Design of activated serine-containing catalytic triads with atomic-level accuracy

Nature Chemical Biology

Volumn 10, Issue 5, 2014, Pages 386-391

  Rajagopalan, Sridharan ^a,d   Wang, Chu ^b   Yu, Kai ^a   Kuzin, Alexandre P ^c   Richter, Florian ^a,d,f   Lew, Scott ^c   Miklos, Aleksandr E ^e   Matthews, Megan L ^b   Seetharaman, Jayaraman ^c   Su, Min ^c   Hunt, John F ^c   Cravatt, Benjamin F ^b   Baker, David ^a,d  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Howard Hughes Medical Institute   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e EXCET INC   (United States)

^f HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLASE; NUCLEOPHILE; ORGANOPHOSPHATE; PHOSPHATASE; SERINE;

ACCURACY; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MOLECULAR MODEL; MUTAGENESIS; NUCLEOPHILICITY; PRIORITY JOURNAL;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HYDROLASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SERINE;

EID: 84899486781     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1498     Document Type: Article

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