Role of pleiotropy during adaptation of TEM-1 β-lactamase to two novel antibiotics

Evolutionary Applications

Volumn 8, Issue 3, 2015, Pages 248-260

  Schenk, Martijn F ^a,b   Witte, Sariette ^b   Salverda, Merijn L M ^b   Koopmanschap, Bertha ^b   Krug, Joachim ^a   de Visser, J Arjan G M ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Antibiotic resistance; Epistasis; Pleiotropy; Protein evolution; TEM 1 lactamase; Trade off

Indexed keywords

EID: 84925373731     PISSN: 17524563     EISSN: 17524571     Source Type: Journal    
DOI: 10.1111/eva.12200     Document Type: Article

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