Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01346358?term=NCT01346358&rank=1 (2014).
    • (2014)
  • 201
    • 84942299382 scopus 로고    scopus 로고
    • US National Library Medicine ClinicalTrials.gov [online]
    • US National Library Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01444404?term=NCT01444404&rank=1 (2015).
    • (2015)
  • 202
    • 84942299383 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01004861?term=NCT01004861&rank=1 (2015).
    • (2015)
  • 203
    • 84942299384 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01234311?term=NCT01234311&rank=1 (2014).
    • (2014)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.