-
1
-
-
75649111192
-
The genetic landscape of a cell
-
doi:10.1126/science.1180823
-
Costanzo, M. et al. 2010 The genetic landscape of a cell. Science 327, 425-431. doi:10.1126/science.1180823
-
(2010)
Science
, vol.327
, pp. 425-431
-
-
Costanzo, M.1
-
2
-
-
21244459227
-
Traversing the conceptual divide between biological and statistical epistasis: Systems biology and a more modern synthesis
-
doi:10.1002/bies.20236
-
Moore, J. H. & Williams, S. M. 2005 Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis. BioEssays 27, 637-646. doi:10.1002/bies.20236
-
(2005)
BioEssays
, vol.27
, pp. 637-646
-
-
Moore, J.H.1
Williams, S.M.2
-
3
-
-
54149088214
-
Epistasis: The essential role of gene interactions in the structure and evolution of genetic systems
-
doi:10.1038/ nrg2452
-
Phillips, P. C. 2008 Epistasis: the essential role of gene interactions in the structure and evolution of genetic systems. Nat. Rev. Genet. 9, 855-867. doi:10.1038/ nrg2452
-
(2008)
Nat. Rev. Genet
, vol.9
, pp. 855-867
-
-
Phillips, P.C.1
-
5
-
-
0017710252
-
The evolution of epistasis and the advantage of recombination in populations of bacteriophage T4
-
Malmberg, R. L. 1977 The evolution of epistasis and the advantage of recombination in populations of bacteriophage T4. Genetics 86, 607-621.
-
(1977)
Genetics
, vol.86
, pp. 607-621
-
-
Malmberg, R.L.1
-
6
-
-
33644745138
-
Sexual reproduction selects for robustness and negative epistasis in artificial gene networks
-
doi:10.1038/ nature04488
-
Azevedo, R. B. R., Lohaus, R., Srinivasan, S., Dang, K. K. & Burch, C. L. 2006 Sexual reproduction selects for robustness and negative epistasis in artificial gene networks. Nature 440, 87-90. doi:10.1038/ nature04488
-
(2006)
Nature
, vol.440
, pp. 87-90
-
-
Azevedo, R.B.R.1
Lohaus, R.2
Srinivasan, S.3
Dang, K.K.4
Burch, C.L.5
-
7
-
-
35548969209
-
Evolution can favor antagonistic epistasis
-
doi:10.1534/genetics.107.075812
-
Desai, M. M., Weissman, D. & Feldman, M. W. 2007 Evolution can favor antagonistic epistasis. Genetics 177, 1001-1010. doi:10.1534/genetics.107.075812
-
(2007)
Genetics
, vol.177
, pp. 1001-1010
-
-
Desai, M.M.1
Weissman, D.2
Feldman, M.W.3
-
8
-
-
67849092403
-
The evolution of epistasis and its links with genetic robustness, complexity and drift in a phenotypic model of adaptation
-
doi:10.1534/gen etics.108.099127
-
Gros, P.-A., Le Nagard, H. & Tenaillon, O. 2009 The evolution of epistasis and its links with genetic robustness, complexity and drift in a phenotypic model of adaptation. Genetics 182, 277-293. doi:10.1534/gen etics.108.099127
-
(2009)
Genetics
, vol.182
, pp. 277-293
-
-
Gros, P.-A.1
Le Nagard, H.2
Tenaillon, O.3
-
9
-
-
39149100619
-
On the evolution of epistasis III: The haploid case with mutation
-
doi:10.1016/j.tpb.2007. 11.010
-
Liberman, U. & Feldman, M. W. 2008 On the evolution of epistasis III: the haploid case with mutation. Theor. Popul. Biol. 73, 307-316. doi:10.1016/j.tpb.2007. 11.010
-
(2008)
Theor. Popul. Biol
, vol.73
, pp. 307-316
-
-
Liberman, U.1
Feldman, M.W.2
-
10
-
-
16244398398
-
On the evolution of epistasis. I: Diploids under selection
-
doi:10.1016/j.tpb.2004.11.001
-
Liberman, U. & Feldman, M. W. 2005 On the evolution of epistasis. I: diploids under selection. Theor. Popul. Biol. 67, 141-160. doi:10.1016/j.tpb.2004.11.001
-
(2005)
Theor. Popul. Biol
, vol.67
, pp. 141-160
-
-
Liberman, U.1
Feldman, M.W.2
-
11
-
-
33846628526
-
On the evolution of epistasis. II: A generalized Wright-Kimura framework
-
doi:10.1016/j.tpb.2006.10.002
-
Liberman, U., Puniyani, A. & Feldman, M.W. 2007 On the evolution of epistasis. II: a generalized Wright-Kimura framework. Theor. Popul. Biol. 71, 230-238. doi:10.1016/j.tpb.2006.10.002
-
(2007)
Theor. Popul. Biol
, vol.71
, pp. 230-238
-
-
Liberman, U.1
Puniyani, A.2
Feldman, M.W.3
-
12
-
-
70649083250
-
Effects of recombination on complex regulatory circuits
-
doi:10.1534/genetics.109.104174
-
Martin, O. C. & Wagner, A. 2009 Effects of recombination on complex regulatory circuits. Genetics 183, 673-684. doi:10.1534/genetics.109.104174
-
(2009)
Genetics
, vol.183
, pp. 673-684
-
-
Martin, O.C.1
Wagner, A.2
-
13
-
-
33646673346
-
Sexual reproduction reshapes the genetic architecture of digital organisms
-
doi:10.1098/ rspb.2005.3338
-
Misevic, D., Ofria, C. & Lenski, R. E. 2006 Sexual reproduction reshapes the genetic architecture of digital organisms. Proc. R. Soc. B 273, 457-464. doi:10.1098/ rspb.2005.3338
-
(2006)
Proc. R. Soc. B
, vol.273
, pp. 457-464
-
-
Misevic, D.1
Ofria, C.2
Lenski, R.E.3
-
14
-
-
0007449015
-
-
London, UK: Harrison and Sons
-
Bateson, W., Saunders, E. R., Punnett, R. C. & Hurst, C. C. 1905 Reports to the Evolution Committee of the Royal Society, Report II. London, UK: Harrison and Sons.
