Extreme synergistic mutational effects in the directed evolution of a baeyer-villiger monooxygenase as catalyst for asymmetric sulfoxidation

Journal of the American Chemical Society

Volumn 136, Issue 49, 2014, Pages 17262-17272

  Zhang, Zhi Gang ^a,b   Lonsdale, Richard ^a,b   Sanchis, Joaquin ^c   Reetz, Manfred T ^a,b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE;

BAEYER-VILLIGER MONOOXYGENASES; DIRECTED EVOLUTION; FITNESS LANDSCAPE; MOLECULAR LEVELS; MUTATIONAL CHANGES; MUTATIONAL EFFECTS; SATURATION MUTAGENESIS; STRUCTURE-BASED;

OXIDATION;

SULFIDE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BAEYER VILLIGER REACTION; CALCULATION; CATALYST; ENANTIOSELECTIVITY; MOLECULAR DOCKING; MUTANT; NONLINEAR SYSTEM; POINT MUTATION; PROTEIN ENGINEERING; SULFOXIDATION;

EID: 84918498017     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja5098034     Document Type: Article

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