Intramolecular epistasis and the evolution of a new enzymatic function

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Noor, Sajid ^a,d   Taylor, Matthew C ^a   Russell, Robyn J ^a   Jermiin, Lars S ^a,b,c   Jackson, Colin J ^d   Oakeshott, John G ^a   Scott, Colin ^a  

^a CSIRO   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ATRAZINE CHLOROHYDROLASE; BACTERIAL ENZYME; ENZYME VARIANT; MELAMINE DEAMINASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BIOPHYSICS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STABILITY; EPISTASIS; MOLECULAR EVOLUTION; MOLECULAR MODEL; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; PROTON TRANSPORT; STRUCTURAL HOMOLOGY;

AMINO ACID SUBSTITUTION; AMINO ACIDS; AMINOHYDROLASES; CATALYTIC DOMAIN; ENZYME STABILITY; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; HYDROLASES; KINETICS; MODELS, MOLECULAR; PSEUDOMONAS; TRANSITION TEMPERATURE;

EID: 84863090430     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039822     Document Type: Article

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