-
(1905)
Reports to the Evolution Committee of The Royal Society, Report II
-
-
Bateson, W.1
Saunders, E.R.2
Punnett, R.C.3
Hurst, C.C.4
-
15
-
-
84971185409
-
The correlations between relatives on the supposition of Mendelian inheritance
-
Fisher, R. A. 1918 The correlations between relatives on the supposition of Mendelian inheritance. Trans. R. Soc. Edinburgh 52, 399-433.
-
(1918)
Trans. R. Soc. Edinburgh
, vol.52
, pp. 399-433
-
-
Fisher, R.A.1
-
16
-
-
0031827525
-
The language of gene interaction (perspective)
-
Phillips, P. C. 1998 The language of gene interaction (perspective). Genetics 149, 1167-1171.
-
(1998)
Genetics
, vol.149
, pp. 1167-1171
-
-
Phillips, P.C.1
-
17
-
-
0035834126
-
Multidimensional epistasis and the disadvantage of sex
-
doi:10. 1073/pnas.211214298
-
Kondrashov, F. A. & Kondrashov, A. S. 2001 Multidimensional epistasis and the disadvantage of sex. Proc. Natl Acad. Sci. USA 98, 12089-12092. doi:10. 1073/pnas.211214298
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 12089-12092
-
-
Kondrashov, F.A.1
Kondrashov, A.S.2
-
18
-
-
21044435697
-
Perspective: Sign epistasis and genetic constraint on evolutionary trajectories
-
Weinreich, D. M., Watson, R. A. & Chao, L. 2005 Perspective: sign epistasis and genetic constraint on evolutionary trajectories. Evolution 59, 1165-1174.
-
(2005)
Evolution
, vol.59
, pp. 1165-1174
-
-
Weinreich, D.M.1
Watson, R.A.2
Chao, L.3
-
19
-
-
0029022154
-
A general model for the evolution of recombination
-
doi:10.1017/ S0016672300033140
-
Barton, N. H. 1995 A general model for the evolution of recombination. Genet. Res. 65, 123-144. doi:10.1017/ S0016672300033140
-
(1995)
Genet. Res
, vol.65
, pp. 123-144
-
-
Barton, N.H.1
-
20
-
-
0023737547
-
Deleterious mutations and the evolution of sexual reproduction
-
doi:10.1038/336435a0
-
Kondrashov, A. S. 1988 Deleterious mutations and the evolution of sexual reproduction. Nature 336, 435-440. doi:10.1038/336435a0
-
(1988)
Nature
, vol.336
, pp. 435-440
-
-
Kondrashov, A.S.1
-
21
-
-
33846277942
-
The evolution of sex: Empirical insights into the roles of epistasis and drift
-
doi:10.1038/ nrg1985
-
de Visser, J. A. G. M. & Elena, S. F. 2007 The evolution of sex: empirical insights into the roles of epistasis and drift. Nat. Rev. Genet. 8, 139-149. doi:10.1038/ nrg1985
-
(2007)
Nat. Rev. Genet
, vol.8
, pp. 139-149
-
-
de Visser, J.A.G.M.1
Elena, S.F.2
-
22
-
-
34248364854
-
Epistasis between deleterious mutations and the evolution of recombination
-
doi:10.1016/j.tree.2007.02.014
-
Kouyos, R. D., Silander, O. K. & Bonhoeffer, S. 2007 Epistasis between deleterious mutations and the evolution of recombination. Trends Ecol. Evol. 22, 308-315. doi:10.1016/j.tree.2007.02.014
-
(2007)
Trends Ecol. Evol
, vol.22
, pp. 308-315
-
-
Kouyos, R.D.1
Silander, O.K.2
Bonhoeffer, S.3
-
23
-
-
0029729215
-
The effect of sex and deleterious mutations on fitness in Chlamydomonas
-
doi:10.1098/rspb.1996.0031
-
de Visser, J. A.G. M., Hoekstra, R. F. & van den Ende, H. 1996 The effect of sex and deleterious mutations on fitness in Chlamydomonas. Proc. R. Soc. Lond. B 263, 193-200. doi:10.1098/rspb.1996.0031
-
(1996)
Proc. R. Soc. Lond. B
, vol.263
, pp. 193-200
-
-
de Visser, J.A.G.M.1
Hoekstra, R.F.2
van den Ende, H.3
-
24
-
-
0031020691
-
An experimental test for synergistic epistasis and its application in Chlamydomonas
-
de Visser, J. A.G. M., Hoekstra, R. F. & van den Ende, H. 1997 An experimental test for synergistic epistasis and its application in Chlamydomonas. Genetics 145, 815-819.
-
(1997)
Genetics
, vol.145
, pp. 815-819
-
-
de Visser, J.A.G.M.1
Hoekstra, R.F.2
van den Ende, H.3
-
25
-
-
0000577181
-
The genetic structure of natural populations of Drosophila melanogaster. VII: Synergistic interaction of spontaneous mutant polygenes controlling viability
-
Mukai, T. 1969 The genetic structure of natural populations of Drosophila melanogaster. VII: synergistic interaction of spontaneous mutant polygenes controlling viability. Genetics 61, 749-761.
