Initial mutations direct alternative pathways of protein evolution

PLoS Genetics

Volumn 7, Issue 3, 2011, Pages

  Salverda, Merijn L M ^a   Dellus, Eynat ^b   Gorter, Florien A ^a   Debets, Alfons J M ^a   van der Oost, John ^a   Hoekstra, Rolf F ^a   Tawfik, Dan S ^b   de Visser, J Arjan G M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE TEM 1; CEFOTAXIME; BETA LACTAMASE; BETA-LACTAMASE TEM-1;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BIODIVERSITY; CONTROLLED STUDY; ENZYME ACTIVITY; EPISTASIS; ESCHERICHIA COLI; GENE MUTATION; GENOTYPE; HYDROLYSIS; MOLECULAR EVOLUTION; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; ADAPTATION; ALLELE; AMINO ACID SEQUENCE; BIOLOGICAL MODEL; DRUG EFFECT; GENETIC EPISTASIS; GENETIC SELECTION; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; PLASMID;

ADAPTATION, PHYSIOLOGICAL; ALLELES; AMINO ACID SEQUENCE; BETA-LACTAMASES; CEFOTAXIME; DRUG RESISTANCE, MICROBIAL; EPISTASIS, GENETIC; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; MODELS, GENETIC; MUTATION; PLASMIDS; SELECTION, GENETIC;

EID: 79953738501     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001321     Document Type: Article

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