How mutational epistasis impairs predictability in protein evolution and design

Protein Science

Volumn , Issue , 2016, Pages 1260-1272

  Miton, Charlotte M ^a   Tokuriki, Nobuhiko ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

adaptive mutations; directed evolution; enzyme evolution; epistasis; evolutionary constraints; protein engineering; rational design

Indexed keywords

ATRAZINE; ATRAZINE CHLORHYDROLASE; BETA HEXACHLOROCYCLOHEXANE; BETA LACTAMASE; BETA LACTAMASE TEM 1; CEFALEXIN; CEFOTAXIME; DIHYDROFOLATE REDUCTASE; EPOXIDE HYDROLASE; HALOALKANE DEHYDROGENASE; MELAMINE; OXIDOREDUCTASE; PARAOXON; PHOSPHOTRIESTERASE; PROTEIN; PYRIMETHAMINE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CATALYST; CONTROLLED STUDY; ENZYME ACTIVITY; EPISTASIS; GENE MUTATION; GENETIC BACKGROUND; MOLECULAR BIOLOGY; MOLECULAR EVOLUTION; MUTATIONAL ANALYSIS; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ENGINEERING; PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; WILD TYPE;

EID: 84976590623     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2876     Document Type: Article

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