-
(1969)
Genetics
, vol.61
, pp. 749-761
-
-
Mukai, T.1
-
26
-
-
0037591302
-
The effects of parasitism and inbreeding on the competitive ability in Daphnia magna: Evidence for synergistic epistasis
-
doi:10.1046/j.1420-9101. 2003.00582.x
-
Salathé, P. & Ebert, D. 2003 The effects of parasitism and inbreeding on the competitive ability in Daphnia magna: evidence for synergistic epistasis. J. Evol. Biol. 16, 976-985. doi:10.1046/j.1420-9101. 2003.00582.x
-
(2003)
J. Evol. Biol
, vol.16
, pp. 976-985
-
-
Salathé, P.1
Ebert, D.2
-
27
-
-
0033709990
-
Factors affecting the genetic load in Drosophila: Synergistic epistasis and correlations among fitness components
-
doi:10.1111/j.0014-3820.2000.tb.00709.x
-
Whitlock, M. C. & Bourguet, D. 2000 Factors affecting the genetic load in Drosophila: synergistic epistasis and correlations among fitness components. Evolution 54, 1654-1660. doi:10.1111/j.0014-3820.2000.tb.00709.x
-
(2000)
Evolution
, vol.54
, pp. 1654-1660
-
-
Whitlock, M.C.1
Bourguet, D.2
-
28
-
-
34047143174
-
Epistatic buffering of fitness loss in yeast double deletion strains
-
doi:10.1038/ng1986
-
Jasnos, L. & Korona, R. 2007 Epistatic buffering of fitness loss in yeast double deletion strains. Nat. Genet. 39, 550-554. doi:10.1038/ng1986
-
(2007)
Nat. Genet
, vol.39
, pp. 550-554
-
-
Jasnos, L.1
Korona, R.2
-
29
-
-
0033549752
-
Genome complexity, robustness and genetic interactions in digital organisms
-
doi:10.1038/23245
-
Lenski, R. E., Ofria, C., Collier, T. C. & Adami, C. 1999 Genome complexity, robustness and genetic interactions in digital organisms. Nature 400, 661-664. doi:10.1038/23245
-
(1999)
Nature
, vol.400
, pp. 661-664
-
-
Lenski, R.E.1
Ofria, C.2
Collier, T.C.3
Adami, C.4
-
30
-
-
28444484984
-
Genomic buffering mitigates the effects of deleterious mutations in bacteria
-
doi:10.1038/ng1676
-
Maisnier-Patin, S., Roth, J. R., Fredriksson, A., Nystrom, T., Berg, O. G. & Andersson, D. I. 2005 Genomic buffering mitigates the effects of deleterious mutations in bacteria. Nat. Genet. 37, 1376-1379. doi:10.1038/ng1676
-
(2005)
Nat. Genet
, vol.37
, pp. 1376-1379
-
-
Maisnier-Patin, S.1
Roth, J.R.2
Fredriksson, A.3
Nystrom, T.4
Berg, O.G.5
Andersson, D.I.6
-
31
-
-
7444221704
-
The contribution of epistasis to the architecture of fitness in an RNA virus
-
doi:10.1073/pnas.0404125101
-
Sanjuán, R., Moya, A. & Elena, S. F. 2004 The contribution of epistasis to the architecture of fitness in an RNA virus. Proc. Natl Acad. Sci. USA 101, 15376-15379. doi:10.1073/pnas.0404125101
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 15376-15379
-
-
Sanjuán, R.1
Moya, A.2
Elena, S.F.3
-
32
-
-
14844363079
-
The number of mutations selected during adaptation in a laboratory population of Saccharomyces cerevisiae
-
doi:10.1534/gen etics.104.027102
-
Zeyl, C. 2005 The number of mutations selected during adaptation in a laboratory population of Saccharomyces cerevisiae. Genetics 169, 1825-1831. doi:10.1534/gen etics.104.027102
-
(2005)
Genetics
, vol.169
, pp. 1825-1831
-
-
Zeyl, C.1
-
33
-
-
0343963783
-
Effect of deleterious mutation-accumulation on the fitness of RNA bacteriophage MS2
-
doi:10.1554/0014-3820(2000)054[0686:EODMAO] 2.0.CO;2
-
de la Peña, M., Elena, S. F. & Moya, A. 2000 Effect of deleterious mutation-accumulation on the fitness of RNA bacteriophage MS2. Evolution 54, 686-691. doi:10.1554/0014-3820(2000)054[0686:EODMAO] 2.0.CO;2
-
(2000)
Evolution
, vol.54
, pp. 686-691
-
-
de la Peña, M.1
Elena, S.F.2
Moya, A.3
-
34
-
-
0030780902
-
Test of interaction between genetic markers that affect fitness in Aspergillus niger
-
doi:10.2307/2411202
-
de Visser, J. A.G. M., Hoekstra, R. F. & van den Ende, H. 1997 Test of interaction between genetic markers that affect fitness in Aspergillus niger. Evolution 51, 1499-1505. doi:10.2307/2411202
-
(1997)
Evolution
, vol.51
, pp. 1499-1505
-
-
de Visser, J.A.G.M.1
Hoekstra, R.F.2
van den Ende, H.3
-
35
-
-
0033278903
-
Little evidence for synergism among deleterious mutations in a nonsegmented RNA virus
-
doi:10.1007/PL00000082
-
Elena, S. F. 1999 Little evidence for synergism among deleterious mutations in a nonsegmented RNA virus. J. Mol. Evol. 49, 703-707. doi:10.1007/PL00000082
-
(1999)
J. Mol. Evol
, vol.49
, pp. 703-707
-
-
Elena, S.F.1
-
36
-
-
0031458777
-
Test of interaction between deleterious mutations in E
-
doi:10.1038/37108
-
Elena, S. F. & Lenski, R. E. 1997 Test of interaction between deleterious mutations in E. coli. Nature 390, 395-398. doi:10.1038/37108
-
(1997)
Coli. Nature
, vol.390
, pp. 395-398
-
-
Elena, S.F.1
Lenski, R.E.2
-
37
-
-
77952007724
-
Fitness epistasis among 6 biosynthetic loci in the budding yeast Saccharomyces cerevisiae
-
doi:10.1093/jhered/esq007
-
Hall, D. W., Agan, M. & Pope, S. C. 2010 Fitness epistasis among 6 biosynthetic loci in the budding yeast Saccharomyces cerevisiae. J. Hered. 101, S75-S84. doi:10.1093/jhered/esq007
-
(2010)
J. Hered
, vol.101
-
-
Hall, D.W.1
Agan, M.2
Pope, S.C.3
-
38
-
-
33645128929
-
Epistasis in monkeyflowers
-
doi:10.1534/genetics.105.041525
-
Kelly, J. 2005 Epistasis in monkeyflowers. Genetics 171, 1917-1931. doi:10.1534/genetics.105.041525
-
(2005)
Genetics
, vol.171
, pp. 1917-1931
-
-
Kelly, J.1
-
39
-
-
11244297914
-
Modular epistasis in yeast metabolism
-
doi:10.1038/ng1489
-
Segre, D. A. D., Church, G. M. & Kishony, R. 2005 Modular epistasis in yeast metabolism. Nat. Genet. 37, 77-83. doi:10.1038/ng1489
-
(2005)
Nat. Genet
, vol.37
, pp. 77-83
-
-
Segre, D.A.D.1
Church, G.M.2
Kishony, R.3
-
40
-
-
77649182884
-
Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks
-
doi:10.1038/ng.524
-
He, X., Qian, W., Wang, Z., Li, Y. & Zhang, J. 2010 Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. Nat. Genet. 42, 272-276. doi:10.1038/ng.524
-
(2010)
Nat. Genet
, vol.42
, pp. 272-276
-
-
He, X.1
Qian, W.2
Wang, Z.3
Li, Y.4
Zhang, J.5
-
41
-
-
76549129324
-
Adaptive landscapes and protein evolution
-
doi:10.1073/pnas.0906192106
-
Carneiro, M. & Hartl, D. L. 2009 Adaptive landscapes and protein evolution. Proc. Natl Acad. Sci. USA 107, 1747-1751. doi:10.1073/pnas.0906192106
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 1747-1751
-
-
Carneiro, M.1
Hartl, D.L.2
-
42
-
-
80052329913
-
Evolutionary accessibility of mutational pathways
-
doi:10.1371/journal. pcbi.1002134
-
Franke, J., Klozer, A., de Visser, J. A. G. M. & Krug, J. 2011 Evolutionary accessibility of mutational pathways. PLoS Comput. Biol. 7, e1002134. doi:10.1371/journal. pcbi.1002134
-
(2011)
PLoS Comput. Biol
, vol.7
-
-
Franke, J.1
Klozer, A.2
de Visser, J.A.G.M.3
Krug, J.4
-
43
-
-
33645666942
-
Darwinian evolution can follow only very few mutational paths to fitter proteins
-
doi:10.1126/science.1123539
-
Weinreich, D. M., Delaney, N. F., DePristo, M. A. & Hartl, D. L. 2006 Darwinian evolution can follow only very few mutational paths to fitter proteins. Science 312, 111-114. doi:10.1126/science.1123539
-
(2006)
Science
, vol.312
, pp. 111-114
-
-
Weinreich, D.M.1
Delaney, N.F.2
Depristo, M.A.3
Hartl, D.L.4
-
44
-
-
27144538817
-
The biochemical architecture of an ancient adaptive landscape
-
doi:10.1126/ science.1115649
-
Lunzer, M., Miller, S. P., Felsheim, R. & Dean, A. M. 2005 The biochemical architecture of an ancient adaptive landscape. Science 310, 499-501. doi:10.1126/ science.1115649
-
(2005)
Science
, vol.310
, pp. 499-501
-
-
Lunzer, M.1
Miller, S.P.2
Felsheim, R.3
Dean, A.M.4
-
45
-
-
51949110360
-
Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases
-
doi:10.1038/nchembio.113
-
O'Maille, P. E. et al. 2008 Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nat. Chem. Biol. 4, 617-623. doi:10.1038/nchembio.113
-
(2008)
Nat. Chem. Biol
, vol.4
, pp. 617-623
-
-
O'Maille, P.E.1
-
46
-
-
67749098058
-
Stepwise acquisition of pyrimethamine resistance in the malaria parasite
-
doi:10.1073/pnas.0905922106
-
Lozovsky, E. R., Chookajorn, T., Browna, K. M., Imwong, M., Shaw, P. J., Kamchonwongpaisan, S., Neafsey, D. E., Weinreich, D. M. & Hartl, D. L. 2009 Stepwise acquisition of pyrimethamine resistance in the malaria parasite. Proc. Natl Acad. Sci. USA 106, 12015-12030. doi:10.1073/pnas.0905922106
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 12015-12030
-
-
Lozovsky, E.R.1
Chookajorn, T.2
Browna, K.M.3
Imwong, M.4
Shaw, P.J.5
Kamchonwongpaisan, S.6
Neafsey, D.E.7
Weinreich, D.M.8
Hartl, D.L.9
-
47
-
-
68549127130
-
Exploring the effect of sex on empirical fitness landscapes
-
doi:10.1086/599081
-
de Visser, J. A. G. M., Park, S.-C. & Krug, J. 2009 Exploring the effect of sex on empirical fitness landscapes. Am. Nat. 174, S15-S30. doi:10.1086/599081
-
(2009)
Am. Nat
, vol.174
-
-
de Visser, J.A.G.M.1
Park, S.-C.2
Krug, J.3
-
48
-
-
79957948242
-
Negative epistasis between beneficial mutations in an evolving bacterial population
-
doi:10.1126/science.1203801
-
Khan, A. I., Dinh, D. M., Schneider, D., Lenski, R. E. & Cooper, T. F. 2011 Negative epistasis between beneficial mutations in an evolving bacterial population. Science 332, 1193-1196. doi:10.1126/science.1203801
-
(2011)
Science
, vol.332
, pp. 1193-1196
-
-
Khan, A.I.1
Dinh, D.M.2
Schneider, D.3
Lenski, R.E.4
Cooper, T.F.5
-
49
-
-
79957958115
-
Diminishing returns epistasis among beneficial mutations decelerates adaptation
-
doi:10.1126/science.1203799
-
Chou, H.-H., Chiu, H.-C., Delaney, N. F., Segre, D. & Marx, C. J. 2011 Diminishing returns epistasis among beneficial mutations decelerates adaptation. Science 332, 1190-1192. doi:10.1126/science.1203799
-
(2011)
Science
, vol.332
, pp. 1190-1192
-
-
Chou, H.-H.1
Chiu, H.-C.2
Delaney, N.F.3
Segre, D.4
Marx, C.J.5
-
50
-
-
77956641491
-
Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region
-
doi:10. 1534/genetics.109.112458
-
da Silva, J., Coetzer, M., Nedellec, R., Pastore, C. & Mosier, D. E. 2010 Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region. Genetics 185, 293-303. doi:10. 1534/genetics.109.112458
-
(2010)
Genetics
, vol.185
, pp. 293-303
-
-
da Silva, J.1
Coetzer, M.2
Nedellec, R.3
Pastore, C.4
Mosier, D.E.5
-
51
-
-
79955423458
-
A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase
-
doi:10.1038/ng.795
-
Hinkley, T., Martins, J., Chappey, C., Haddad, M., Stawiski, E., Whitcomb, J. M., Petropoulos, C. J. & Bonhoeffer, S. 2011 A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase. Nat. Genet. 43, 487-490. doi:10.1038/ng.795
-
(2011)
Nat. Genet
, vol.43
, pp. 487-490
-
-
Hinkley, T.1
Martins, J.2
Chappey, C.3
Haddad, M.4
Stawiski, E.5
Whitcomb, J.M.6
Petropoulos, C.J.7
Bonhoeffer, S.8
-
52
-
-
79955590028
-
Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape
-
Kvitek,D. J. & Sherlock,G, doi:10.1371/journal.pgen.1002056
-
Kvitek,D. J. & Sherlock,G. 2011 Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape. PLoS Genet. 7, e1002056. doi:10.1371/journal.pgen.1002056
-
(2011)
PLoS Genet
, vol.7
-
-
-
53
-
-
79251553136
-
Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for Rifampicin resistance in Pseudomonas aeruginosa
-
doi:10.1534/genetics.110. 123083
-
MacLean, R. C., Perron, G. G. & Gardner, A. 2010 Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for Rifampicin resistance in Pseudomonas aeruginosa. Genetics 186, 1345-1354. doi:10.1534/genetics.110. 123083
-
(2010)
Genetics
, vol.186
, pp. 1345-1354
-
-
Maclean, R.C.1
Perron, G.G.2
Gardner, A.3
-
54
-
-
79959826609
-
Epistasis between beneficial mutations and the phenotype-to-fitness map for a ssDNA virus
-
doi:10. 1371/journal.pgen.1002075
-
Rokyta, D. R., Joyce, P., Caudle, S. B., Miller, C., Beisel, C. J. & Wichman, H. A. 2011 Epistasis between beneficial mutations and the phenotype-to-fitness map for a ssDNA virus. PLoS Genet. 7, e1002075. doi:10. 1371/journal.pgen.1002075
-
(2011)
PLoS Genet
, vol.7
-
-
Rokyta, D.R.1
Joyce, P.2
Caudle, S.B.3
Miller, C.4
Beisel, C.J.5
Wichman, H.A.6
-
55
-
-
79953738501
-
Initial mutations direct alternative pathways of protein evolution
-
doi:10.1371/journal.pgen. 1001321
-
Salverda, M. L. M., Dellus, E., Gorter, F. A., Debets, A. J. M., Van der Oost, J., Hoekstra, R. F., Tawfik, D. S. & de Visser, J. A. G. M. 2011 Initial mutations direct alternative pathways of protein evolution. PLoS Genet. 7, e1001321. doi:10.1371/journal.pgen. 1001321
-
(2011)
PLoS Genet
, vol.7
-
-
Salverda, M.L.M.1
Dellus, E.2
Gorter, F.A.3
Debets, A.J.M.4
van der Oost, J.5
Hoekstra, R.F.6
Tawfik, D.S.7
de Visser, J.A.G.M.8
-
56
-
-
34247603929
-
Experimental rugged fitness landscape in protein sequence space
-
doi:10. 1371/journal.pone.0000096
-
Hayashi, Y., Aita, T., Toyota, H., Husimi, Y., Urabe, I. & Yomo, T. 2006 Experimental rugged fitness landscape in protein sequence space. PLoS ONE 1, e96. doi:10. 1371/journal.pone.0000096
-
(2006)
PLoS ONE
, vol.1
-
-
Hayashi, Y.1
Aita, T.2
Toyota, H.3
Husimi, Y.4
Urabe, I.5
Yomo, T.6
-
57
-
-
0037649306
-
Long-term experimental evolution in Escherichia coli. XI. Rejection of non-transitive interactions as cause of declining rate of adaptation
-
doi:10.1186/ 1471-2148-2-19
-
de Visser, J. A. G. M. & Lenski, R. E. 2002 Long-term experimental evolution in Escherichia coli. XI. Rejection of non-transitive interactions as cause of declining rate of adaptation. BMC Evol. Biol. 2, 19. doi:10.1186/ 1471-2148-2-19
-
(2002)
BMC Evol. Biol
, vol.2
, pp. 19
-
-
de Visser, J.A.G.M.1
Lenski, R.E.2
-
58
-
-
73249126286
-
The dynamics of adaptation on correlated fitness landscapes
-
doi:10. 1073/pnas.0905497106
-
Kryazhimskiy, S., Tkacik, G. & Plotkin, J. B. 2009 The dynamics of adaptation on correlated fitness landscapes. Proc. Natl Acad. Sci. USA 276, 18638-18643. doi:10. 1073/pnas.0905497106
-
(2009)
Proc. Natl Acad. Sci. USA 276
, pp. 18638-18643
-
-
Kryazhimskiy, S.1
Tkacik, G.2
Plotkin, J.B.3
-
59
-
-
79960642108
-
Molecular mechanisms of epistasis within and between genes
-
doi:10.1016/j.tig.2011.05.007
-
Lehner, B. 2011 Molecular mechanisms of epistasis within and between genes. Trends Genet. 27, 323-331. doi:10.1016/j.tig.2011.05.007
-
(2011)
Trends Genet
, vol.27
, pp. 323-331
-
-
Lehner, B.1
-
60
-
-
0036239186
-
Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage T7
-
You, L. & Yin, J. 2002 Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage T7. Genetics 160, 1273-1281.
-
(2002)
Genetics
, vol.160
, pp. 1273-1281
-
-
You, L.1
Yin, J.2
-
61
-
-
34347332311
-
A genomescale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information
-
doi:10.1038/ msb4100155
-
Feist, A. M., Henry, C. S., Reed, J. L., Krummenacker, M., Joyce, A. R., Karp, P. D., Broadbelt, L. J., Hatzimanikatis, V. & Palsson, B. Ø. 2007 A genomescale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information. Mol. Syst. Biol. 3, 121. doi:10.1038/ msb4100155
-
(2007)
Mol. Syst. Biol
, vol.3
, pp. 121
-
-
Feist, A.M.1
Henry, C.S.2
Reed, J.L.3
Krummenacker, M.4
Joyce, A.R.5
Karp, P.D.6
Broadbelt, L.J.7
Hatzimanikatis, V.8
Palsson, B.O.9
-
62
-
-
79959687662
-
An integrated approach to characterize genetic interaction networks in yeast metabolism
-
doi:10.1038/ ng.846
-
Szappanos, B. et al. 2011 An integrated approach to characterize genetic interaction networks in yeast metabolism. Nat. Genet. 43, 656-662. doi:10.1038/ ng.846
-
(2011)
Nat. Genet
, vol.43
, pp. 656-662
-
-
Szappanos, B.1
-
63
-
-
0022500302
-
Fitness as a function of b-galactosidase function in Escherichia coli
-
doi:10.1017/ S0016672300024587
-
Dean, A. M., Dykhuizen, D. E. & Hartl, D. L. 1986 Fitness as a function of b-galactosidase function in Escherichia coli. Genet. Res. 48, 1-8. doi:10.1017/ S0016672300024587
-
(1986)
Genet. Res
, vol.48
, pp. 1-8
-
-
Dean, A.M.1
Dykhuizen, D.E.2
Hartl, D.L.3
-
65
-
-
0027463626
-
Do deleterious mutations interact synergistically? Metabolic control theory provides a partial answer
-
Szathmary, E. 1993 Do deleterious mutations interact synergistically? Metabolic control theory provides a partial answer. Genetics 133, 127-132.
-
(1993)
Genetics
, vol.133
, pp. 127-132
-
-
Szathmary, E.1
-
66
-
-
68249108837
-
Positive epistasis drives the acquisition ofmultidrug resistance
-
doi:10.1371/journal.pgen.1000578
-
Trindade, S., Sousa, A., Bivar Xavier, K., Dionisio, F., Godinho Ferreira, M. & Gordo, I. 2009 Positive epistasis drives the acquisition ofmultidrug resistance. PLoS Genet. 5, e1000578. doi:10.1371/journal.pgen.1000578
-
(2009)
PLoS Genet
, vol.5
-
-
Trindade, S.1
Sousa, A.2
Bivar Xavier, K.3
Dionisio, F.4
Godinho Ferreira, M.5
Gordo, I.6
-
67
-
-
77954656202
-
Environmental duress and epistasis: How does stress affect the strength of selection on new mutations?
-
doi:10.1016/j.tree.2010.05.003
-
Agrawal, A. F. & Whitlock, M. C. 2010 Environmental duress and epistasis: how does stress affect the strength of selection on new mutations? Trends Ecol. Evol. 25, 450-458. doi:10.1016/j.tree.2010.05.003
-
(2010)
Trends Ecol. Evol
, vol.25
, pp. 450-458
-
-
Agrawal, A.F.1
Whitlock, M.C.2
-
68
-
-
9444282038
-
Evidence for positive epistasis in HIV-1
-
doi:10. 1126/science.1101786
-
Bonhoeffer, S., Chappey, C., Parkin, N. T., Whitcomb, J. M. & Petropoulos, C. J. 2004 Evidence for positive epistasis in HIV-1. Science 306, 1547-1550. doi:10. 1126/science.1101786
-
(2004)
Science
, vol.306
, pp. 1547-1550
-
-
Bonhoeffer, S.1
Chappey, C.2
Parkin, N.T.3
Whitcomb, J.M.4
Petropoulos, C.J.5
-
69
-
-
3142755598
-
Epistasis and its relationship to canalization in the RNA virus w6
-
doi:10.1534/genetics.103.021196
-
Burch, C. L. & Chao, L. 2004 Epistasis and its relationship to canalization in the RNA virus w6. Genetics 157, 559-567. doi:10.1534/genetics.103.021196
-
(2004)
Genetics
, vol.157
, pp. 559-567
-
-
Burch, C.L.1
Chao, L.2
-
71
-
-
34047099379
-
Distributions of epistasis in microbes fit predictions from a fitness landscape model
-
doi:10.1038/ng1998
-
Martin, G., Elena, S. F. & Lenormand, T. 2007 Distributions of epistasis in microbes fit predictions from a fitness landscape model. Nat. Genet. 39, 555-560. doi:10.1038/ng1998
-
(2007)
Nat. Genet
, vol.39
, pp. 555-560
-
-
Martin, G.1
Elena, S.F.2
Lenormand, T.3
-
72
-
-
23944490117
-
Missense meanderings in sequence space: A biophysical view of protein evolution
-
doi:10.1038/nrg1672
-
DePristo, M. A., Weinreich, D. M. & Hartl, D. L. 2005 Missense meanderings in sequence space: a biophysical view of protein evolution. Nat. Rev. Genet. 6, 678-687. doi:10.1038/nrg1672
-
(2005)
Nat. Rev. Genet
, vol.6
, pp. 678-687
-
-
Depristo, M.A.1
Weinreich, D.M.2
Hartl, D.L.3
-
73
-
-
0036295508
-
Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs
-
doi:10.1016/S0022-2836(02)00400-X
-
Wang, X., Minasov, G. & Shoichet, B. K. 2002 Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs. J. Mol. Biol. 320, 85-95. doi:10.1016/S0022-2836(02)00400-X
-
(2002)
J. Mol. Biol
, vol.320
, pp. 85-95
-
-
Wang, X.1
Minasov, G.2
Shoichet, B.K.3
-
74
-
-
0042373060
-
Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance
-
doi:10.1126/ science.287.5457.1479
-
Bjorkman, J., Nagaev, I., Berg, O. G., Hughes, D. & Andersson, D. I. 2000 Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. Science 287, 1479-1482. doi:10.1126/ science.287.5457.1479
-
(2000)
Science
, vol.287
, pp. 1479-1482
-
-
Bjorkman, J.1
Nagaev, I.2
Berg, O.G.3
Hughes, D.4
Andersson, D.I.5
-
75
-
-
0001498391
-
Experimental studies of pleiotropy and epistasis in Escherichia coli. II. Compensation for maladaptive effects associated with resistance to virus T4
-
doi:10.2307/2409029
-
Lenski, R. E. 1988 Experimental studies of pleiotropy and epistasis in Escherichia coli. II. Compensation for maladaptive effects associated with resistance to virus T4. Evolution 42, 433-440. doi:10.2307/2409029
-
(1988)
Evolution
, vol.42
, pp. 433-440
-
-
Lenski, R.E.1
-
76
-
-
0034089028
-
Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria
-
Levin, B. R., Perrot, V. & Walker, N. 2000 Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria. Genetics 154, 985-997.
-
(2000)
Genetics
, vol.154
, pp. 985-997
-
-
Levin, B.R.1
Perrot, V.2
Walker, N.3
-
77
-
-
34247578808
-
Mitotic recombination accelerates adaptation in the fungus Aspergillus nidulans
-
doi:10.1371/journal.pgen.0030068
-
Schoustra, S. E., Debets, A. J. M., Slakhorst, M. & Hoekstra, R. F. 2007 Mitotic recombination accelerates adaptation in the fungus Aspergillus nidulans. PLoS Genet. 3, e68. doi:10.1371/journal.pgen.0030068
-
(2007)
PLoS Genet
, vol.3
-
-
Schoustra, S.E.1
Debets, A.J.M.2
Slakhorst, M.3
Hoekstra, R.F.4
-
78
-
-
2542635754
-
The evolution of a pleiotropic fitness tradeoff in Pseudomonas fluorescens
-
doi:10.1073/pnas.0307195101
-
MacLean, R. C., Bell, G. & Rainey, P. B. 2004 The evolution of a pleiotropic fitness tradeoff in Pseudomonas fluorescens. Proc. Natl Acad. Sci. USA 101, 8072-8077. doi:10.1073/pnas.0307195101
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 8072-8077
-
-
Maclean, R.C.1
Bell, G.2
Rainey, P.B.3
-
79
-
-
34249794251
-
A negative relationship between mutation pleiotropy and fitness effect in yeast
-
doi:10.1111/j.1558-5646.2007.00109.x
-
Cooper, T. F., Ostrowski, E. A. & Travisano, M. 2007 A negative relationship between mutation pleiotropy and fitness effect in yeast. Evolution 61, 1495-1499. doi:10.1111/j.1558-5646.2007.00109.x
-
(2007)
Evolution
, vol.61
, pp. 1495-1499
-
-
Cooper, T.F.1
Ostrowski, E.A.2
Travisano, M.3
-
80
-
-
21044438202
-
The rate of compensatory mutation in the DNA bacteriophage wX174
-
doi:10.1534/genetics.104.039438
-
Poon, A. & Chao, L. 2005 The rate of compensatory mutation in the DNA bacteriophage wX174. Genetics 170, 989-999. doi:10.1534/genetics.104.039438
-
(2005)
Genetics
, vol.170
, pp. 989-999
-
-
Poon, A.1
Chao, L.2
-
81
-
-
33751310355
-
Functional origins of fitness effect sizes of compensatory mutations in the DNA bacteriophage wX174
-
Poon, A. F. Y. & Chao, L. 2006 Functional origins of fitness effect sizes of compensatory mutations in the DNA bacteriophage wX174. Evolution 60, 2032-2043.
-
(2006)
Evolution
, vol.60
, pp. 2032-2043
-
-
Poon, A.F.Y.1
Chao, L.2
-
82
-
-
1842483226
-
Pervasive joint influence of epistasis and plasticity on mutational effects in Escherichia coli
-
doi:10. 1038/ng1324
-
Remold, S. K. & Lenski, R. E. 2004 Pervasive joint influence of epistasis and plasticity on mutational effects in Escherichia coli. Nat. Genet. 36, 423-426. doi:10. 1038/ng1324
-
(2004)
Nat. Genet
, vol.36
, pp. 423-426
-
-
Remold, S.K.1
Lenski, R.E.2
-
83
-
-
0018343295
-
Efficiency of truncation selection
-
doi:10.1073/pnas.76.1.396
-
Crow, J. F. & Kimura, M. 1979 Efficiency of truncation selection. Proc. Natl Acad. Sci. USA 76, 396-399. doi:10.1073/pnas.76.1.396
-
(1979)
Proc. Natl Acad. Sci. USA
, vol.76
, pp. 396-399
-
-
Crow, J.F.1
Kimura, M.2
-
84
-
-
0025301417
-
Sexual reproduction as an adaptation to resist parasites (a review)
-
doi:10.1073/pnas.87.9.3566
-
Hamilton, W. D., Axelrod, R. & Tanese, R. 1990 Sexual reproduction as an adaptation to resist parasites (a review). Proc. Natl Acad. Sci. USA 87, 3566-3573. doi:10.1073/pnas.87.9.3566
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, pp. 3566-3573
-
-
Hamilton, W.D.1
Axelrod, R.2
Tanese, R.3
-
85
-
-
45849153892
-
Interactions between stressful environment and gene deletions alleviate the expected average loss of fitness in yeast
-
doi:10.1534/ genetics.107.084533
-
Jasnos, L., Tomala, K., Paczesniak, D. & Korona, R. 2008 Interactions between stressful environment and gene deletions alleviate the expected average loss of fitness in yeast. Genetics 178, 2105-2111. doi:10.1534/ genetics.107.084533
-
(2008)
Genetics
, vol.178
, pp. 2105-2111
-
-
Jasnos, L.1
Tomala, K.2
Paczesniak, D.3
Korona, R.4
-
86
-
-
0041853578
-
Environmental stresses can alleviate the average deleterious effect of mutations
-
doi:10.1186/1475-4924-2-14
-
Kishony, R. & Leibler, S. 2003 Environmental stresses can alleviate the average deleterious effect of mutations. J. Biol. 2, 14. doi:10.1186/1475-4924-2-14
-
(2003)
J. Biol
, vol.2
, pp. 14
-
-
Kishony, R.1
Leibler, S.2
-
87
-
-
65649124513
-
Drug interactions and the evolution of antibiotic resistance
-
doi:10. 1038/nrmicro2133
-
Yeh, P. J., Hegreness, M. J., Aiden, A. P. & Kishony, R. 2009 Drug interactions and the evolution of antibiotic resistance. Nat. Rev. Microbiol. 7, 460-466. doi:10. 1038/nrmicro2133
-
(2009)
Nat. Rev. Microbiol
, vol.7
, pp. 460-466
-
-
Yeh, P.J.1
Hegreness, M.J.2
Aiden, A.P.3
Kishony, R.4
-
88
-
-
77649133888
-
Experimental evolution with E. coli in diverse resource environments. I. Fluctuating environments promote divergence of replicate populations
-
doi:10.1186/1471-2148-10-11
-
Cooper, T. F. & Lenski, R. E. 2010 Experimental evolution with E. coli in diverse resource environments. I. Fluctuating environments promote divergence of replicate populations. BMC Evol. Biol. 10, 11. doi:10.1186/1471-2148-10-11
-
(2010)
BMC Evol. Biol
, vol.10
, pp. 11
-
-
Cooper, T.F.1
Lenski, R.E.2
-
89
-
-
0028598147
-
Evidence for multiple adaptive peaks from populations of bacteria evolving in a structured habitat
-
doi:10. 1073/pnas.91.19.9037
-
Korona, R., Nakatsu, C. H., Forney, L. J. & Lenski, R. E. 1994 Evidence for multiple adaptive peaks from populations of bacteria evolving in a structured habitat. Proc. Natl Acad. Sci. USA 91, 9037-9041. doi:10. 1073/pnas.91.19.9037
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 9037-9041
-
-
Korona, R.1
Nakatsu, C.H.2
Forney, L.J.3
Lenski, R.E.4
-
90
-
-
45849137874
-
Heterogeneous adaptive trajectories of small populations on complex fitness landscapes
-
doi:10.1371/jour nal.pone.0001715
-
Rozen, D. E., Habets, M. G. J. L., Handel, A. & de Visser, J. A. G. M. 2008 Heterogeneous adaptive trajectories of small populations on complex fitness landscapes. PLoS ONE 3, e1715. doi:10.1371/jour nal.pone.0001715
-
(2008)
PLoS ONE
, vol.3
-
-
Rozen, D.E.1
Habets, M.G.J.L.2
Handel, A.3
de Visser, J.A.G.M.4
-
91
-
-
25444448797
-
Spontaneous evolution of modularity and network motifs
-
doi:10.1073/pnas.0503610102
-
Kashtan, N. & Alon, U. 2005 Spontaneous evolution of modularity and network motifs. Proc. Natl Acad. Sci. USA 102, 13773-13778. doi:10.1073/pnas.0503610102
-
(2005)
Proc. Natl Acad. Sci. USA 102
, pp. 13773-13778
-
-
Kashtan, N.1
Alon, U.2
-
92
-
-
10744228524
-
Perspective: Evolution and detection of genetic robustness
-
doi:10.1554/02-750R
-
de Visser, J. A. G. M. et al. 2003 Perspective: evolution and detection of genetic robustness. Evolution 57, 1959-1972. doi:10.1554/02-750R
-
(2003)
Evolution
, vol.57
, pp. 1959-1972
-
-
de Visser, J.A.G.M.1
-
93
-
-
14344253574
-
Robustness and evolvability in living systems
-
Princeton, NJ: Princeton University Press
-
Wagner, A. 2005 Robustness and evolvability in living systems. Princeton Studies in Complexity. Princeton, NJ: Princeton University Press.
-
(2005)
Princeton Studies In Complexity
-
-
Wagner, A.1
-
94
-
-
0034919014
-
Interaction between directional epistasis and average mutational effects
-
doi:10.1098/ rspb.2001.1690
-
Wilke, C. O. & Adami, C. 2001 Interaction between directional epistasis and average mutational effects. Proc. R. Soc. Lond. B 268, 1469-1474. doi:10.1098/ rspb.2001.1690
-
(2001)
Proc. R. Soc. Lond. B
, vol.268
, pp. 1469-1474
-
-
Wilke, C.O.1
Adami, C.2
-
95
-
-
33749242962
-
Epistasis correlates to genomic complexity
-
doi:10.1073/pnas.0604543103
-
Sanjuan, R. & Elena, S. F. 2006 Epistasis correlates to genomic complexity. Proc. Natl Acad. Sci. USA 103, 14402-14405. doi:10.1073/pnas.0604543103
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 14402-14405
-
-
Sanjuan, R.1
Elena, S.F.2
-
96
-
-
50549091013
-
A network model for the correlation between epistasis and genomic complexity
-
doi:10.1371/journal.pone. 0002663
-
Sanjuan, R. & Nebot, M. R. 2008 A network model for the correlation between epistasis and genomic complexity. PLoS ONE 3, e2663. doi:10.1371/journal.pone. 0002663
-
(2008)
PLoS ONE
, vol.3
-
-
Sanjuan, R.1
Nebot, M.R.2
-
97
-
-
0345306751
-
The origins of genome complexity
-
doi:10.1126/ science.1089370
-
Lynch, M. & Conery, J. S. 2003 The origins of genome complexity. Science 302, 1401-1404. doi:10.1126/ science.1089370
-
(2003)
Science
, vol.302
, pp. 1401-1404
-
-
Lynch, M.1
Conery, J.S.2
-
98
-
-
0035913336
-
Evolution of digital organisms at high mutation rates leads to survival of the flattest
-
doi:10.1038/35085569
-
Wilke, C. O., Wang, J. L., Ofria, C., Lenski, R. E. & Adami, C. 2001 Evolution of digital organisms at high mutation rates leads to survival of the flattest. Nature 412, 331-333. doi:10.1038/35085569
-
(2001)
Nature
, vol.412
, pp. 331-333
-
-
Wilke, C.O.1
Wang, J.L.2
Ofria, C.3
Lenski, R.E.4
Adami, C.5
-
99
-
-
21044446722
-
Rapid evolutionary escape by large populations from local fitness peaks is likely in nature
-
Weinreich, D. M. & Chao, L. 2005 Rapid evolutionary escape by large populations from local fitness peaks is likely in nature. Evolution 59, 1175-1182.
-
(2005)
Evolution
, vol.59
, pp. 1175-1182
-
-
Weinreich, D.M.1
Chao, L.2
-
100
-
-
36248936497
-
The road to modularity
-
doi:10.1038/nrg2267
-
Wagner, G. P., Pavlicev, M. & Cheverud, J. M. 2007 The road to modularity. Nat. Rev. Genet. 8, 921-931. doi:10.1038/nrg2267
-
(2007)
Nat. Rev. Genet
, vol.8
, pp. 921-931
-
-
Wagner, G.P.1
Pavlicev, M.2
Cheverud, J.M.3
-
101
-
-
79251503942
-
Genome structure and the benefits of sex
-
doi:10.1111/j.1558-5646.2010.01144.x
-
Watson, R. A., Weinreich, D. M. & Wakeley, J. 2011 Genome structure and the benefits of sex. Evolution 65, 523-536. doi:10.1111/j.1558-5646.2010.01144.x
-
(2011)
Evolution
, vol.65
, pp. 523-536
-
-
Watson, R.A.1
Weinreich, D.M.2
Wakeley, J.3
-
102
-
-
79957944389
-
Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme
-
doi:10.1038/nature10083
-
Hayden, E. J., Ferrada, E. & Wagner, A. 2011 Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme. Nature 474, 92-95. doi:10.1038/nature10083
-
(2011)
Nature
, vol.474
, pp. 92-95
-
-
Hayden, E.J.1
Ferrada, E.2
Wagner, A.3
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